{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:50:52Z","timestamp":1787061052461,"version":"build-2736575974"},"reference-count":84,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010782","name":"Exzellenzclusters Entz\u00fcndungsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2167"],"award-info":[{"award-number":["EXC 2167"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 306\/2"],"award-info":[{"award-number":["EXC 306\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 1727\/1-2"],"award-info":[{"award-number":["GRK 1727\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 303\/1-2"],"award-info":[{"award-number":["KFO 303\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LU877\/10-1"],"award-info":[{"award-number":["LU877\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2012-1875"],"award-info":[{"award-number":["2012-1875"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005390","name":"Alfred \u00d6sterlunds Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005753","name":"Kungliga Fysiografiska S\u00e4llskapet i Lund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jid.2021.08.448","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T10:52:51Z","timestamp":1636973571000},"page":"1552-1564.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multiple Modes of Action Mediate the Therapeutic Effect of Intravenous IgG in Experimental Epidermolysis Bullosa Acquisita"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-1576","authenticated-orcid":false,"given":"Elena","family":"Pipi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-0900","authenticated-orcid":false,"given":"Anika","family":"Kasprick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-2735","authenticated-orcid":false,"given":"Hiroaki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-4290","authenticated-orcid":false,"given":"Stephanie","family":"Goletz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9644-556X","authenticated-orcid":false,"given":"Jennifer E.","family":"Hundt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-2108","authenticated-orcid":false,"given":"Hengameh","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6193-1149","authenticated-orcid":false,"given":"Leon F.","family":"Schmidt-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-8913","authenticated-orcid":false,"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-9623","authenticated-orcid":false,"given":"Jonathan","family":"Sj\u00f6gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5668-307X","authenticated-orcid":false,"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-4098","authenticated-orcid":false,"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-7410","authenticated-orcid":false,"given":"Mattias","family":"Collin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-6683","authenticated-orcid":false,"given":"Katja","family":"Bieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.08.448_bib1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature10134","article-title":"Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway","volume":"475","author":"Anthony","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jid.2021.08.448_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jaci.2010.10.030","article-title":"The IgG molecule as a biological immune response modifier: mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders","volume":"127","author":"Ballow","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3233\/HAB-160293","article-title":"The effect of intravenous immunoglobulin (IVIG) on \u2216textit{ex\u00a0vivo} activation of human leukocytes","volume":"24","author":"Basyreva","year":"2016","journal-title":"Hum Antibodies"},{"key":"10.1016\/j.jid.2021.08.448_bib4","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/exd.13415","article-title":"In\u00a0vitro and in\u00a0vivo models to investigate the pathomechanisms and novel treatments for pemphigoid diseases","volume":"26","author":"Bieber","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib5","doi-asserted-by":"crossref","first-page":"38357","DOI":"10.1038\/srep38357","article-title":"T\u00a0cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita","volume":"6","author":"Bieber","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2021.08.448_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.transci.2016.12.017","article-title":"Mechanisms of action of intravenous immunoglobulin","volume":"56","author":"Chaigne","year":"2017","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.jid.2021.08.448_bib7","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1039\/c1cc10589b","article-title":"A\u00a0specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production","volume":"47","author":"Chen","year":"2011","journal-title":"Chem Commun (Camb)"},{"key":"10.1016\/j.jid.2021.08.448_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/path.2157","article-title":"NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage","volume":"212","author":"Chiriac","year":"2007","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2021.08.448_bib9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/ACI.0000000000000215","article-title":"Secondary antibody deficiencies","volume":"15","author":"Dhalla","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1568-9972(03)00052-1","article-title":"Immune deficiency and autoimmunity","volume":"2","author":"Etzioni","year":"2003","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2021.08.448_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0001-2998(88)80042-4","article-title":"Detection of acute inflammation with 111in-labeled nonspecific polyclonal IgG","volume":"18","author":"Fischman","year":"1988","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.jid.2021.08.448_bib12","first-page":"37","article-title":"Radionuclide imaging with human polyclonal immunoglobulin (Tc-HIG) and bone scan in patients with rheumatoid arthritis and serum-negative polyarthritis","volume":"15","author":"Gerasimou","year":"2011","journal-title":"Hippokratia"},{"key":"10.1016\/j.jid.2021.08.448_bib13","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.4049\/jimmunol.1100796","article-title":"Complement-fixing anti-type VII collagen antibodies are induced in Th1-polarized lymph nodes of epidermolysis bullosa acquisita-susceptible mice","volume":"187","author":"Hammers","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.saa.2013.05.061","article-title":"Study on the proteins-luminol binding by use of luminol as a fluorescence