{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:12:18Z","timestamp":1776795138597,"version":"3.51.2"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014365","name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01324"],"award-info":[{"award-number":["PI17\/01324"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jid.2021.07.179","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T10:55:26Z","timestamp":1630925726000},"page":"653-661.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"PA","title":["Activin A Sustains the Metastatic Phenotype of Tumor-Associated Macrophages and Is a Prognostic Marker in Human Cutaneous Melanoma"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-3932","authenticated-orcid":false,"given":"Alba","family":"Guti\u00e9rrez-Seijo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-4287","authenticated-orcid":false,"given":"Elena","family":"Garc\u00eda-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2789-1363","authenticated-orcid":false,"given":"Celia","family":"Barrio-Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-5478","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Parra-Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-4392","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Avil\u00e9s-Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-4445","authenticated-orcid":false,"given":"Paloma","family":"S\u00e1nchez-Mateos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-7332","authenticated-orcid":false,"given":"Rafael","family":"Samaniego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.07.179_bib1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ncomms1585","article-title":"Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response","volume":"2","author":"Antsiferova","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.07.179_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.15252\/emmm.201606493","article-title":"Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages","volume":"9","author":"Antsiferova","year":"2017","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jid.2021.07.179_bib3","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jid.2021.07.179_bib4","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-\u03b2 signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2021.07.179_bib5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/bjc.2016.255","article-title":"Transforming growth factor \u03b2 as regulator of cancer stemness and metastasis","volume":"115","author":"Bellomo","year":"2016","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jid.2021.07.179_bib6","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.jid.2017.07.845","article-title":"Paracrine activin-A signaling promotes melanoma growth and metastasis through immune evasion","volume":"137","author":"Donovan","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.179_bib7","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1242\/jcs.053157","article-title":"Moesin orchestrates cortical polarity of melanoma\u00a0tumour cells to initiate 3D invasion","volume":"122","author":"Estecha","year":"2009","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2021.07.179_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.trecan.2015.11.004","article-title":"Ontogeny of tumor-associated macrophages and its implication in cancer regulation","volume":"2","author":"Franklin","year":"2016","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jid.2021.07.179_bib9","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1245\/s10434-018-6513-7","article-title":"Melanoma staging: American Joint Committee on Cancer (AJCC) 8th edition and beyond [published correction appears in Ann Surg Oncol 2018;25(Suppl. 3):993\u20134]","volume":"25","author":"Gershenwald","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jid.2021.07.179_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature22396","article-title":"PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity","volume":"545","author":"Gordon","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jid.2021.07.179_bib11","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1182\/blood-2016-01-695395","article-title":"Evaluation of the potential therapeutic benefits of macrophage reprogramming in multiple myeloma","volume":"128","author":"Guti\u00e9rrez-Gonz\u00e1lez","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jid.2021.07.179_bib12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/jid.2014.328","article-title":"Activin A is anti-lymphangiogenic in a melanoma mouse model","volume":"135","author":"Heinz","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.179_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1158\/2326-6066.CIR-16-0400","article-title":"Constitutive IDO1 expression in human tumors is driven by cyclooxygenase-2 and mediates intrinsic immune resistance","volume":"5","author":"Hennequart","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.jid.2021.07.179_bib14","doi-asserted-by":"crossref","first-page":"13388","DOI":"10.18632\/oncotarget.7796","article-title":"High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma","volume":"7","author":"Hoda","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2021.07.179_bib15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-0749.2006.00322.x","article-title":"Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature","volume":"19","author":"Hoek","year":"2006","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2021.07.179_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jid.2021.07.179_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/cancers7010070","article-title":"Intertwining of activin A and TGF\u03b2 signaling: dual roles in cancer progression and cancer cell invasion","volume":"7","author":"Loomans","year":"2014","journal-title":"Cancers"},{"key":"10.1016\/j.jid.2021.07.179_bib18","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1158\/0008-5472.CAN-12-4115","article-title":"Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms","volume":"73","author":"Mao","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2021.07.179_bib19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0960-9822(06)00294-6","article-title":"Activin has direct long-range signalling activity and can form a concentration gradient by diffusion","volume":"7","author":"McDowell","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.jid.2021.07.179_bib20","doi-asserted-by":"crossref","first-page":"102314","DOI":"10.1016\/j.jaut.2019.102314","article-title":"Activin-A in the regulation of immunity in health and disease","volume":"104","author":"Morianos","year":"2019","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2021.07.179_bib21","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1158\/2159-8290.CD-17-1124","article-title":"YAP is essential for Treg-mediated suppression of antitumor immunity","volume":"8","author":"Ni","year":"2018","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jid.2021.07.179_bib22","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10138","article-title":"CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis","volume":"475","author":"Qian","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jid.2021.07.179_bib23","doi-asserted-by":"crossref","first-page":"eaat7527","DOI":"10.1126\/scisignal.aat7527","article-title":"Therapeutic blockade of activin-A improves NK cell function and antitumor immunity","volume":"12","author":"Rautela","year":"2019","journal-title":"Sci Signal"},{"key":"10.1016\/j.jid.2021.07.179_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40257-019-00475-1","article-title":"Biomarkers predictive of survival and response to immune checkpoint inhibitors in melanoma","volume":"21","author":"Rizk","year":"2020","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jid.2021.07.179_bib25","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1038\/jid.2013.88","article-title":"Mesenchymal contribution to recruitment, infiltration, and positioning of leukocytes in human melanoma tissues","volume":"133","author":"Samaniego","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.179_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1158\/2326-6066.CIR-17-0198","article-title":"CCL20 expression by tumor-associated macrophages predicts progression of human primary cutaneous melanoma","volume":"6","author":"Samaniego","year":"2018","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.jid.2021.07.179_bib27","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1158\/0008-5472.CAN-14-3510","article-title":"Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-\/-IL2R\u03b3null immunodeficient mice","volume":"75","author":"Sanmamed","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2021.07.179_bib28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(18)31559-9","article-title":"Melanoma [published correction appears in Lancet 2019;393:746","volume":"392","author":"Schadendorf","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2021.07.179_bib29","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMe1711199","article-title":"Adjuvant melanoma therapy - head-spinning progress","volume":"377","author":"Schuchter","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2021.07.179_bib30","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1158\/2159-8290.CD-13-1007","article-title":"The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNF\u03b1","volume":"4","author":"Smith","year":"2014","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jid.2021.07.179_bib31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1476-4598-13-126","article-title":"Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer","volume":"13","author":"Togashi","year":"2014","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jid.2021.07.179_bib32","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1158\/0008-5472.CAN-19-0458","article-title":"Defining the hallmarks of metastasis","volume":"79","author":"Welch","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2021.07.179_bib33","first-page":"4371","article-title":"Activin A as a novel biomarker for colorectal adenocarcinoma in humans","volume":"19","author":"Wu","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jid.2021.07.179_bib34","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1158\/0008-5472.CAN-18-1367","article-title":"Diverse functions of macrophages in different tumor microenvironments","volume":"78","author":"Yang","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2021.07.179_bib35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1158\/2326-6066.CIR-17-0198","article-title":"CCL20 expression by tumor-associated macrophages predicts progression of human primary cutaneous melanoma","volume":"6","author":"Samaniego","year":"2018","journal-title":"Cancer Immunol Res"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21021710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21021710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:48:02Z","timestamp":1762206482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21021710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022202X21021710"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.07.179","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activin A Sustains the Metastatic Phenotype of Tumor-Associated Macrophages and Is a Prognostic Marker in Human Cutaneous Melanoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.07.179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}