{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:04:07Z","timestamp":1791497047526,"version":"4.3.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jid.2020.08.025","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T01:02:17Z","timestamp":1603155737000},"page":"1363-1366.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Targeted Knockout of \u03b2-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-1342","authenticated-orcid":false,"given":"Madeleine","family":"Le Coz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-3245","authenticated-orcid":false,"given":"Zackie","family":"Aktary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Pouteaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-1218","authenticated-orcid":false,"given":"Nisamanee","family":"Charoenchon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Motohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1651-2716","authenticated-orcid":false,"given":"Takahiro","family":"Kunisada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Corvelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-6107","authenticated-orcid":false,"given":"Lionel","family":"Larue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2020.08.025_bib1","series-title":"Melanins and melanosomes: biosynthesis, structure, physiological and pathological function","first-page":"21","article-title":"Classical and non-classical melanocytes in vertebrates","author":"Colombo","year":"2011"},{"key":"10.1016\/j.jid.2020.08.025_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fnana.2015.00149","article-title":"Meningeal melanocytes in the mouse: distribution and dependence on Mitf","volume":"9","author":"Gudjohnsen","year":"2015","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.jid.2020.08.025_bib3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1034\/j.1600-0749.2002.02039.x","article-title":"Expression of cre recombinase in pigment cells","volume":"15","author":"Guyonneau","year":"2002","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2020.08.025_bib4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/pcmr.12048","article-title":"Postnatal lineage mapping of follicular melanocytes with the Tyr::CreER(T) (2) transgene","volume":"26","author":"Harris","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2020.08.025_bib5","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1242\/dev.067447","article-title":"Biological and mathematical modeling of melanocyte development","volume":"138","author":"Luciani","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.jid.2020.08.025_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1242\/dev.106567","article-title":"The melanocyte lineage in development and disease [published correction appears in Development 2015;142:1387]","volume":"142","author":"Mort","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.jid.2020.08.025_bib7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1755-148X.2011.00855.x","article-title":"Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation","volume":"24","author":"Nishimura","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2020.08.025_bib8","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/416854a","article-title":"Dominant role of the niche in melanocyte stem-cell fate determination","volume":"416","author":"Nishimura","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jid.2020.08.025_bib9","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1242\/dev.02161","article-title":"Molecular characterization of melanocyte stem cells in their niche","volume":"132","author":"Osawa","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.jid.2020.08.025_bib10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/exd.13061","article-title":"Any route for melanoblasts to colonize the skin!","volume":"25","author":"Petit","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2020.08.025_bib11","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2011.05.004","article-title":"Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration","volume":"145","author":"Rabbani","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jid.2020.08.025_bib12","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.celrep.2016.04.006","article-title":"EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling","volume":"15","author":"Takeo","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2020.08.025_bib13","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s00018-019-03049-w","article-title":"From neural crest cells to melanocytes: cellular plasticity during development and beyond","volume":"76","author":"Vandamme","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jid.2020.08.025_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/gene.20182","article-title":"Spatiotemporal gene control by the Cre-ERT2 system in melanocytes","volume":"44","author":"Yajima","year":"2006","journal-title":"Genesis"},{"key":"10.1016\/j.jid.2020.08.025_bib15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1755-148X.2008.00483.x","article-title":"The location of heart melanocytes is specified and the level of pigmentation in the heart may correlate with coat color","volume":"21","author":"Yajima","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2020.08.025_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.276.5311.409","article-title":"Effect of transmembrane and cytoplasmic domains of IgE on the IgE response","volume":"276","author":"Achatz","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jid.2020.08.025_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1755-148X.2011.00912.x","article-title":"General strategy to analyse coat colour phenotypes in mice","volume":"25","author":"Berlin","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2020.08.025_bib18","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","article-title":"Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development","volume":"128","author":"Brault","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.jid.2020.08.025_bib19","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1101\/gad.450107","article-title":"Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development","volume":"21","author":"Delmas","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2020.08.025_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/gene.10197","article-title":"Cre-mediated recombination in the skin melanocyte lineage","volume":"36","author":"Delmas","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.jid.2020.08.025_bib21","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/nar\/27.22.4324","article-title":"Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases","volume":"27","author":"Indra","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2020.08.025_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2020.08.025_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/gene.20182","article-title":"Spatiotemporal gene control by the Cre-ERT2 system in melanocytes","volume":"44","author":"Yajima","year":"2006","journal-title":"Genesis"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20321461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X20321461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:20:16Z","timestamp":1758302416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X20321461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0022202X20321461"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2020.08.025","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted Knockout of \u03b2-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2020.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}