{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:01:13Z","timestamp":1791021673243,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jid.2017.06.019","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T15:17:17Z","timestamp":1501168637000},"page":"2316-2325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis"],"prefix":"10.1016","volume":"137","author":[{"given":"Heena","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe-Olivier","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Mashiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Desjardins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martial","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Sen\u00e9cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Constante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela M.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Sarfati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2017.06.019_bib1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jaci.2011.10.025","article-title":"Low diversity of the gut microbiota in infants with atopic eczema","volume":"129","author":"Abrahamsson","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jaci.2010.09.028","article-title":"Dexamethasone regulation of thymic stromal lymphopoietin receptor expression on mast cells and their precursors","volume":"127","author":"Allakhverdi","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jaci.2008.10.022","article-title":"CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation","volume":"123","author":"Allakhverdi","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib4","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1038\/jid.2014.127","article-title":"High Rhodotorula sequences in skin transcriptome of patients with diffuse systemic sclerosis","volume":"134","author":"Arron","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.06.019_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/1874285801509010167","article-title":"The murine lung microbiome changes during lung inflammation and intranasal vancomycin treatment","volume":"9","author":"Barfod","year":"2015","journal-title":"Open Microbiol J"},{"key":"10.1016\/j.jid.2017.06.019_bib6","doi-asserted-by":"crossref","first-page":"19189","DOI":"10.1038\/srep19189","article-title":"Streptomycin treatment alters the intestinal microbiome, pulmonary T cell profile and airway hyperresponsiveness in a cystic fibrosis mouse model","volume":"6","author":"Bazett","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2017.06.019_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1684\/ecn.2013.0325","article-title":"T\u00a0cell abnormalities in systemic sclerosis with a focus on Th17 cells","volume":"23","author":"Brembilla","year":"2012","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.jid.2017.06.019_bib8","doi-asserted-by":"crossref","first-page":"e0125448","DOI":"10.1371\/journal.pone.0125448","article-title":"Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes","volume":"10","author":"Candon","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2017.06.019_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2017.06.019_bib10","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/art.37859","article-title":"Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor beta","volume":"65","author":"Christmann","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2017.06.019_bib11","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm.4176","article-title":"Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation","volume":"22","author":"Fujimura","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2017.06.019_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/1529-0131(199802)41:2<327::AID-ART17>3.0.CO;2-S","article-title":"Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients","volume":"41","author":"Giacomelli","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2017.06.019_bib13","first-page":"2015","article-title":"IL13RA2 gene polymorphisms are associated with systemic sclerosis","volume":"33","author":"Granel","year":"2006","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jid.2017.06.019_bib14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00251-006-0135-0","article-title":"Evaluation of interleukin 13 polymorphisms in systemic sclerosis","volume":"58","author":"Granel","year":"2006","journal-title":"Immunogenetics"},{"key":"10.1016\/j.jid.2017.06.019_bib15","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.ajpath.2011.11.024","article-title":"Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets","volume":"180","author":"Greenblatt","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2017.06.019_bib16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/art.1780400321","article-title":"Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-\u03b3 and tumor necrosis factor \u03b1 in the early disease stage","volume":"40","author":"Gruschwitz","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2017.06.019_bib17","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/s00125-012-2564-7","article-title":"Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse","volume":"55","author":"Hansen","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.jid.2017.06.019_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01548-14","article-title":"Intestinal dysbiosis associated with systemic lupus erythematosus","volume":"5","author":"Hevia","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.jid.2017.06.019_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jaut.2016.05.001","article-title":"Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice","volume":"72","author":"Hu","year":"2016","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2017.06.019_bib20","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.4049\/jimmunol.1500884","article-title":"Maternal antibiotic treatment protects offspring from diabetes development in nonobese diabetic mice by generation of tolerogenic APCs","volume":"195","author":"Hu","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/cei.12609","article-title":"Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1 mice","volume":"181","author":"Johnson","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrendo.2015.218","article-title":"The role of the intestinal microbiota in type 1 diabetes mellitus","volume":"12","author":"Knip","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jid.2017.06.019_bib23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/art.39443","article-title":"Resolution of skin fibrosis by neutralization of the antifibrinolytic function of plasminogen activator inhibitor 1","volume":"68","author":"Lemaire","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2017.06.019_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000082331","article-title":"Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma","volume":"135","author":"Matsushita","year":"2004","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib25","doi-asserted-by":"crossref","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","article-title":"Phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2017.06.019_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08916934.2016.1230848","article-title":"Topoisomerase I peptide-loaded dendritic cells induce autoantibody response as well as skin and lung fibrosis","volume":"49","author":"Mehta","year":"2016","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jid.2017.06.019_bib27","article-title":"Dabigatran aggravates topoisomerase I peptide-loaded dendritic cells-induced lung and skin fibrosis","author":"Mehta","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jid.2017.06.019_bib28","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1225152","article-title":"Compartmentalized