{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:14:22Z","timestamp":1791983662151,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jid.2017.03.036","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T16:45:14Z","timestamp":1493225114000},"page":"1731-1739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["E-Cadherin\u2013Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis"],"prefix":"10.1016","volume":"137","author":[{"given":"Guojiang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuangui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangzhong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Ramot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2017.03.036_bib1","doi-asserted-by":"crossref","first-page":"e39521","DOI":"10.1371\/journal.pone.0039521","article-title":"Persistent DNA damage after high dose in\u00a0vivo gamma exposure of minipig skin","volume":"7","author":"Ahmed","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2017.03.036_bib2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.ecoenv.2008.09.021","article-title":"Exposure to gamma rays induces early alterations in skin in rodents: mechanical, biochemical and structural responses","volume":"72","author":"Balli","year":"2009","journal-title":"Ecotox Environ Safe"},{"key":"10.1016\/j.jid.2017.03.036_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13555-016-0120-y","article-title":"Acute and chronic cutaneous reactions to ionizing radiation therapy","volume":"6","author":"Bray","year":"2016","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.jid.2017.03.036_bib4","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1158\/1078-0432.CCR-12-2747","article-title":"Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER\/PI3K\/Akt\/mTOR and IAP pathways","volume":"19","author":"Brouxhon","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jid.2017.03.036_bib5","doi-asserted-by":"crossref","first-page":"e89234","DOI":"10.1371\/journal.pone.0089234","article-title":"Dissecting the molecular mechanism of ionizing radiation-induced tissue damage in the feather follicle","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2017.03.036_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/10715760400027987","article-title":"PTPs versus PTKs: the redox side of the coin","volume":"39","author":"Chiarugi","year":"2005","journal-title":"Free Radic Res"},{"key":"10.1016\/j.jid.2017.03.036_bib7","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/S0006-3495(95)80142-6","article-title":"H2O2-treated actin: assembly and polymer interactions with cross-linking proteins","volume":"69","author":"DalleDonne","year":"1995","journal-title":"Biophys J"},{"key":"10.1016\/j.jid.2017.03.036_bib8","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1242\/dev.126.20.4557","article-title":"Multiple roles for activated LEF\/TCF transcription complexes during hair follicle development and differentiation","volume":"126","author":"DasGupta","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.jid.2017.03.036_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/1523-1747.ep12682056","article-title":"Ultrastructural alterations in X-irradiated epidermis. I: Basal and spinous layer","volume":"60","author":"De Ray","year":"1973","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2307\/3575081","article-title":"Ultrastructural stereology of X-irradiated epidermis","volume":"77","author":"De Rey","year":"1979","journal-title":"Radiat Res"},{"key":"10.1016\/j.jid.2017.03.036_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.devcel.2010.12.007","article-title":"Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion","volume":"20","author":"DeGennaro","year":"2011","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2017.03.036_bib12","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.peptides.2009.05.010","article-title":"Identification of a novel dual E- and N-cadherin antagonist","volume":"30","author":"Devemy","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.jid.2017.03.036_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1365-2133.2005.06804.x","article-title":"Early epidermal response after a single dose of gamma-rays in organotypic culture of human breast skin","volume":"153","author":"Donetti","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ydbio.2016.05.004","article-title":"Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development","volume":"414","author":"Gauron","year":"2016","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1667\/RR3326.1","article-title":"Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation","volume":"180","author":"Ha","year":"2013","journal-title":"Radiat Res"},{"key":"10.1016\/j.jid.2017.03.036_bib16","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1089\/ars.2012.5000","article-title":"Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases","volume":"20","author":"Holley","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jid.2017.03.036_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaad.2005.08.054","article-title":"Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006","volume":"54","author":"Hymes","year":"2006","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb3136","article-title":"E-cadherin junctions as active mechanical integrators in tissue dynamics","volume":"17","author":"Lecuit","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jid.2015.12.021","article-title":"p53 is a direct transcriptional repressor of keratin 17: lessons from a rat model of radiation dermatitis","volume":"136","author":"Liao","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib20","doi-asserted-by":"crossref","first-page":"173sr2","DOI":"10.1126\/scitranslmed.3005148","article-title":"New paradigms and future challenges in radiation oncology: an update of biological targets and technology","volume":"5","author":"Liauw","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2017.03.036_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ceb.2005.08.009","article-title":"The regulation of cadherin-mediated adhesion by tyrosine phosphorylation\/dephosphorylation of beta-catenin","volume":"17","author":"Lilien","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib22","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s12013-014-9859-x","article-title":"Genistein alleviates radiation-induced pneumonitis by depressing Ape1\/Ref-1 expression to down-regulate inflammatory cytokines","volume":"69","author":"Liu","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.jid.2017.03.036_bib23","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1046\/j.0022-202x.2001.01368.x","article-title":"Patterns of proliferation and apoptosis during murine hair follicle