{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:27Z","timestamp":1791229587144,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR061106"],"award-info":[{"award-number":["R01 AR061106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002886","name":"Foundation for Ichthyosis and Related Skin Types","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002886","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Helen Diller Family Comprehensive Cancer Center","award":["P30 CA082103"],"award-info":[{"award-number":["P30 CA082103"]}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jid.2018.11.005","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T06:07:57Z","timestamp":1542866877000},"page":"760-768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte\u00a0Lipid Envelope"],"prefix":"10.1016","volume":"139","author":[{"given":"Debra","family":"Crumrine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Khnykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Krieg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Qiang","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Celli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-0070","authenticated-orcid":false,"given":"Theodora M.","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan S.","family":"Wakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopinathan","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Mauldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Miner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meei-Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Brash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Sprecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz P.W.","family":"Radner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Choate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Roop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2018.11.005_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdermsci.2017.06.002","article-title":"Corneocyte lipid envelope (CLE), the key structure for skin barrier function and ichthyosis pathogenesis","volume":"88","author":"Akiyama","year":"2017","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2018.11.005_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1523-1747.2000.00846.x","article-title":"Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function","volume":"114","author":"Behne","year":"2000","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib3","doi-asserted-by":"crossref","first-page":"23679","DOI":"10.1074\/jbc.274.34.23679","article-title":"Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate","volume":"274","author":"Brash","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2018.11.005_bib4","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1111\/j.1742-4658.2007.05909.x","article-title":"The hepoxilin connection in the epidermis","volume":"274","author":"Brash","year":"2007","journal-title":"FEBS J"},{"key":"10.1016\/j.jid.2018.11.005_bib5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jid.2018.11.005_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/jamadermatol.2014.3369","article-title":"Cellular basis of secondary infections and impaired desquamation in certain inherited ichthyoses","volume":"151","author":"Chan","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib7","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1038\/jid.2013.153","article-title":"Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length","volume":"133","author":"Eckl","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1523-1747.2000.00124-5.x","article-title":"Origin\u00a0of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes","volume":"115","author":"Elias","year":"2000","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbalip.2013.09.011","article-title":"Formation and functions of the corneocyte lipid envelope (CLE)","volume":"1841","author":"Elias","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2018.11.005_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1600-0625.2001.110308.x","article-title":"Basis for the permeability barrier abnormality in lamellar ichthyosis","volume":"11","author":"Elias","year":"2002","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib11","article-title":"Ichthyoses\u2014clinical, biochemical, pathogenic, and diagnostic assessment","volume":"vol. 39","author":"Elias","year":"2010"},{"key":"10.1016\/j.jid.2018.11.005_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1001\/archderm.135.7.823","article-title":"Altered lamellar body secretion and stratum corneum membrane structure in Netherton syndrome: differentiation from other infantile erythrodermas and pathogenic implications","volume":"135","author":"Fartasch","year":"1999","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib13","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/jid.2009.57","article-title":"Autosomal recessive congenital ichthyosis","volume":"129","author":"Fischer","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/ng1325","article-title":"Mutations in VPS33B, encoding a regulator of\u00a0SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome","volume":"36","author":"Gissen","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2018.11.005_bib15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jid.2016.08.036","article-title":"PNPLA1 deficiency in mice and humans leads to a defect in the synthesis of omega-O-acylceramides","volume":"137","author":"Grond","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jid.2016.09.025","article-title":"Skin barrier development depends on CGI-58 protein expression during late-stage keratinocyte differentiation","volume":"137","author":"Grond","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib17","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jid.2016.12.010","article-title":"Autosomal recessive keratoderma-ichthyosis-deafness (ARKID) syndrome is caused by VPS33B mutations affecting Rab protein interaction and collagen modification","volume":"137","author":"Gruber","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib18","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/sj.jid.5700288","article-title":"Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome","volume":"126","author":"Hachem","year":"2006","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1001\/archderm.144.3.334","article-title":"Defective lamellar granule secretion in arthrogryposis, renal dysfunction, and cholestasis syndrome caused by a mutation in VPS33B","volume":"144","author":"Hershkovitz","year":"2008","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0022-2275(20)41537-8","article-title":"Structure and evolution of the lipase superfamily","volume":"33","author":"Hide","year":"1992","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jid.2018.11.005_bib21","doi-asserted-by":"crossref","first-page":"14609","DOI":"10.1038\/ncomms14609","article-title":"PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis","volume":"8","author":"Hirabayashi","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2018.11.005_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cbd.2010.05.004","article-title":"Comparative studies of mammalian acid lipases: evidence for a new gene family in mouse and rat (Lipo)","volume":"5","author":"Holmes","year":"2010","journal-title":"Comp Biochem Physiol Part D Genomics Proteomics"},{"key":"10.1016\/j.jid.2018.11.005_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/1523-1747.ep12461361","article-title":"Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction","volume":"96","author":"Hou","year":"1991","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ajhg.2011.02.011","article-title":"A\u00a0mutation in LIPN, encoding epidermal lipase N, causes a late-onset form of autosomal-recessive congenital ichthyosis","volume":"88","author":"Israeli","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2018.11.005_bib25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/hmg\/ddr494","article-title":"Loss of ceramide synthase 3 causes lethal skin barrier