{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:14:36Z","timestamp":1790140476876,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CL 419\/2-1"],"award-info":[{"award-number":["CL 419\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VIDI 917-76-365"],"award-info":[{"award-number":["VIDI 917-76-365"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","award":["0414F"],"award-info":[{"award-number":["0414F"]}],"id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jid.2019.06.132","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T12:25:12Z","timestamp":1561724712000},"page":"132-142.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis"],"prefix":"10.1016","volume":"140","author":[{"given":"Anna","family":"Brand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Diener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja P.","family":"Zahner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Tripp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Backer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalad","family":"Karram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Mellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Stoitzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn E.","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.06.132_bib1","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1182\/blood-2009-06-228353","article-title":"Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling","volume":"114","author":"Banh","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jid.2019.06.132_bib2","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1002\/eji.200737126","article-title":"Characterization of mouse CD4 T cell subsets defined by expression of KLRG1","volume":"37","author":"Beyersdorf","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib3","doi-asserted-by":"crossref","first-page":"10492","DOI":"10.1073\/pnas.1119178109","article-title":"Autocrine\/paracrine TGF-beta1 inhibits Langerhans cell migration","volume":"109","author":"Bobr","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jid.2019.06.132_bib4","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1002\/eji.1830241129","article-title":"Expression of E-cadherin by murine dendritic cells: E-cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells","volume":"24","author":"Borkowski","year":"1994","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0925-4773(02)00090-4","article-title":"E-cadherin is a survival factor for the lactating mouse mammary gland","volume":"115","author":"Boussadia","year":"2002","journal-title":"Mech Dev"},{"key":"10.1016\/j.jid.2019.06.132_bib6","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1084\/jem.20071966","article-title":"Identification of a novel population of langerin+ dendritic cells","volume":"204","author":"Bursch","year":"2007","journal-title":"J\u00a0Exp Med"},{"issue":"4","key":"10.1016\/j.jid.2019.06.132_bib7","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing \u03b3\u03b4T cells in skin inflammation","volume":"35","author":"Cai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2019.06.132_bib8","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen","volume":"204","author":"Caton","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2019.06.132_bib9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/372190a0","article-title":"Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin","volume":"372","author":"Cepek","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.06.132_bib10","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/jid.2008.265","article-title":"Cadherin-mediated cell-cell contact regulates keratinocyte differentiation","volume":"129","author":"Charest","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.06.132_bib11","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1084\/jem.20091586","article-title":"Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network","volume":"206","author":"Chorro","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2019.06.132_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3389\/fimmu.2015.00534","article-title":"Functional specialization of skin dendritic cell subsets in regulating T cell responses","volume":"6","author":"Clausen","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni768","article-title":"Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice","volume":"3","author":"Fukao","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib14","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1084\/jem.20071733","article-title":"Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state","volume":"204","author":"Ginhoux","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2019.06.132_bib15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.15252\/emmm.201404114","article-title":"Specific roles for dendritic cell subsets during initiation and progression of psoriasis","volume":"6","author":"Glitzner","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jid.2019.06.132_bib16","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.4049\/jimmunol.176.3.1311","article-title":"Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1","volume":"176","author":"Gr\u00fcndemann","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/icb.2010.34","article-title":"Disentangling the complexity of the skin dendritic cell network","volume":"88","author":"Henri","year":"2010","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jid.2019.06.132_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.semcdb.2014.02.009","article-title":"The clash of Langerhans cell homeostasis in skin: should I stay or should I go?","volume":"41","author":"Hieronymus","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jid.2019.06.132_bib19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.20120340","article-title":"Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages","volume":"209","author":"Hoeffel","year":"2012","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2019.06.132_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1084\/jem.20051986","article-title":"Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity","volume":"203","author":"Ito","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2019.06.132_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1046\/j.1523-1747.1999.00475.x","article-title":"Characterization of E-cadherin-containing junctions involving skin-derived dendritic cells","volume":"112","author":"Jakob","year":"1999","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.06.132_bib22","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.4049\/jimmunol.160.8.4067","article-title":"Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in\u00a0vivo","volume":"160","author":"Jakob","year":"1998","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib23","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.immuni.2007.08.015","article-title":"Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation","volume":"27","author":"Jiang","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2019.06.132_bib59","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1084\/jem.20102318","article-title":"Langerhans cells are negative regulators of the anti-Leishmania response","volume":"208","author":"Kautz-Neu","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jid.2019.06.132_bib24","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.4049\/jimmunol.1000981","article-title":"TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis","volume":"185","author":"Kel","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/eji.201343681","article-title":"Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1\/2","volume":"44","author":"Konradi","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib26","first-page":"149","article-title":"Murine dendritic epidermal T cells (DETC) express the homophilic adhesion molecule E-cadherin","volume":"3","author":"Lee","year":"1994","journal-title":"Epithelial Cell Biol"},{"key":"10.1016\/j.jid.2019.06.132_bib27","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1126\/science.1188510","article-title":"Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine","volume":"329","author":"Manicassamy","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jid.2019.06.132_bib28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1126\/science.1194185","article-title":"Immunology. Beta-catenin balances immunity","volume":"329","author":"Mellman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jid.2019.06.132_bib29","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/ni852","article-title":"Langerhans