{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:10:50Z","timestamp":1793459450781,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIA AR041199"],"award-info":[{"award-number":["ZIA AR041199"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jid.2021.07.187","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T05:39:45Z","timestamp":1633066785000},"page":"924-935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"PB","title":["Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7706-1464","authenticated-orcid":false,"given":"Carmelo","family":"Carmona-Rivera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5580-6472","authenticated-orcid":false,"given":"Liam J.","family":"O\u2019Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-1257","authenticated-orcid":false,"given":"Eduardo","family":"Patino-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-0610","authenticated-orcid":false,"given":"William D.","family":"Shipman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-9450","authenticated-orcid":false,"given":"Chengsong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7257-0489","authenticated-orcid":false,"given":"Quan-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-613X","authenticated-orcid":false,"given":"Michelle L.","family":"Kerns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-0101","authenticated-orcid":false,"given":"Leandra A.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-3532","authenticated-orcid":false,"given":"Julie A.","family":"Caffrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7841-9392","authenticated-orcid":false,"given":"Sewon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-0815","authenticated-orcid":false,"given":"Mariana J.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1316-4023","authenticated-orcid":false,"given":"Ginette A.","family":"Okoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-4247","authenticated-orcid":false,"given":"Angel S.","family":"Byrd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.07.187_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF03261881","article-title":"Blocking interleukin-1 as a novel therapeutic strategy for secondary prevention of cardiovascular events","volume":"26","author":"Abbate","year":"2012","journal-title":"BioDrugs"},{"key":"10.1016\/j.jid.2021.07.187_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2020.01.045","article-title":"Anti-Saccharomyces cerevisiae IgG and IgA antibodies are associated with systemic inflammation and advanced disease in hidradenitis suppurativa","volume":"146","author":"Assan","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.07.187_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5021\/ad.2012.24.4.393","article-title":"Acne inversa: evaluating antimicrobial peptides and proteins","volume":"24","author":"Bechara","year":"2012","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/rheumatology\/kel019","article-title":"Association of a non-synonymous single-nucleotide polymorphism of DNASEI with SLE susceptibility","volume":"45","author":"Boda\u00f1o","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jid.2021.07.187_bib5","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1002\/jcp.27436","article-title":"Inflammation and pericarditis: are neutrophils actors behind the scenes?","volume":"234","author":"Bonaventura","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jid.2021.07.187_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav5908","article-title":"Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa","volume":"11","author":"Byrd","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2021.07.187_bib7","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/bjd.16600","article-title":"Collagen deposition in chronic hidradenitis suppurativa: potential role for CD163+ macrophages","volume":"179","author":"Byrd","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139388","article-title":"Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis","volume":"5","author":"Carmona-Rivera","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2021.07.187_bib9","article-title":"Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis [published correction appears in Sci Immunol 2020;5:eaaz9319]","volume":"2","author":"Carmona-Rivera","year":"2017","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jid.2021.07.187_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-1-4939-0326-9_11","article-title":"Detection of SLE antigens in neutrophil extracellular traps (NETs)","volume":"1134","author":"Carmona-Rivera","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2021.07.187_bib11","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1136\/annrheumdis-2013-204837","article-title":"Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2","volume":"74","author":"Carmona-Rivera","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2021.07.187_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X19895488","article-title":"Hidradenitis suppurativa: infection, autoimmunity, or both?","volume":"11","author":"Constantinou","year":"2019","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.jid.2021.07.187_bib13","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41584-019-0277-8","article-title":"The IL-1 family of cytokines and receptors in rheumatic diseases","volume":"15","author":"Dinarello","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2021.07.187_bib14","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2133.2011.10765.x","article-title":"Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa\/acne inversa","volume":"166","author":"Emelianov","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fimmu.2019.00302","article-title":"Commentary: hidradenitis suppurativa: a systematic review integrating inflammatory pathways into a cohesive pathogenic model","volume":"10","author":"Frew","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.07.187_bib16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jaci.2020.03.022","article-title":"Anti-Saccharomyces cervisiae antibodies in hidradenitis suppurativa: more than a gut feeling","volume":"146","author":"Frew","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.07.187_bib17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/exd.14092","article-title":"Beyond antibodies: B cells in hidradenitis suppurativa: bystanders, contributors or therapeutic targets?","volume":"29","author":"Frew","year":"2020","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib18","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.12688\/f1000research.17268.1","article-title":"A\u00a0systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa","volume":"7","author":"Frew","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.jid.2021.07.187_bib19","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1001\/jamadermatol.2017.0201","article-title":"Sex- and age-adjusted population analysis of prevalence estimates for hidradenitis suppurativa in the United States","volume":"153","author":"Garg","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib20","article-title":"Comorbidity screening in hidradenitis suppurativa: evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations [e-pub ahead of print]","author":"Garg","year":"2021","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/BOR.0000000000000667","article-title":"Deadliest catch: neutrophil extracellular traps in autoimmunity","volume":"32","author":"Goel","year":"2020","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jid.2021.07.187_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1189\/jlb.5BT0615-247R","article-title":"At