probe","volume":"114","author":"He","year":"2013","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"10.1016\/j.jid.2021.08.448_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1084\/jem.169.1.59","article-title":"Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets","volume":"169","author":"Heinzel","year":"1989","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2021.08.448_bib16","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10875-014-0056-x","article-title":"Autoimmunity and inflammation in X-linked agammaglobulinemia","volume":"34","author":"Hernandez-Trujillo","year":"2014","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib17","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1136\/jcp.2007.051177","article-title":"Antibody deficiency","volume":"61","author":"Herriot","year":"2008","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jid.2021.08.448_bib18","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2011.12.038","article-title":"Both the Fab and Fc domains of IgG are essential for ROS emission from TNF-\u03b1-primed neutrophils by IVIG","volume":"417","author":"Higurashi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2021.08.448_bib19","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2119\/molmed.2015.00206","article-title":"Reduced skin blistering in experimental epidermolysis bullosa acquisita after anti-TNF treatment","volume":"22","author":"Hirose","year":"2016","journal-title":"Mol Med"},{"key":"10.1016\/j.jid.2021.08.448_bib20","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/jid.2014.453","article-title":"Effects of intravenous immunoglobulins on mice with experimental epidermolysis bullosa acquisita","volume":"135","author":"Hirose","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41467-020-20604-3","article-title":"Granzyme B inhibition reduces disease severity in autoimmune blistering diseases","volume":"12","author":"Hiroyasu","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.08.448_bib22","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.3389\/fimmu.2019.01090","article-title":"High-dose intravenous immunoglobulin in skin autoimmune disease","volume":"10","author":"Hoffmann","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib23","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.4049\/jimmunol.1300310","article-title":"B\u00a0cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita","volume":"191","author":"Iwata","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13023-018-0896-1","article-title":"Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients","volume":"13","author":"Iwata","year":"2018","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jid.2021.08.448_bib25","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1182\/blood.2019001705","article-title":"The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies","volume":"134","author":"Jandus","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jid.2021.08.448_bib26","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00221-006-0752-8","article-title":"IVIG enters the central nervous system during treatment of experimental autoimmune encephalomyelitis and is localised to inflammatory lesions","volume":"178","author":"Jorgensen","year":"2007","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.jid.2021.08.448_bib27","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3389\/fimmu.2017.01669","article-title":"Anti-idiotypic antibodies against BP-IgG prevent type XVII collagen depletion","volume":"8","author":"Kamaguchi","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib28","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1129594","article-title":"Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation","volume":"313","author":"Kaneko","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jid.2021.08.448_bib29","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/nm.2862","article-title":"Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of Fc\u03b3RIIB and dectin-1","volume":"18","author":"Karsten","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2021.08.448_bib30","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1002\/cpph.55","article-title":"Drug discovery for pemphigoid diseases","volume":"84","author":"Kasprick","year":"2019","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.jid.2021.08.448_bib31","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jid.2017.08.030","article-title":"The anti-C1s antibody TNT003 prevents complement activation in the skin induced by bullous pemphigoid autoantibodies","volume":"138","author":"Kasprick","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.4049\/jimmunol.132.2.745","article-title":"Modulation of mononuclear phagocyte function by intravenous gamma-globulin","volume":"132","author":"Kimberly","year":"1984","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fmed.2018.00362","article-title":"Epidermolysis bullosa acquisita: the 2019 update","volume":"5","author":"Koga","year":"2019","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jid.2021.08.448_bib34","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.autrev.2019.06.007","article-title":"Epidermolysis bullosa acquisita: a comprehensive review","volume":"18","author":"Kridin","year":"2019","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2021.08.448_bib35","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1182\/blood-2012-03-415695","article-title":"Mouse background and IVIG dosage are critical in establishing the role of inhibitory Fc\u03b3 receptor for the amelioration of experimental ITP","volume":"119","author":"Leontyev","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jid.2021.08.448_bib36","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jid.2018.02.020","article-title":"Modes of action of intravenous immunoglobulin in bullous pemphigoid","volume":"138","author":"Li","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib37","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1172\/JCI24394","article-title":"Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases","volume":"115","author":"Li","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2021.08.448_bib38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1172\/JCI3693","article-title":"A\u00a0critical role for neutrophil elastase in experimental bullous pemphigoid","volume":"105","author":"Liu","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2021.08.448_bib39","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/exd.13335","article-title":"Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita","volume":"26","author":"Ludwig","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib40","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of autoantibody-induced