{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:34:31Z","timestamp":1758317671243,"version":"3.44.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jid.2020.01.017","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T06:05:55Z","timestamp":1589954755000},"page":"1131-1133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["It Takes Two to Tango"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-7228","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Guevara-Pati\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1795-185X","authenticated-orcid":false,"given":"Lourdes","family":"Plaza-Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2020.01.017_bib1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.285.5428.727","article-title":"Activation of NK cells and T\u00a0cells by NKG2D, a receptor for stress-inducible MICA","volume":"285","author":"Bauer","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jid.2020.01.017_bib2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1074-7613(00)80222-8","article-title":"Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice","volume":"12","author":"Cerwenka","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2020.01.017_bib3","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1073\/pnas.201238598","article-title":"Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in\u00a0vivo","volume":"98","author":"Cerwenka","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2020.01.017_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1074-7613(01)00095-4","article-title":"ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor","volume":"14","author":"Cosman","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2020.01.017_bib5","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.4049\/jimmunol.1501798","article-title":"CXCR3 blockade inhibits T cell migration into the skin and prevents development of alopecia areata","volume":"197","author":"Dai","year":"2016","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2020.01.017_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/77793","article-title":"Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages","volume":"1","author":"Diefenbach","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2020.01.017_bib7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nm1363","article-title":"Autoimmunity and tumor immunity induced by immune responses to mutations in self","volume":"12","author":"Engelhorn","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2020.01.017_bib8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jaad.2015.07.039","article-title":"Vitiligo is not a cosmetic disease","volume":"73","author":"Ezzedine","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2020.01.017_bib9","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.4049\/jimmunol.0902778","article-title":"Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice","volume":"184","author":"Gregg","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2020.01.017_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/imr.12369","article-title":"Cellular stress and innate inflammation in organ-specific autoimmunity: lessons learned from vitiligo","volume":"269","author":"Harris","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2020.01.017_bib23","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jid.2019.11.013","article-title":"NKG2D defines a subset of skin effector memory CD8 T cells with proinflammatory functions in vitiligo","volume":"140","author":"Jacquemin","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2020.01.017_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.immuni.2011.11.014","article-title":"RAE1\u03b5 ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition","volume":"36","author":"Markiewicz","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2020.01.017_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2004.06.020","article-title":"Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL\u00a0into lymphokine-activated killer cells in\u00a0celiac disease","volume":"21","author":"Meresse","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2020.01.017_bib13","doi-asserted-by":"crossref","first-page":"174ra28","DOI":"10.1126\/scitranslmed.3005127","article-title":"Mutant HSP70 reverses autoimmune depigmentation in vitiligo","volume":"5","author":"Mosenson","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2020.01.017_bib14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1074-7613(01)00187-X","article-title":"Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60","volume":"15","author":"O'Callaghan","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2020.01.017_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40425-019-0531-2","article-title":"NKG2D signaling certifies effector CD8 T cells for memory formation","volume":"7","author":"Perez","year":"2019","journal-title":"J\u00a0Immunother Cancer"},{"key":"10.1016\/j.jid.2020.01.017_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature09114","article-title":"Genome-wide association study in alopecia areata implicates both innate and adaptive immunity","volume":"466","author":"Petukhova","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jid.2020.01.017_bib17","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1084\/jem.20150303","article-title":"Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease","volume":"212","author":"Tang","year":"2015","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2020.01.017_bib18","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"van den Boorn","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.01.017_bib19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.3645","article-title":"Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition","volume":"20","author":"Xing","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2020.01.017_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051040","article-title":"Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2020.01.017_bib21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nm.2683","article-title":"NKG2D signaling on CD8(+) T cells represses T-bet and rescues CD4-unhelped CD8(+) T cell memory recall but not effector responses","volume":"18","author":"Zloza","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2020.01.017_bib22","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/08916934.2011.593599","article-title":"Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo","volume":"44","author":"Zloza","year":"2011","journal-title":"Autoimmunity"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20301317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20301317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:18:12Z","timestamp":1758302292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X20301317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0022202X20301317"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2020.01.017","relation":{},"ISSN":["0022-202X"],"issn-type":[{"type":"print","value":"0022-202X"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"It Takes Two to Tango","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2020.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2019.11.013","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}