{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:00:43Z","timestamp":1790355643662,"version":"4.1.0"},"reference-count":113,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Graduate Program of Biotechnology in Medicine"},{"DOI":"10.13039\/501100005057","name":"National Tsing Hua University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005057","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NHRI"},{"name":"Ministry of Science and Technology"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jid.2019.07.702","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T11:25:59Z","timestamp":1566213959000},"page":"404-414.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nicastrin Deficiency Induces Tyrosinase-Dependent Depigmentation and Skin Inflammation"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6920-0316","authenticated-orcid":false,"given":"Chia-Hao","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-8516","authenticated-orcid":false,"given":"Gunn-Guang","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-7306","authenticated-orcid":false,"given":"Yun-Jin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.07.702_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.devcel.2006.11.012","article-title":"A\u00a0morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans","volume":"12","author":"Abraham","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2019.07.702_bib2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/bjo.67.3.153","article-title":"Vitiligo and disorders of the retinal pigment epithelium","volume":"67","author":"Albert","year":"1983","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jid.2019.07.702_bib3","doi-asserted-by":"crossref","first-page":"12792","DOI":"10.1073\/pnas.0403929101","article-title":"Identification of 315 genes essential for early zebrafish development","volume":"101","author":"Amsterdam","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.07.702_bib4","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.mod.2004.06.006","article-title":"Melanophore sublineage-specific requirement for zebrafish touchtone during neural crest development","volume":"121","author":"Arduini","year":"2004","journal-title":"Mech Dev"},{"key":"10.1016\/j.jid.2019.07.702_bib5","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.2353\/ajpath.2009.090219","article-title":"Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria","volume":"175","author":"Area-Gomez","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.07.702_bib6","doi-asserted-by":"crossref","first-page":"e0121674","DOI":"10.1371\/journal.pone.0121674","article-title":"Multimodal holographic microscopy: distinction between apoptosis and oncosis","volume":"10","author":"Balvan","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.07.702_bib7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/pde.13044","article-title":"Successful treatment of vitiligo associated with Vogt-Koyanagi-Harada disease","volume":"34","author":"Bayer","year":"2017","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/pcmr.12205","article-title":"oca2 Regulation of chromatophore differentiation and number is cell type specific in zebrafish","volume":"27","author":"Beirl","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2019.07.702_bib9","doi-asserted-by":"crossref","first-page":"12780","DOI":"10.1074\/jbc.274.18.12780","article-title":"A\u00a0cytoplasmic sequence in human tyrosinase defines a second class of di-leucine-based sorting signals for late endosomal and lysosomal delivery","volume":"274","author":"Calvo","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.07.702_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1600-0749.1988.tb00420.x","article-title":"Photo-induced events in the human melanocytic system: photoaggression and photoprotection","volume":"1","author":"Cesarini","year":"1988","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2019.07.702_bib11","doi-asserted-by":"crossref","first-page":"19974","DOI":"10.1074\/jbc.M210049200","article-title":"Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain","volume":"278","author":"Chen","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.07.702_bib12","doi-asserted-by":"crossref","first-page":"e65096","DOI":"10.1371\/journal.pone.0065096","article-title":"Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish","volume":"8","author":"Clancey","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.07.702_bib13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.mod.2004.06.005","article-title":"Touchtone promotes survival of embryonic melanophores in zebrafish","volume":"121","author":"Cornell","year":"2004","journal-title":"Mech Dev"},{"key":"10.1016\/j.jid.2019.07.702_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ydbio.2010.04.023","article-title":"Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest","volume":"344","author":"Curran","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2004.09.073","article-title":"Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing","volume":"373","author":"Deary","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jid.2019.07.702_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/pcmr.12053","article-title":"Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease","volume":"26","author":"Dooley","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2019.07.702_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1083\/jcb.8.1.165","article-title":"Electron microscope studies of epidermal melanocytes, and the fine structure of melanin granules","volume":"8","author":"Drochmans","year":"1960","journal-title":"J\u00a0Biophys Biochem Cytol"},{"key":"10.1016\/j.jid.2019.07.702_bib18","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jid.2017.02.004","article-title":"Pigmentation traits, Sun exposure, and risk of incident vitiligo in women","volume":"137","author":"Dunlap","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cub.2005.02.050","article-title":"Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7","volume":"15","author":"Elizondo","year":"2005","journal-title":"Curr Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib20","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1182\/blood-2010-10-314120","article-title":"mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish","volume":"117","author":"Ellett","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jid.2019.07.702_bib21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/archneur.65.8.1031","article-title":"Phase 