{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:43:04Z","timestamp":1784893384969,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["W1212"],"award-info":[{"award-number":["W1212"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P27129"],"award-info":[{"award-number":["P27129"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["I4300-B"],"award-info":[{"award-number":["I4300-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jid.2022.02.014","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T16:27:55Z","timestamp":1647275275000},"page":"2446-2454.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["BMPR1a Is Required for the Optimal TGF\u03b21-Dependent CD207+ Langerhans Cell Differentiation and Limits Skin Inflammation through CD11c+ Cells"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-4393","authenticated-orcid":false,"given":"Mathias","family":"Hochgerner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-7140","authenticated-orcid":false,"given":"Thomas","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-8045","authenticated-orcid":false,"given":"Victoria","family":"Zyulina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-4076","authenticated-orcid":false,"given":"Elisabeth","family":"Glitzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-3996","authenticated-orcid":false,"given":"Sarah","family":"Warsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6525-5499","authenticated-orcid":false,"given":"Joanne E.","family":"Konkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3123-6342","authenticated-orcid":false,"given":"Carmen","family":"Tam-Amersdorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-2114","authenticated-orcid":false,"given":"Wanjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2353-2531","authenticated-orcid":false,"given":"Stefan","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6129-5613","authenticated-orcid":false,"given":"Maria","family":"Sibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-4977","authenticated-orcid":false,"given":"Herbert","family":"Strobl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.02.014_bib1","first-page":"1237","article-title":"Ex-vivo skin explant culture is a model for TSLP-mediated skin barrier immunity","volume":"11","author":"Bauer","year":"2021","journal-title":"Life (Basel)"},{"key":"10.1016\/j.jid.2022.02.014_bib2","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.20120493","article-title":"Identification of Axl as a downstream effector of TGF-\u03b21 during Langerhans cell differentiation and epidermal homeostasis","volume":"209","author":"Bauer","year":"2012","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.02.014_bib3","doi-asserted-by":"crossref","first-page":"10492","DOI":"10.1073\/pnas.1119178109","article-title":"Autocrine\/paracrine TGF-\u03b21 inhibits Langerhans cell migration","volume":"109","author":"Bobr","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.02.014_bib4","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.4049\/jimmunol.1001802","article-title":"Acute ablation of Langerhans cells enhances skin immune responses","volume":"185","author":"Bobr","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib5","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jaci.2019.12.011","article-title":"BMP7 aberrantly induced in the psoriatic epidermis instructs inflammation-associated Langerhans cells","volume":"145","author":"Borek","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib6","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1084\/jem.184.6.2417","article-title":"A\u00a0role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells","volume":"184","author":"Borkowski","year":"1996","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.02.014_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1172\/JCI119567","article-title":"A\u00a0role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice","volume":"100","author":"Borkowski","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.02.014_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.immuni.2015.06.017","article-title":"Distinct murine mucosal langerhans cell subsets develop from pre-dendritic cells and monocytes","volume":"43","author":"Capucha","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2022.02.014_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0923-1811(03)00107-5","article-title":"Downregulation of TGFbeta isoforms and their receptors contributes to keratinocyte hyperproliferation in psoriasis vulgaris","volume":"33","author":"Doi","year":"2003","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.02.014_bib10","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1084\/jem.187.6.961","article-title":"Transforming growth factor beta1, in the presence of granulocyte\/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells","volume":"187","author":"Geissmann","year":"1998","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.02.014_bib11","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.15252\/emmm.201404114","article-title":"Specific roles for dendritic cell subsets during initiation and progression of psoriasis","volume":"6","author":"Glitzner","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jid.2022.02.014_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.semcdb.2014.02.009","article-title":"The clash of Langerhans cell homeostasis in skin: should I stay or should I go?","volume":"41","author":"Hieronymus","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jid.2022.02.014_bib13","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.it.2018.08.007","article-title":"Mucosal and skin Langerhans cells - nurture calls","volume":"39","author":"Hovav","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib14","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.4049\/jimmunol.163.3.1409","article-title":"A\u00a0CD1a+\/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells","volume":"163","author":"Ito","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib15","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jid.2017.06.005","article-title":"TGF\u03b2\/SMAD\/microRNA-486-3p