{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:47:50Z","timestamp":1772963270395,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007267","name":"Joe Andruzzi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002537"],"award-info":[{"award-number":["UL1 TR002537"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 TR001356"],"award-info":[{"award-number":["U54 TR001356"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jid.2019.01.034","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T11:59:25Z","timestamp":1552391965000},"page":"1860-1866.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases"],"prefix":"10.1016","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-0722","authenticated-orcid":false,"given":"Kelly N.","family":"Messingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7697-6128","authenticated-orcid":false,"given":"Adam D.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-0003","authenticated-orcid":false,"given":"Nandakumar S.","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-7210","authenticated-orcid":false,"given":"Samuel J.","family":"Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-0486","authenticated-orcid":false,"given":"Janet A.","family":"Fairley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.01.034_bib1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/jid.2010.301","article-title":"Risk factors for bullous pemphigoid in the elderly: a prospective case-control study","volume":"131","author":"Bastuji-Garin","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jaad.2014.02.030","article-title":"Incidence of bullous pemphigoid and mortality of patients with bullous pemphigoid in Olmsted County, Minnesota, 1960 through 2009","volume":"71","author":"Brick","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng0795-301","article-title":"The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1","volume":"10","author":"Brown","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2019.01.034_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000315393","article-title":"Sera of elderly bullous pemphigoid patients with associated neurological diseases recognize bullous pemphigoid antigens in the human brain","volume":"57","author":"Chen","year":"2011","journal-title":"Gerontology"},{"key":"10.1016\/j.jid.2019.01.034_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2133.2011.10386.x","article-title":"Comorbidity profiles among patients with bullous pemphigoid: a nationwide population-based study","volume":"165","author":"Chen","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000106574","article-title":"Neurological disorders in patients with bullous pemphigoid","volume":"215","author":"Cordel","year":"2007","journal-title":"Dermatology"},{"key":"10.1016\/j.jid.2019.01.034_bib7","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1172\/JCI114812","article-title":"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome","volume":"86","author":"Diaz","year":"1990","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.01.034_bib8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jaci.2008.11.035","article-title":"Pathogenicity of IgE in autoimmunity: successful treatment of bullous pemphigoid with omalizumab","volume":"123","author":"Fairley","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2019.01.034_bib9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jaad.2012.09.012","article-title":"Missing the target: characterization of bullous pemphigoid patients who are negative using the BP180 enzyme-linked immunosorbant assay","volume":"68","author":"Fairley","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib10","doi-asserted-by":"crossref","first-page":"37125","DOI":"10.1038\/srep37125","article-title":"Psychiatric and neurological disorders are associated with bullous pemphigoid\u2014a nationwide Finnish Care Register study","volume":"6","author":"F\u00f6rsti","year":"2016","journal-title":"Sci Rep"},{"issue":"5 Pt. 1","key":"10.1016\/j.jid.2019.01.034_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0151-9638(06)70935-8","article-title":"Correlation between the presence of type-2 anti-pemphigoid antibodies and dementia in elderly subjects with no clinical signs of pemphigoid","volume":"133","author":"Foureur","year":"2006","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jid.2019.01.034_bib12","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.4049\/jimmunol.151.10.5742","article-title":"Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain","volume":"151","author":"Giudice","year":"1993","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.01.034_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5114\/ceji.2017.67322","article-title":"Analysis of the autoimmune response against BP180 and BP230 in ethnic Poles with neurodegenerative disorders and bullous pemphigoid","volume":"42","author":"Gornowicz-Porowska","year":"2017","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.jid.2019.01.034_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/bjd.15114","article-title":"Detection of IgE autoantibodies to BP180 and BP230 and their relationship to clinical features in bullous pemphigoid","volume":"177","author":"Hashimoto","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib15","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.jid.2016.07.013","article-title":"Prevalence and age distribution of pemphigus and pemphigoid diseases in Germany","volume":"136","author":"Hubner","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/archdermatol.2007.9","article-title":"Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid","volume":"144","author":"Iwata","year":"2008","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib17","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/jid.2012.35","article-title":"Incidence and mortality of bullous pemphigoid in France","volume":"132","author":"Joly","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib18","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/bjd.15405","article-title":"Increased frequency of multiple