{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:54:45Z","timestamp":1790243685947,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000764","name":"King&apos;s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004941","name":"Guy&apos;s and St Thomas&apos; NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["083259\/B\/07\/C"],"award-info":[{"award-number":["083259\/B\/07\/C"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["097903\/z\/11\/z"],"award-info":[{"award-number":["097903\/z\/11\/z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jid.2019.01.037","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T11:18:15Z","timestamp":1554722295000},"page":"1936-1945.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Disruption of the Sensory System Affects Sterile Cutaneous Inflammation In\u00a0Vivo"],"prefix":"10.1016","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-6566","authenticated-orcid":false,"given":"Federica","family":"La Russa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulye","family":"Argunhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Brain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Bevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.H.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.01.037_bib1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/1523-1747.ep12525745","article-title":"Ultraviolet light depletes surface markers of Langerhans cells","volume":"76","author":"Aberer","year":"1981","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.037_bib2","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress","volume":"28","author":"Andersson","year":"2008","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2019.01.037_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.jid.2019.01.037_bib4","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2567.2004.01786.x","article-title":"Nerve fibres are required to evoke a contact sensitivity response in mice","volume":"111","author":"Beresford","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2019.01.037_bib5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pain.2006.12.014","article-title":"Characterisation of ultraviolet-B-induced inflammation as a model of hyperalgesia in the rat","volume":"131","author":"Bishop","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.jid.2019.01.037_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1476-5381.1989.tb11926.x","article-title":"Interactions between the tachykinins and calcitonin gene-related peptide lead to the modulation of oedema formation and blood flow in rat skin","volume":"97","author":"Brain","year":"1989","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jid.2019.01.037_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.jid.2019.01.037_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.01.037_bib9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pain.2007.06.006","article-title":"The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans","volume":"132","author":"Chizh","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.jid.2019.01.037_bib10","doi-asserted-by":"crossref","first-page":"PL193","DOI":"10.1016\/0024-3205(95)02100-W","article-title":"Anti-inflammatory activity of amylin and CGRP in different experimental models of inflammation","volume":"57","author":"Clementi","year":"1995","journal-title":"Life Sci"},{"key":"10.1016\/j.jid.2019.01.037_bib11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1440-1711.2001.01047.x","article-title":"Ultraviolet light induced injury: immunological and inflammatory effects","volume":"79","author":"Clydesdale","year":"2001","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jid.2019.01.037_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/1523-1747.ep12363639","article-title":"Neutrophils, differentiated macrophages, and monocyte\/macrophage antigen presenting cells infiltrate murine epidermis after UV injury","volume":"101","author":"Cooper","year":"1993","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.037_bib13","doi-asserted-by":"crossref","first-page":"e93338","DOI":"10.1371\/journal.pone.0093338","article-title":"Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation","volume":"9","author":"Dawes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2019.01.037_bib14","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1046\/j.1523-1747.1998.00220.x","article-title":"UVB radiation preferentially induces recruitment of memory CD4+ T cells in normal human skin: long-term effect after a single exposure","volume":"110","author":"Di Nuzzo","year":"1998","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.037_bib15","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1172\/JCI42843","article-title":"Nociceptors: the sensors of the pain pathway","volume":"120","author":"Dubin","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.01.037_bib16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/jcbfm.1987.126","article-title":"Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects","volume":"7","author":"Edvinsson","year":"1987","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.jid.2019.01.037_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.det.2014.03.005","article-title":"Photoimmunology","volume":"32","author":"Elmets","year":"2014","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2019.01.037_bib18","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.4049\/jimmunol.145.4.1105","article-title":"Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions","volume":"145","author":"Girolomoni","year":"1990","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.01.037_bib19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/01.shk.0000183395.29014.7c","article-title":"Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia","volume":"24","author":"Gomes","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.jid.2019.01.037_bib20","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/apha.12442","article-title":"Calcitonin gene-related peptide: key regulator of cutaneous immunity","volume":"213","author":"Granstein","year":"2015","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.jid.2019.01.037_bib21","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"Immunological Genome Project Consortium. The Immunological Genome Project: networks of gene expression in immune cells","volume":"9","author":"Heng","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2019.01.037_bib22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1084\/jem.20091964","article-title":"CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells","volume":"207","author":"Henri","year":"2010","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2019.01.037_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/363159a0","article-title":"Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide","volume":"363","author":"Hosoi","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.01.037_bib24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2019.01.037_bib25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/jid.2012.359","article-title":"Gene profiling of narrowband UVB-induced skin injury defines cellular and molecular innate immune responses","volume":"133","author":"Kennedy