{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:06:15Z","timestamp":1790744775335,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FDT20140930932"],"award-info":[{"award-number":["FDT20140930932"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019920","name":"Soci\u00e9t\u00e9 d'Acc\u00e9l\u00e9ration du Transfert de Technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-CE16-0010-01"],"award-info":[{"award-number":["ANR-14-CE16-0010-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jid.2019.04.030","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T19:37:37Z","timestamp":1562182657000},"page":"223-234.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Cutaneous Wound Healing in Diabetic Mice Is Improved by Topical Mineralocorticoid Receptor Blockade"],"prefix":"10.1016","volume":"140","author":[{"given":"Van Tuan","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Farman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Palacios-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sbeih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Behar-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9lim","family":"Aractingi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Jaisser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 7","key":"10.1016\/j.jid.2019.04.030_bib1","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.12968\/jowc.2016.25.Sup7.S35","article-title":"Immune and vascular dysfunction in diabetic wound healing","volume":"25","author":"Ahmed","year":"2016","journal-title":"J\u00a0Wound Care"},{"key":"10.1016\/j.jid.2019.04.030_bib2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/jid.2010.291","article-title":"Exploring the \u201chair growth\u2013wound healing connection\u201d: anagen phase promotes wound re-epithelialization","volume":"131","author":"Ansell","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1524-475X.2011.00748.x","article-title":"Tumor necrosis factor-alpha (TNF-\u03b1) is a therapeutic target for impaired cutaneous wound healing","volume":"20","author":"Ashcroft","year":"2012","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2019.04.030_bib4","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.kint.2017.12.016","article-title":"The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling","volume":"93","author":"Barrera-Chimal","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.jid.2019.04.030_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2019.04.030_bib6","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1073\/pnas.0510847103","article-title":"Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury","volume":"103","author":"Berger","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.04.030_bib7","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41419-018-0673-z","article-title":"Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation","volume":"9","author":"Bigas","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2019.04.030_bib8","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.jid.2016.07.018","article-title":"Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses","volume":"136","author":"Boix","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.1700223","article-title":"Macrophage-mediated inflammation in normal and diabetic wound healing","volume":"199","author":"Boniakowski","year":"2017","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.04.030_bib10","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0140-6736(05)67698-2","article-title":"The global burden of diabetic foot disease","volume":"366","author":"Boulton","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2019.04.030_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-0-444-53480-4.00008-4","article-title":"Diabetic neuropathy and foot complications","volume":"126","author":"Boulton","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.jid.2019.04.030_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ajpath.2010.08.003","article-title":"Wound macrophages as key regulators of repair","volume":"178","author":"Brancato","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.04.030_bib13","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.04.030_bib14","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1042\/CS20171592","article-title":"More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases","volume":"132","author":"Buonafine","year":"2018","journal-title":"Clin Sci"},{"key":"10.1016\/j.jid.2019.04.030_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/sji.12245","article-title":"Lipocalin-2 promotes m1 macrophages polarization in a mouse cardiac ischaemia-reperfusion injury model","volume":"81","author":"Cheng","year":"2015","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jid.2019.04.030_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/dme.13313","article-title":"New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK Annual Professional Conference Symposium","volume":"34","author":"Clokie","year":"2017","journal-title":"Diabet Med"},{"key":"10.1016\/j.jid.2019.04.030_bib17","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.2337\/db12-0227","article-title":"Mechanisms involved in the development and healing of diabetic foot ulceration","volume":"61","author":"Dinh","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jid.2019.04.030_bib18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/dom.13508","article-title":"Effectiveness of dapagliflozin versus comparators on renal endpoints in the real world: A multicentre retrospective study","volume":"21","author":"Fadini","year":"2019","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jid.2019.04.030_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-0625.2009.01011.x","article-title":"The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?","volume":"19","author":"Farman","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib20","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/S0002-9440(10)63754-6","article-title":"Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells","volume":"164","author":"Galiano","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.04.030_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2019.04.030_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0094-1298(02)00066-4","article-title":"Wound healing and diabetes mellitus","volume":"30","author":"Greenhalgh","year":"2003","journal-title":"Clin Plast Surg"},{"key":"10.1016\/j.jid.2019.04.030_bib23","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1161\/CIRCULATIONAHA.107.748640","article-title":"Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-\u03b3, and