signaling axis mediates keratin 17 expression and keratinocyte hyperproliferation in psoriasis","volume":"137","author":"Jiang","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.02.014_bib16","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1084\/jem.20071401","article-title":"Autocrine\/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells","volume":"204","author":"Kaplan","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.02.014_bib17","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.4049\/jimmunol.1000981","article-title":"TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis","volume":"185","author":"Kel","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-020-2134-y","article-title":"A\u00a0conserved dendritic-cell regulatory program limits antitumour immunity [published correction appears in Nature 2020;582:E17]","volume":"580","author":"Maier","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jid.2022.02.014_bib19","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1182\/blood-2014-04-568311","article-title":"Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-\u03b2","volume":"124","author":"Mart\u00ednez-Cingolani","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.02.014_bib20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1182\/blood-2014-08-593582","article-title":"CD1c+ blood dendritic cells have Langerhans cell potential","volume":"125","author":"Milne","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.02.014_bib21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/bbrc.1995.1043","article-title":"Genomic organization and chromosomal location of the mouse type I BMP-2\/4 receptor","volume":"206","author":"Mishina","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2022.02.014_bib22","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/ni.3396","article-title":"Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-\u03b2","volume":"17","author":"Mohammed","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib23","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3390\/cells8121579","article-title":"Specification of BMP signaling","volume":"8","author":"Nickel","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jid.2022.02.014_bib24","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/BF02518889","article-title":"Reconstructed human epidermis composed of keratinocytes, melanocytes and Langerhans cells","volume":"36","author":"R\u00e9gnier","year":"1998","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.jid.2022.02.014_bib25","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2010.04.015","article-title":"Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming","volume":"7","author":"Samavarchi-Tehrani","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jid.2022.02.014_bib26","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.jaci.2020.09.038","article-title":"Bone morphogenetic protein signaling regulates skin inflammation via modulating dendritic cell function","volume":"147","author":"Sconocchia","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib27","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.157.4.1499","article-title":"TGF-beta 1 promotes in\u00a0vitro development of dendritic cells from CD34+ hemopoietic progenitors","volume":"157","author":"Strobl","year":"1996","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.02.014_bib28","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1084\/jem.20170729","article-title":"Cbf\u03b22 deficiency preserves Langerhans cell precursors by lack of selective TGF\u03b2 receptor signaling","volume":"214","author":"Tenno","year":"2017","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.02.014_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0923-1811(95)00438-6","article-title":"Differential localization of TGF-beta-precursor isotypes in psoriatic human skin","volume":"11","author":"Wataya-Kaneda","year":"1996","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.02.014_bib30","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1084\/jem.20130275","article-title":"Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation","volume":"210","author":"Yasmin","year":"2013","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.02.014_bib31","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.jid.2020.10.028","article-title":"ALK3 is not required for the embryonic development, homeostasis, and repopulation of epidermal Langerhans cells in steady and inflammatory states","volume":"141","author":"Yu","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.02.014_bib32","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1242\/dev.01079","article-title":"BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice","volume":"131","author":"Yuhki","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.jid.2022.02.014_bib33","doi-asserted-by":"crossref","first-page":"8094","DOI":"10.1074\/jbc.M413102200","article-title":"Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney","volume":"280","author":"Zeisberg","year":"2005","journal-title":"J\u00a0Biol Chem"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22001956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22001956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:08:56Z","timestamp":1777417736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22001956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0022202X22001956"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.02.014","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BMPR1a Is Required for the Optimal TGF\u03b21-Dependent CD207+ Langerhans Cell Differentiation and Limits Skin Inflammation through CD11c+ Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}