{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:16:55Z","timestamp":1791303415318,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100016193","name":"University of Colorado School of Medicine, Anschutz Medical Campus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jid.2020.07.016","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T02:20:38Z","timestamp":1597285238000},"page":"638-647.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-3767","authenticated-orcid":false,"given":"Nathaniel B.","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-4648","authenticated-orcid":false,"given":"Andrea","family":"Steel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-8190","authenticated-orcid":false,"given":"Chauncey C.","family":"Barbulescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4448-8119","authenticated-orcid":false,"given":"Maranke I.","family":"Koster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-7685","authenticated-orcid":false,"given":"Michael J.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bifeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Woessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-4294","authenticated-orcid":false,"given":"Zachary","family":"Trottier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-7189","authenticated-orcid":false,"given":"Jen","family":"Pakieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-7916","authenticated-orcid":false,"given":"Junxiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-711X","authenticated-orcid":false,"given":"Karoline A.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-5753","authenticated-orcid":false,"given":"Yiqun G.","family":"Shellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-1925","authenticated-orcid":false,"given":"Mayumi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1875-9691","authenticated-orcid":false,"given":"William A.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-5880","authenticated-orcid":false,"given":"Dennis R.","family":"Roop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-737X","authenticated-orcid":false,"given":"David A.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5899-8956","authenticated-orcid":false,"given":"Stanca A.","family":"Birlea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2020.07.016_bib1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ncb1400","article-title":"Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling","volume":"8","author":"Asanuma","year":"2006","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jid.2020.07.016_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jid.2019.03.1142","article-title":"Harnessing the power of regenerative therapy for vitiligo and alopecia areata","volume":"140","author":"Barbulescu","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/med.21426","article-title":"Trends in regenerative medicine: repigmentation in vitiligo through melanocyte stem cell mobilization","volume":"37","author":"Birlea","year":"2017","journal-title":"Med Res Rev"},{"key":"10.1016\/j.jid.2020.07.016_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.det.2016.11.015","article-title":"Repigmentation through melanocyte regeneration in vitiligo","volume":"35","author":"Birlea","year":"2017","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2020.07.016_bib5","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1093\/emboj\/20.17.4912","article-title":"Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation","volume":"20","author":"Damalas","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2020.07.016_bib6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/pcmr.12284","article-title":"Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation","volume":"27","author":"Eby","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2020.07.016_bib7","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/jid.2015.126","article-title":"Narrow band ultraviolet B treatment for human vitiligo is associated with proliferation, migration, and differentiation of melanocyte precursors","volume":"135","author":"Goldstein","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib8","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jid.2017.09.040","article-title":"Repigmentation of human vitiligo skin by NBUVB is controlled by transcription of GLI1 and activation of the \u03b2-catenin pathway in the hair follicle bulge stem cells","volume":"138","author":"Goldstein","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib9","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1158\/0008-5472.CAN-12-0775","article-title":"RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage","volume":"72","author":"Ho","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2020.07.016_bib10","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/pcmr.12058","article-title":"RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics","volume":"26","author":"Ho","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2020.07.016_bib11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.dnarep.2017.01.003","article-title":"The crosstalk between Wnt\/\u03b2-catenin signaling pathway with DNA damage response and oxidative stress: implications in cancer therapy","volume":"51","author":"Karimaian","year":"2017","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.jid.2020.07.016_bib12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/srep00164","article-title":"Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection","volume":"1","author":"Kasamatsu","year":"2011","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2020.07.016_bib13","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/sj.onc.1205229","article-title":"Cdc25C\u00a0interacts with PCNA at G2\/M transition","volume":"21","author":"Kawabe","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jid.2020.07.016_bib14","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.3390\/ijms14036414","article-title":"Molecular mechanisms of UV-induced apoptosis and its effects on skin residential cells: the implication in UV-based phototherapy","volume":"14","author":"Lee","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2020.07.016_bib15","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1755-148X.2010.00762.x","article-title":"The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis","volume":"23","author":"Luecke","year":"2010","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2020.07.016_bib74","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0006-291X(03)01497-9","article-title":"Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less","volume":"308","author":"Masuhara","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2020.07.016_bib16","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1074\/jbc.M805570200","article-title":"The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling","volume":"284","author":"Murase","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2020.07.016_bib17","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.cellsig.2015.03.009","article-title":"PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling","volume":"27","author":"Olaisen","year":"2015","journal-title":"Cell Signal"},{"key":"10.1016\/j.jid.2020.07.016_bib18","doi-asserted-by":"crossref","first-page":"18457","DOI":"10.1074\/jbc.M117.793034","article-title":"Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress","volume":"292","author":"Opalko","year":"2017","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2020.07.016_bib19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/sj.cdd.4401183","article-title":"Decision making by p53: life, death and