2 safety trial targeting amyloid beta production with a \u03b3-secretase inhibitor in Alzheimer disease","volume":"65","author":"Fleisher","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jid.2019.07.702_bib22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/embo-reports\/kvf124","article-title":"A\u00a0\u03b3-secretase inhibitor blocks Notch signaling in\u00a0vivo and causes a severe neurogenic phenotype in zebrafish","volume":"3","author":"Geling","year":"2002","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jid.2019.07.702_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tibs.2006.11.001","article-title":"Cell death by necrosis: towards a molecular definition","volume":"32","author":"Golstein","year":"2007","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jid.2019.07.702_bib24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature10400","article-title":"Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis","volume":"477","author":"G\u00fcnther","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.07.702_bib25","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.286.5441.916","article-title":"The presenilins in Alzheimer's disease--proteolysis holds the key","volume":"286","author":"Haass","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jid.2019.07.702_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/34800","article-title":"Alzheimer's disease. A technical KO of amyloid-beta peptide","volume":"391","author":"Haass","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.07.702_bib27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1600-0749.2005.00213.x","article-title":"Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation","volume":"18","author":"Hall","year":"2005","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2019.07.702_bib28","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1124\/jpet.104.082735","article-title":"Insulin receptor-protein kinase C-gamma signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons","volume":"313","author":"Hamabe","year":"2005","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jid.2019.07.702_bib29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1242\/dev.099804","article-title":"Involvement of Delta\/Notch signaling in zebrafish adult pigment stripe patterning","volume":"141","author":"Hamada","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.jid.2019.07.702_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/jid.2009.214","article-title":"Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation","volume":"130","author":"Hariharan","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-0749.1987.tb00408.x","article-title":"Eumelanin causes DNA strand breaks and kills cells","volume":"1","author":"Hill","year":"1987","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2019.07.702_bib32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.07.702_bib33","first-page":"13518","article-title":"Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch","volume":"30","author":"Hu","year":"2015","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.jid.2019.07.702_bib34","doi-asserted-by":"crossref","first-page":"e0206155","DOI":"10.1371\/journal.pone.0206155","article-title":"The zebrafish orthologue of familial Alzheimer's disease gene presenilin 2 is required for normal adult melanotic skin pigmentation","volume":"13","author":"Jiang","year":"2018","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.07.702_bib35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng.2272","article-title":"Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo","volume":"44","author":"Jin","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2019.07.702_bib36","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1056\/NEJMoa0908547","article-title":"Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo","volume":"362","author":"Jin","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2019.07.702_bib37","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng0692-226","article-title":"Light is a dominant mouse mutation resulting in premature cell death","volume":"1","author":"Johnson","year":"1992","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2019.07.702_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0070-2153(10)92006-1","article-title":"\u03b3-secretase and the intramembrane proteolysis of Notch","volume":"92","author":"Jorissen","year":"2010","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib39","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1365-2133.1999.02761.x","article-title":"Increased prevalence of vitiligo, but no evidence of premature\u00a0ageing, in the skin of patients with bp 3243 mutation in mitochondrial DNA in the mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome (MELAS)","volume":"140","author":"Karvonen","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1242\/dev.123.1.369","article-title":"Zebrafish pigmentation mutations and the processes of neural crest development","volume":"123","author":"Kelsh","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.jid.2019.07.702_bib41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/dbio.2000.9840","article-title":"Genetic analysis of melanophore development in zebrafish embryos","volume":"225","author":"Kelsh","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev Dyn"},{"key":"10.1016\/j.jid.2019.07.702_bib43","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/pcmr.12272","article-title":"A\u00a0dominant mutation in tyrp1A leads to melanophore death in zebrafish","volume":"27","author":"Krauss","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2019.07.702_bib44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1755-148X.2007.00423.x","article-title":"Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis","volume":"21","author":"Kumano","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2019.07.702_bib45","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1073\/pnas.0402248101","article-title":"In\u00a0vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish","volume":"101","author":"Langenau","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.07.702_bib46","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.cdd.4401994","article-title":"A\u00a0necrotic