{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:09:24Z","timestamp":1790140164306,"version":"4.0.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jid.2016.11.017","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T18:01:04Z","timestamp":1480010464000},"page":"905-909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of\u00a0Melanoma"],"prefix":"10.1016","volume":"137","author":[{"given":"Rachel D.","family":"Melamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraz T.","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geena Susan","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Silvers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Emmett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Rabadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julide Tok","family":"Celebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2016.11.017_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0190-9622(95)90006-3","article-title":"Case-control study of melanocytic nevi on the buttocks in atypical mole syndrome: role of solar radiation in the pathogenesis of atypical moles","volume":"33","author":"Abadir","year":"1995","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.11.017_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.11.017_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jnci\/dju107","article-title":"FBXW7 mutations in melanoma and a new therapeutic paradigm","volume":"106","author":"Aydin","year":"2014","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jid.2016.11.017_bib4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature11071","article-title":"Melanoma genome sequencing reveals frequent PREX2 mutations","volume":"485","author":"Berger","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.11.017_bib5","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/jid.2013.429","article-title":"NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi","volume":"134","author":"Charbel","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2016.11.017_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2016.11.017_bib7","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ng.356","article-title":"Braf(V600E) cooperates with Pten loss to induce metastatic melanoma","volume":"41","author":"Dankort","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2016.11.017_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2012.02.047","article-title":"The dysplastic nevus: from historical perspective to management in the modern era: Part I. Historical, histologic, and clinical aspects","volume":"67","author":"Duffy","year":"2012","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2016.11.017_bib9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1365-2559.2009.03450.x","article-title":"Dysplastic naevi: an update","volume":"56","author":"Elder","year":"2010","journal-title":"Histopathology"},{"key":"10.1016\/j.jid.2016.11.017_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A\u00a0landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jid.2016.11.017_bib11","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ng.2359","article-title":"Exome sequencing identifies recurrent\u00a0somatic RAC1 mutations in melanoma","volume":"44","author":"Krauthammer","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2016.11.017_bib12","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2016.11.017_bib13","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with burrows-wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2016.11.017_bib14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1158\/2159-8290.CD-12-0313","article-title":"Elucidating distinct roles for NF1 in melanomagenesis","volume":"3","author":"Maertens","year":"2013","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jid.2016.11.017_bib15","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of human naevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jid.2016.11.017_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ng.1026","article-title":"Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma","volume":"44","author":"Nikolaev","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2016.11.017_bib17","doi-asserted-by":"crossref","first-page":"E2423","DOI":"10.1002\/humu.22771","article-title":"Oncotator: cancer variant annotation tool","volume":"36","author":"Ramos","year":"2015","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jid.2016.11.017_bib18","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1056\/NEJMoa1502583","article-title":"The genetic evolution of melanoma from precursor lesions","volume":"373","author":"Shain","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2016.11.017_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00008390-199908000-00011","article-title":"Non-random spatial association of melanoma and naevi\u2014a morphometric analysis","volume":"9","author":"Smolle","year":"1999","journal-title":"Melanoma Res"},{"key":"10.1016\/j.jid.2016.11.017_bib20","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic classification of cutaneous melanoma","volume":"161","year":"2015","journal-title":"Cell"},{"issue":"Suppl. 2","key":"10.1016\/j.jid.2016.11.017_bib21","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1752-0509-7-S2-S2","article-title":"SAVI: a statistical algorithm for variant frequency identification","volume":"7","author":"Trifonov","year":"2013","journal-title":"BMC Syst Biol"},{"key":"10.1016\/j.jid.2016.11.017_bib22","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1101\/gad.191999.112","article-title":"Melanoma: from mutations to medicine","volume":"26","author":"Tsao","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2016.11.017_bib23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nature13298","article-title":"Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53","volume":"511","author":"Viros","year":"2014","journal-title":"Nature"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1632663X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X1632663X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:10:12Z","timestamp":1758301812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X1632663X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0022202X1632663X"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2016.11.017","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of\u00a0Melanoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2016.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}