{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:18:54Z","timestamp":1792891134135,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jid.2018.09.001","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T01:30:58Z","timestamp":1539999058000},"page":"2295-2300.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":284,"title":["Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool"],"prefix":"10.1016","volume":"138","author":[{"given":"Helen","family":"Alexander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Danby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Flohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2018.09.001_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1034\/j.1600-0846.2001.007001040.x","article-title":"Physical and physiological effects of stratum corneum tape stripping","volume":"7","author":"Bashir","year":"2001","journal-title":"Skin Res Technol"},{"key":"10.1016\/j.jid.2018.09.001_bib2","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.jaci.2007.08.067","article-title":"Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data","volume":"120","author":"Baurecht","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2018.09.001_bib3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1046\/j.1523-1747.2001.01262.x","article-title":"Attenuated total reflection-Fourier transform infrared spectroscopy as a possible method to investigate biophysical parameters of stratum corneum in\u00a0vivo","volume":"116","author":"Brancaleon","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1067\/mjd.2002.124617","article-title":"Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity","volume":"47","author":"Chamlin","year":"2002","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/jid.2009.272","article-title":"The extent of orthorhombic lipid phases in the stratum corneum determines the barrier efficiency of human skin in\u00a0vivo","volume":"130","author":"Damien","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2133.2011.10395.x","article-title":"The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis","volume":"165","author":"Danby","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib7","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/bjd.14684","article-title":"A\u00a0functional mechanistic study of the effect of emollients on the structure and function of the skin barrier","volume":"175","author":"Danby","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejpb.2016.12.012","article-title":"Assessment of skin barrier function and biochemical changes of ex\u00a0vivo human skin in response to physical and chemical barrier disruption","volume":"116","author":"D\u00f6ge","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.jid.2018.09.001_bib9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11882-008-0048-0","article-title":"Skin barrier function","volume":"8","author":"Elias","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jid.2018.09.001_bib10","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.tiv.2009.06.030","article-title":"Transepidermal water loss for probing full-thickness skin barrier function: correlation with tritiated water flux, sensitivity to punctures and diverse surfactant exposures","volume":"23","author":"Elmahjoubi","year":"2009","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.jid.2018.09.001_bib11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1600-0846.2009.00376.x","article-title":"Measuring transepidermal water loss: A comparative in\u00a0vivo study of condenser-chamber, unventilated-chamber and open-chamber systems","volume":"15","author":"Farahmand","year":"2009","journal-title":"Ski Res Technol"},{"issue":"Suppl","key":"10.1016\/j.jid.2018.09.001_bib12","doi-asserted-by":"crossref","first-page":"S417","DOI":"10.1194\/jlr.R800039-JLR200","article-title":"The outer frontier: the importance of lipid metabolism in the skin","volume":"50","author":"Feingold","year":"2009","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jid.2018.09.001_bib13","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1365-2133.2010.10068.x","article-title":"Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age","volume":"163","author":"Flohr","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1600-0625.2006.00437.x","article-title":"Transepidermal water loss reflects permeability barrier status: validation in human and rodent in\u00a0vivo and ex\u00a0vivo models","volume":"15","author":"Fluhr","year":"2006","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib15","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1172\/JCI117919","article-title":"The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model","volume":"95","author":"Ghadially","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2018.09.001_bib16","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.0022-202X.2005.23651.x","article-title":"Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factor-alpha and interferon-gamma in human epidermis","volume":"124","author":"Hatano","year":"2005","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.alit.2015.09.004","article-title":"Transepidermal water loss measurement during infancy can predict the subsequent development of atopic dermatitis regardless of filaggrin mutations","volume":"65","author":"Horimukai","year":"2016","journal-title":"Allergol Int"},{"key":"10.1016\/j.jid.2018.09.001_bib18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1468-2494.2008.00476.x","article-title":"Closed-chamber transepidermal water loss measurement: microclimate, calibration