{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:38:34Z","timestamp":1790483914841,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jid.2021.09.009","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T18:19:13Z","timestamp":1635272353000},"page":"1206-1216.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["An Epidermal-Specific Role for Arginase1 during Cutaneous Wound Repair"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5878-9292","authenticated-orcid":false,"given":"Rachel A.","family":"Crompton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-501X","authenticated-orcid":false,"given":"Helen","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-3917","authenticated-orcid":false,"given":"Laura","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-5334","authenticated-orcid":false,"given":"Lim","family":"Hui Kheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-001X","authenticated-orcid":false,"given":"Charis","family":"Saville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-4288","authenticated-orcid":false,"given":"David M.","family":"Ansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-3302","authenticated-orcid":false,"given":"Adam","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2592-3226","authenticated-orcid":false,"given":"Jason","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-684X","authenticated-orcid":false,"given":"Leah A.","family":"Vardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-5074","authenticated-orcid":false,"given":"Matthew J.","family":"Hardman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-5475","authenticated-orcid":false,"given":"Sheena M.","family":"Cruickshank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.09.009_bib1","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1002\/jcp.29812","article-title":"A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer [published correction appears in J Cell Physiol 2021]","volume":"235","author":"Abd El-Aleem","year":"2020","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jid.2021.09.009_bib2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH654>3.0.CO;2-S","article-title":"Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers","volume":"191","author":"Abd-El-Aleem","year":"2000","journal-title":"J Pathol"},{"key":"10.1016\/j.jid.2021.09.009_bib3","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1172\/JCI16288","article-title":"Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor","volume":"111","author":"Ashcroft","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jid.2021.09.009_bib4","doi-asserted-by":"crossref","first-page":"2021S","DOI":"10.1093\/jn\/138.10.2021S","article-title":"Proline precursors to sustain mammalian collagen synthesis","volume":"138","author":"Barbul","year":"2008","journal-title":"J Nutr"},{"key":"10.1016\/j.jid.2021.09.009_bib5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1471-4906(03)00132-7","article-title":"L-arginine metabolism in myeloid cells controls T-lymphocyte functions","volume":"24","author":"Bronte","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jid.2021.09.009_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2021.09.009_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)63811-4","article-title":"Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation","volume":"162","author":"Bruch-Gerharz","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2021.09.009_bib8","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/jid.2013.164","article-title":"Local arginase 1 activity is required for cutaneous wound healing","volume":"133","author":"Campbell","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0022-1759(94)90027-2","article-title":"Determination of arginase activity in macrophages: a micromethod","volume":"174","author":"Corraliza","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jid.2021.09.009_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/bbrc.1997.6945","article-title":"Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia","volume":"236","author":"Coulombe","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2021.09.009_bib11","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/jid.2012.228","article-title":"Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R\/ER\u03b1 cross talk","volume":"132","author":"Emmerson","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.324.7330.160","article-title":"Science, medicine and the future: healing chronic wounds","volume":"324","author":"Harding","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.jid.2021.09.009_bib13","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2008-9-5-r80","article-title":"Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly","volume":"9","author":"Hardman","year":"2008","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2021.09.009_bib14","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/1523-1747.ep12606176","article-title":"The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins","volume":"104","author":"Hohl","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0305-0491(95)02138-8","article-title":"Comparative properties of arginases","volume":"114","author":"Jenkinson","year":"1996","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"10.1016\/j.jid.2021.09.009_bib16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s001250051224","article-title":"The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1","volume":"42","author":"Jude","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.jid.2021.09.009_bib17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/bies.10144","article-title":"Epithelial barrier function: assembly and structural features of the cornified cell envelope","volume":"24","author":"Kalinin","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.jid.2021.09.009_bib18","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1046\/j.1523-1747.2003.12610.x","article-title":"Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair","volume":"121","author":"K\u00e4mpfer","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.surg.2011.07.012","article-title":"Arginase