{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:58:08Z","timestamp":1793051888399,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T00:00:00Z","timestamp":1648944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014461","name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust\/Institute of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jid.2022.03.013","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:05:36Z","timestamp":1649192736000},"page":"2660-2667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"title":["T Helper 2 IL-4\/IL-13 Dual Blockade with Dupilumab Is Linked to Some Emergent T Helper 17\u2012Type Diseases, Including Seronegative Arthritis and Enthesitis\/Enthesopathy, but Not to Humoral Autoimmune Diseases"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-4633","authenticated-orcid":false,"given":"Charlie","family":"Bridgewood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-4926","authenticated-orcid":false,"given":"Miriam","family":"Wittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7903-2990","authenticated-orcid":false,"given":"Tom","family":"Macleod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-8027","authenticated-orcid":false,"given":"Abdulla","family":"Watad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-1486","authenticated-orcid":false,"given":"Darren","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-9886","authenticated-orcid":false,"given":"Kanchan","family":"Bhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5406-7716","authenticated-orcid":false,"given":"Howard","family":"Amital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2390-6505","authenticated-orcid":false,"given":"Giovanni","family":"Damiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-3550","authenticated-orcid":false,"given":"Sami","family":"Giryes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-868X","authenticated-orcid":false,"given":"Nicola Luigi","family":"Bragazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-8226","authenticated-orcid":false,"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.03.013_bib1","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.3390\/cells10102547","article-title":"miR-21-3p\/IL-22 axes are major drivers of psoriasis pathogenesis by modulating keratinocytes proliferation-survival balance and inflammatory response","volume":"10","author":"Abdallah","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jid.2022.03.013_bib2","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jid.2022.03.013_bib3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.abd.2020.07.001","article-title":"Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity","volume":"95","author":"Alatas","year":"2020","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.jid.2022.03.013_bib4","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/jdv.16246","article-title":"Phenotypic switch to eczema in patients receiving biologics for plaque psoriasis: a systematic review","volume":"34","author":"Al-Janabi","year":"2020","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.03.013_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.23736\/S1120-4826.19.02556-4","article-title":"Dupilumab to target interleukin 4 for inflammatory bowel disease? Hypothesis based on a translational message","volume":"31","author":"Armandi","year":"2019","journal-title":"Minerva Biotecnol"},{"key":"10.1016\/j.jid.2022.03.013_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jid.2022.03.013_bib7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jdcr.2020.11.012","article-title":"A\u00a0case report of uveitis secondary to dupilumab treatment for atopic dermatitis","volume":"7","author":"Ayasse","year":"2021","journal-title":"JAAD Case Rep"},{"key":"10.1016\/j.jid.2022.03.013_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/jama.2015.19330","article-title":"Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial","volume":"315","author":"Bachert","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jid.2022.03.013_bib9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3390\/cells9020462","article-title":"The role of gamma delta T cells in autoimmune rheumatic diseases","volume":"9","author":"Bank","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jid.2022.03.013_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2165\/00002018-200730070-00011","article-title":"Bayesian confidence propagation neural network","volume":"30","author":"Bate","year":"2007","journal-title":"Drug Saf"},{"key":"10.1016\/j.jid.2022.03.013_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1165\/ajrcmb.16.2.9032124","article-title":"Th1\/Th2 cell distribution in pulmonary sarcoidosis","volume":"16","author":"B\u00e4umer","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jid.2022.03.013_bib12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1161\/01.CIR.0000112569.27151.F7","article-title":"Role of aortic root motion in the pathogenesis of aortic dissection","volume":"109","author":"Beller","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jid.2022.03.013_bib13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/ijms19020530","article-title":"Role of the IL-23\/IL-17 axis in psoriasis and psoriatic arthritis: the clinical importance of its divergence in skin and joints","volume":"19","author":"Boutet","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2022.03.013_bib14","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1136\/ard.2010.143123","article-title":"Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris","volume":"70","author":"Bowes","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2022.03.013_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101520","article-title":"Unexpected connections of the IL-23\/IL-17 and IL-4\/IL-13 cytokine axes in inflammatory arthritis and enthesitis","author":"Bridgewood","year":"2021","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jid.2022.03.013_bib16","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1093\/rheumatology\/keaa568","article-title":"Regulation