{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:05Z","timestamp":1790775725444,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"ATIP-AVENIR"},{"name":"ANR JCJC"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jid.2019.11.013","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T23:45:43Z","timestamp":1577144743000},"page":"1143-1153.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["NKG2D Defines a Subset of Skin Effector Memory CD8 T Cells with Proinflammatory Functions in Vitiligo"],"prefix":"10.1016","volume":"140","author":[{"given":"Cl\u00e9ment","family":"Jacquemin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Lucchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Thiolat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Taieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Seneschal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Boniface","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.11.013_bib1","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1136\/gutjnl-2016-311824","article-title":"Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn\u2019s disease: a randomised controlled trial","volume":"66","author":"Allez","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jid.2019.11.013_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/bjd.12034","article-title":"Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo","volume":"168","author":"Benzekri","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/pcmr.12219","article-title":"Type I interferon signature in the initiation of the immune response in vitiligo","volume":"27","author":"Bertolotti","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2019.11.013_bib4","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/1523-1747.ep12338641","article-title":"Interleukin-15 mRNA is expressed by human keratinocytes Langerhans cells, and blood-derived dendritic cells and is downregulated by ultraviolet B radiation","volume":"106","author":"Blauvelt","year":"1996","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jid.2017.08.038","article-title":"Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3","volume":"138","author":"Boniface","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/exd.13879","article-title":"Vitiligo as a skin memory disease: the need for early intervention with immunomodulating agents and a maintenance therapy to target resident memory T cells","volume":"28","author":"Boniface","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12016-017-8622-7","article-title":"Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy","volume":"54","author":"Boniface","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib8","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/jid.2013.540","article-title":"A\u00a0quantitative increase in regulatory T cells controls development of vitiligo","volume":"134","author":"Chatterjee","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2019.05.011","article-title":"Oxidative stress-induced IL-15 transtrans-presentation in keratinocytes contributes to CD8+ T cells activation via JAK-STAT pathway in vitiligo","volume":"139","author":"Chen","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jid.2019.11.013_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2017.01.009","article-title":"CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin","volume":"46","author":"Cheuk","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2019.11.013_bib11","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.176.7.4431","article-title":"The vast majority of CLA+ T cells are resident in normal skin","volume":"176","author":"Clark","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib12","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.jid.5700199","article-title":"A\u00a0novel method for the isolation of skin resident T cells from normal and diseased human skin","volume":"126","author":"Clark","year":"2006","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib13","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1002\/eji.201444990","article-title":"Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity","volume":"45","author":"Cox","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib14","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1001\/jamadermatol.2015.1520","article-title":"Tofacitinib citrate for the treatment of vitiligo: a pathogenesis-directed therapy","volume":"151","author":"Craiglow","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.coi.2018.02.004","article-title":"NKG2D and its ligands in cancer","volume":"51","author":"Dhar","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2019.11.013_bib17","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.4049\/jimmunol.0902778","article-title":"Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice","volume":"184","author":"Gregg","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib18","first-page":"643","article-title":"IFN-\u03b3 in vitiligo, is it the fuel or the fire?","volume":"95","author":"Harris","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2019.11.013_bib19","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/jid.2011.463","article-title":"A\u00a0mouse model of vitiligo with focused epidermal depigmentation requires IFN-\u03b3 for autoreactive CD8+ T-cell accumulation in the skin","volume":"132","author":"Harris","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jaad.2015.09.073","article-title":"Rapid skin repigmentation on oral Ruxolitinib in a patient with coexistent vitiligo and alopecia areata (AA)","volume":"74","author":"Harris","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib21","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/bjd.15550","article-title":"Heat shock protein 70 potentiates interferon alpha production by plasmacytoid dendritic cells: relevance for cutaneous lupus and vitiligo pathogenesis","volume":"177","author":"Jacquemin","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib22","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4049\/jimmunol.170.3.1249","article-title":"Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection","volume":"170","author":"Jinushi","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib23","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/eji.201646805","article-title":"NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice","volume":"47","author":"Kavazovi\u0107","year":"2017","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jaad.2017.05.043","article-title":"Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure","volume":"77","author":"Liu","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/pcmr.12559","article-title":"Differential expression of CXCL9, CXCL10, and IFN-\u03b3 in vitiligo and alopecia areata patients","volume":"30","author":"Maouia","year":"2017","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2019.11.013_bib26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.autrev.2006.03.012","article-title":"Therapeutic implications of autoimmune vitiligo T cells","volume":"5","author":"Oyarbide-Valencia","year":"2006","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2019.11.013_bib27","doi-asserted-by":"crossref","first-page":"223ra23","DOI":"10.1126\/scitranslmed.3007811","article-title":"CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo","volume":"6","author":"Rashighi","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2019.11.013_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.humimm.2012.01.011","article-title":"The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells","volume":"73","author":"Reimann","year":"2012","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jid.2018.10.032","article-title":"Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo","volume":"139","author":"Richmond","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam7710","article-title":"Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo","volume":"10","author":"Richmond","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2019.11.013_bib31","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jaad.2017.02.049","article-title":"Treatment of vitiligo with the topical Janus kinase inhibitor Ruxolitinib","volume":"76","author":"Rothstein","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1074-7613(00)80169-7","article-title":"Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism","volume":"12","author":"San Jos\u00e9","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2019.11.013_bib33","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jaad.2015.05.014","article-title":"Confetti-like depigmentation: a potential sign of rapidly progressing vitiligo","volume":"73","author":"Sosa","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0749.2006.00355.x","article-title":"The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force","volume":"20","author":"Ta\u00efeb","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2019.11.013_bib35","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"van den Boorn","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib36","article-title":"Th17 cells and activated dendritic cells are increased in vitiligo lesions","volume":"6","author":"Wang","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.11.013_bib37","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/bjd.14416","article-title":"Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo","volume":"174","author":"Wang","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.11.013_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3389\/fimmu.2018.00441","article-title":"NKG2D: a master regulator of immune cell responsiveness","volume":"9","author":"Wensveen","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2019.11.013_bib39","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2340\/00015555-2080","article-title":"Interferon-gamma inhibits melanogenesis and induces apoptosis in melanocytes: a pivotal role of CD8+ cytotoxic T lymphocytes in vitiligo","volume":"95","author":"Yang","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2019.11.013_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051040","article-title":"Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin","volume":"7","author":"Yu","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2019.11.013_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1034\/j.1600-0749.2002.00065.x","article-title":"Dermal nevus cells from congenital nevi cannot penetrate the dermis in skin reconstructs","volume":"15","author":"Gontier","year":"2002","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2019.11.013_bib41","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/bjd.15550","article-title":"Heat shock protein 70 potentiates interferon alpha production by plasmacytoid dendritic cells: relevance for cutaneous lupus and vitiligo pathogenesis","volume":"177","author":"Jacquemin","year":"2017","journal-title":"Br J Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19334955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X19334955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:44:50Z","timestamp":1762206290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X19334955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0022202X19334955"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.11.013","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NKG2D Defines a Subset of Skin Effector Memory CD8 T Cells with Proinflammatory Functions in Vitiligo","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}