inhibition promotes wound healing in mice","volume":"151","author":"Kavalukas","year":"2012","journal-title":"Surgery"},{"key":"10.1016\/j.jid.2021.09.009_bib20","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1152\/japplphysiol.91393.2008","article-title":"Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats","volume":"107","author":"Kim","year":"2009","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.jid.2021.09.009_bib21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1083\/jcb.151.2.389","article-title":"Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein","volume":"151","author":"Koch","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jid.2021.09.009_bib22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/1479164116643916","article-title":"Amino acid metabolism reflecting arginase activity is increased in patients with type 2 diabetes and associated with endothelial dysfunction","volume":"13","author":"K\u00f6vamees","year":"2016","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.jid.2021.09.009_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00726-019-02719-0","article-title":"The role of polyamines in the regulation of macrophage polarization and function","volume":"52","author":"Latour","year":"2020","journal-title":"Amino Acids"},{"key":"10.1016\/j.jid.2021.09.009_bib24","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1152\/ajpregu.2002.282.1.R64","article-title":"Activities of arginase I and II are limiting for endothelial cell proliferation","volume":"282","author":"Li","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jid.2021.09.009_bib25","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1016\/j.jid.2018.05.029","article-title":"Polyamine regulator AMD1 promotes cell migration in epidermal wound healing","volume":"138","author":"Lim","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.immuni.2020.06.004","article-title":"Excessive polyamine generation in keratinocytes promotes self-RNA sensing by dendritic cells in psoriasis","volume":"53","author":"Lou","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2021.09.009_bib27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0379-0738(90)90311-L","article-title":"A study on the vital reaction in wounded skin: simultaneous determination of histamine and polyamines in injured rat skin by high-performance liquid chromatography","volume":"46","author":"Maeno","year":"1990","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jid.2021.09.009_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.imbio.2011.01.001","article-title":"Macrophages in skin injury and repair","volume":"216","author":"Mahdavian Delavary","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.jid.2021.09.009_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1467-2494.2007.00377.x","article-title":"Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases","volume":"29","author":"M\u00e9chin","year":"2007","journal-title":"Int J Cosmet Sci"},{"key":"10.1016\/j.jid.2021.09.009_bib30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s13670-013-0060-7","article-title":"Functions and mechanisms of arginase in age-associated cardiovascular diseases","volume":"2","author":"Ming","year":"2013","journal-title":"Curr Transl Geriatr Exp Gerontol Rep"},{"key":"10.1016\/j.jid.2021.09.009_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0304-4165(74)90347-X","article-title":"Changes in polyamine metabolism during wound healing in rat skin","volume":"338","author":"Mizutani","year":"1974","journal-title":"Biochim biophys acta"},{"key":"10.1016\/j.jid.2021.09.009_bib32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exger.2018.12.011","article-title":"The role of arginase in aging: a systematic review","volume":"116","author":"Moretto","year":"2019","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jid.2021.09.009_bib33","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1371\/journal.pntd.0000235","article-title":"Age-related alteration of arginase activity impacts on severity of leishmaniasis","volume":"2","author":"M\u00fcller","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.jid.2021.09.009_bib34","doi-asserted-by":"crossref","first-page":"8532","DOI":"10.1038\/ncomms9532","article-title":"KCNJ15\/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis","volume":"6","author":"Nakajima","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.09.009_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/014860710102500123","article-title":"Effects of L-arginine on the proliferation of T lymphocyte subpopulations","volume":"25","author":"Ochoa","year":"2001","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.jid.2021.09.009_bib36","series-title":"Wound regeneration and repair: methods and protocols","first-page":"255","article-title":"Chapter 14: human ex vivo wound healing model","author":"Olivera","year":"2013"},{"key":"10.1016\/j.jid.2021.09.009_bib37","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/wound.2013.0473","article-title":"Epithelialization in wound healing: a comprehensive review","volume":"3","author":"Pastar","year":"2014","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.jid.2021.09.009_bib38","doi-asserted-by":"crossref","first-page":"C212","DOI":"10.1152\/ajpcell.1982.243.5.C212","article-title":"Polyamine metabolism and function","volume":"243","author":"Pegg","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jid.2021.09.009_bib39","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.0022-202X.2005.23636.x","article-title":"Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine\/spermine N-acetyltransferase overexpression","volume":"124","author":"Pietil\u00e4","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib40","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1016\/j.jid.2021.01.039","article-title":"The