{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:36:42Z","timestamp":1789771002261,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-18-058-0"],"award-info":[{"award-number":["RSG-18-058-0"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR072655"],"award-info":[{"award-number":["R01AR072655"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000983","name":"Mary Kay Foundation","doi-asserted-by":"publisher","award":["P30 CA142543"],"award-info":[{"award-number":["P30 CA142543"]}],"id":[{"id":"10.13039\/100000983","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000983","name":"Mary Kay Foundation","doi-asserted-by":"publisher","award":["RP180805"],"award-info":[{"award-number":["RP180805"]}],"id":[{"id":"10.13039\/100000983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jid.2021.10.009","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T20:12:54Z","timestamp":1635451974000},"page":"1280-1290.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Human Papillomavirus\u2012Positive and \u2012Negative Vulvar Squamous Cell Carcinoma Are Biologically but Not Clinically Distinct"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4664-2063","authenticated-orcid":false,"given":"Elysha","family":"Kolitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-1089","authenticated-orcid":false,"given":"Elena","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-0565","authenticated-orcid":false,"given":"Gregory A.","family":"Hosler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-9329","authenticated-orcid":false,"given":"Jiwoong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-8257","authenticated-orcid":false,"given":"Suntrea","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-6475","authenticated-orcid":false,"given":"Cheryl","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-4457","authenticated-orcid":false,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-4125","authenticated-orcid":false,"given":"Andrew T.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9676-0965","authenticated-orcid":false,"given":"Melissa","family":"Mauskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8657-4309","authenticated-orcid":false,"given":"Jayanthi S.","family":"Lea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4543-8295","authenticated-orcid":false,"given":"Richard C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.10.009_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2147\/IJWH.S68979","article-title":"Vulvar cancer: epidemiology, clinical presentation, and management options","volume":"7","author":"Alkatout","year":"2015","journal-title":"Int J Womens Health"},{"key":"10.1016\/j.jid.2021.10.009_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/PGP.0000000000000620","article-title":"HPV-independent vulvar squamous cell carcinoma is associated with significantly worse prognosis compared with HPV-associated tumors","volume":"39","author":"Allo","year":"2020","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.jid.2021.10.009_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2021.10.009_bib5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/gyno.1994.1028","article-title":"Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva: detection and prognostic significance","volume":"52","author":"Ansink","year":"1994","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib6","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/ijc.27650","article-title":"EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease","volume":"131","author":"Arbyn","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jid.2021.10.009_bib7","first-page":"3739075","article-title":"The clinical relevance of p16 and p53 status in patients with squamous cell carcinoma of the vulva","volume":"2020","author":"Barlow","year":"2020","journal-title":"J\u00a0Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib8","author":"Berek"},{"key":"10.1016\/j.jid.2021.10.009_bib9","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.18632\/aging.101520","article-title":"Circ-BPTF promotes bladder cancer progression and recurrence through the miR-31-5p\/RAB27A axis [published correction appears in Aging (Albany NY) 2021;13:3162\u20134]","volume":"10","author":"Bi","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jid.2021.10.009_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/gcc.22006","article-title":"Focal aberrations indicate EYA2 and hsa-miR-375 as oncogene and tumor suppressor in cervical carcinogenesis","volume":"52","author":"Bierkens","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.jid.2021.10.009_bib11","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.ijrobp.2013.08.029","article-title":"Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck","volume":"88","author":"Blitzer","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jid.2021.10.009_bib12","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1080\/21645515.2016.1147634","article-title":"Morbidity and mortality of vulvar and vaginal cancers: impact of 2-, 4-, and 9-valent HPV vaccines","volume":"12","author":"Buchanan","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.jid.2021.10.009_bib13","first-page":"1269","article-title":"Vulvar cancer","volume":"66","author":"Canavan","year":"2002","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jid.2021.10.009_bib14","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.18632\/oncotarget.27234","article-title":"Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma","volume":"10","author":"Chamseddin","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2021.10.009_bib15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00428-018-2364-7","article-title":"PD-L1 receptor expression in vulvar carcinomas is HPV-independent","volume":"473","author":"Choschzick","year":"2018","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jid.2021.10.009_bib16","doi-asserted-by":"crossref","first-page":"102866","DOI":"10.1016\/j.critrevonc.2020.102866","article-title":"Precursor lesions of vulvar squamous