the bench: neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases","volume":"99","author":"Grayson","year":"2016","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2021.07.187_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139930","article-title":"Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis","volume":"5","author":"Gudjonsson","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2021.07.187_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrneph.2016.71","article-title":"The role of neutrophils and NETosis in autoimmune and renal diseases","volume":"12","author":"Gupta","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jid.2021.07.187_bib25","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.1073\/pnas.0909927107","article-title":"Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis","volume":"107","author":"Hakkim","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2021.07.187_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203672","article-title":"Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature","volume":"13","author":"Hoffman","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.jid.2021.07.187_bib27","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.jid.2016.04.036","article-title":"Intrinsic defect in keratinocyte function leads to inflammation in hidradenitis suppurativa","volume":"136","author":"Hotz","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib28","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2133.2007.08425.x","article-title":"Toll-like receptor 2 is highly expressed in lesions of acne inversa and colocalizes with C-type lectin receptor","volume":"158","author":"Hunger","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib29","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/ijd.13937","article-title":"Prevalence of hidradenitis suppurativa in Brazil: a population survey","volume":"57","author":"Ianhez","year":"2018","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib30","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/bjd.12048","article-title":"Absence of pathogenic \u03b3-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa)","volume":"168","author":"Ingram","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jid.2018.10.020","article-title":"Apocrine gland-rich skin has a non-inflammatory IL-17-related immune milieu, that turns to inflammatory IL-17-mediated disease in hidradenitis suppurativa","volume":"139","author":"Jenei","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib32","article-title":"Novel insights into the NLRP 3 inflammasome in atherosclerosis","volume":"8","author":"Jin","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jid.2021.07.187_bib33","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.4049\/jimmunol.1202388","article-title":"Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages","volume":"190","author":"Kahlenberg","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.07.187_bib34","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/bjd.14075","article-title":"Dysregulated cytokine expression in lesional and nonlesional skin in hidradenitis suppurativa","volume":"173","author":"Kelly","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib35","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.1959","article-title":"Netting neutrophils in autoimmune small-vessel vasculitis","volume":"15","author":"Kessenbrock","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2021.07.187_bib36","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2021.07.187_bib37","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/1346-8138.12881","article-title":"Questionnaire surveillance of hidradenitis suppurativa in Japan","volume":"42","author":"Kurokawa","year":"2015","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib38","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/hep4.1582","article-title":"Exploratory study of autoantibody profiling in drug-induced liver injury with an autoimmune phenotype","volume":"4","author":"Lammert","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jid.2021.07.187_bib39","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1159\/000486741","article-title":"Hidradenitis suppurativa: disease burden and etiology in skin of color","volume":"233","author":"Lee","year":"2017","journal-title":"Dermatology"},{"key":"10.1016\/j.jid.2021.07.187_bib40","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1111\/ajd.13107","article-title":"A\u00a0gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: an update","volume":"61","author":"Li","year":"2020","journal-title":"Australas J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib41","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/bjd.14214","article-title":"Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa","volume":"174","author":"Lima","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib42","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/bjd.14482","article-title":"Genetic analysis of NCSTN for potential association with hidradenitis suppurativa in familial and nonfamilial patients","volume":"175","author":"Liu","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib43","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139932","article-title":"Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-\u03b1 therapy","volume":"5","author":"Lowe","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2021.07.187_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/FJC.0000000000000717","article-title":"NLRP3 inflammasome in acute myocardial infarction","volume":"74","author":"Mauro","year":"2019","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.jid.2021.07.187_bib45","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/bjd.12068","article-title":"Impaired Notch signalling: the unifying mechanism explaining the pathogenesis of hidradenitis suppurativa (acne inversa)","volume":"168","author":"Melnik","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib46","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrrheum.2011.52","article-title":"Pathogenesis of antiphospholipid syndrome: understanding the antibodies","volume":"7","author":"Meroni","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2021.07.187_bib47","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jid.2021.07.187_bib48","first-page":"5","article-title":"Anti-SSB\/La antibodies in Sj\u00f6gren\u2019s syndrome and related autoimmune diseases. Results of a quantitative immunoassay using a highly purified antigen","volume":"7","author":"Montecucco","year":"1989","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jid.2021.07.187_bib49","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.jid.2017.05.033","article-title":"Hidradenitis suppurativa is characterized by dysregulation of the Th17:Treg cell axis, which is corrected by anti-TNF therapy","volume":"137","author":"Moran","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib50","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1111\/jdv.16095","article-title":"Investigating race and gender in age at onset of hidradenitis suppurativa","volume":"34","author":"Morss","year":"2020","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2021.07.187_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2019.08.453","article-title":"Enrichment of plasma cells in the peripheral blood and skin of patients with hidradenitis suppurativa","volume":"140","author":"Musilova","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41584-018-0145-y","article-title":"Pathogenesis