{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:44:48Z","timestamp":1792205088968,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003038","name":"Elektrobit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH-18-1-0382"],"award-info":[{"award-number":["W81XWH-18-1-0382"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002077","name":"Epidermolysis Bullosa Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jid.2019.01.011","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T02:44:25Z","timestamp":1548297865000},"page":"1497-1505.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Thrombospondin-1 Is a Major Activator of TGF-\u03b2 Signaling in Recessive Dystrophic Epidermolysis Bullosa Fibroblasts"],"prefix":"10.1016","volume":"139","author":[{"given":"Velina S.","family":"Atanasova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yok Zuan","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suma","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacia","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Guttmann-Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7307-3898","authenticated-orcid":false,"given":"Julio C.","family":"Salas-Alanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Fertala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"South","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.01.011_bib1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0002-9440(10)64243-5","article-title":"The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1\/TSP2-null mice","volume":"161","author":"Agah","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.01.011_bib2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0945-053X(98)90100-7","article-title":"Two-hybrid analysis reveals multiple direct interactions for thrombospondin 1","volume":"17","author":"Aho","year":"1998","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2019.01.011_bib3","doi-asserted-by":"crossref","first-page":"32167","DOI":"10.1074\/jbc.M003834200","article-title":"Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity","volume":"275","author":"Bein","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.01.011_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbrc.2006.03.034","article-title":"High-affinity binding of the NC1 domain of collagen VII to laminin 5 and collagen IV","volume":"343","author":"Brittingham","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2019.01.011_bib5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/1523-1747.ep12365129","article-title":"Type VII collagen, anchoring fibrils, and epidermolysis bullosa","volume":"101","author":"Burgeson","year":"1993","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.011_bib6","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1172\/JCI115212","article-title":"Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma","volume":"87","author":"Castle","year":"1991","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.01.011_bib7","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1158\/0008-5472.CAN-10-2941","article-title":"Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term T\u03b2RI\/II kinase inhibition with LY2109761","volume":"71","author":"Connolly","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2019.01.011_bib8","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(00)81460-9","article-title":"Thrombospondin-1 is a major activator of TGF-\u03b21 in\u00a0vivo","volume":"93","author":"Crawford","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jid.2019.01.011_bib9","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.2337\/db07-0551","article-title":"Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in\u00a0vivo","volume":"56","author":"Daniel","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jid.2019.01.011_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/art.22289","article-title":"Recombinant human anti-transforming growth factor \u03b21 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I\/II trial of CAT-192","volume":"56","author":"Denton","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2019.01.011_bib11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2741\/1184","article-title":"Wound healing: an overview of acute, fibrotic and delayed healing","volume":"9","author":"Diegelmann","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.jid.2019.01.011_bib12","first-page":"1851","article-title":"Thrombospondin 1 synthesis and function in wound repair","volume":"148","author":"DiPietro","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.01.011_bib13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaad.2008.09.035","article-title":"Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986\u20132006","volume":"60","author":"Fine","year":"2009","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.01.011_bib14","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1172\/JCI34292","article-title":"A\u00a0hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy","volume":"118","author":"Fritsch","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.01.011_bib15","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1083\/jcb.104.5.1413","article-title":"Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy","volume":"104","author":"Galvin","year":"1987","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jid.2019.01.011_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1593\/neo.04640","article-title":"A\u00a0specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers","volume":"7","author":"Halder","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.jid.2019.01.011_bib17","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/ndt\/gfg159","article-title":"The thrombospondin 1-TGF-\u03b2 axis in fibrotic renal disease","volume":"18","author":"Hugo","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jid.2019.01.011_bib18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/bjs.9765","article-title":"Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor \u03b2 signal activation and liver regeneration after hepatectomy in an experimental model","volume":"102","author":"Kuroki","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.jid.2019.01.011_bib19","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/jid.2014.185","article-title":"Loss of collagen VII is associated with reduced transglutaminase 2 abundance and activity","volume":"134","author":"Kuttner","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.011_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/msb.2013.17","article-title":"Global remodelling of cellular microenvironment due to loss of collagen VII","volume":"9","author":"Kuttner","year":"2013","journal-title":"Mol Syst Biol"},{"key":"10.1016\/j.jid.2019.01.011_bib21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/1523-1747.ep12560795","article-title":"Type VII collagen is a normal component of epidermal basement membrane, which shows altered expression in recessive dystrophic epidermolysis bullosa","volume":"90","author":"Leigh","year":"1988","journal-title":"J\u00a0Invest Dermatol"},{"issue":"1","key":"10.1016\/j.jid.2019.01.011_bib22","doi-asserted-by":"crossref","first-page":"djv293","DOI":"10.1093\/jnci\/djv293","article-title":"Suppression of TGF\u03b2 and angiogenesis by type VII collagen in cutaneous SCC","volume":"108","author":"Martins","year":"2016","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jid.2019.01.011_bib23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/(SICI)1097-4644(19971001)67:1<75::AID-JCB8>3.0.CO;2-T","article-title":"Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1","volume":"67","author":"Merle","year":"1997","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jid.2019.01.011_bib24","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1158\/0008-5472.CAN-15-1348","article-title":"Injury-driven stiffening of the dermis expedites skin carcinoma progression","volume":"76","author":"Mittapalli","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2019.01.011_bib25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1182\/blood.V66.5.1098.1098","article-title":"Localization of thrombospondin in clots formed in situ","volume":"66","author":"Murphy-Ullrich","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.jid.2019.01.011_bib26","first-page":"28","article-title":"Thrombospondin-1 