cell carcinoma \u2013 histology and biomarkers: a systematic review","volume":"147","author":"Dasgupta","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.jid.2021.10.009_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/his.12034","article-title":"Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma","volume":"62","author":"Del Pino","year":"2013","journal-title":"Histopathology"},{"key":"10.1016\/j.jid.2021.10.009_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2021.10.009_bib19","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.2147\/CMAR.S290629","article-title":"Depletion of circular RNA circ_CORO1C suppresses gastric cancer development by modulating miR-138-5p\/KLF12 axis","volume":"13","author":"Fan","year":"2021","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.jid.2021.10.009_bib20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/LGT.0b013e3182472947","article-title":"Prevalence of human papillomavirus types in invasive vulvar cancers and vulvar intraepithelial neoplasia 3 in the United States before vaccine introduction","volume":"16","author":"Gargano","year":"2012","journal-title":"J\u00a0Low Genit Tract Dis"},{"key":"10.1016\/j.jid.2021.10.009_bib21","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2021.10.009_bib22","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s00432-020-03226-6","article-title":"Molecular pathways in vulvar squamous cell carcinoma: implications for target therapeutic strategies","volume":"146","author":"Giulia Mantovani","year":"2020","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/ijd.13697","article-title":"The possible role of human papillomavirus infection in the development of lichen sclerosus","volume":"57","author":"Hald","year":"2018","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jid.2021.10.009_bib24","doi-asserted-by":"crossref","first-page":"92890","DOI":"10.18632\/oncotarget.21641","article-title":"Tumoral PD-L1 expression defines a subgroup of poor-prognosis vulvar carcinomas with non-viral etiology","volume":"8","author":"Hecking","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2021.10.009_bib25","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1038\/s41598-021-83317-7","article-title":"Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial","volume":"11","author":"How","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2021.10.009_bib26","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2021.10.009_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2021.10.009_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.molcel.2017.02.017","article-title":"Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis","volume":"66","author":"Legnini","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.jid.2021.10.009_bib29","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2021.10.009_bib30","doi-asserted-by":"crossref","first-page":"66352","DOI":"10.18632\/oncotarget.18558","article-title":"Prognostic value of HPV DNA status in cervical cancer before treatment: a systematic review and meta-analysis","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2021.10.009_bib31","doi-asserted-by":"crossref","first-page":"83986","DOI":"10.18632\/oncotarget.20233","article-title":"Prognostic significance of PD-L1 expression and tumor infiltrating lymphocyte in surgically resectable non-small cell lung cancer","volume":"8","author":"Lin","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2021.10.009_bib32","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/sj.emboj.7600651","article-title":"HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs","volume":"24","author":"Longworth","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2021.10.009_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41544-019-0046-5","article-title":"Circular RNA: functions, applications and prospects","volume":"2","author":"Lu","year":"2020","journal-title":"ExRNA"},{"key":"10.1016\/j.jid.2021.10.009_bib34","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2021.10.009_bib36","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1200\/JCO.19.00739","article-title":"Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: results from the phase I\/II CheckMate 358 trial","volume":"37","author":"Naumann","year":"2019","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2016.07.007","article-title":"Risk factors and treatment for recurrent vulvar squamous cell carcinoma","volume":"106","author":"Nooij","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.jid.2021.10.009_bib38","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/jclinpath-2016-203676","article-title":"Stathmin is a highly sensitive and specific biomarker for vulvar high-grade squamous intraepithelial lesions","volume":"69","author":"Nooij","year":"2016","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jid.2021.10.009_bib39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ygyno.2020.06.482","article-title":"Genomic characterization of vulvar squamous cell carcinoma","volume":"158","author":"Prieske","year":"2020","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/PAP.0000000000000155","article-title":"Role of human papillomavirus in vulvar cancer","volume":"24","author":"Rakislova","year":"2017","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.jid.2021.10.009_bib41","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/ijc.31139","article-title":"Does HPV status influence survival after vulvar cancer?","volume":"142","author":"Rasmussen","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jid.2021.10.009_bib42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13000-017-0631-6","article-title":"Programmed death-ligand 1 (PD-L1) is expressed in a significant number of the uterine cervical carcinomas","volume":"12","author":"Reddy","year":"2017","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.jid.2021.10.009_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"Suppl. 