cancer","volume":"10","author":"Oren","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jid.2020.07.016_bib20","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2011.05.004","article-title":"Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration","volume":"145","author":"Rabbani","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jid.2020.07.016_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.det.2016.11.014","article-title":"Vitiligo pathogenesis and emerging treatments","volume":"35","author":"Rashighi","year":"2017","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2020.07.016_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003253","article-title":"A\u00a0kinome-wide RNAi screen in Drosophila glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma","volume":"9","author":"Read","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2020.07.016_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112275","article-title":"KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development","volume":"9","author":"Ren","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2020.07.016_bib24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ajhg.2019.06.013","article-title":"Family clustering of autoimmune vitiligo results principally from polygenic inheritance of common risk alleles","volume":"105","author":"Roberts","year":"2019","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2020.07.016_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006913","article-title":"The RhoJ-BAD signaling network: an Achilles' heel for BRAF mutant melanomas","volume":"13","author":"Ruiz","year":"2017","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2020.07.016_bib75","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2020.07.016_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/excr.1997.3765","article-title":"Alpha-melanocyte-stimulating hormone and endothelin-1 have opposing effects on melanocyte adhesion, migration, and pp125FAK phosphorylation","volume":"237","author":"Scott","year":"1997","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jid.2020.07.016_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1600-0749.2003.00022.x","article-title":"The cAMP signaling pathway has opposing effects on Rac and Rho in B16F10 cells: implications for dendrite formation in melanocytic cells","volume":"16","author":"Scott","year":"2003","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2020.07.016_bib28","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nmat4829","article-title":"Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche","volume":"16","author":"Shao","year":"2017","journal-title":"Nat Mater"},{"key":"10.1016\/j.jid.2020.07.016_bib29","doi-asserted-by":"crossref","first-page":"6386412","DOI":"10.1155\/2016\/6386412","article-title":"The role of RhoJ in endothelial cell biology and tumor pathology","volume":"2016","author":"Shi","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jid.2020.07.016_bib30","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1128\/MCB.15.12.6785","article-title":"Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter","volume":"15","author":"Shivakumar","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jid.2020.07.016_bib31","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.7973727","article-title":"Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen","volume":"266","author":"Smith","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jid.2020.07.016_bib32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.det.2016.11.013","article-title":"Genetics of vitiligo","volume":"35","author":"Spritz","year":"2017","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2020.07.016_bib33","doi-asserted-by":"crossref","first-page":"14348","DOI":"10.3390\/ijms150814348","article-title":"Mesenchymal stem cell-derived microparticles: a promising therapeutic strategy","volume":"15","author":"Tan","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2020.07.016_bib76","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3389\/fimmu.2019.00819","article-title":"Emerging role of lymphocyte antigen-6 family of genes in cancer and immune cells","volume":"10","author":"Upadhyay","year":"2019","journal-title":"Front. Immunol"},{"key":"10.1016\/j.jid.2020.07.016_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jcb.22026","article-title":"KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation","volume":"106","author":"Wang","year":"2009","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jid.2020.07.016_bib77","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1128\/MCB.19.1.12","article-title":"p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation","volume":"19","author":"Xu","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jid.2020.07.016_bib35","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1038\/jid.2013.235","article-title":"Wnt\/\u03b2-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation","volume":"133","author":"Yamada","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib36","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1128\/JVI.00476-14","article-title":"Comparison of varicella-zoster virus RNA sequences in human neurons and fibroblasts","volume":"88","author":"Baird","year":"2014","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jid.2020.07.016_bib37","first-page":"43","article-title":"Quantitative proteomics identifies activation of hallmark pathways of cancer in patient melanoma","volume":"6","author":"Byrum","year":"2013","journal-title":"J\u00a0Proteomics Bioinform"},{"key":"10.1016\/j.jid.2020.07.016_bib38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1089\/scd.2013.0038","article-title":"Boosting and rescuing epidermal superior population from fresh keratinocyte cultures","volume":"23","author":"Cerqueira","year":"2014","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jid.2020.07.016_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-0625.2011.01425.x","article-title":"Patterning skin by planar cell polarity: the multi-talented hair designer","volume":"21","author":"Chen","year":"2012","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/cdd.2012.104","article-title":"Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia","volume":"20","author":"Dai","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jid.2020.07.016_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.envres.2016.07.009","article-title":"The effect of simultaneous exposure of HEMn-DP and HEMn-LP melanocytes to nicotine and UV-radiation on the cell viability and melanogenesis","volume":"151","author":"Delijewski","year":"2016","journal-title":"Environ Res"},{"key":"10.1016\/j.jid.2020.07.016_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.63","article-title":"Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis","volume":"8","author":"Deshmukh","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2020.07.016_bib43","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00441-016-2446-2","article-title":"Integrin-mediated regulation of epidermal wound functions","volume":"365","author":"DiPersio","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jid.2020.07.016_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20050104","article-title":"RhoGDI: multiple functions in the regulation of Rho family GTPase