{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:58:37Z","timestamp":1770541117027,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jid.2019.08.443","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T19:01:39Z","timestamp":1568055699000},"page":"583-592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exploratory Assessment of Oxygen Flow\u2013Assisted Cutaneous Administration of\u00a0Methotrexate for Superficial Basal Cell\u00a0Carcinoma, Mycosis Fungoides, and\u00a0Extramammary Paget Disease"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-1599","authenticated-orcid":false,"given":"Eve","family":"Lebas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-4157","authenticated-orcid":false,"given":"Corinne","family":"Chapelier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-9655","authenticated-orcid":false,"given":"Pascale","family":"Quatresooz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-269X","authenticated-orcid":false,"given":"Laurence","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5240-4806","authenticated-orcid":false,"given":"A.F.","family":"Nikkels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.08.443_bib1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1470-2045(13)70143-8","article-title":"Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial","volume":"14","author":"Arits","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jid.2019.08.443_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.hoc.2018.09.003","article-title":"Extramammary Paget's disease","volume":"33","author":"Asel","year":"2019","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.jid.2019.08.443_bib3","first-page":"655","article-title":"Skin directed therapy for mycosis fungoides: a review","volume":"7","author":"Berthelot","year":"2008","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1001\/archderm.138.3.325","article-title":"Phase 1 and 2 trial of bexarotene gel for skin-directed treatment of patients with cutaneous T-cell lymphoma","volume":"138","author":"Breneman","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib5","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1001\/archderm.139.5.624","article-title":"Phase 1\/2 pilot study of methotrexate-laurocapram topical gel for the treatment of patients with early-stage mycosis fungoides","volume":"139","author":"Demierre","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib6","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jaad.2003.11.066","article-title":"Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies","volume":"50","author":"Geisse","year":"2004","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.ctrv.2014.06.005","article-title":"Systematic review of combination therapies for mycosis fungoides","volume":"40","author":"Humme","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jid.2019.08.443_bib8","doi-asserted-by":"crossref","first-page":"205.e1","DOI":"10.1016\/j.jaad.2013.07.049","article-title":"Primary cutaneous T-cell lymphoma (mycosis fungoides and S\u00e9zary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers","volume":"70","author":"Jawed","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib9","doi-asserted-by":"crossref","first-page":"223.e1","DOI":"10.1016\/j.jaad.2013.08.033","article-title":"Primary cutaneous T-cell lymphoma (mycosis fungoides and S\u00e9zary syndrome): part II. Prognosis, management, and future directions","volume":"70","author":"Jawed","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/1874372201711010098","article-title":"Prospective pilot evaluation of the efficacy and safety of topical ingenol mebutate gel for localized patch\/plaque stage mycosis fungoides","volume":"11","author":"Lebas","year":"2017","journal-title":"Open Dermatol J"},{"key":"10.1016\/j.jid.2019.08.443_bib11","first-page":"117","article-title":"Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery","volume":"5","author":"Lin","year":"2010","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jid.2019.08.443_bib12","first-page":"155","article-title":"Bexarotene gel: a new skin-directed treatment option for cutaneous T-cell lymphomas","volume":"2","author":"Martin","year":"2003","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.det.2015.05.004","article-title":"Skin-directed therapies in cutaneous T-cell lymphoma","volume":"33","author":"Nguyen","year":"2015","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2019.08.443_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/pharmaceutics10030117","article-title":"Electrically and ultrasonically enhanced transdermal delivery of methotrexate","volume":"10","author":"Nguyen","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jid.2019.08.443_bib15","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood-2015-02-630335","article-title":"Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma","volume":"126","author":"Rook","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jid.2019.08.443_bib16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2133.2012.11061.x","article-title":"Overall\u00a0treatment success after treatment of primary superficial basal\u00a0cell carcinoma: a systematic review and meta-analysis of randomized\u00a0and nonrandomized trials","volume":"167","author":"Roozeboom","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/01443615.2013.790348","article-title":"Imiquimod therapy for extramammary Paget's disease of the vulva: a viable non-surgical alternative","volume":"33","author":"Sanderson","year":"2013","journal-title":"J\u00a0Obstet Gynaecol"},{"key":"10.1016\/j.jid.2019.08.443_bib18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1346-8138.14117","article-title":"Imiquimod 5% cream as a therapeutic option for extramammary Paget's disease","volume":"45","author":"Sawada","year":"2018","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2019.08.443_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1874325001307010057","article-title":"Transcutaneous treatment with vetdrop(\u00ae) sustains the adjacent cartilage in a microfracturing joint defect model in sheep","volume":"7","author":"Sidler","year":"2013","journal-title":"Open Orthop J"},{"key":"10.1016\/j.jid.2019.08.443_bib20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12917-014-0268-6","article-title":"Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop\u00ae in a microfracture joint defect model in sheep","volume":"10","author":"Sidler","year":"2014","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jid.2019.08.443_bib21","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/17425247.2015.1031216","article-title":"Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation","volume":"12","author":"Taudorf","year":"2015","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.jid.2019.08.443_bib22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/lsm.22484","article-title":"Fractional laser-assisted drug delivery: laser channel depth influences biodistribution and skin deposition of methotrexate","volume":"48","author":"Taudorf","year":"2016","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.jid.2019.08.443_bib23","unstructured":"Teslenko A, Gulik D, Von Hahn F inventors; Percutaneous application system. US\u00a0patent 9,943,671, http:\/\/patft.uspto.gov\/netacgi\/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=9,943,671.PN.&OS=PN\/9,943,671&RS=PN\/9,943,671; 2013 (accessed 17 April 2018)."},{"key":"10.1016\/j.jid.2019.08.443_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejca.2017.02.027","article-title":"European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides\/S\u00e9zary syndrome - Update 2017","volume":"77","author":"Trautinger","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jid.2019.08.443_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1211\/jpp.60.1.0004","article-title":"Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate","volume":"60","author":"Vemulapalli","year":"2008","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.jid.2019.08.443_bib26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/TCRM.S154745","article-title":"Update on subcutaneous methotrexate for inflammatory arthritis and psoriasis","volume":"14","author":"Vena","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.jid.2019.08.443_bib27","first-page":"CD008946","article-title":"Interventions for mycosis fungoides","volume":"9","author":"Weberschock","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jid.2019.08.443_bib28","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/ajh.24876","article-title":"Cutaneous T-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management","volume":"92","author":"Wilcox","year":"2017","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jid.2019.08.443_bib29","first-page":"891","article-title":"Methotrexate for topical application in an extemporaneous preparation","volume":"13","author":"Wohlrab","year":"2015","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.jid.2019.08.443_bib30","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0190-9622(03)01591-3","article-title":"Low-dose methotrexate to treat mycosis fungoides: a retrospective study in 69 patients","volume":"49","author":"Zackheim","year":"2003","journal-title":"J\u00a0Am Acad Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19332154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19332154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:17:34Z","timestamp":1758302254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19332154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0022202X19332154"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.08.443","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploratory Assessment of Oxygen Flow\u2013Assisted Cutaneous Administration of\u00a0Methotrexate for Superficial Basal Cell\u00a0Carcinoma, Mycosis Fungoides, and\u00a0Extramammary Paget Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.08.443","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}