2","key":"10.1016\/j.jid.2021.10.009_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ijgo.12609","article-title":"Cancer of the vulva","volume":"143","author":"Rogers","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.jid.2021.10.009_bib45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.oraloncology.2016.02.008","article-title":"RNA in-situ hybridization is a practical and effective method for determining HPV status of oropharyngeal squamous cell carcinoma including discordant cases that are p16 positive by immunohistochemistry but HPV negative by DNA in-situ hybridization","volume":"55","author":"Rooper","year":"2016","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib46","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.mex.2018.05.018","article-title":"Molecular detection of human papillomavirus (HPV) in highly fragmented DNA from cervical cancer biopsies using double-nested PCR","volume":"5","author":"Tawe","year":"2018","journal-title":"MethodsX"},{"key":"10.1016\/j.jid.2021.10.009_bib47","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41379-020-00651-3","article-title":"Molecular characterization of invasive and in situ squamous neoplasia of the vulva and implications for morphologic diagnosis and outcome","volume":"34","author":"Tessier-Cloutier","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jid.2021.10.009_bib48","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s00432-019-02915-1","article-title":"Clinical impact of PD-L1 and PD-1 expression in squamous cell cancer of the vulva","volume":"145","author":"Thangarajah","year":"2019","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib49","doi-asserted-by":"crossref","first-page":"86503","DOI":"10.18632\/oncotarget.21220","article-title":"FcGBP was upregulated by HPV infection and correlated to longer survival time of HNSCC patients","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2021.10.009_bib50","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1158\/1078-0432.CCR-16-3230","article-title":"Vulvar squamous cell carcinoma (VSCC) as two diseases: HPV status identifies distinct mutational profiles including oncogenic fibroblast growth factor receptor 3","volume":"23","author":"Weberpals","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jid.2021.10.009_bib51","doi-asserted-by":"crossref","first-page":"595.e1","DOI":"10.1016\/j.ajog.2020.12.1220","article-title":"p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie Chemo and Radiotherapy in Epithelial Vulvar Cancer study group","volume":"224","author":"Woelber","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jid.2021.10.009_bib52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/jnci\/djx166","article-title":"Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis [published correction appears in J Natl Cancer Inst 2018;110:1147]","volume":"110","author":"Yang","year":"2018","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jid.2021.10.009_bib53","first-page":"421","article-title":"[Circular RNA-UBXN7 promotes proliferation, migration and suppresses apoptosis in hepatocellular cancer]","volume":"28","author":"Yao","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"10.1016\/j.jid.2021.10.009_bib54","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/1878-0261.12045","article-title":"ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways [published correction appears in Mol Oncol 2019;13:2511]","volume":"11","author":"Yao","year":"2017","journal-title":"Mol Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib55","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1136\/ijgc-2019-000526","article-title":"Prognostic factors in patients with vulvar cancer: the VULCAN study [published correction appears in Int J Gynecol Cancer 2020;30:2023]","volume":"30","author":"Zapardiel","year":"2020","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.jid.2021.10.009_bib56","article-title":"Prevalence of human papillomavirus and its prognostic value in vulvar cancer: a systematic review and meta-analysis","volume":"13","author":"Zhang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2021.10.009_bib57","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1038\/s41467-019-10246-5","article-title":"Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.10.009_bib58","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1038\/ncomms11215","article-title":"Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.10.009_bib59","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fonc.2019.00398","article-title":"CircPCMTD1 acts as the sponge of miR-224-5p to promote glioma progression","volume":"9","author":"Zheng","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib60","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ygyno.2020.05.034","article-title":"Genes, pathways and vulvar carcinoma - new insights from next-generation sequencing studies","volume":"158","author":"Zi\u0119ba","year":"2020","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib61","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ygyno.2018.06.026","article-title":"Somatic mutation profiling of vulvar cancer: exploring therapeutic targets","volume":"150","author":"Zi\u0119ba","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jid.2021.10.009_bib62","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.3390\/ijms21144880","article-title":"Somatic mutation profiling in premalignant lesions of vulvar squamous cell carcinoma","volume":"21","author":"Zi\u0119ba","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21023812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21023812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:49:32Z","timestamp":1762206572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21023812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0022202X21023812"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.10.009","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human Papillomavirus\u2012Positive and \u2012Negative Vulvar Squamous Cell Carcinoma Are Biologically but Not Clinically Distinct","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}