and performance","volume":"31","author":"Imhof","year":"2009","journal-title":"Int J Cosmet Sci"},{"key":"10.1016\/j.jid.2018.09.001_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2014.12.013","article-title":"Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year","volume":"135","author":"Kelleher","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2018.09.001_bib20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000211136","article-title":"In\u00a0vivo evaluation of the stratum corneum barrier function in blacks, Caucasians and Asians with two noninvasive methods","volume":"6","author":"Kompaore","year":"1993","journal-title":"Skin Pharmacol"},{"key":"10.1016\/j.jid.2018.09.001_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00403-012-1313-6","article-title":"Transepidermal water loss in young and aged healthy humans: A systematic review and meta-analysis","volume":"305","author":"Kottner","year":"2013","journal-title":"Arch Dermatol Res"},{"issue":"1\u20132","key":"10.1016\/j.jid.2018.09.001_bib22","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijpharm.2007.08.028","article-title":"Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model","volume":"354","author":"Kuntsche","year":"2008","journal-title":"Int J Pharm"},{"key":"10.1016\/j.jid.2018.09.001_bib23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1046\/j.0022-202x.2001.01433.x","article-title":"Analysis of circadian and ultradian rhythms of skin surface properties of face and forearm of healthy women","volume":"117","author":"Le Fur","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jconrel.2004.11.035","article-title":"The correlation between transepidermal water loss and percutaneous absorption: an overview","volume":"103","author":"Levin","year":"2005","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.jid.2018.09.001_bib25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000314138","article-title":"Sun-induced changes in stratum corneum function are gender and dose dependent in a Chinese population","volume":"23","author":"Liu","year":"2010","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.jid.2018.09.001_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1034\/j.1600-0846.2003.00354.x","article-title":"Impact of stress of marital dissolution on skin barrier recovery: tape stripping and measurement of trans-epidermal water loss (TEWL)","volume":"9","author":"Muizzuddin","year":"2003","journal-title":"Skin Res Technol"},{"key":"10.1016\/j.jid.2018.09.001_bib27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF02441040","article-title":"Measurement of water exchange through skin","volume":"15","author":"Nilsson","year":"1977","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.jid.2018.09.001_bib28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/BF00376819","article-title":"Development of a stratum corneum and barrier function in an organotypic skin culture","volume":"285","author":"Nolte","year":"1993","journal-title":"Arch Dermatol\u00a0Res"},{"key":"10.1016\/j.jid.2018.09.001_bib29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0536.1990.tb01553.x","article-title":"Guidelines for transepidermal water loss (TEWL) measurement","volume":"22","author":"Pinnagoda","year":"1990","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2018.09.001_bib30","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1001\/archderm.1995.01690220040008","article-title":"Skin type, but neither race nor gender, influence epidermal permeability barrier function","volume":"131","author":"Reed","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000056341","article-title":"EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences","volume":"14","author":"Rogiers","year":"2001","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1016\/j.jid.2018.09.001_bib32","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archderm.139.11.1417","article-title":"The Objective Severity Assessment of Atopic Dermatitis Score","volume":"139","author":"Sugarman","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib33","first-page":"434","article-title":"Pilot comparative study of the topical action of a novel, crosslinked resilient hyaluronic acid on skin hydration and barrier function in a dynamic, three-dimensional human explant model","volume":"15","author":"Sundaram","year":"2016","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.jid.2018.09.001_bib34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tiv.2018.04.009","article-title":"Transepidermal water loss and skin conductance as barrier integrity tests","volume":"51","author":"Zhang","year":"2018","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.jid.2018.09.001_bib35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.mad.2017.11.011","article-title":"Age influences the skin reaction pattern to mechanical stress and its repair level through skin care products","volume":"170","author":"Zouboulis","year":"2018","journal-title":"Mech Ageing Dev"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X18325764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X18325764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T19:07:27Z","timestamp":1572635247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X18325764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0022202X18325764"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2018.09.001","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2018.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Society for Investigative Dermatology","name":"copyright","label":"Copyright"}]}}