and therapeutic interventions for ANCA-associated vasculitis [published correction appears in Nat Rev Rheumatol 2019;15:123]","volume":"15","author":"Nakazawa","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2021.07.187_bib53","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.12688\/f1000research.26083.1","article-title":"The most recent advances in understanding and managing hidradenitis suppurativa","volume":"9","author":"Narla","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.jid.2021.07.187_bib54","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/bjd.18556","article-title":"Interleukin 17C is elevated in lesional tissue of hidradenitis suppurativa","volume":"182","author":"Navrazhina","year":"2020","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib55","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.jid.2021.02.742","article-title":"In-depth analysis of the hidradenitis suppurativa serum proteome identifies distinct inflammatory subtypes","volume":"141","author":"Navrazhina","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib56","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.autrev.2016.12.004","article-title":"Anti-RO\/SSA and anti-La\/SSB antibodies: association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus","volume":"16","author":"Novak","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2021.07.187_bib57","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1172\/JCI136254","article-title":"Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia","volume":"130","author":"Perez-Diez","year":"2020","journal-title":"J\u00a0Clin Invest"},{"issue":"Suppl. 1","key":"10.1016\/j.jid.2021.07.187_bib58","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.jaad.2015.07.045","article-title":"Pathophysiology of hidradenitis suppurativa: an update","volume":"73","author":"Prens","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib59","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1038\/jid.2014.220","article-title":"Ethnicity and hidradenitis suppurativa","volume":"134","author":"Reeder","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib60","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1001\/jama.2017.16691","article-title":"Hidradenitis suppurativa: advances in diagnosis and treatment","volume":"318","author":"Saunte","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jid.2021.07.187_bib61","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jaad.2010.07.010","article-title":"Expression of the IL-23\/Th17 pathway in lesions of hidradenitis suppurativa","volume":"65","author":"Schlapbach","year":"2011","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib62","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134189","article-title":"Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies","volume":"5","author":"Seto","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2021.07.187_bib63","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00011-017-1074-y","article-title":"The critical role of macrophages in the pathogenesis of hidradenitis suppurativa","volume":"66","author":"Shah","year":"2017","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jid.2021.07.187_bib64","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/ced.13959","article-title":"Transcriptome patterns in hidradenitis suppurativa: support for the role of antimicrobial peptides and interferon pathways in disease pathogenesis","volume":"44","author":"Shanmugam","year":"2019","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib65","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1177\/1203475418803077","article-title":"African American patients with hidradenitis suppurativa have significant health care disparities: a retrospective study","volume":"23","author":"Soliman","year":"2019","journal-title":"J\u00a0Cutan Med Surg"},{"key":"10.1016\/j.jid.2021.07.187_bib66","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/ar4579","article-title":"Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility","volume":"16","author":"Sur Chowdhury","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jid.2021.07.187_bib67","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.clindermatol.2018.04.008","article-title":"Clinical significance of autoantibodies in dermatomyositis and systemic sclerosis","volume":"36","author":"Tartar","year":"2018","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib68","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/exd.13482","article-title":"Elevated levels of the antimicrobial peptide LL-37 in hidradenitis suppurativa are associated with a Th1\/Th17 immune response","volume":"27","author":"Thomi","year":"2018","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib69","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2133.2011.10643.x","article-title":"Alterations in leucocyte subsets and histomorphology in normal-appearing perilesional skin and early and chronic hidradenitis suppurativa lesions","volume":"166","author":"van der Zee","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib70","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jaci.2020.04.017","article-title":"Anti-Saccharomyces cerevisiae antibodies could reflect distinct phenotypes in hidradenitis suppurativa","volume":"146","author":"van Straalen","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.07.187_bib71","doi-asserted-by":"crossref","first-page":"990","DOI":"10.2340\/00015555-2176","article-title":"Hidradenitis suppurativa disproportionately affects African Americans: a single-center retrospective analysis","volume":"95","author":"Vlassova","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2021.07.187_bib72","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/all.13665","article-title":"Novel cytokine and chemokine markers of hidradenitis suppurativa reflect chronic inflammation and itch","volume":"74","author":"Vossen","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2021.07.187_bib73","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1196284","article-title":"Gamma-secretase gene mutations in familial acne inversa","volume":"330","author":"Wang","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jid.2021.07.187_bib74","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jid.2018.11.018","article-title":"The IL-1 pathway is hyperactive in hidradenitis suppurativa and contributes to skin infiltration and destruction","volume":"139","author":"Witte-H\u00e4ndel","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib75","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/exd.14214","article-title":"What causes hidradenitis suppurativa?-15 years after","volume":"29","author":"Zouboulis","year":"2020","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.07.187_bib76","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/cvr\/cvy304","article-title":"Innate immunity as a target for acute cardioprotection","volume":"115","author":"Zuurbier","year":"2019","journal-title":"Cardiovasc Res"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21022867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21022867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:48:22Z","timestamp":1762206502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21022867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0022202X21022867"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.07.187","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.07.187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}