{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:54:12Z","timestamp":1793757252895,"version":"4.6.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1181"],"award-info":[{"award-number":["CRC1181"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["A08"],"award-info":[{"award-number":["A08"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jid.2021.12.021","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:05:47Z","timestamp":1640822747000},"page":"2149-2158.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Transcriptomes of MPO-Deficient Patients with Generalized Pustular Psoriasis Reveals Expansion of CD4+ Cytotoxic T Cells and an Involvement of the Complement System"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-9074","authenticated-orcid":false,"given":"Stefan","family":"Haskamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-3351","authenticated-orcid":false,"given":"Benjamin","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-0185","authenticated-orcid":false,"given":"Ina","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-327X","authenticated-orcid":false,"given":"Anja","family":"Schulz-Kuhnt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2708-9688","authenticated-orcid":false,"given":"Imke","family":"Atreya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0229-8931","authenticated-orcid":false,"given":"Carola","family":"Berking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-2873","authenticated-orcid":false,"given":"David","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-7066","authenticated-orcid":false,"given":"Arif B.","family":"Ekici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-0319","authenticated-orcid":false,"given":"Johannes","family":"Berges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-7647","authenticated-orcid":false,"given":"Rotraut","family":"M\u00f6\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-7192","authenticated-orcid":false,"given":"Dagmar","family":"Wilsmann-Theis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-3938","authenticated-orcid":false,"given":"Michael","family":"Sticherling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-7637","authenticated-orcid":false,"given":"Steffen","family":"Uebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-2318","authenticated-orcid":false,"given":"Philipp","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-4671","authenticated-orcid":false,"given":"Ulrike","family":"H\u00fcffmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2021.12.021_bib1","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1136\/gutjnl-2016-311824","article-title":"Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn's disease: a randomised controlled trial","volume":"66","author":"Allez","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jid.2021.12.021_bib2","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.jid.2017.12.024","article-title":"Unopposed IL-36 activity promotes clonal CD4+ T-cell responses with IL-17A production in generalized pustular psoriasis","volume":"138","author":"Arakawa","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMc1811317","article-title":"Inhibition of the interleukin-36 pathway for the treatment of generalized pustular psoriasis","volume":"380","author":"Bachelez","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2021.12.021_bib5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2133.1968.tb11947.x","article-title":"Generalized pustular psoriasis. A clinical and epidemiological study of 104 cases","volume":"80","author":"Baker","year":"1968","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0005-2744(78)90197-3","article-title":"Characterization and quantification of the peroxidase in human monocytes","volume":"525","author":"Bos","year":"1978","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2021.12.021_bib7","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1038\/jid.2011.234","article-title":"Inter-regulation of Th17 cytokines and the IL-36 cytokines in\u00a0vitro and in\u00a0vivo: implications in psoriasis pathogenesis","volume":"131","author":"Carrier","year":"2011","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jid.2019.08.444","article-title":"IL-36 promotes systemic IFN-I responses in severe forms of psoriasis","volume":"140","author":"Catapano","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fimmu.2019.00353","article-title":"Effector functions of CD4+ T cells at the site of local autoimmune inflammation-lessons from rheumatoid arthritis","volume":"10","author":"Chemin","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib10","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.4049\/jimmunol.1301481","article-title":"IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin","volume":"192","author":"Foster","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib11","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.jid.2019.11.024","article-title":"Rare loss-of-function mutation in SERPINA3 in generalized pustular psoriasis","volume":"140","author":"Frey","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib12","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jid.2021.12.021_bib13","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ajhg.2020.07.001","article-title":"Myeloperoxidase modulates inflammation in generalized pustular psoriasis and additional rare pustular skin diseases","volume":"107","author":"Haskamp","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2021.12.021_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.exphem.2018.09.004","article-title":"The human cell atlas bone marrow single-cell interactive web portal","volume":"68","author":"Hay","year":"2018","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jid.2021.12.021_bib15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/jid.2012.456","article-title":"CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-\u03b3, IL-13, IL-17, and IL-22","volume":"133","author":"Hijnen","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib16","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/1346-8138.13306","article-title":"Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: a 52-week analysis from phase III open-label multicenter Japanese study","volume":"43","author":"Imafuku","year":"2016","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jaci.2016.08.056","article-title":"IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis","volume":"140","author":"Johnston","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib18","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ajhg.2012.03.012","article-title":"PSORS2 is due to mutations in CARD14","volume":"90","author":"Jordan","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2021.12.021_bib19","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nri3754","article-title":"Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?","volume":"14","author":"Kambayashi","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib20","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJMoa1013068","article-title":"Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis","volume":"365","author":"Marrakchi","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2021.12.021_bib21","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/bjd.15867","article-title":"The genetic basis for most patients with pustular skin disease remains elusive","volume":"178","author":"M\u00f6ssner","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib22","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1182\/blood-2012-09-456483","article-title":"Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function","volume":"121","author":"Odobasic","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jid.2021.12.021_bib23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ajhg.2011.07.022","article-title":"Mutations in IL36RN\/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis","volume":"89","author":"Onoufriadis","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2021.12.021_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1189\/JLB.0109046","article-title":"IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines","volume":"86","author":"Ortega","year":"2009","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2021.12.021_bib25","series-title":"R: