{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:23:35Z","timestamp":1787783015036,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI10\/02234"],"award-info":[{"award-number":["PI10\/02234"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jid.2018.07.026","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T11:59:37Z","timestamp":1534593577000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus"],"prefix":"10.1016","volume":"139","author":[{"given":"Cristina","family":"Sol\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Molin\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Ordi-Ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Cort\u00e9s-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2018.07.026_bib1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13075-015-0706-2","article-title":"Pathophysiology of cutaneous lupus erythematosus","volume":"17","author":"Actman","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jid.2018.07.026_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.autrev.2008.12.014","article-title":"Histologic features of cutaneous lupus erythematosus","volume":"8","author":"Baltaci","year":"2009","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2018.07.026_bib3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ni.f.209","article-title":"MicroRNAs: new regulators of immune cell development and function","volume":"9","author":"Baltimore","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2018.07.026_bib4","first-page":"869","article-title":"Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils ant T lymphocytes","volume":"139","author":"Barker","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2018.07.026_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","article-title":"The two NF-\u03baB activation pathways and their role in innate and adaptive immunity","volume":"25","author":"Bonizzi","year":"2004","journal-title":"Trends Immunol"},{"issue":"5","key":"10.1016\/j.jid.2018.07.026_bib6","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/j.jid.2017.02.001","article-title":"The molecular revolution in cutaneous biology: noncoding RNAs: new molecular players in dermatology and cutaneous biology","volume":"137","author":"Botchkareva","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.07.026_bib7","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1056\/NEJMcibr060065","article-title":"MicroRNAs as therapeutic targets","volume":"354","author":"Czech","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2018.07.026_bib8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ygeno.2014.06.003","article-title":"Differential gene expression analysis in CCLE lesions provides new insights regarding the genetics basis of skin vs. systemic disease","volume":"104","author":"Dey-Rao","year":"2014","journal-title":"Genomics"},{"key":"10.1016\/j.jid.2018.07.026_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13395-016-0110-x","article-title":"PGC-1\u03b1 modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle","volume":"6","author":"Dinulovi","year":"2016","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.jid.2018.07.026_bib10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1046\/j.1365-2249.1999.01026.x","article-title":"Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody-mediated cytotoxicity","volume":"118","author":"Furukawa","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2018.07.026_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fimmu.2012.00245","article-title":"The role of the PI3K signaling pathway in CD4+ T cell differentiation and function","volume":"3","author":"Han","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2018.07.026_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/jid.2013.269","article-title":"Dominant Th1 and minimal Th17 skewing in discoid lupus revealed by transcriptomic comparison with psoriasis","volume":"134","author":"Jabbari","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.07.026_bib13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.0906-6705.2005.00279.x","article-title":"UVB-induced leucocyte trafficking in the epidermis of photosensitive lupus erythematosus patients: normal depletion of Langerhans cells","volume":"14","author":"Janssens","year":"2005","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2018.07.026_bib14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2018.07.026_bib15","doi-asserted-by":"crossref","first-page":"15923","DOI":"10.1038\/srep15923","article-title":"Evidence for microRNA-31 dependent Bim-Bax interaction preceding mitochondrial Bax translocation during radiation-induced apoptosis","volume":"5","author":"Kuma","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2018.07.026_bib16","doi-asserted-by":"crossref","first-page":"e2159","DOI":"10.1038\/cddis.2016.27","article-title":"MiR485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1\u03b1 expression","volume":"7","author":"Lou","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2018.07.026_bib17","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00109-012-0924-x","article-title":"MicroRNA-31 modulates tumour sensitivity to radiation in\u00a0oesophageal adenocarcinoma","volume":"90","author":"Lynam-Lennon","year":"2012","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.jid.2018.07.026_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2500\/aap.2017.38.4013","article-title":"Involvement of microRNAs in skin disorders: a literature review","volume":"38","author":"Mannucci","year":"2017","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jid.2018.07.026_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nri2708","article-title":"Physiological and pathological roles for microRNAs in the immune system","volume":"10","author":"O\u2019Connell","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2018.07.026_bib20","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/art.10577","article-title":"Involvement of the interferon-gamma-induced T cell-attracting chemokines, inteferon-gamma-inducible 10-kd protein (CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions of patients with Sj\u00f6gren\u2019s syndrome","volume":"46","author":"Ogawa","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2018.07.026_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.berh.2013.07.008","article-title":"Cutaneous lupus erythematosus: diagnosis and treatment","volume":"27","author":"Onkon","year":"2013","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jid.2018.07.026_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","article-title":"T\u00a0cell activation","volume":"27","author":"Smith-Garvin","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2018.07.026_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/bjd.14539","article-title":"Microarray study reveals a transforming growth factor-\u03b2-dependent mechanism of fibrosis in discoid lupus erythematosus","volume":"175","author":"Sol\u00e9","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2018.07.026_bib24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/mrd.22678","article-title":"Function and regulation of microRNA-31 in development and disease","volume":"83","author":"Stepicheva","year":"2016","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.jid.2018.07.026_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000353358","article-title":"Neutrophil-derived cytokines involved in physiological and pathological angiogenesis","volume":"99","author":"Tecchio","year":"2014","journal-title":"Chem Immunol Allergy"},{"key":"10.1016\/j.jid.2018.07.026_bib26","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1161\/ATVBAHA.114.304650","article-title":"Non-classical patrolling monocyte function in the vasculature","volume":"35","author":"Thomas","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2018.07.026_bib27","doi-asserted-by":"crossref","first-page":"e2817","DOI":"10.1371\/journal.pntd.0002817","article-title":"Circulating CD14brightCD16+ \u2018intermediate\u2019 monocyte exhibit enhanced parasite pattern recognition in human helminth infection","volume":"8","author":"Turner","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jid.2018.07.026_bib28","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1073\/pnas.84.16.5788","article-title":"Transforming growth factor type beta induces monocytes chemotaxis and\u00a0growth factor production","volume":"84","author":"Wahl","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2018.07.026_bib29","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.18632\/oncotarget.12534","article-title":"Role of an imbalanced miRNAs axis in pathogenesis of psoriasis: novel perspectives based on review of the literature","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2018.07.026_bib30","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1113\/JP270453","article-title":"Protein kinase C bidirectionally modulates Ih and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons","volume":"13","author":"Williams","year":"2015","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.jid.2018.07.026_bib31","doi-asserted-by":"crossref","first-page":"678","DOI":"10.4049\/jimmunol.1202695","article-title":"MicroRNA-31 is overexpressed in psoriasis and modulates\u00a0inflammatory cytokine and chemokine production in keratinocytes via\u00a0targeting serine\/threonine kinase 40","volume":"190","author":"Xu","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2018.07.026_bib32","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.1038\/ncomms8652","article-title":"NF-\u03baB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis","volume":"6","author":"Yan","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2018.07.026_bib33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4110\/in.2014.14.3.138","article-title":"MicroRNA regulation in systemic lupus erythematosus pathogenesis","volume":"14","author":"Yan","year":"2014","journal-title":"Immune Netw"},{"key":"10.1016\/j.jid.2018.07.026_bib34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaut.2013.01.007","article-title":"Immunologic and genetic considerations of cutaneous lupus erythematosus: a comprehensive review","volume":"41","author":"Yu","year":"2013","journal-title":"J\u00a0Autoimmun"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X18324795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X18324795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:41:39Z","timestamp":1762206099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X18324795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0022202X18324795"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2018.07.026","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2018.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}