activities","volume":"390","author":"Dovas","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2020.07.016_bib45","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1002\/cncr.23076","article-title":"Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression","volume":"110","author":"Einspahr","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.jid.2020.07.016_bib46","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.191.4.669","article-title":"Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn","volume":"191","author":"Fitzer-Attas","year":"2000","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2020.07.016_bib47","doi-asserted-by":"crossref","first-page":"31663","DOI":"10.18632\/oncotarget.9421","article-title":"microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA\/NF-\u03baB","volume":"7","author":"Giles","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2020.07.016_bib48","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/exd.13072","article-title":"Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection","volume":"25","author":"Goldstein","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib49","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jid.2017.09.040","article-title":"Repigmentation of human vitiligo skin by NBUVB is controlled by transcription of GLI1 and activation of the \u03b2-catenin pathway in the hair follicle bulge stem cells","volume":"138","author":"Goldstein","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib50","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1038\/jid.2014.257","article-title":"Cadherin 11, a miR-675 target, induces N-cadherin expression and epithelial-mesenchymal transition in melasma","volume":"134","author":"Kim","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017197","article-title":"In\u00a0vitro dedifferentiation of melanocytes from adult epidermis","volume":"6","author":"Kormos","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2020.07.016_bib52","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1073\/pnas.0806753106","article-title":"Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r","volume":"106","author":"Le Pape","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2020.07.016_bib53","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In\u00a0vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in\u00a0vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jid.2020.07.016_bib54","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13045-017-0418-y","article-title":"Paxillin: a crossroad in pathological cell migration","volume":"10","author":"L\u00f3pez-Colom\u00e9","year":"2017","journal-title":"J\u00a0Hematol Oncol"},{"key":"10.1016\/j.jid.2020.07.016_bib55","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.celrep.2014.10.061","article-title":"Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest","volume":"9","author":"Manderfield","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2020.07.016_bib56","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1242\/jcs.108167","article-title":"FGF receptors 1 and 2 are key regulators of keratinocyte migration in\u00a0vitro and in wounded skin","volume":"125","author":"Meyer","year":"2012","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2020.07.016_bib57","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1600-0625.1994.tb00292.x","article-title":"Enhanced expression of IL-8 in normal human keratinocytes and human keratinocyte cell line HaCaT in\u00a0vitro after stimulation with contact sensitizers, tolerogens and irritants","volume":"3","author":"Mohamadzadeh","year":"1994","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib58","series-title":"Vitiligo","first-page":"140","article-title":"Natural history and prognosis","author":"Parsad","year":"2010"},{"key":"10.1016\/j.jid.2020.07.016_bib59","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2353\/ajpath.2008.080136","article-title":"Semaphorin 3E expression correlates inversely with plexin D1 during tumor progression","volume":"173","author":"Roodink","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2020.07.016_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006913","article-title":"The RhoJ-BAD signaling network: an Achilles' heel for BRAF mutant melanomas","volume":"13","author":"Ruiz","year":"2017","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2020.07.016_bib61","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jid.2015.10.056","article-title":"Integrin-linked kinase is indispensable for keratinocyte differentiation and epidermal barrier function","volume":"136","author":"Sayedyahossein","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib62","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2020.07.016_bib63","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/sj.jid.5700567","article-title":"Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activation","volume":"127","author":"Scott","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/1523-1747.ep12365595","article-title":"Cultured human melanocytes express\u00a0the\u00a0intermediate filament vimentin","volume":"101","author":"Si","year":"1993","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2020.07.016_bib65","doi-asserted-by":"crossref","first-page":"33175","DOI":"10.1074\/jbc.M102866200","article-title":"Identification of another actin-related protein (Arp) 2\/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2\/3 complex activating (VCA) domain of N-WASP","volume":"276","author":"Suetsugu","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2020.07.016_bib66","first-page":"674","article-title":"Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation","volume":"63","author":"Suzuki","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2020.07.016_bib67","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2020.07.016_bib68","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1101\/gad.978802","article-title":"Role of Rho family GTPases in epithelial morphogenesis","volume":"16","author":"Van Aelst","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2020.07.016_bib69","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12943-015-0448-4","article-title":"P-cadherin and the journey to cancer metastasis","volume":"14","author":"Vieira","year":"2015","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jid.2020.07.016_bib70","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00005-015-0382-6","article-title":"Novel insights into the roles of Rho kinase in cancer","volume":"64","author":"Wei","year":"2016","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1016\/j.jid.2020.07.016_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084073","article-title":"OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis","volume":"8","author":"Wroblewski","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2020.07.016_bib78","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/bioinformatics\/btq057","article-title":"Fast and SNP-tolerant detection of complex variants and splicing in short reads","volume":"26","author":"Wu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2020.07.016_bib72","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1101\/gad.361406","article-title":"Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin","volume":"20","author":"Wu","year":"2006","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2020.07.016_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121551","article-title":"Nitric oxide enhances keratinocyte cell migration by regulating Rho GTPase via cGMP-PKG signalling","volume":"10","author":"Zhan","year":"2015","journal-title":"PLoS One"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20319540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20319540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:19:24Z","timestamp":1758302364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X20319540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0022202X20319540"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2020.07.016","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2020.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}