pathology","volume":"8","author":"Ludwig","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib41","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3389\/fimmu.2018.00535","article-title":"Specific inhibition of complement activation significantly ameliorates autoimmune blistering disease in mice","volume":"9","author":"Mihai","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib42","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2249.2010.04265.x","article-title":"Efficacy of intravenous immunoglobulin (IVIG) affinity-purified anti-desmoglein anti-idiotypic antibodies in the treatment of an experimental model of pemphigus vulgaris","volume":"162","author":"Mimouni","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib43","first-page":"251","article-title":"A\u00a0review of human anti-globulin antibody (HAGA, HAMA, HACA, HAHA) responses to monoclonal antibodies. Not four letter words","volume":"48","author":"Mirick","year":"2004","journal-title":"Q\u00a0J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jid.2021.08.448_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/JID.2015.361","article-title":"Dimethylfumarate impairs neutrophil functions","volume":"136","author":"M\u00fcller","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib45","doi-asserted-by":"crossref","first-page":"40542","DOI":"10.1074\/jbc.M307159200","article-title":"Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1 [published correction appears in J Biol Chem 2003;278:49662]","volume":"278","author":"M\u00fctze","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2021.08.448_bib46","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.jid.2020.01.022","article-title":"Epidermal damage induces Th1 polarization and defines the site of inflammation in murine epidermolysis bullosa acquisita","volume":"140","author":"Niebuhr","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib47","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/exd.13439","article-title":"Evidence for a contributory role of a xenogeneic immune response in experimental epidermolysis bullosa acquisita","volume":"26","author":"Niebuhr","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib48","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/MOH.0000000000000609","article-title":"New insights into IVIg mechanisms and alternatives in autoimmune and inflammatory diseases","volume":"27","author":"Norris","year":"2020","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jid.2021.08.448_bib49","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2217\/imt.14.54","article-title":"Immunoglobulin replacement therapy for primary immunodeficiencies","volume":"6","author":"Peter","year":"2014","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jid.2021.08.448_bib50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","article-title":"Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency","volume":"27","author":"Quinti","year":"2007","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib51","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jaut.2009.11.003","article-title":"Pathogenicity of IgG subclass autoantibodies to type VII collagen: induction of dermal-epidermal separation","volume":"34","author":"Recke","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2021.08.448_bib52","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.molimm.2007.10.043","article-title":"Proteolysis of purified IgGs by human and bacterial enzymes in\u00a0vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid","volume":"45","author":"Ryan","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib53","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jid.2018.01.005","article-title":"Intravenous IgG reduces pathogenic autoantibodies, serum IL-6 levels, and disease severity in experimental bullous pemphigoid models","volume":"138","author":"Sasaoka","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib54","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2021.08.448_bib55","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nri3401","article-title":"Intravenous immunoglobulin therapy: how does IgG modulate the immune system?","volume":"13","author":"Schwab","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib56","first-page":"205","article-title":"Oxygen consumption by stimulated human neutrophils","volume":"65","author":"Segal","year":"1978","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.jid.2021.08.448_bib57","doi-asserted-by":"crossref","first-page":"e31357","DOI":"10.1371\/journal.pone.0031357","article-title":"Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production","volume":"7","author":"Semple","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.08.448_bib58","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1074\/jbc.M209264200","article-title":"Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species","volume":"278","author":"Setsukinai","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2021.08.448_bib59","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.ajpath.2018.08.010","article-title":"A\u00a0contrast in pathogenic responses between C57BL\/6J and BALB\/cJ mice using a model of retinal injury","volume":"188","author":"Shi","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2021.08.448_bib60","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/path.1674","article-title":"Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid","volume":"204","author":"Shimanovich","year":"2004","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2021.08.448_bib61","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.177.5.3461","article-title":"Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice","volume":"177","author":"Sitaru","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib62","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.jid.2020.04.025","article-title":"Propranolol is an effective topical and systemic treatment option for experimental epidermolysis bullosa acquisita","volume":"140","author":"St\u00fcssel","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib63","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1084\/jem.186.7.1015","article-title":"Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: a possible initiating role of B cells","volume":"186","author":"Tsuji","year":"1997","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2021.08.448_bib64","first-page":"E1297","article-title":"Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity [published correction appears in Proc Natl Acad Sci USA 