cell death model in a protist","volume":"14","author":"Laporte","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jid.2019.07.702_bib47","first-page":"1219","article-title":"Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance","volume":"148","author":"Le Poole","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2019.07.702_bib48","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1006\/excr.1993.1102","article-title":"Phagocytosis by normal human melanocytes in\u00a0vitro","volume":"205","author":"Le Poole","year":"1993","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jid.2019.07.702_bib49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/189176a0","article-title":"Effect of alpha- and betamelanocyte stimulating hormones on the skin colour of man","volume":"189","author":"Lerner","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.07.702_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1346-8138.1978.tb01041.x","article-title":"Vitiligo: the loss of pigment in skin, hair and eyes","volume":"5","author":"Lerner","year":"1978","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib51","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd4627","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jid.2019.07.702_bib52","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1600-0749.2006.00320.x","article-title":"The zebrafish mutant vps18 as a model for vesicle-traffic related hypopigmentation diseases","volume":"19","author":"Maldonado","year":"2006","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2019.07.702_bib53","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/sj.jid.5700710","article-title":"Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis","volume":"127","author":"McNeill","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib54","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.200509084","article-title":"Notch signaling via Hes1 transcription factor maintains survival of\u00a0melanoblasts and melanocyte stem cells","volume":"173","author":"Moriyama","year":"2006","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib55","doi-asserted-by":"crossref","first-page":"15058","DOI":"10.1038\/cddiscovery.2015.58","article-title":"Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa","volume":"1","author":"Murakami","year":"2015","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jid.2019.07.702_bib56","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1073\/pnas.0530113100","article-title":"Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program","volume":"100","author":"Niquet","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.07.702_bib57","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1016\/j.yexcr.2009.06.023","article-title":"Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos","volume":"315","author":"Nornes","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jid.2019.07.702_bib58","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1167\/iovs.08-2743","article-title":"The vacuolar-ATPase complex regulates retinoblast proliferation and survival, photoreceptor morphogenesis, and pigmentation in the zebrafish eye","volume":"50","author":"Nuckels","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jid.2019.07.702_bib59","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1242\/dev.126.15.3425","article-title":"Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes but is not essential for hematopoiesis or primordial germ cell development","volume":"126","author":"Parichy","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.jid.2019.07.702_bib60","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1242\/dev.00307","article-title":"Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development","volume":"130","author":"Parichy","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.jid.2019.07.702_bib61","doi-asserted-by":"crossref","first-page":"750","DOI":"10.14348\/molcells.2016.0173","article-title":"Innate color preference of zebrafish and its use in behavioral analyses","volume":"39","author":"Park","year":"2016","journal-title":"Mol Cells"},{"key":"10.1016\/j.jid.2019.07.702_bib62","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/emboj\/21.3.221","article-title":"The ATP synthase is involved in generating mitochondrial cristae morphology","volume":"21","author":"Paumard","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2019.07.702_bib63","doi-asserted-by":"crossref","first-page":"15011","DOI":"10.1038\/nrdp.2015.11","article-title":"Vitiligo","volume":"1","author":"Picardo","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jid.2019.07.702_bib64","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cdd.2009.195","article-title":"Molecular mechanisms of late apoptotic\/necrotic cell clearance","volume":"17","author":"Poon","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jid.2019.07.702_bib111","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jmicro\/dfm036","article-title":"Vogt-Koyanagi-Harada disease and vitiligo","volume":"57","author":"Prignano","year":"2008","journal-title":"Where does the illness begin? J Electron Microsc (Tokyo)"},{"key":"10.1016\/j.jid.2019.07.702_bib65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1756-0500-6-39","article-title":"The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype","volume":"6","author":"Ramos-Balderas","year":"2013","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.jid.2019.07.702_bib66","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.coi.2013.10.010","article-title":"Innate immune mechanisms in vitiligo: danger from within","volume":"25","author":"Richmond","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jid.2019.07.702_bib67","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ydbio.2003.07.003","article-title":"A\u00a0Notch feeling of somite segmentation and beyond","volume":"265","author":"Rida","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2016.10.048","article-title":"New