cells renew in the skin throughout life under steady-state conditions","volume":"3","author":"Merad","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature14052","article-title":"Commensal-dendritic-cell interaction specifies a unique protective skin immune signature","volume":"520","author":"Naik","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.06.132_bib31","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1225152","article-title":"Compartmentalized control of skin immunity by resident commensals","volume":"337","author":"Naik","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jid.2019.06.132_bib32","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","volume":"361","author":"Nestle","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2019.06.132_bib33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.jid.5700107","article-title":"Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli","volume":"126","author":"Nishibu","year":"2006","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.06.132_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4939-6786-5_3","article-title":"Monitoring skin dendritic cells in steady state and inflammation by immunofluorescence microscopy and flow cytometry","volume":"1559","author":"Ober-Bl\u00f6baum","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2019.06.132_bib35","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1084\/jem.20111718","article-title":"Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome","volume":"208","author":"Ouchi","year":"2011","journal-title":"J\u00a0Exp Med"},{"issue":"6","key":"10.1016\/j.jid.2019.06.132_bib36","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1172\/JCI61862","article-title":"Rorgammat+ innate lymphocytes and \u03b3\u03b4T cells initiate psoriasiform plaque formation in mice","volume":"122","author":"Pantelyushin","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2019.06.132_bib37","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1084\/jem.20071724","article-title":"The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells","volume":"204","author":"Poulin","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2019.06.132_bib38","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1182\/blood.V96.13.4276","article-title":"Ligation of E-cadherin on in\u00a0vitro-generated immature Langerhans-type dendritic cells inhibits their maturation","volume":"96","author":"Riedl","year":"2000","journal-title":"Blood"},{"issue":"3 Pt 2","key":"10.1016\/j.jid.2019.06.132_bib39","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/jid.2011.437","article-title":"Changing views of the role of Langerhans cells","volume":"132","author":"Romani","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.06.132_bib40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.0105-2896.2009.00886.x","article-title":"Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin","volume":"234","author":"Romani","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2019.06.132_bib41","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1002\/eji.200838690","article-title":"Interaction of KLRG1 with E-cadherin: new functional and structural insights","volume":"38","author":"Rosshart","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib42","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3389\/fimmu.2018.00517","article-title":"The impact of the epithelial-mesenchymal transition regulator hepatocyte growth factor receptor\/met on skin immunity by modulating langerhans cell migration","volume":"9","author":"Sagi","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib43","doi-asserted-by":"crossref","first-page":"13581","DOI":"10.1038\/ncomms13581","article-title":"Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation","volume":"7","author":"Singh","year":"2016","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.jid.2019.06.132_bib44","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2360","article-title":"WNT signalling in the immune system: WNT is spreading its wings","volume":"8","author":"Staal","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib45","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev.immunol.21.120601.141040","article-title":"Tolerogenic dendritic cells","volume":"21","author":"Steinman","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib46","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.4049\/jimmunol.174.9.5444","article-title":"A\u00a0role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection","volume":"174","author":"Suffia","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/361082a0","article-title":"Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin","volume":"361","author":"Tang","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.06.132_bib48","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.4049\/jimmunol.1500551","article-title":"Dynamics and transcriptomics of skin dendritic cells and macrophages in an imiquimod-induced, biphasic mouse model of psoriasis","volume":"195","author":"Terhorst","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib49","first-page":"567305","article-title":"E-cadherin\/beta-catenin complex and the epithelial barrier","volume":"2011","author":"Tian","year":"2011","journal-title":"J\u00a0Biomed Biotechnol"},{"key":"10.1016\/j.jid.2019.06.132_bib50","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fimmu.2018.00515","article-title":"Tissue-resident memory CD8(+) T cells: from phenotype to function","volume":"9","author":"Topham","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib51","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.4049\/jimmunol.1003853","article-title":"Role for E-cadherin as an inhibitory receptor on epidermal gammadelta T cells","volume":"186","author":"Uchida","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib52","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1182\/blood-2011-10-384289","article-title":"Regulation and function of the E-cadherin\/catenin complex in cells of the monocyte-macrophage lineage and DCs","volume":"119","author":"Van den Bossche","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jid.2019.06.132_bib53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/eji.201243168","article-title":"E-cadherin: from epithelial glue to immunological regulator","volume":"43","author":"Van den Bossche","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib54","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.06.132_bib55","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"van Roy","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jid.2019.06.132_bib56","doi-asserted-by":"crossref","first-page":"10723","DOI":"10.1073\/pnas.1307569110","article-title":"Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice","volume":"110","author":"Wohn","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.06.132_bib57","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1038\/jid.2014.98","article-title":"IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing \u03b3\u03b4T cells","volume":"134","author":"Yoshiki","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.06.132_bib58","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1093\/emboj\/cdg560","article-title":"E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles","volume":"22","author":"Young","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2019.06.132_bib60","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1523-1747.2003.12042.x","article-title":"Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin\/CD207","volume":"120","author":"Stoitzner","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2019.06.132_bib61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-1-4939-1212-4_16","article-title":"Aldara-induced psoriasis-like skin inflammation: isolation and characterization of cutaneous dendritic cells and innate lymphocytes","volume":"1193","author":"Wohn","year":"2014","journal-title":"Methods Mol Biol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19317993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19317993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:42:26Z","timestamp":1762206146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19317993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0022202X19317993"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.06.132","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.06.132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}