proinflammatory adipokines","volume":"117","author":"Guo","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jid.2019.04.030_bib24","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1210\/me.2014-1092","article-title":"Lipocalin 2 is a regulator of macrophage polarization and NF-\u03baB\/STAT3 pathway activation","volume":"28","author":"Guo","year":"2014","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jid.2019.04.030_bib25","doi-asserted-by":"crossref","first-page":"36416","DOI":"10.1038\/srep36416","article-title":"AGEs induced autophagy impairs cutaneous wound healing via stimulating macrophage polarization to M1 in diabetes","volume":"6","author":"Guo","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2019.04.030_bib26","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.jid.2017.02.984","article-title":"Dysfunctional skin-derived glucocorticoid synthesis is a pathogenic mechanism of psoriasis","volume":"137","author":"Hannen","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.molimm.2017.06.249","article-title":"IL-33 improves wound healing through enhanced M2 macrophage polarization in diabetic mice","volume":"90","author":"He","year":"2017","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jid.2019.04.030_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/cvr\/cvp191","article-title":"Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice","volume":"84","author":"Hirata","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jid.2019.04.030_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1124\/pr.115.011106","article-title":"Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in Clinical Pharmacology","volume":"68","author":"Jaisser","year":"2015","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jid.2019.04.030_bib30","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.ajpath.2015.02.011","article-title":"Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype","volume":"185","author":"Leal","year":"2015","journal-title":"Am J Pathol"},{"issue":"Suppl. 2","key":"10.1016\/j.jid.2019.04.030_bib31","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S1078-5884(11)60012-9","article-title":"Chapter V: Diabetic foot","volume":"42","author":"Lepantalo","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jid.2019.04.030_bib32","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.2337\/db13-0483","article-title":"Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes","volume":"63","author":"Liu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jid.2019.04.030_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2337\/diabetes.53.1.195","article-title":"Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes","volume":"53","author":"Loomans","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.jid.2019.04.030_bib34","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","article-title":"Differential roles of macrophages in diverse phases of skin repair","volume":"184","author":"Lucas","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.04.030_bib35","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.imbio.2011.01.001","article-title":"Macrophages in skin injury and repair","volume":"216","author":"Mahdavian Delavary","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.jid.2019.04.030_bib36","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jid.2019.04.030_bib37","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1172\/JCI36858","article-title":"Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice","volume":"120","author":"Marrotte","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.04.030_bib38","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/HYPERTENSIONAHA.117.09791","article-title":"Aldosterone target NGAL (neutrophil gelatinase\u2013associated lipocalin) is involved in cardiac remodeling after myocardial infarction through NF\u03baB pathway","volume":"70","author":"Mart\u00ednez-Mart\u00ednez","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.jid.2019.04.030_bib39","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.2353\/ajpath.2007.060018","article-title":"Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing","volume":"170","author":"Maruyama","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.04.030_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.steroids.2014.05.001","article-title":"Mineralocorticoid receptor in adipocytes and macrophages: a promising target to fight metabolic syndrome","volume":"91","author":"Marzolla","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.jid.2019.04.030_bib41","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/jid.2015.44","article-title":"Topical mineralocorticoid receptor blockade limits glucocorticoid-induced epidermal atrophy in human skin","volume":"135","author":"Maubec","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mehy.2016.08.009","article-title":"Hair follicle characteristics as early marker of Type 2 Diabetes","volume":"95","author":"Miranda","year":"2016","journal-title":"Med Hypo"},{"key":"10.1016\/j.jid.2019.04.030_bib43","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/jid.2010.155","article-title":"Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin","volume":"130","author":"Mitts","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib44","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.jid.2016.05.101","article-title":"Re-epithelialization of pathological cutaneous wounds is improved by local mineralocorticoid receptor antagonism","volume":"136","author":"Nguyen","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"issue":"3 Pt 1","key":"10.1016\/j.jid.2019.04.030_bib45","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/jid.2011.356","article-title":"CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic mice","volume":"132","author":"Nishimura","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.dsx.2016.06.023","article-title":"Understanding diabetic foot infection and its management","volume":"11","author":"Noor","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.jid.2019.04.030_bib47","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.ajpath.2013.06.034","article-title":"Phenotypic transitions of macrophages orchestrate tissue repair","volume":"183","author":"Novak","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.04.030_bib48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biopha.2014.10.020","article-title":"Suppressed recruitment of alternatively activated macrophages reduces TGF-beta1 and impairs wound healing in