discoveries in the pathogenesis and classification of vitiligo","volume":"77","author":"Rodrigues","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cell.2016.05.020","article-title":"Restricted location of PSEN2\/gamma-Secretase determines substrate specificity and generates an intracellular Abeta pool","volume":"166","author":"Sannerud","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jid.2019.07.702_bib70","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/08830185.2013.771183","article-title":"Macrophages and recently identified forms of cell death","volume":"33","author":"Sanz","year":"2014","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.jid.2019.07.702_bib71","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1242\/dev.006098","article-title":"The zebrafish mutant lbk\/vam6 resembles human multisystemic disorders caused by aberrant trafficking of endosomal vesicles","volume":"135","author":"Schonthaler","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.jid.2019.07.702_bib72","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ydbio.2005.06.001","article-title":"A\u00a0mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision","volume":"284","author":"Schonthaler","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib73","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jid.2019.07.702_bib74","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1073\/pnas.0408901102","article-title":"Differential contribution of the three Aph1 genes to \u03b3-secretase activity in\u00a0vivo","volume":"102","author":"Serneels","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.07.702_bib75","doi-asserted-by":"crossref","first-page":"e0147582","DOI":"10.1371\/journal.pone.0147582","article-title":"Cell death in the epithelia of the intestine and hepatopancreas in Neocaridina Heteropoda (Crustacea, Malacostraca)","volume":"11","author":"Sonakowska","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.07.702_bib76","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2174\/156652410793937813","article-title":"The retinal pigment epithelium in health and disease","volume":"10","author":"Sparrow","year":"2010","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jid.2019.07.702_bib77","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1523\/JNEUROSCI.1320-09.2009","article-title":"Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration","volume":"29","author":"Tabuchi","year":"2009","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2019.07.702_bib78","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1167\/iovs.10-5957","article-title":"The loss of vacuolar protein sorting 11 (vps11) causes retinal pathogenesis in a vertebrate model of syndromic albinism","volume":"52","author":"Thomas","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jid.2019.07.702_bib79","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jdermsci.2015.02.001","article-title":"Biochemical, cytological, and immunological mechanisms of rhododendrol-induced leukoderma","volume":"77","author":"Tokura","year":"2015","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2019.07.702_bib80","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/019262339702500116","article-title":"The pathways of cell death: oncosis, apoptosis, and necrosis","volume":"25","author":"Trump","year":"1997","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.jid.2019.07.702_bib81","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/jid.2011.16","article-title":"Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy","volume":"131","author":"van den Boorn","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.07.702_bib82","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1196284","article-title":"\u03b3-secretase gene mutations in familial acne inversa","volume":"330","author":"Wang","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jid.2019.07.702_bib83","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1073\/pnas.0509822102","article-title":"Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation","volume":"103","author":"Wang","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.07.702_bib84","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00403-017-1730-7","article-title":"Differences in the melanosome distribution within the epidermal melanin units and its association with the impairing background of leukoderma in vitiligo and halo nevi: a retrospective study","volume":"309","author":"Xiong","year":"2017","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2019.07.702_bib85","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.07.702_bib86","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1089\/zeb.2015.1208","article-title":"A\u00a0sketch of the Taiwan zebrafish Core facility","volume":"13","author":"You","year":"2016","journal-title":"Zebrafish"},{"key":"10.1016\/j.jid.2019.07.702_bib87","doi-asserted-by":"crossref","first-page":"e51040","DOI":"10.1371\/journal.pone.0051040","article-title":"Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin","volume":"7","author":"Yu","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.07.702_bib88","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1073\/pnas.1100735108","article-title":"Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk","volume":"108","author":"Zampese","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.07.702_bib89","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1074\/jbc.M707528200","article-title":"The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction","volume":"283","author":"Zhang","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.07.702_bib90","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.1074\/jbc.M409467200","article-title":"Nicastrin is critical for stability and trafficking but not association of other presenilin\/\u03b3-secretase components","volume":"280","author":"Zhang","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2019.07.702_bib91","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1523\/JNEUROSCI.3826-09.2010","article-title":"Gamma-secretase composed of PS1\/Pen2\/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin","volume":"30","author":"Zhao","year":"2010","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2019.07.702_bib92","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1111\/j.1460-9568.2009.06942.x","article-title":"Analysis