polyamine regulator AMD1 upregulates spermine levels to drive epidermal differentiation","volume":"141","author":"Rahim","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib41","doi-asserted-by":"crossref","first-page":"e66823","DOI":"10.1371\/journal.pone.0066823","article-title":"Increased erythrocytes by-products of arginine catabolism are associated with hyperglycemia and could be involved in the pathogenesis of type 2 diabetes mellitus","volume":"8","author":"Ram\u00edrez-Zamora","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.09.009_bib42","doi-asserted-by":"crossref","first-page":"e22564","DOI":"10.1371\/journal.pone.0022564","article-title":"Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions","volume":"6","author":"Ramot","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.09.009_bib43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/jsre.2002.6471","article-title":"Effect of supplemental ornithine on wound healing","volume":"106","author":"Shi","year":"2002","journal-title":"J Surg Res"},{"key":"10.1016\/j.jid.2021.09.009_bib44","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI44490","article-title":"An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice","volume":"121","author":"Sindrilaru","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jid.2021.09.009_bib45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0002-9440(10)62953-7","article-title":"Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing","volume":"167","author":"Stojadinovic","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2021.09.009_bib46","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1111\/j.1582-4934.2008.00321.x","article-title":"Deregulation of keratinocyte differentiation and\u00a0activation: a hallmark of venous ulcers","volume":"12","author":"Stojadinovic","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jid.2021.09.009_bib47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s41038-018-0123-2","article-title":"Electrically stimulated cell migration and its contribution to wound healing","volume":"6","author":"Tai","year":"2018","journal-title":"Burns Trauma"},{"key":"10.1016\/j.jid.2021.09.009_bib48","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/path.4016","article-title":"Direct evidence that PKC\u03b1 positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness","volume":"227","author":"Thomason","year":"2012","journal-title":"J Pathol"},{"key":"10.1016\/j.jid.2021.09.009_bib49","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2174\/1389557043403305","article-title":"Cellular and physiological effects of arginine","volume":"4","author":"Tong","year":"2004","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.jid.2021.09.009_bib50","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1042\/bst0260571","article-title":"Regulation of polyamine acetylation and efflux in human cancer cells","volume":"26","author":"Wallace","year":"1998","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jid.2021.09.009_bib51","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-2230.2004.01627.x","article-title":"Altered expression of L-arginine metabolism pathway genes in chronic wounds in recessive dystrophic epidermolysis bullosa","volume":"29","author":"Wessagowit","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib52","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.jid.2018.04.014","article-title":"Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2","volume":"138","author":"Williams","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2021.09.009_bib53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/jsre.2002.6443","article-title":"Upregulation of arginase expression in wound-derived fibroblasts","volume":"105","author":"Witte","year":"2002","journal-title":"J Surg Res"},{"key":"10.1016\/j.jid.2021.09.009_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2021.09.009_bib55","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ni.1671","article-title":"Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens","volume":"9","author":"El Kasmi","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2021.09.009_bib56","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1152\/ajpendo.2001.280.1.E75","article-title":"Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells","volume":"280","author":"Li","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jid.2021.09.009_bib57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1073\/pnas.98.1.31","article-title":"Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection","volume":"98","author":"Li","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jid.2021.09.009_bib58","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/35076576","article-title":"Computational analysis of microarray data","volume":"2","author":"Quackenbush","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jid.2021.09.009_bib59","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"10.1016\/j.jid.2021.09.009_bib60","series-title":"R: A Language and Environment for Statistical Computing","author":"Team","year":"2008"},{"key":"10.1016\/j.jid.2021.09.009_bib61","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.jid.2018.04.014","article-title":"Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2","volume":"138","author":"Williams","year":"2018","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21022880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21022880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:27:16Z","timestamp":1758302836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21022880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0022202X21022880"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.09.009","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Epidermal-Specific Role for Arginase1 during Cutaneous Wound Repair","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}