a language and environment for statistical computing","year":"2013"},{"key":"10.1016\/j.jid.2021.12.021_bib26","doi-asserted-by":"crossref","first-page":"e14108","DOI":"10.1371\/journal.pone.0014108","article-title":"Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis","volume":"5","author":"Res","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.jid.2021.12.021_bib27","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1161\/CIRCULATIONAHA.105.588533","article-title":"Modulation of CD4(+)CD28null T lymphocytes by tumor necrosis factor-alpha blockade in patients with unstable angina","volume":"113","author":"Rizzello","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jid.2021.12.021_bib28","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/jdv.12773","article-title":"Efficacy and safety of open-label ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis","volume":"29","author":"Saeki","year":"2015","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2021.12.021_bib29","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.ajhg.2014.04.005","article-title":"AP1S3 mutations are associated with pustular psoriasis and impaired toll-like receptor 3 trafficking","volume":"94","author":"Setta-Kaffetzi","year":"2014","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2021.12.021_bib30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1172\/JCI111221","article-title":"Myeloperoxidase modulates the phagocytic activity of polymorphonuclear neutrophil leukocytes. Studies with cells from a myeloperoxidase-deficient patient","volume":"73","author":"Stendahl","year":"1984","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2021.12.021_bib31","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jid.2021.12.021_bib32","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/jid.2014.46","article-title":"CARD14 c.526G>C (p.Asp176His) is a significant risk factor for generalized pustular psoriasis with psoriasis vulgaris in the Japanese cohort","volume":"134","author":"Sugiura","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib33","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2133.1977.tb05194.x","article-title":"Demonstration of C3 cleavage product in leukotactic substances of scale extract from pustular psoriasis","volume":"96","author":"Tagami","year":"1977","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fimmu.2017.00194","article-title":"CD4 CTL, a cytotoxic subset of CD4+ T cells, their differentiation and function","volume":"8","author":"Takeuchi","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/art.41555","article-title":"Efficacy and safety of E6011, an anti-fractalkine monoclonal antibody, in patients with active rheumatoid arthritis with inadequate response to methotrexate: results of a randomized, double-blind, placebo-controlled phase II study","volume":"73","author":"Tanaka","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2021.12.021_bib36","doi-asserted-by":"crossref","first-page":"13677","DOI":"10.1074\/jbc.M400117200","article-title":"Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs","volume":"279","author":"Towne","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2021.12.021_bib37","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jaci.2018.06.038","article-title":"Clinical and genetic differences between pustular psoriasis subtypes","volume":"143","author":"Twelves","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ajhg.2020.06.020","article-title":"Loss-of-function myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease [published correction in Am J Hum Genet 2021;108:757]","volume":"107","author":"Vergnano","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2021.12.021_bib39","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1182\/blood-2011-05-356873","article-title":"IL-36R ligands are potent regulators of dendritic and T cells","volume":"118","author":"Vigne","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jid.2021.12.021_bib40","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/1346-8138.14318","article-title":"Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations","volume":"45","author":"Wilsmann-Theis","year":"2018","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib41","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/bjd.14702","article-title":"Efficacy and safety of Brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study","volume":"176","author":"Yamasaki","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib42","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2021.12.021_bib43","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1093\/intimm\/dxh320","article-title":"Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes","volume":"17","author":"Bade","year":"2005","journal-title":"Int Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib44","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jid.2019.08.444","article-title":"IL-36 promotes systemic IFN-I responses in severe forms of psoriasis","volume":"140","author":"Catapano","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/bs.mie.2019.03.003","article-title":"Analysis of the immune status from peripheral whole blood with a single-tube multicolor flow cytometry assay","volume":"632","author":"Donaubauer","year":"2020","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jid.2021.12.021_bib46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4939-8958-4_8","article-title":"One-tube multicolor flow cytometry assay (OTMA) for comprehensive immunophenotyping of peripheral blood","volume":"1904","author":"Donaubauer","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2021.12.021_bib47","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.jid.2019.11.024","article-title":"Rare loss-of-function mutation in SERPINA3 in generalized pustular psoriasis","volume":"140","author":"Frey","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2021.12.021_bib48","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jid.2021.12.021_bib49","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ajhg.2020.07.001","article-title":"Myeloperoxidase modulates inflammation in generalized pustular psoriasis and additional rare pustular skin diseases","volume":"107","author":"Haskamp","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2021.12.021_bib50","series-title":"R: A language and environment for statistical computing","year":"2013"},{"key":"10.1016\/j.jid.2021.12.021_bib51","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3390\/ijms17081316","article-title":"Development of a modular assay for detailed immunophenotyping of peripheral human whole blood samples by multicolor flow cytometry","volume":"17","author":"R\u00fchle","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2021.12.021_bib52","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3389\/fimmu.2020.00691","article-title":"ILC2 lung-homing in cystic fibrosis patients: functional involvement of CCR6 and impact on respiratory failure","volume":"11","author":"Schulz-Kuhnt","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2021.12.021_bib53","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jid.2021.12.021_bib54","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21026397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X21026397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:09:14Z","timestamp":1777417754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X21026397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0022202X21026397"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2021.12.021","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomes of MPO-Deficient Patients with Generalized Pustular Psoriasis Reveals Expansion of CD4+ Cytotoxic T Cells and an Involvement of the Complement System","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2021.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}