{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:56:02Z","timestamp":1790661362144,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006196","name":"Jet Propulsion Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","award":["NCT03036995"],"award-info":[{"award-number":["NCT03036995"]}],"id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jid.2019.11.031","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T19:42:10Z","timestamp":1580240530000},"page":"1533-1537.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Apremilast in Combination with Narrowband UVB in the Treatment of Vitiligo: A 52-Week Monocentric Prospective Randomized Placebo-Controlled Study"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-5875","authenticated-orcid":false,"given":"Abdallah","family":"Khemis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-9626","authenticated-orcid":false,"given":"Eric","family":"Fontas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-2593","authenticated-orcid":false,"given":"Sophie","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-4829","authenticated-orcid":false,"given":"Henri","family":"Montaudi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-2053","authenticated-orcid":false,"given":"Jean-Philippe","family":"Lacour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"Thierry","family":"Passeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2019.11.031_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059782","article-title":"Vitiligo: a possible model of degenerative diseases","volume":"8","author":"Bellei","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2019.11.031_bib2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1001\/jama.2016.12399","article-title":"Interventions for vitiligo","volume":"316","author":"Ezzedine","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jid.2019.11.031_bib3","first-page":"2386234","article-title":"Repigmentation of tenacious vitiligo on apremilast","volume":"2017","author":"Huff","year":"2017","journal-title":"Case Rep Dermatol Med"},{"key":"10.1016\/j.jid.2019.11.031_bib4","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng.2272","article-title":"Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo","volume":"44","author":"Jin","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2019.11.031_bib5","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1101\/gad.1937710","article-title":"Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit","volume":"24","author":"Khaled","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2019.11.031_bib6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/bjd.13432","article-title":"Vitiligo Area Scoring Index and Vitiligo European Task Force assessment: reliable and responsive instruments to measure the degree of depigmentation in vitiligo","volume":"172","author":"Komen","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1755-148X.2011.00945.x","article-title":"Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris","volume":"25","author":"Kotobuki","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2019.11.031_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/jamadermatol.2014.1875","article-title":"Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: a randomized multicenter trial","volume":"151","author":"Lim","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jaad.2017.05.043","article-title":"Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure","volume":"77","author":"Liu","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib10","article-title":"Apremilast is effective in controlling the progression of adult vitiligo: a case series","volume":"32","author":"Majid","year":"2019","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jid.2019.11.031_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jaad.2015.03.049","article-title":"Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of apremilast in Psoriasis [ESTEEM] 1)","volume":"73","author":"Papp","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.det.2016.11.007","article-title":"Medical and maintenance treatments for vitiligo","volume":"35","author":"Passeron","year":"2017","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2019.11.031_bib13","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1038\/jid.2012.328","article-title":"Activation of the unfolded protein response in vitiligo: the missing link?","volume":"132","author":"Passeron","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib14","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/bjd.14164","article-title":"Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate-to-severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)","volume":"173","author":"Paul","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jid.2016.09.016","article-title":"Keratinocyte-derived chemokines orchestrate T-cell positioning in the epidermis during vitiligo and may serve as biomarkers of disease","volume":"137","author":"Richmond","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/039463201002300424","article-title":"The presence of non-segmental vitiligo modifies intracellular cytokine subsets in patients with chronic lymphocytic thyroiditis","volume":"23","author":"Santaguida","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jid.2019.11.031_bib17","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.cellsig.2014.05.014","article-title":"Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity","volume":"26","author":"Schafer","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.jid.2019.11.031_bib18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1476-5381.2009.00559.x","article-title":"Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in\u00a0vitro and in a model of psoriasis","volume":"159","author":"Schafer","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jid.2019.11.031_bib19","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1096\/fj.12-226779","article-title":"Basic evidence for epidermal H2O2\/ONOO(-)-mediated oxidation\/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS","volume":"27","author":"Schallreuter","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.jid.2019.11.031_bib20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/jid.2011.321","article-title":"Six decades of vitiligo genetics: genome-wide studies provide insights into autoimmune pathogenesis","volume":"132","author":"Spritz","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0749.2006.00355.x","article-title":"The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force","volume":"20","author":"Ta\u00efeb","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2019.11.031_bib22","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/s41467-019-09963-8","article-title":"Innate\u00a0lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo","volume":"10","author":"Tulic","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2019.11.031_bib23","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jid.2015.12.040","article-title":"Development and validation of the Vitiligo Extent Score (VES): an international collaborative initiative","volume":"136","author":"van Geel","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2019.11.031_bib24","article-title":"Th17 cells and activated dendritic cells are increased in vitiligo lesions","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2019.11.031_bib25","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1038\/jid.2013.235","article-title":"Wnt\/beta-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation","volume":"133","author":"Yamada","year":"2013","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20300671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20300671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:03:46Z","timestamp":1777417426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X20300671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0022202X20300671"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2019.11.031","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apremilast in Combination with Narrowband UVB in the Treatment of Vitiligo: A 52-Week Monocentric Prospective Randomized Placebo-Controlled Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}