{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:07:02Z","timestamp":1790744822471,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jid.2021.07.170","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:47:40Z","timestamp":1631702860000},"page":"382-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Transcriptomic Repositioning Analysis Identifies mTOR Inhibitor as Potential Therapy for Epidermolysis Bullosa Simplex"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-5348","authenticated-orcid":false,"given":"Gun Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-2571","authenticated-orcid":false,"given":"Ramrada","family":"Lekwuttikarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-2117","authenticated-orcid":false,"given":"Elidia","family":"Tafoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-583X","authenticated-orcid":false,"given":"Monica","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-3053","authenticated-orcid":false,"given":"Kavita Y.","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-6807","authenticated-orcid":false,"given":"Joyce M.","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.07.170_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/archdermatol.2008.546","article-title":"Treatment of epidermolysis bullosa simplex, Weber-Cockayne type, with botulinum toxin type A","volume":"145","author":"Abitbol","year":"2009","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib2","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1038\/s41598-018-29472-w","article-title":"RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways","volume":"8","author":"Ahn","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2021.07.170_bib3","doi-asserted-by":"crossref","first-page":"e1528","DOI":"10.1097\/MD.0000000000001528","article-title":"Proinflammatory cytokines and antiskin autoantibodies in patients with inherited epidermolysis bullosa","volume":"94","author":"Annicchiarico","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jid.2021.07.170_bib4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/jdv.17012","article-title":"Novel insights into the epidemiology of epidermolysis bullosa (EB) from the Dutch EB Registry: EB more common than previously assumed?","volume":"35","author":"Baardman","year":"2021","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2021.07.170_bib5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jdermsci.2015.01.001","article-title":"Gene expression profiling in pachyonychia congenita skin","volume":"77","author":"Cao","year":"2015","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2021.07.170_bib6","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.jid.2016.03.001","article-title":"Identification of alpha-adrenergic agonists as potential therapeutic agents for dermatomyositis through drug- repurposing using public expression datasets","volume":"136","author":"Cho","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1124\/mol.119.118166","article-title":"Pathogen-associated molecular pattern-induced TLR2 and TLR4 activation increases keratinocyte production of inflammatory mediators and is inhibited by phosphatidylglycerol [published correction appears in Mol Pharmacol 2020;97:354]","volume":"97","author":"Choudhary","year":"2020","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jid.2021.07.170_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/MOP.0000000000000380","article-title":"Advancement in management of epidermolysis bullosa","volume":"28","author":"Cohn","year":"2016","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jid.2021.07.170_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.tips.2012.07.004","article-title":"Platelet GPVI: A target for antithrombotic therapy?!","volume":"33","author":"D\u00fctting","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jid.2021.07.170_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086147","article-title":"From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract","volume":"9","author":"Ebeling","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.07.170_bib11","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3390\/ijms17101625","article-title":"Autoimmunity and cytokine imbalance in inherited epidermolysis bullosa","volume":"17","author":"Esposito","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2021.07.170_bib12","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1038\/jid.2008.19","article-title":"TNF-alpha impairs the S-G2\/M cell cycle checkpoint and cyclobutane pyrimidine dimer repair in premalignant skin cells: role of the PI3K-Akt pathway","volume":"128","author":"Faurschou","year":"2008","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib13","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1001\/jamadermatol.2016.2473","article-title":"Epidemiology of inherited epidermolysis bullosa based on incidence and prevalence estimates from the national epidermolysis bullosa registry","volume":"152","author":"Fine","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41419-020-2440-1","article-title":"Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression","volume":"11","author":"Fu","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2021.07.170_bib15","doi-asserted-by":"crossref","first-page":"R1140","DOI":"10.1186\/ar1797","article-title":"Tumour necrosis factor activates the mitogen-activated protein kinases p38alpha and ERK in the synovial membrane in\u00a0vivo","volume":"7","author":"G\u00f6rtz","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jid.2021.07.170_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161158","article-title":"IGF1R derived PI3K\/AKT signaling maintains growth in a subset of human T-cell acute lymphoblastic