Crispin","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.037_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.jid.2019.01.037_bib27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1468-1331.2005.01260.x","article-title":"EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy","volume":"12","author":"Lauria","year":"2005","journal-title":"Eur J Neurol"},{"issue":"Suppl 2","key":"10.1016\/j.jid.2019.01.037_bib28","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1093\/annonc\/12.suppl_2.S19","article-title":"Nerve-driven immunity: neuropeptides regulate cytokine secretion of T cells and intestinal epithelial cells in a direct, powerful and contextual manner","volume":"12","author":"Levite","year":"2001","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jid.2019.01.037_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/cns.12444","article-title":"Ultraviolet radiation on the skin: a painful experience?","volume":"22","author":"Lopes","year":"2016","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.jid.2019.01.037_bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrn3946","article-title":"Crosstalk between the nociceptive and immune systems in host defence and disease","volume":"16","author":"McMahon","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jid.2019.01.037_bib31","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/1523-1747.ep12326032","article-title":"In human dermis, ultraviolet radiation induces expansion of a CD36+ CD11b+ CD1- macrophage subset by infiltration and proliferation; CD1+ Langerhans-like dendritic antigen-presenting cells are concomitantly depleted","volume":"105","author":"Meunier","year":"1995","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.037_bib32","series-title":"Wall and Melzack's textbook of pain","first-page":"3","article-title":"Peripheral mechanisms of cutaneous nociception","author":"Meyer","year":"2008"},{"key":"10.1016\/j.jid.2019.01.037_bib33","doi-asserted-by":"crossref","first-page":"6886","DOI":"10.4049\/jimmunol.1100028","article-title":"Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions","volume":"186","author":"Mikami","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.01.037_bib34","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1124\/pr.112.006163","article-title":"Unravelling the mystery of capsaicin: a tool to understand and treat pain","volume":"64","author":"O'Neill","year":"2012","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jid.2019.01.037_bib35","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/jid.2011.60","article-title":"Cutaneous denervation of psoriasiform mouse skin improves acanthosis and inflammation in a sensory neuropeptide-dependent manner","volume":"131","author":"Ostrowski","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.037_bib36","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0006-291X(05)81356-7","article-title":"Potent anti-inflammatory action of calcitonin gene-related peptide","volume":"180","author":"Raud","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2019.01.037_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.01.037_bib38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2007.08.002","article-title":"Ultra violet-induced localized inflammatory hyperalgesia in awake rats and the role of sensory and sympathetic innervation of the skin","volume":"22","author":"Saad\u00e9","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jid.2019.01.037_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/sj.jidsp.5640182","article-title":"Effect of ultraviolet light on the release of neuropeptides and neuroendocrine hormones in the skin: mediators of photodermatitis and cutaneous inflammation","volume":"4","author":"Scholzen","year":"1999","journal-title":"J\u00a0Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jid.2019.01.037_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081228","article-title":"Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice","volume":"8","author":"Sisignano","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2019.01.037_bib41","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/HYPERTENSIONAHA.113.02517","article-title":"An ongoing role of alpha-calcitonin gene-related peptide as part of a protective network against hypertension, vascular hypertrophy, and oxidative stress","volume":"63","author":"Smillie","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.jid.2019.01.037_bib42","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2016.11.007","article-title":"The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery","volume":"167","author":"Stunnenberg","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jid.2019.01.037_bib43","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A\u00a0gene atlas of the mouse and human protein-encoding transcriptomes","volume":"101","author":"Su","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.01.037_bib44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/000155501750208100","article-title":"Occurrence of neutrophils and activated Th1 cells in UVB-induced erythema","volume":"81","author":"Terui","year":"2001","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2019.01.037_bib45","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.4049\/jimmunol.168.8.3732","article-title":"Ultraviolet B radiation induces a transient appearance of IL-4+ neutrophils, which support the development of Th2 responses","volume":"168","author":"Teunissen","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.01.037_bib46","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/jlb.61.2.216","article-title":"Regulation of cytokine expression in macrophages and the Langerhans cell-like line XS52 by calcitonin gene-related peptide","volume":"61","author":"Torii","year":"1997","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2019.01.037_bib47","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.0705923104","article-title":"4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1","volume":"104","author":"Trevisani","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.01.037_bib48","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors--noxious stimulus detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.jid.2019.01.037_bib49","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.0022-202X.2003.22101.x","article-title":"Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression","volume":"122","author":"Yano","year":"2004","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.01.037_bib50","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/archderm.1970.04000030056008","article-title":"The effect of sunlight on human epidermis. A quantitative electron microscopic study of dendritic cells","volume":"101","author":"Zelickson","year":"1970","journal-title":"Arch Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19314551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19314551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:44:02Z","timestamp":1762206242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19314551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0022202X19314551"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.01.037","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of the Sensory System Affects Sterile Cutaneous Inflammation In\u00a0Vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.01.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}