{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:58:13Z","timestamp":1788526693102,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jid.2021.05.022","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:06:14Z","timestamp":1624320374000},"page":"876-883.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"PB","title":["Immunophenotypic Analysis Reveals Differences in Circulating Immune Cells in the Peripheral Blood of Patients with Segmental and Nonsegmental Vitiligo"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-6734","authenticated-orcid":false,"given":"Marcella","family":"Willemsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-0492","authenticated-orcid":false,"given":"Nicoline F.","family":"Post","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-1065","authenticated-orcid":false,"given":"Nathalie O.P.","family":"van Uden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4328-1132","authenticated-orcid":false,"given":"Vidhya S.","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-517X","authenticated-orcid":false,"given":"Saskia","family":"Chielie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-8916","authenticated-orcid":false,"given":"E. Helen","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-9762","authenticated-orcid":false,"given":"Marcel W.","family":"Bekkenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-0721","authenticated-orcid":false,"given":"Rosalie M.","family":"Luiten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.05.022_bib1","first-page":"117","article-title":"Evaluation of circulating CD4+CD25highFoxP3+ T lymphocytes in active non-segmental vitiligo","volume":"20","author":"Abdallah","year":"2009","journal-title":"J\u00a0Pan-Arab League Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","article-title":"Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families","volume":"16","author":"Alkhateeb","year":"2003","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2021.05.022_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4103\/0019-5154.119949","article-title":"Segmental and generalized vitiligo: both forms demonstrate inflammatory histopathological features and clinical mosaicism","volume":"58","author":"Attili","year":"2013","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1755-148X.2011.00920.x","article-title":"Functional defects of peripheral regulatory T lymphocytes in patients with progressive vitiligo","volume":"25","author":"Ben Ahmed","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2021.05.022_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000506103","article-title":"Vitiligo: a review","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatology"},{"key":"10.1016\/j.jid.2021.05.022_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12016-017-8622-7","article-title":"Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy","volume":"54","author":"Boniface","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jid.2021.05.022_bib7","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/ijd.14055","article-title":"Comorbidities in vitiligo: comprehensive review","volume":"57","author":"Dahir","year":"2018","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/pcmr.12105","article-title":"Decreased regulatory T-cells and CD4(+)\/CD8(+) ratio correlate with disease onset and progression in patients with generalized vitiligo","volume":"26","author":"Dwivedi","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2021.05.022_bib9","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","article-title":"Revised classification\/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference","volume":"25","author":"Ezzedine","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2021.05.022_bib10","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3389\/fimmu.2018.01637","article-title":"T\u00a0follicular helper cells in autoimmune disorders","volume":"9","author":"Gensous","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.05.022_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaad.2015.08.063","article-title":"Comorbid autoimmune diseases in patients with vitiligo: a cross-sectional study","volume":"74","author":"Gill","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib12","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/pcmr.12862","article-title":"Altered expression of nuclear factor of activated T cells, forkhead box P3, and immune-suppressive genes in regulatory T cells of generalized vitiligo patients","volume":"33","author":"Giri","year":"2020","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2021.05.022_bib13","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jaad.2019.07.036","article-title":"Comorbid diseases of vitiligo: a 10-year cross-sectional retrospective study of an urban US population","volume":"82","author":"Hadi","year":"2020","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib14","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/1523-1747.ep12492607","article-title":"Relation between the incidence and level of pigment cell antibodies and disease activity in vitiligo","volume":"97","author":"Harning","year":"1991","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib15","doi-asserted-by":"crossref","first-page":"145409","DOI":"10.1155\/2015\/145409","article-title":"Decreased circulating T regulatory cells in Egyptian patients with nonsegmental vitiligo: correlation with disease activity","volume":"2015","author":"Hegab","year":"2015","journal-title":"Dermatol Res Pract"},{"key":"10.1016\/j.jid.2021.05.022_bib16","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jid.2019.11.013","article-title":"NKG2D defines a subset of skin effector memory CD8 T cells with proinflammatory functions in vitiligo","volume":"140","author":"Jacquemin","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.autrev.2006.09.010","article-title":"Autoantibody responses to melanocytes in the depigmenting skin disease