2015;112:E4339]","volume":"112","author":"Washburn","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2021.08.448_bib65","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1038\/jid.2010.230","article-title":"Fc\u03b3RIIA and Fc\u03b3RIIIB are required for autoantibody-induced tissue damage in experimental human models of bullous pemphigoid [published correction appears in J Invest Dermatol 2012;132:1938]","volume":"130","author":"Yu","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib66","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/jnnp.2010.205856","article-title":"IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy","volume":"82","author":"Yuki","year":"2011","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jid.2021.08.448_bib67","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature10134","article-title":"Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway","volume":"475","author":"Anthony","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jid.2021.08.448_bib68","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3389\/fimmu.2017.01628","article-title":"Regulatory T cells suppress inflammation and blistering in pemphigoid diseases","volume":"8","author":"Bieber","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib69","doi-asserted-by":"crossref","first-page":"38357","DOI":"10.1038\/srep38357","article-title":"T\u00a0cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita","volume":"6","author":"Bieber","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2021.08.448_bib70","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/1523-1747.ep12507222","article-title":"An in\u00a0vitro model of immune complex-mediated basement membrane zone separation caused by pemphigoid antibodies, leukocytes, and complement","volume":"78","author":"Gammon","year":"1982","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib71","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.4049\/jimmunol.1100796","article-title":"Complement-fixing anti-type VII collagen antibodies are induced in Th1-polarized lymph nodes of epidermolysis bullosa acquisita-susceptible mice","volume":"187","author":"Hammers","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib72","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1129594","article-title":"Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation","volume":"313","author":"Kaneko","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jid.2021.08.448_bib73","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1002\/cpph.55","article-title":"Drug discovery for pemphigoid diseases","volume":"84","author":"Kasprick","year":"2019","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.jid.2021.08.448_bib74","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jid.2017.08.030","article-title":"The anti-C1s antibody TNT003 prevents complement activation in the skin induced by bullous pemphigoid autoantibodies","volume":"138","author":"Kasprick","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib75","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00403-015-1606-7","article-title":"Immunoadsorber for specific apheresis of autoantibodies in the treatment of bullous pemphigoid","volume":"308","author":"Mersmann","year":"2016","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2021.08.448_bib76","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2249.2010.04265.x","article-title":"Efficacy of intravenous immunoglobulin (IVIG) affinity-purified anti-desmoglein anti-idiotypic antibodies in the treatment of an experimental model of pemphigus vulgaris","volume":"162","author":"Mimouni","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2021.08.448_bib77","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/JID.2015.361","article-title":"Dimethylfumarate impairs neutrophil functions","volume":"136","author":"M\u00fcller","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib78","doi-asserted-by":"crossref","first-page":"40542","DOI":"10.1074\/jbc.M307159200","article-title":"Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1 [published correction appears in J Biol Chem 2003;278:49662]","volume":"278","author":"M\u00fctze","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2021.08.448_bib79","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.jid.2020.01.022","article-title":"Epidermal damage induces Th1 polarization and defines the site of inflammation in murine epidermolysis bullosa acquisita","volume":"140","author":"Niebuhr","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib80","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/exd.13439","article-title":"Evidence for a contributory role of a xenogeneic immune response in experimental epidermolysis bullosa acquisita","volume":"26","author":"Niebuhr","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib81","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jaut.2009.11.003","article-title":"Pathogenicity of IgG subclass autoantibodies to type VII collagen: induction of dermal-epidermal separation","volume":"34","author":"Recke","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2021.08.448_bib82","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.jid.2020.04.025","article-title":"Propranolol is an effective topical and systemic treatment option for experimental epidermolysis bullosa acquisita","volume":"140","author":"St\u00fcssel","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib83","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jid.2017.09.009","article-title":"Calcitriol treatment ameliorates inflammation and blistering in mouse models of epidermolysis bullosa acquisita","volume":"138","author":"Tukaj","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.08.448_bib84","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1038\/jid.2010.230","article-title":"Fc\u03b3RIIA and Fc\u03b3RIIIB are required for autoantibody-induced tissue damage in experimental human models of bullous pemphigoid [published correction appears in J Invest Dermatol 2012;132:1938]","volume":"130","author":"Yu","year":"2010","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21024817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21024817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:48:07Z","timestamp":1762206487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21024817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0022202X21024817"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.08.448","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple Modes of Action Mediate the Therapeutic Effect of Intravenous IgG in Experimental Epidermolysis Bullosa Acquisita","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.08.448","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}