leukemias","volume":"11","author":"Gusscott","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.07.170_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u03baB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jid.2021.07.170_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1357-4310(99)01544-0","article-title":"p38 MAPK signalling cascades in inflammatory disease","volume":"5","author":"Herlaar","year":"1999","journal-title":"Mol Med Today"},{"key":"10.1016\/j.jid.2021.07.170_bib19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jdermsci.2009.07.008","article-title":"Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients","volume":"56","author":"Hickerson","year":"2009","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2021.07.170_bib20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jdcr.2016.05.003","article-title":"Treatment of symptomatic epidermolysis bullosa simplex with botulinum toxin in a pediatric patient","volume":"2","author":"Holahan","year":"2016","journal-title":"JAAD Case Rep"},{"key":"10.1016\/j.jid.2021.07.170_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11010-017-3041-x","article-title":"Rotundarpene inhibits TNF-\u03b1-induced activation of the Akt, mTOR, and NF-\u03baB pathways, and the JNK and p38 associated with production of reactive oxygen species","volume":"434","author":"Kim","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jid.2021.07.170_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2021.07.170_bib23","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00204-015-1472-2","article-title":"Compromised MAPK signaling in human diseases: an update","volume":"89","author":"Kim","year":"2015","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jid.2021.07.170_bib24","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2021.07.170_bib25","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jid.2017.12.002","article-title":"Identification of atorvastatin for moderate to severe hidradenitis through drug repositioning using public gene expression datasets","volume":"138","author":"Kuo","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2021.07.170_bib27","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1074\/jbc.M407517200","article-title":"Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase\/Akt\/mammalian target of\u00a0rapamycin (PI3K\/Akt\/mTOR) pathway","volume":"280","author":"Latres","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2021.07.170_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070123","article-title":"MMP-9 and CXCL8\/IL-8 are potential therapeutic targets in epidermolysis bullosa simplex","volume":"8","author":"Lettner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.07.170_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jid.2021.07.170_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2147\/DDDT.S52354","article-title":"Genistein suppresses tumor necrosis factor \u03b1-induced inflammation via modulating reactive oxygen species\/Akt\/nuclear factor \u03baB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells","volume":"8","author":"Li","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.jid.2021.07.170_bib31","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1046\/j.0022-202x.2001.01608.x","article-title":"The p38-MAPK\/SAPK pathway is required for human keratinocyte migration on dermal collagen","volume":"117","author":"Li","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2021.07.170_bib33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.imbio.2019.01.004","article-title":"Aberrant IGF1\u2013PI3K\/AKT\/MTOR signaling pathway regulates the local immunity of oral lichen planus","volume":"224","author":"Ma","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.jid.2021.07.170_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm2672","article-title":"Molecular mechanisms of mTOR-mediated translational control","volume":"10","author":"Ma","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jid.2021.07.170_bib35","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1523\/JNEUROSCI.1700-08.2009","article-title":"Insulin-like growth factor-1 promotes G(1)\/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase\/Akt pathway in developing rat cerebral cortex","volume":"29","author":"Mairet-Coello","year":"2009","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2021.07.170_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97071","article-title":"Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment","volume":"2","author":"Mirza","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2021.07.170_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173981","article-title":"Diacerein inhibits the pro-atherogenic & pro-inflammatory effects of IL-1 on human keratinocytes & endothelial cells","volume":"12","author":"Mohan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.07.170_bib38","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jid.2016.09.036","article-title":"GPVI and thromboxane receptor on platelets promote proinflammatory macrophage phenotypes during cutaneous inflammation","volume":"137","author":"Pierre","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib39","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/exd.13979","article-title":"Epidermolysis bullosa: advances in research and treatment","volume":"28","author":"Prodinger","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ncb1101-1009","article-title":"Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K\/Akt\/mTOR and PI(3)K\/Akt\/GSK3 pathways","volume":"3","author":"Rommel","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jid.2021.07.170_bib41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.smim.2014.02.009","article-title":"TNF and MAP kinase signalling pathways","volume":"26","author":"Sabio","year":"2014","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jid.2021.07.170_bib42","doi-asserted-by":"crossref","first-page":"5068969","DOI":"10.1155\/2017\/5068969","article-title":"Betulin-based