streptozotocin-induced diabetic mice","volume":"70","author":"Okizaki","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jid.2019.04.030_bib49","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.mcna.2013.04.005","article-title":"Diagnosis and management of infection in the diabetic foot","volume":"97","author":"Peters","year":"2013","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.jid.2019.04.030_bib50","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.jid.2018.04.010","article-title":"Macrophages promote wound-induced hair follicle regeneration in a CX3CR1- and TGF-\u03b21\u2013Dependent manner","volume":"138","author":"Rahmani","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib51","doi-asserted-by":"crossref","first-page":"14164","DOI":"10.1038\/s41598-018-32589-7","article-title":"Impaired wound healing in type 1 diabetes is dependent on 5-lipoxygenase products","volume":"8","author":"Ramalho","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2019.04.030_bib52","doi-asserted-by":"crossref","first-page":"846","DOI":"10.2353\/ajpath.2007.060991","article-title":"Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia","volume":"171","author":"Sainte Marie","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.04.030_bib53","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/wrr.12035","article-title":"Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin","volume":"21","author":"Serra","year":"2013","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2019.04.030_bib54","doi-asserted-by":"crossref","first-page":"E1906","DOI":"10.3390\/ijms19071906","article-title":"Roles of the glucocorticoid and mineralocorticoid receptors in skin pathophysiology","volume":"19","author":"Sevilla","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2019.04.030_bib55","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jid.2016.03.002","article-title":"Increased Lipocalin-2 contributes to the pathogenesis of psoriasis by modulating neutrophil chemotaxis and cytokine secretion","volume":"136","author":"Shao","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib56","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI44490","article-title":"An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice","volume":"121","author":"Sindrilaru","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.04.030_bib57","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/exd.12376","article-title":"Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity","volume":"23","author":"Slominski","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.steroids.2015.04.006","article-title":"On the role of skin in the regulation of local and systemic steroidogenic activities","volume":"103","author":"Slominski","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.jid.2019.04.030_bib59","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.jid.2016.07.025","article-title":"Mineralocorticoid receptor antagonists\u2014A new sprinkle of salt and youth","volume":"136","author":"Stojadinovic","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib60","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1172\/JCI64162","article-title":"11beta-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects","volume":"123","author":"Tiganescu","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.04.030_bib61","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1172\/JCI67911","article-title":"Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes","volume":"123","author":"Warszawska","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.04.030_bib62","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","article-title":"Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis","volume":"49","author":"Zhang","year":"2017","journal-title":"Ann Med"},{"key":"10.1016\/j.jid.2019.04.030_bib63","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI79590","article-title":"Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation","volume":"126","author":"Adamson","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.04.030_bib64","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1073\/pnas.0510847103","article-title":"Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury","volume":"103","author":"Berger","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.04.030_bib65","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.0506352103","article-title":"COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model","volume":"103","author":"Cho","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.04.030_bib66","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.ajpath.2010.12.044","article-title":"Pregnancy promotes melanoma metastasis through enhanced lymphangiogenesis","volume":"178","author":"Khosrotehrani","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.04.030_bib67","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/jid.2015.44","article-title":"Topical mineralocorticoid receptor blockade limits glucocorticoid-induced epidermal atrophy in human skin","volume":"135","author":"Maubec","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.04.030_bib68","doi-asserted-by":"crossref","first-page":"11142","DOI":"10.1038\/s41598-018-29465-9","article-title":"Pigment epithelium-derived factor (PEDF) as a regulator of wound angiogenesis","volume":"8","author":"Michalczyk","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2019.04.030_bib69","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1096\/fj.11-180695","article-title":"Fetal progenitor cells naturally transferred through pregnancy participate in inflammation and angiogenesis during wound healing","volume":"26","author":"Nassar","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.jid.2019.04.030_bib70","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jid.2015.11.005","article-title":"Delayed healing of sickle cell ulcers is due to impaired angiogenesis and CXCL12 secretion in skin wounds","volume":"136","author":"Nguyen","year":"2016","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19318494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19318494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:42:34Z","timestamp":1762206154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19318494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0022202X19318494"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.04.030","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cutaneous Wound Healing in Diabetic Mice Is Improved by Topical Mineralocorticoid Receptor Blockade","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}