sclerosis among patients with bullous pemphigoid: a population-based cohort study on comorbidities anchored around the diagnosis of bullous pemphigoid","volume":"176","author":"Kibsgaard","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jid.2016.09.010","article-title":"Increased levels of the bullous pemphigoid BP180 autoantibody are associated with more severe dementia in Alzheimer\u2019s disease","volume":"137","author":"Kokkonen","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/exd.12877","article-title":"One gene but different proteins and diseases: the complexity of dystonin and bullous pemphigoid antigen 1","volume":"25","author":"Kunzli","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/jid.2010.357","article-title":"The relationship between neurological disease and bullous pemphigoid: a population-based case-control study","volume":"131","author":"Langan","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib22","doi-asserted-by":"crossref","first-page":"a180","DOI":"10.1136\/bmj.a180","article-title":"Bullous pemphigoid and pemphigus vulgaris\u2014incidence and mortality in the UK: population based cohort study","volume":"337","author":"Langan","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jid.2019.01.034_bib23","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1365-2133.2009.09122.x","article-title":"Sera from patients with bullous pemphigoid (BP) associated with neurological diseases recognized BP antigen 1 in the skin and brain","volume":"160","author":"Li","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1365-2133.2009.09300.x","article-title":"Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study","volume":"161","author":"Marazza","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib25","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jid.2015.12.005","article-title":"Autoantibodies to collagen XVII are present in Parkinson\u2019s disease and localize to tyrosine-hydroxylase positive neurons","volume":"136","author":"Messingham","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"issue":"1\u20132","key":"10.1016\/j.jid.2019.01.034_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jim.2009.04.013","article-title":"A\u00a0novel ELISA reveals high frequencies of BP180-specific IgE production in bullous pemphigoid","volume":"346","author":"Messingham","year":"2009","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jid.2019.01.034_bib27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaad.2011.06.032","article-title":"Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts","volume":"66","author":"Murrell","year":"2012","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib28","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1212\/WNL.0000000000002461","article-title":"Age at onset and Parkinson disease phenotype","volume":"86","author":"Pagano","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.jid.2019.01.034_bib29","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/bjd.14538","article-title":"Parkinson disease and multiple sclerosis are not associated with autoantibodies against structural proteins of the dermal-epidermal junction","volume":"175","author":"Recke","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/bjd.14821","article-title":"Hospitalization, inpatient burden and comorbidities associated with bullous pemphigoid in the U.S.A","volume":"176","author":"Ren","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib31","doi-asserted-by":"crossref","first-page":"240570","DOI":"10.1155\/2013\/240570","article-title":"Collagen XVII: a shared antigen in neurodermatological interactions?","volume":"2013","author":"Sepp\u00e4nen","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.jid.2019.01.034_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.matbio.2005.11.004","article-title":"Collagen XVII is expressed in human CNS neurons","volume":"25","author":"Sepp\u00e4nen","year":"2006","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2019.01.034_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000249506","article-title":"Multiple sclerosis and bullous pemphigoid","volume":"170","author":"Simjee","year":"1985","journal-title":"Dermatologica"},{"key":"10.1016\/j.jid.2019.01.034_bib34","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1172\/JCI113803","article-title":"Isolation of complementary DNA for bullous pemphigoid antigen by use of patients\u2019 autoantibodies","volume":"82","author":"Stanley","year":"1988","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.01.034_bib35","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/archdermatol.2010.322","article-title":"The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study","volume":"146","author":"Taghipour","year":"2010","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jid.2018.09.010","article-title":"BP180 autoantibodies target different epitopes in multiple sclerosis or Alzheimer\u2019s disease than in bullous pemphigoid","volume":"139","author":"Tuusa","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.034_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4103\/0378-6323.198451","article-title":"Bullous pemphigoid and antecedent neurological diseases: an association with dementia","volume":"83","author":"Yu Phuan","year":"2017","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.jid.2019.01.034_bib38","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/1523-1747.ep12337492","article-title":"Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies","volume":"109","author":"Zillikens","year":"1997","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19313284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19313284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:43:49Z","timestamp":1762206229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19313284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0022202X19313284"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.01.034","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.01.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}