{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:52:26Z","timestamp":1789786346742,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ek0109028h0002"],"award-info":[{"award-number":["15ek0109028h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jid.2017.04.034","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T17:31:14Z","timestamp":1495042274000},"page":"1975-1983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["CXCL1 Inhibition Regulates UVB-Induced Skin Inflammation and Tumorigenesis in Xpa-Deficient Mice"],"prefix":"10.1016","volume":"137","author":[{"given":"Makoto","family":"Kunisada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Hosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Takemori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nishigori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2017.04.034_bib1","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nprot.2009.120","article-title":"Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications","volume":"4","author":"Abel","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jid.2017.04.034_bib2","first-page":"2151","article-title":"Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase\/apurinic, apyrimidinic lyase, a functional mutM homologue","volume":"57","author":"Aburatani","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2017.04.034_bib3","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1073\/pnas.88.22.10124","article-title":"A\u00a0role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma","volume":"88","author":"Brash","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2017.04.034_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/carcin\/bgs349","article-title":"Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma","volume":"34","author":"Burns","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jid.2017.04.034_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0002-9440(10)62956-2","article-title":"X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness","volume":"167","author":"Cui","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2017.04.034_bib33","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/jid.2011.426","article-title":"Shining a light on xeroderma pigmentosum","volume":"132","author":"DiGiovanna","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2017.04.034_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0163-7258(92)90051-Z","article-title":"Multistage carcinogenesis in mouse skin","volume":"54","author":"DiGiovanni","year":"1992","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jid.2017.04.034_bib34","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/368769a0","article-title":"Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II","volume":"368","author":"Drapkin","year":"1994","journal-title":"Nature"},{"issue":"9573","key":"10.1016\/j.jid.2017.04.034_bib7","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(07)60747-8","article-title":"British Doctors Aspirin T, the UKTIAAT. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies","volume":"369","author":"Flossmann","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2017.04.034_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/carcin\/bgp014","article-title":"The COX-2\/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment","volume":"30","author":"Greenhough","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jid.2017.04.034_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/1523-1747.ep12365625","article-title":"8-hydroxy-2\u2032-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure","volume":"107","author":"Hattori","year":"1996","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.04.034_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1073\/pnas.94.1.11","article-title":"Sunlight and skin cancer: another link revealed","volume":"94","author":"Kraemer","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2017.04.034_bib11","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/hmg\/ddp089","article-title":"Requirement for Shh and Fox family genes at different stages in sweat gland development","volume":"18","author":"Kunisada","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2017.04.034_bib12","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1038\/sj.jid.5701001","article-title":"Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer","volume":"127","author":"Kunisada","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.04.034_bib13","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1158\/0008-5472.CAN-05-0724","article-title":"8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis","volume":"65","author":"Kunisada","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2017.04.034_bib14","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.ajpath.2011.08.042","article-title":"Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis","volume":"179","author":"Kunisada","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2017.04.034_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1523-1747.2000.0883x.x","article-title":"Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice","volume":"114","author":"Kuwamoto","year":"2000","journal-title":"J\u00a0Invest Dermatol"},{"issue":"6357","key":"10.1016\/j.jid.2017.04.034_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/355273a0","article-title":"MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis","volume":"355","author":"Maki","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.jid.2017.04.034_bib17","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.4049\/jimmunol.166.9.5782","article-title":"Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2","volume":"166","author":"Miyauchi-Hashimoto","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2017.04.034_bib18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.0022-202X.2005.23717.x","article-title":"Ultraviolet radiation-induced impairment of tumor rejection is enhanced in xeroderma pigmentosum A gene-deficient mice","volume":"124","author":"Miyauchi-Hashimoto","year":"2005","journal-title":"J\u00a0Invest Dermatol"},{"issue":"6545","key":"10.1016\/j.jid.2017.04.034_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/377165a0","article-title":"High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene","volume":"377","author":"Nakane","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jid.2017.04.034_bib20","doi-asserted-by":"crossref","first-page":"10354","DOI":"10.1073\/pnas.93.19.10354","article-title":"Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes","volume":"93","author":"Nishigori","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2017.04.034_bib21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1039\/B507471A","article-title":"Cellular aspects of photocarcinogenesis","volume":"5","author":"Nishigori","year":"2006","journal-title":"Photochem Photobiol Sci"},{"key":"10.1016\/j.jid.2017.04.034_bib22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1346-8138.2012.01566.x","article-title":"Suppressive effect of recombinant human thioredoxin on ultraviolet light-induced inflammation and apoptosis in murine skin","volume":"39","author":"Ono","year":"2012","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2017.04.034_bib23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2013.09.006","article-title":"Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits","volume":"141","author":"Rushworth","year":"2014","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jid.2017.04.034_bib24","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.bbagen.2013.04.016","article-title":"The chemistry and biological activities of N-acetylcysteine","volume":"1830","author":"Samuni","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2017.04.034_bib25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jdermsci.2016.10.011","article-title":"Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis","volume":"85","author":"Takemori","year":"2017","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2017.04.034_bib26","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/01.HYP.0000184197.11226.71","article-title":"Generation of reactive oxygen species by neutrophils and endothelial cell injury in normal and preeclamptic pregnancies","volume":"46","author":"Tsukimori","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.jid.2017.04.034_bib27","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1084\/jem.20052124","article-title":"CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer","volume":"203","author":"Wang","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2017.04.034_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/mc.10141","article-title":"Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment","volume":"38","author":"Wilgus","year":"2003","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.jid.2017.04.034_bib29","doi-asserted-by":"crossref","first-page":"9311","DOI":"10.1074\/jbc.M111.332395","article-title":"Platelet-activating factor receptor agonists mediate xeroderma pigmentosum A photosensitivity","volume":"287","author":"Yao","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2017.04.034_bib30","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1038\/jid.2014.188","article-title":"Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis","volume":"134","author":"Yogianti","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.04.034_bib31","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/mutage\/ges029","article-title":"Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype","volume":"27","author":"Yogianti","year":"2012","journal-title":"Mutagenesis"},{"key":"10.1016\/j.jid.2017.04.034_bib32","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/372773a0","article-title":"Sunburn and p53 in the onset of skin cancer","volume":"372","author":"Ziegler","year":"1994","journal-title":"Nature"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X17315361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X17315361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T19:31:38Z","timestamp":1656012698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X17315361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0022202X17315361"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2017.04.034","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CXCL1 Inhibition Regulates UVB-Induced Skin Inflammation and Tumorigenesis in Xpa-Deficient Mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2017.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}