disruption","volume":"21","author":"Jennemann","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2018.11.005_bib26","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1242\/jcs.114.17.3069","article-title":"Assembly of the epidermal cornified cell envelope","volume":"114","author":"Kalinin","year":"2001","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2018.11.005_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plipres.2016.04.001","article-title":"Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides","volume":"63","author":"Kihara","year":"2016","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jid.2018.11.005_bib28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.bbalip.2013.08.005","article-title":"The role of lipoxygenases in epidermis","volume":"1841","author":"Krieg","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2018.11.005_bib29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jid.2012.250","article-title":"Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation","volume":"133","author":"Krieg","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib30","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1038\/jid.2012.173","article-title":"Cellular changes that accompany shedding of human corneocytes","volume":"132","author":"Lin","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/intimm\/dxv013","article-title":"Dissecting the formation, structure and barrier function of the stratum corneum","volume":"27","author":"Matsui","year":"2015","journal-title":"Int Immunol"},{"key":"10.1016\/j.jid.2018.11.005_bib32","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.ajpath.2018.02.008","article-title":"Cellular and metabolic basis for the Ichthyotic phenotype in NIPAL4 (Ichthyin)-deficient canines","volume":"188","author":"Mauldin","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2018.11.005_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s004030000160","article-title":"Relationship between covalently bound ceramides and transepidermal water loss (TEWL)","volume":"292","author":"Meguro","year":"2000","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2018.11.005_bib34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2133.1992.tb00675.x","article-title":"Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation","volume":"126","author":"Menon","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/1523-1747.ep12355263","article-title":"Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis","volume":"86","author":"Menon","year":"1986","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib36","doi-asserted-by":"crossref","first-page":"15912","DOI":"10.1074\/jbc.M701779200","article-title":"Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4\/Fatp4 mutant mice","volume":"282","author":"Moulson","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2018.11.005_bib37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbalip.2013.08.020","article-title":"The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier","volume":"1841","author":"Munoz-Garcia","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2018.11.005_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/emm.1999.2","article-title":"Bricks and mortar of the\u00a0epidermal barrier","volume":"31","author":"Nemes","year":"1999","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jid.2018.11.005_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2133.1994.tb08452.x","article-title":"Quantification of stratum corneum ceramides and lipid envelope ceramides in the hereditary ichthyoses","volume":"131","author":"Paige","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1023\/A:1026438917856","article-title":"Microwave incubation improves lipolytic enzyme preservation for ultrastructural cytochemistry","volume":"29","author":"Rassner","year":"1997","journal-title":"Histochem J"},{"key":"10.1016\/j.jid.2018.11.005_bib41","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.0022-202X.2004.22431.x","article-title":"Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)","volume":"122","author":"Schmuth","year":"2004","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yadr.2007.07.011","article-title":"Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders","volume":"23","author":"Schmuth","year":"2007","journal-title":"Adv Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib43","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1194\/jlr.R800001-JLR200","article-title":"Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology","volume":"49","author":"Schmuth","year":"2008","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jid.2018.11.005_bib44","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1091\/mbc.10.12.4247","article-title":"Initiation of assembly of the cell envelope barrier structure of stratified squamous epithelia","volume":"10","author":"Steinert","year":"1999","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jid.2018.11.005_bib45","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/j.0022-202X.2004.23491.x","article-title":"Decreased levels of covalently bound ceramide are associated with ultraviolet B-induced perturbation of the skin barrier","volume":"123","author":"Takagi","year":"2004","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib46","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1038\/jid.2010.145","article-title":"Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome","volume":"130","author":"Uchida","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jdermsci.2008.01.002","article-title":"Omega-O-acylceramide, a lipid essential for mammalian survival","volume":"51","author":"Uchida","year":"2008","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2018.11.005_bib48","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/0006-291X(86)90323-2","article-title":"Covalent attachment of \u03c9-hydroxyacid derivatives to epidermal macromolecules: a preliminary characterization","volume":"137","author":"Wertz","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2018.11.005_bib49","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/1523-1747.ep12277394","article-title":"The role of the corneocyte lipid envelope in cohesion of the stratum corneum","volume":"93","author":"Wertz","year":"1989","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib50","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1040-0486(00)90011-5","article-title":"Ichthyosis: where we have\u00a0been. Disorders of cornification: where we are going","volume":"12","author":"Williams","year":"2000","journal-title":"Curr Probl Dermatol"},{"key":"10.1016\/j.jid.2018.11.005_bib51","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1194\/jlr.R200007-JLR200","article-title":"The lipase gene family","volume":"43","author":"Wong","year":"2002","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jid.2018.11.005_bib52","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11745-007-3054-4","article-title":"Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPAR\u03b1","volume":"42","author":"Yu","year":"2007","journal-title":"Lipids"},{"key":"10.1016\/j.jid.2018.11.005_bib53","doi-asserted-by":"crossref","first-page":"e0161465","DOI":"10.1371\/journal.pone.0161465","article-title":"Defects in stratum corneum desquamation are the predominant effect of impaired Abca12 function in a novel mouse model of harlequin ichthyosis","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2018.11.005_bib54","doi-asserted-by":"crossref","first-page":"24046","DOI":"10.1074\/jbc.M111.251496","article-title":"Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope","volume":"286","author":"Zheng","year":"2011","journal-title":"J\u00a0Biol Chem"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X18328288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X18328288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:12:36Z","timestamp":1758301956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X18328288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0022202X18328288"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2018.11.005","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte\u00a0Lipid Envelope","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2018.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}