vitiligo","volume":"6","author":"Kemp","year":"2007","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2021.05.022_bib18","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1172\/JCI0214643","article-title":"The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo","volume":"109","author":"Kemp","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2021.05.022_bib19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1755-148X.2010.00688.x","article-title":"Reduced skin homing by functional Treg in vitiligo [published correction appears in Pigment Cell Melanoma Res 2010;23:477]","volume":"23","author":"Klarquist","year":"2010","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2021.05.022_bib20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4049\/jimmunol.1800986","article-title":"With a little help from T follicular helper friends: humoral immunity to influenza vaccination","volume":"202","author":"Koutsakos","year":"2019","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.05.022_bib21","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.jisp.2016.10.023","article-title":"Replenishing regulatory T cells to halt depigmentation in vitiligo","volume":"18","author":"Le Poole","year":"2017","journal-title":"J\u00a0Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jid.2021.05.022_bib22","doi-asserted-by":"crossref","first-page":"e37513","DOI":"10.1371\/journal.pone.0037513","article-title":"Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo","volume":"7","author":"Lili","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.05.022_bib23","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1126\/science.aaa1292","article-title":"Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals","volume":"346","author":"Maeda","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jid.2021.05.022_bib24","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/phpp.12104","article-title":"Effect of narrow band-ultraviolet B on CD4(+) CD25(high) FoxP3(+) T-lymphocytes in the peripheral blood of vitiligo patients","volume":"30","author":"Moftah","year":"2014","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1016\/j.jid.2021.05.022_bib25","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/1523-1747.ep12522891","article-title":"Detection of antibodies to melanocytes in vitiligo by specific immunoprecipitation","volume":"81","author":"Naughton","year":"1983","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0190-9622(86)70260-0","article-title":"Correlation between vitiligo antibodies and extent of depigmentation in vitiligo","volume":"15","author":"Naughton","year":"1986","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib27","doi-asserted-by":"crossref","first-page":"36166","DOI":"10.18632\/oncotarget.26322","article-title":"Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood","volume":"9","author":"Niedzielska","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2021.05.022_bib28","doi-asserted-by":"crossref","first-page":"624131","DOI":"10.3389\/fimmu.2021.624131","article-title":"The role of the NKG2D in vitiligo","volume":"12","author":"Plaza-Rojas","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.05.022_bib29","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.3389\/fimmu.2018.02707","article-title":"Lymphoid stress surveillance response contributes to vitiligo pathogenesis","volume":"9","author":"Raam","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.05.022_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2016.10.048","article-title":"New discoveries in the pathogenesis and classification of vitiligo","volume":"77","author":"Rodrigues","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib31","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/ced.12852","article-title":"Involvement of T cells in early evolving segmental vitiligo","volume":"41","author":"Shin","year":"2016","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2021.05.022_bib32","doi-asserted-by":"crossref","first-page":"568447","DOI":"10.3389\/fimmu.2020.568447","article-title":"Autoimmunity in segmental vitiligo","volume":"11","author":"Speeckaert","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.05.022_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.det.2016.11.013","article-title":"Genetics of vitiligo","volume":"35","author":"Spritz","year":"2017","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2021.05.022_bib34","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/s41467-019-09963-8","article-title":"Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo","volume":"10","author":"Tulic","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.05.022_bib35","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/jdv.15604","article-title":"Clinical visible signs of disease activity in vitiligo: a systematic review and meta-analysis","volume":"33","author":"van Geel","year":"2019","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2021.05.022_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1755-148X.2010.00703.x","article-title":"First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi","volume":"23","author":"van Geel","year":"2010","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2021.05.022_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jdermsci.2016.07.006","article-title":"The changes of gene expression profiling between segmental vitiligo, generalized vitiligo and healthy individual","volume":"84","author":"Wang","year":"2016","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2021.05.022_bib38","doi-asserted-by":"crossref","first-page":"e51040","DOI":"10.1371\/journal.pone.0051040","article-title":"Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS One"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X2101349X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X2101349X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:28:05Z","timestamp":1758302885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X2101349X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022202X2101349X"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.05.022","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunophenotypic Analysis Reveals Differences in Circulating Immune Cells in the Peripheral Blood of Patients with Segmental and Nonsegmental Vitiligo","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}