oleogel to improve wound healing in dystrophic epidermolysis bullosa: a prospective controlled proof-of-concept study","volume":"2017","author":"Schwieger-Briel","year":"2017","journal-title":"Dermatol Res Pract"},{"key":"10.1016\/j.jid.2021.07.170_bib43","article-title":"Mechanism of oleogel-S10: a triterpene preparation for the treatment of epidermolysis bullosa","volume":"32","author":"Schwieger-Briel","year":"2019","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jid.2021.07.170_bib44","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A\u00a0next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jid.2021.07.170_bib45","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1365-2133.2010.09927.x","article-title":"Botulinum toxin in the treatment of sweat-worsened foot problems in patients with epidermolysis bullosa simplex and pachyonychia congenita","volume":"163","author":"Swartling","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib46","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jid.2015.10.050","article-title":"Progress toward treatment and cure of epidermolysis bullosa: summary of the DEBRA international research symposium EB2015","volume":"136","author":"Uitto","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jdermsci.2016.12.021","article-title":"Altered balance of epidermis-related chemokines in epidermolysis bullosa","volume":"86","author":"Ujiie","year":"2017","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2021.07.170_bib48","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jaad.2018.01.019","article-title":"Diacerein orphan drug development for epidermolysis bullosa simplex: a phase 2\/3 randomized, placebo-controlled, double-blind clinical trial","volume":"78","author":"Wally","year":"2018","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1750-1172-8-69","article-title":"Topical diacerein for epidermolysis bullosa: a randomized controlled pilot study","volume":"8","author":"Wally","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jid.2021.07.170_bib50","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/jid.2013.31","article-title":"The pathogenetic role of IL-1\u03b2 in severe epidermolysis bullosa simplex","volume":"133","author":"Wally","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1046\/j.1365-2133.2004.05816.x","article-title":"Tetracycline and epidermolysis bullosa simplex: a double-blind, placebo-controlled, crossover randomized clinical trial","volume":"150","author":"Weiner","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib52","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/sj.onc.1203458","article-title":"IL-4 regulation of IL-6 production involves Rac\/Cdc42- and p38 MAPK-dependent pathways in keratinocytes","volume":"19","author":"Wery-Zennaro","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.jid.2021.07.170_bib53","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.3324\/haematol.2018.208363","article-title":"Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice","volume":"104","author":"Wichaiyo","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.jid.2021.07.170_bib54","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/cmi.2014.113","article-title":"Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K\/mTOR pathway and HIF-1 transcription complex","volume":"13","author":"Wyszynski","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jid.2021.07.170_bib55","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jneuroim.2015.04.003","article-title":"Interleukin-1\u03b2 plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K\/Akt\/mTOR signaling pathway in hippocampal neurons","volume":"282","author":"Xiao","year":"2015","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.jid.2021.07.170_bib56","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5021\/ad.2015.27.2.152","article-title":"Mechanism of macrophage-derived chemokine\/CCL22 production by HaCaT keratinocytes","volume":"27","author":"Yano","year":"2015","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jid.2021.07.170_bib57","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3892\/ijmm.2015.2146","article-title":"Toll-like receptor family members in skin fibroblasts are functional and have a higher expression compared to skin keratinocytes","volume":"35","author":"Yao","year":"2015","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jid.2021.07.170_bib58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2011.10.046","article-title":"IGF-1 induces hypoxia-inducible factor 1\u03b1-mediated GLUT3 expression through PI3K\/Akt\/mTOR dependent pathways in PC12 cells","volume":"1430","author":"Yu","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.jid.2021.07.170_bib59","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/jamadermatol.2019.4141","article-title":"Targeted inhibition of the epidermal growth factor receptor and mammalian target of rapamycin signaling pathways in Olmsted syndrome","volume":"156","author":"Zhang","year":"2020","journal-title":"JAMA Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21021606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21021606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:25:01Z","timestamp":1758302701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21021606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0022202X21021606"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.07.170","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic Repositioning Analysis Identifies mTOR Inhibitor as Potential Therapy for Epidermolysis Bullosa Simplex","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.07.170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}