control of skin immunity by resident commensals","volume":"337","author":"Naik","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jid.2017.06.019_bib29","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/1529-0131(200011)43:11<2583::AID-ANR28>3.0.CO;2-U","article-title":"Oral antibiotics as a novel therapy for arthritis: evidence for a beneficial effect of intestinal Escherichia coli","volume":"43","author":"Nieuwenhuis","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2017.06.019_bib30","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.4049\/jimmunol.0900747","article-title":"Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis","volume":"183","author":"Ochoa-Reparaz","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib31","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1002\/art.34643","article-title":"Potential roles of interleukin-17A in the development of skin fibrosis in mice","volume":"64","author":"Okamoto","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2017.06.019_bib32","unstructured":"Oksanen J, Blanchet FG, Kindt R, Legendre P, Minchin PR, O'Hara RB, et\u00a0al. vegan: Community Ecology Package. R package version 2.3-2. http:\/\/CRAN.R-project.org\/package=vegan;\u00a02015. Accessed 18 July 2016."},{"key":"10.1016\/j.jid.2017.06.019_bib33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.1219328","article-title":"Microbial exposure during early life has persistent effects on natural killer T cell function","volume":"336","author":"Olszak","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jid.2017.06.019_bib34","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","article-title":"Pathogenesis of systemic sclerosis","volume":"6","author":"Pattanaik","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jaci.2013.05.043","article-title":"Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood","volume":"132","author":"Penders","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib36","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. http:\/\/www.R-project.org\/;\u00a02015. Accessed 18 July 2016."},{"key":"10.1016\/j.jid.2017.06.019_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1084\/jem.20150567","article-title":"Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses","volume":"213","author":"Ruane","year":"2016","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2017.06.019_bib38","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/embor.2012.32","article-title":"Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma","volume":"13","author":"Russell","year":"2012","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jid.2017.06.019_bib39","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jaci.2014.06.027","article-title":"Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases","volume":"135","author":"Russell","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib40","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4161\/gmic.23567","article-title":"Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma","volume":"4","author":"Russell","year":"2013","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jid.2017.06.019_bib41","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fmicb.2015.01085","article-title":"Regulation of lung immunity and host defense by the intestinal microbiota","volume":"6","author":"Samuelson","year":"2015","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jid.2017.06.019_bib42","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/art.39658","article-title":"Identification of optimal mouse models of systemic sclerosis by interspecies comparative genomics","volume":"68","author":"Sargent","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2017.06.019_bib43","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1093\/rheumatology\/keu246","article-title":"Involvement of CD161+ Vdelta1+ gammadelta T cells in systemic sclerosis: association with interstitial pneumonia","volume":"53","author":"Segawa","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.jid.2017.06.019_bib44","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/art.37860","article-title":"Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement","volume":"65","author":"Truchetet","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2017.06.019_bib45","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1002\/art.39817","article-title":"Platelets induce thymic stromal lymphopoietin production by endothelial cells: contribution to human systemic sclerosis fibrosis","volume":"68","author":"Truchetet","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2017.06.019_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jdermsci.2012.10.003","article-title":"Circulating gamma\/delta T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts","volume":"69","author":"Ueda-Hayakawa","year":"2013","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2017.06.019_bib47","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1136\/annrheumdis-2012-202279","article-title":"A\u00a0profibrotic role for thymic stromal lymphopoietin in systemic sclerosis","volume":"72","author":"Usategui","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2017.06.019_bib48","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/art.39572","article-title":"Association of systemic sclerosis with a unique colonic microbial consortium","volume":"68","author":"Volkmann","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2017.06.019_bib49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-immunol-032712-095937","article-title":"The immunology of fibrosis","volume":"31","author":"Wick","year":"2013","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.jid.2017.06.019_bib50","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1186\/ar4430","article-title":"Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction","volume":"16","author":"Yang","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jid.2017.06.019_bib51","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/jid.2013.228","article-title":"The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation","volume":"133","author":"Yockey","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2017.06.019_bib52","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.2353\/ajpath.2008.080622","article-title":"NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora","volume":"173","author":"Yokote","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2017.06.019_bib53","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.chom.2015.04.010","article-title":"Microbiota and autoimmunity: exploring new avenues","volume":"17","author":"Yurkovetskiy","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jid.2017.06.019_bib54","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1038\/ncomms9424","article-title":"Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis","volume":"6","author":"Zanvit","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2017.06.019_bib55","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/bioinformatics\/btt593","article-title":"PEAR: a fast and accurate Illumina Paired-End reAd mergeR","volume":"30","author":"Zhang","year":"2014","journal-title":"Bioinformatics"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X17318547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X17318547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T14:07:58Z","timestamp":1602598078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X17318547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":55,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0022202X17318547"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2017.06.019","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2017.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}