morphogenesis","volume":"116","author":"Magerl","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib24","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.1073\/pnas.82.19.6576","article-title":"Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells","volume":"82","author":"Maher","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2017.03.036_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/1523-1747.ep12479347","article-title":"Radiobiology of the skin: review of some effects on epidermis and hair","volume":"77","author":"Malkinson","year":"1981","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib26","doi-asserted-by":"crossref","first-page":"e12921","DOI":"10.1371\/journal.pone.0012921","article-title":"Abrogation of E-cadherin-mediated cellular aggregation allows proliferation of pluripotent mouse embryonic stem cells in shake flask bioreactors","volume":"5","author":"Mohamet","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2017.03.036_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.critrevonc.2014.05.006","article-title":"Radiation-enhanced cell migration\/invasion process: a review","volume":"92","author":"Moncharmont","year":"2014","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.jid.2017.03.036_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00455575","article-title":"Ultrastructural studies of epidermis in acute radiation dermatitis. Basal lamina thickening and coated vesicles","volume":"262","author":"Oguchi","year":"1978","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2017.03.036_bib29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.devcel.2006.10.010","article-title":"Catenins: keeping cells from getting their signals crossed","volume":"11","author":"Perez-Moreno","year":"2006","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2017.03.036_bib30","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj20011804","article-title":"Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress","volume":"368","author":"Rao","year":"2002","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2017.03.036_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2014.09.010","article-title":"ROS-dependent signal transduction","volume":"33","author":"Reczek","year":"2015","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1083\/jcb.200503009","article-title":"beta-catenin controls cell sorting at the notochord-somite boundary independently of cadherin-mediated adhesion","volume":"170","author":"Reintsch","year":"2005","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phrs.2015.01.003","article-title":"Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors","volume":"94","author":"Roskoski","year":"2015","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jid.2017.03.036_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/bs.ircmb.2015.07.004","article-title":"New insight into the role of reactive oxygen species (ROS) in cellular signal-transduction processes","volume":"319","author":"Russell","year":"2015","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/jid.2011.411","article-title":"Ionizing radiation: the good, the bad, and the ugly","volume":"132","author":"Ryan","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib36","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1667\/RR3031.1","article-title":"Cytokines in radiobiological responses: a review","volume":"178","author":"Schaue","year":"2012","journal-title":"Radiat Res"},{"key":"10.1016\/j.jid.2017.03.036_bib37","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s40257-016-0186-4","article-title":"Radiodermatitis: a review of our current understanding","volume":"17","author":"Singh","year":"2016","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molonc.2009.11.002","article-title":"New specific molecular targets for radio-chemotherapy of rectal cancer","volume":"4","author":"Snipstad","year":"2010","journal-title":"Mol Oncol"},{"key":"10.1016\/j.jid.2017.03.036_bib40","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.canlet.2015.06.008","article-title":"Radioprotective effects of genistein on HL-7702 cells via the inhibition of apoptosis and DNA damage","volume":"366","author":"Song","year":"2015","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jid.2017.03.036_bib41","series-title":"Walter and Miller\u2019s textbook of radiotherapy: radiation physics, therapy and oncology, 7th edition","author":"Symonds","year":"2012"},{"key":"10.1016\/j.jid.2017.03.036_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/09553002.2014.934929","article-title":"Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: the pivotal role of mitochondria","volume":"91","author":"Szumiel","year":"2015","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.jid.2017.03.036_bib43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.devcel.2011.12.025","article-title":"Abl regulates planar polarzed junctional dynamics through b-catenin tyrosine phosphorylation","volume":"22","author":"Tamada","year":"2012","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2017.03.036_bib44","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/j.1460-2075.1992.tb05225.x","article-title":"The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions","volume":"11","author":"Volberg","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2017.03.036_bib45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01756381","article-title":"Radiation enhancement of metastasis: a review","volume":"9","author":"von Essen","year":"1991","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.jid.2017.03.036_bib46","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/jid.2014.409","article-title":"Testing chemotherapeutic agents in the feather follicle identifies a selective blockade of cell proliferation and a key role for sonic hedgehog signaling in chemotherapy-induced tissue damage","volume":"135","author":"Xie","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.03.036_bib47","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","article-title":"Hippo pathway in organ size control, tissue homeostasis, and cancer","volume":"163","author":"Yu","year":"2015","journal-title":"Cell"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X17314288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X17314288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T23:28:24Z","timestamp":1658964504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X17314288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0022202X17314288"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2017.03.036","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"E-Cadherin\u2013Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2017.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}