{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:01:41Z","timestamp":1782536501741,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AA027065"],"award-info":[{"award-number":["R01AA027065"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR077183"],"award-info":[{"award-number":["R01AR077183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK103901"],"award-info":[{"award-number":["R01DK103901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.jid.2021.03.015","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T19:02:35Z","timestamp":1617303755000},"page":"2499-2508.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mechanisms of Broad-Band UVB Irradiation\u2012Induced Itch in Mice"],"prefix":"10.1016","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4739-4145","authenticated-orcid":false,"given":"Liang","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-2535","authenticated-orcid":false,"given":"Xueping","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6192-4130","authenticated-orcid":false,"given":"Yonghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8578-8268","authenticated-orcid":false,"given":"Lixia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-6780","authenticated-orcid":false,"given":"Zili","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8828-990X","authenticated-orcid":false,"given":"Yi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-6770","authenticated-orcid":false,"given":"Sha","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-3746","authenticated-orcid":false,"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-7912","authenticated-orcid":false,"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-7522","authenticated-orcid":false,"given":"Hongzhen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.03.015_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2340\/00015555-0962","article-title":"Differential itch- and pain-related behavioral responses and \u03bc-opoid modulation in mice","volume":"90","author":"Akiyama","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2021.03.015_bib2","doi-asserted-by":"crossref","first-page":"e09674","DOI":"10.7554\/eLife.09674","article-title":"Keratinocytes can modulate and directly initiate nociceptive responses","volume":"4","author":"Baumbauer","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jid.2021.03.015_bib3","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1073\/pnas.1215555110","article-title":"UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes","volume":"110","author":"Bellono","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2021.03.015_bib4","first-page":"19","article-title":"Sunburn and hell's itch: how to get relief","volume":"3","author":"Berry","year":"2018","journal-title":"Med News Today"},{"key":"10.1016\/j.jid.2021.03.015_bib5","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1074\/jbc.M116.716464","article-title":"Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch","volume":"291","author":"Chen","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2021.03.015_bib6","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/s41419-018-1130-8","article-title":"Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint","volume":"9","author":"de Pedro","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2021.03.015_bib7","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jaci.2017.03.035","article-title":"The antimicrobial peptide human beta-defensin 2 promotes itch through toll-like receptor 4 signaling in mice","volume":"140","author":"Feng","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.03.015_bib8","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41467-017-01056-8","article-title":"Sensory TRP channels contribute differentially to skin inflammation and persistent itch","volume":"8","author":"Feng","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.03.015_bib9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1089\/wound.2012.0366","article-title":"Ultraviolet radiation in wound care: sterilization and stimulation","volume":"2","author":"Gupta","year":"2013","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.jid.2021.03.015_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2165\/00128071-200405010-00006","article-title":"Management of acute sunburn","volume":"5","author":"Han","year":"2004","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jid.2021.03.015_bib11","doi-asserted-by":"crossref","first-page":"e13075","DOI":"10.1111\/acel.13075","article-title":"Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B","volume":"19","author":"Hsu","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.jid.2021.03.015_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.191.3.561","article-title":"Sensitivity to sunburn is associated with susceptibility to ultraviolet radiation-induced suppression of cutaneous cell-mediated immunity","volume":"191","author":"Kelly","year":"2000","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2021.03.015_bib13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-0625.2008.00806.x","article-title":"Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in\u00a0vivo","volume":"18","author":"Lee","year":"2009","journal-title":"Exp Dermatol"},{"issue":"Suppl. 1","key":"10.1016\/j.jid.2021.03.015_bib14","first-page":"25","article-title":"Atopic dermatitis: immunobiology and treatment with immune modulators","volume":"107","author":"Leung","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2021.03.015_bib15","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1097\/ALN.0000000000000850","article-title":"Spinal IL-33\/ST2 signaling contributes to neuropathic pain via neuronal CaMKII-CREB and astroglial JAK2-STAT3 cascades in mice","volume":"123","author":"Liu","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jid.2021.03.015_bib16","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jaci.2017.05.051","article-title":"Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch","volume":"141","author":"Luo","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.03.015_bib17","doi-asserted-by":"crossref","first-page":"E3225","DOI":"10.1073\/pnas.1312933110","article-title":"UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling","volume":"110","author":"Moore","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2021.03.015_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","article-title":"Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jid.2021.03.015_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jid.2021.03.015_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0625.2012.01438.x","article-title":"Dermal mast cells affect the development of sunlight-induced skin tumours","volume":"21","author":"Sarchio","year":"2012","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.03.015_bib21","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/s41590-019-0493-z","article-title":"House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation","volume":"20","author":"Serhan","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2021.03.015_bib22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2340\/00015555-1364","article-title":"Opioid modulation of facial itch- and pain-related responses and grooming behavior in rats","volume":"92","author":"Spradley","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2021.03.015_bib23","doi-asserted-by":"crossref","first-page":"22664","DOI":"10.1074\/jbc.M302561200","article-title":"Impaired pressure sensation in mice lacking TRPV4","volume":"278","author":"Suzuki","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2021.03.015_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0781.2007.00260.x","article-title":"Comparison of broadband UVB, narrowband UVB, broadband UVA and UVA1 on activation of apoptotic pathways in human peripheral blood mononuclear cells","volume":"23","author":"Tuchinda","year":"2007","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1016\/j.jid.2021.03.015_bib25","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jid.2019.12.011","article-title":"The return of the mast cell: new roles in neuroimmune itch biology","volume":"140","author":"Wang","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.03.015_bib26","doi-asserted-by":"crossref","first-page":"tay124","DOI":"10.1093\/jtm\/tay124","article-title":"Hell's itch due to sunburn","volume":"26","author":"Wilder-Smith","year":"2019","journal-title":"J\u00a0Travel Med"},{"key":"10.1016\/j.jid.2021.03.015_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3390\/ph11040100","article-title":"TRP channels as drug targets to relieve itch","volume":"11","author":"Xie","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jid.2021.03.015_bib28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1089\/wound.2012.0366","article-title":"Ultraviolet radiation in wound care: sterilization and stimulation","volume":"2","author":"Gupta","year":"2013","journal-title":"Adv Wound Care (New Rochelle)"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21011295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21011295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:46:57Z","timestamp":1762206417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21011295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0022202X21011295"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.03.015","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of Broad-Band UVB Irradiation\u2012Induced Itch in Mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}