regulation of latent TGF-\u03b2 activation: a therapeutic target for fibrotic disease","volume":"68\u201369","author":"Murphy-Ullrich","year":"2017","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2019.01.011_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0968-0004(98)01183-9","article-title":"CLAMP: a biosensor kinetic data analysis program","volume":"23","author":"Myszka","year":"1998","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jid.2019.01.011_bib28","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/0008-5472.CAN-11-2996","article-title":"Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa","volume":"72","author":"Ng","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2019.01.011_bib29","first-page":"51321","article-title":"Tissue engineering of tumor stromal microenvironment with application to cancer cell invasion","volume":"85","author":"Ng","year":"2014","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.jid.2019.01.011_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.matbio.2018.01.016","article-title":"Injury- and inflammation-driven skin fibrosis: the paradigm of epidermolysis bullosa","volume":"68\u201369","author":"Nystr\u00f6m","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2019.01.011_bib31","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.15252\/emmm.201505061","article-title":"Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms","volume":"7","author":"Nystr\u00f6m","year":"2015","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jid.2019.01.011_bib32","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1172\/JCI68127","article-title":"Collagen VII plays a dual role in wound healing","volume":"123","author":"Nystr\u00f6m","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.01.011_bib33","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1093\/hmg\/ddu102","article-title":"Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-\u03b2 signalling in modifying disease severity","volume":"23","author":"Odorisio","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2019.01.011_bib34","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/bjd.12599","article-title":"Fibroblast cell therapy enhances initial healing in recessive dystrophic epidermolysis bullosa wounds: results of a randomized, vehicle-controlled trial","volume":"169","author":"Petrof","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.011_bib35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/1523-1747.ep12461198","article-title":"Thrombospondin in early human wound tissue","volume":"89","author":"Raugi","year":"1987","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.011_bib36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.matbio.2014.01.012","article-title":"Current understanding of the thrombospondin-1 interactome","volume":"37","author":"Resovi","year":"2014","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2019.01.011_bib37","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1074\/jbc.274.19.13586","article-title":"The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-\u03b2","volume":"274","author":"Ribeiro","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.01.011_bib38","doi-asserted-by":"crossref","first-page":"12485","DOI":"10.1073\/pnas.171460498","article-title":"Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor","volume":"98","author":"Rodriguez-Manzaneque","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.01.011_bib39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1083\/jcb.109.1.309","article-title":"Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture","volume":"109","author":"Sato","year":"1989","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jid.2019.01.011_bib40","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1074\/jbc.270.13.7304","article-title":"Regulation of transforming growth factor-\u03b2 activation by discrete sequences of thrombospondin 1","volume":"270","author":"Schultz-Cherry","year":"1995","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.01.011_bib41","doi-asserted-by":"crossref","first-page":"26783","DOI":"10.1016\/S0021-9258(18)47087-1","article-title":"The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta","volume":"269","author":"Schultz-Cherry","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.01.011_bib42","doi-asserted-by":"crossref","first-page":"26775","DOI":"10.1016\/S0021-9258(18)47086-X","article-title":"Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system","volume":"269","author":"Schultz-Cherry","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.01.011_bib43","doi-asserted-by":"crossref","first-page":"5068969","DOI":"10.1155\/2017\/5068969","article-title":"Betulin-based oleogel to improve wound healing in dystrophic epidermolysis bullosa: a prospective controlled proof-of-concept study","volume":"2017","author":"Schwieger-Briel","year":"2017","journal-title":"Dermatol Res Pract"},{"key":"10.1016\/j.jid.2019.01.011_bib44","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1001\/jama.2016.15588","article-title":"Safety and wound outcomes following genetically corrected autologous epidermal grafts in patients with recessive dystrophic epidermolysis bullosa","volume":"316","author":"Siprashvili","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jid.2019.01.011_bib45","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/emboj\/19.13.3272","article-title":"Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice","volume":"19","author":"Streit","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2019.01.011_bib46","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1056\/NEJMoa0910501","article-title":"Bone marrow transplantation for recessive dystrophic epidermolysis bullosa","volume":"363","author":"Wagner","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2019.01.011_bib47","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0002-9610(99)80340-7","article-title":"The effect of thrombospondin on oral squamous carcinoma cell invasion of collagen","volume":"170","author":"Wang","year":"1995","journal-title":"Am J Surg"},{"issue":"9","key":"10.1016\/j.jid.2019.01.011_bib48","doi-asserted-by":"crossref","first-page":"e0137639","DOI":"10.1371\/journal.pone.0137639","article-title":"Lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa","volume":"10","author":"Watt","year":"2015","journal-title":"PLoS One"},{"issue":"6281","key":"10.1016\/j.jid.2019.01.011_bib49","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/346281a0","article-title":"Negative regulation of transforming growth factor-beta by the proteoglycan decorin","volume":"346","author":"Yamaguchi","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.01.011_bib50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1101\/gad.14.2.163","article-title":"Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-\u03b2 and promotes tumor invasion and angiogenesis","volume":"14","author":"Yu","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2019.01.011_bib51","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1111\/jcmm.13565","article-title":"Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions","volume":"22","author":"Zhao","year":"2018","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.jid.2019.01.011_bib52","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bbrc.2005.11.060","article-title":"Thrombospondin 1 mediates angiotensin II induction of TGF-\u03b2 activation by cardiac and renal cells under both high and low glucose conditions","volume":"339","author":"Zhou","year":"2006","journal-title":"Biochem Biophys Res Comms"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19300284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19300284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:42:48Z","timestamp":1762206168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19300284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0022202X19300284"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.01.011","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombospondin-1 Is a Major Activator of TGF-\u03b2 Signaling in Recessive Dystrophic Epidermolysis Bullosa Fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}