of the nicastrin promoter rs10752637 polymorphism and its association with Alzheimer's disease","volume":"30","author":"Zhong","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jid.2019.07.702_bib93","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.devcel.2006.11.012","article-title":"A\u00a0morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans","volume":"12","author":"Abraham","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2019.07.702_bib94","doi-asserted-by":"crossref","first-page":"e0121674","DOI":"10.1371\/journal.pone.0121674","article-title":"Multimodal holographic microscopy: distinction between apoptosis and oncosis","volume":"10","author":"Balvan","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.07.702_bib113","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nmeth.2075","article-title":"(2012). Icy: an open bioimage informatics platform for extended reproducible research","volume":"9","author":"de Chaumont","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2019.07.702_bib112","doi-asserted-by":"crossref","first-page":"e644","DOI":"10.7717\/peerj.644","article-title":"Unipro UGENE NGS pipelines and components for variant calling, RNA-seq and ChIP-seq data analyses","volume":"2","author":"Golosova","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.jid.2019.07.702_bib95","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature10400","article-title":"Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis","volume":"477","author":"G\u00fcnther","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jid.2019.07.702_bib96","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1124\/jpet.104.082735","article-title":"Insulin receptor-protein kinase C-gamma signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons","volume":"313","author":"Hamabe","year":"2005","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jid.2019.07.702_bib97","doi-asserted-by":"crossref","first-page":"10673","DOI":"10.1038\/srep10673","article-title":"A\u00a0new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect","volume":"5","author":"Hsu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2019.07.702_bib98","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/cdd.2008.42","article-title":"BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals","volume":"15","author":"Jette","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jid.2019.07.702_bib99","doi-asserted-by":"crossref","first-page":"e1565","DOI":"10.1038\/cddis.2014.514","article-title":"Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia","volume":"5","author":"Kavanagh","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2019.07.702_bib100","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1091\/mbc.e09-02-0109","article-title":"Udu deficiency activates DNA damage checkpoint","volume":"20","author":"Lim","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jid.2019.07.702_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-213X-6-1","article-title":"Proteomics of early zebrafish embryos","volume":"6","author":"Link","year":"2006","journal-title":"BMC Dev Biol"},{"key":"10.1016\/j.jid.2019.07.702_bib102","doi-asserted-by":"crossref","first-page":"15058","DOI":"10.1038\/cddiscovery.2015.58","article-title":"Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa","volume":"1","author":"Murakami","year":"2015","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jid.2019.07.702_bib103","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/cdd.2017.36","article-title":"Caspase-dependent non-apoptotic processes in development","volume":"24","author":"Nakajima","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jid.2019.07.702_bib104","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1073\/pnas.0530113100","article-title":"Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program","volume":"100","author":"Niquet","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2019.07.702_bib105","doi-asserted-by":"crossref","first-page":"750","DOI":"10.14348\/molcells.2016.0173","article-title":"Innate color preference of zebrafish and its use in behavioral analyses","volume":"39","author":"Park","year":"2016","journal-title":"Mol Cells"},{"key":"10.1016\/j.jid.2019.07.702_bib106","doi-asserted-by":"crossref","first-page":"e0147582","DOI":"10.1371\/journal.pone.0147582","article-title":"Cell death in the epithelia of the intestine and hepatopancreas in Neocaridina Heteropoda (Crustacea, Malacostraca)","volume":"11","author":"Sonakowska","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.07.702_bib107","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1093\/nar\/gni124","article-title":"SiteFinding-PCR: a simple and efficient PCR method for chromosome walking","volume":"33","author":"Tan","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2019.07.702_bib108","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jid.2019.07.702_bib109","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/019262339702500116","article-title":"The pathways of cell death: oncosis, apoptosis, and necrosis","volume":"25","author":"Trump","year":"1997","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.jid.2019.07.702_bib110","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.apsb.2013.12.008","article-title":"Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol","volume":"4","author":"Uchida","year":"2014","journal-title":"Acta Pharm Sin B"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19327009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19327009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:18:52Z","timestamp":1758302332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19327009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":113,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0022202X19327009"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.07.702","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicastrin Deficiency Induces Tyrosinase-Dependent Depigmentation and Skin Inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.07.702","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}