of entheseal IL-23 expression by IL-4 and IL-13 as an explanation for arthropathy development under dupilumab therapy","volume":"60","author":"Bridgewood","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jid.2022.03.013_bib17","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/BOR.0000000000000529","article-title":"Spondyloarthritis: new insights into clinical aspects, translational immunology and therapeutics","volume":"30","author":"Bridgewood","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jid.2022.03.013_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00002018-199920020-00002","article-title":"The medical dictionary for regulatory activities (MedDRA)","volume":"20","author":"Brown","year":"1999","journal-title":"Drug Saf"},{"key":"10.1016\/j.jid.2022.03.013_bib19","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2022.03.013_bib20","doi-asserted-by":"crossref","first-page":"D296","DOI":"10.1093\/nar\/gkx1067","article-title":"miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions","volume":"46","author":"Chou","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.03.013_bib21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/1529-0131(199904)42:4<742::AID-ANR18>3.0.CO;2-I","article-title":"Cytokine profiles in Wegener's granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation","volume":"42","author":"Csernok","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2022.03.013_bib22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1084\/jem.181.2.537","article-title":"Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production","volume":"181","author":"D'Andrea","year":"1995","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.03.013_bib23","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1093\/rheumatology\/keab771","article-title":"Dupilumab-induced enthesoarthritis and refractory atopic dermatitis successfully treated with baricitinib","volume":"61","author":"De Stefano","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jid.2022.03.013_bib24","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1136\/ard.2010.147421","article-title":"IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients","volume":"70","author":"Eder","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2022.03.013_bib25","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1053\/j.gastro.2008.08.055","article-title":"IL-13 signaling via IL-13R\u03b12 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis","volume":"135","author":"Fichtner\u2013Feigl","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jid.2022.03.013_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/1744666X.2017.1298443","article-title":"Commonality of the IL-4\/IL-13 pathway in atopic diseases","volume":"13","author":"Gandhi","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jid.2022.03.013_bib27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nm804","article-title":"Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease","volume":"9","author":"Ghoreschi","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.03.013_bib28","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1073\/pnas.1416922112","article-title":"IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells","volume":"112","author":"Guenova","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.03.013_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1074-7613(02)00453-3","article-title":"Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells","volume":"17","author":"Heller","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2022.03.013_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s40264-014-0150-2","article-title":"The Weber effect and the United States Food and Drug Administration\u2019s Adverse Event Reporting System (FAERS): analysis of sixty-two drugs approved from 2006 to 2010","volume":"37","author":"Hoffman","year":"2014","journal-title":"Drug Saf"},{"key":"10.1016\/j.jid.2022.03.013_bib31","doi-asserted-by":"crossref","first-page":"457835","DOI":"10.1155\/2015\/457835","article-title":"MoI. Expression of microRNAs in the eyes of Lewis rats with experimental autoimmune anterior uveitis","volume":"2015","author":"Hsu","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jid.2022.03.013_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3892\/mmr.2020.11689","article-title":"MicroRNA-21-5p protects melanocytes via targeting STAT3 and modulating Treg\/Teff balance to alleviate vitiligo","volume":"23","author":"Huo","year":"2021","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jid.2022.03.013_bib33","article-title":"Eosinophilic gastritis in a patient previously treated with dupilumab","volume":"2020","author":"Iwamuro","year":"2020","journal-title":"Case Rep Gastrointest Med"},{"key":"10.1016\/j.jid.2022.03.013_bib34","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1111\/jdv.17050","article-title":"De novo psoriasis in atopic dermatitis patients treated with dupilumab: a retrospective cohort","volume":"35","author":"Jaulent","year":"2021","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.03.013_bib35","article-title":"Reactome: a knowledgebase of biological pathways","volume":"33","author":"Joshi-Tope","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.jid.2022.03.013_bib36","doi-asserted-by":"crossref","first-page":"D142","DOI":"10.1093\/nar\/gkz1022","article-title":"miRPathDB 2.0: a novel release of the miRNA pathway dictionary","volume":"48","author":"Kehl","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.03.013_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/sj.gene.6363779","article-title":"Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases","volume":"2","author":"Klein","year":"2001","journal-title":"Genes Immun"},{"key":"10.1016\/j.jid.2022.03.013_bib38","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.hjc.2020.01.002","article-title":"Mir-335-5p as a potential regulator of LRP1 expression in abdominal aortic aneurysm","volume":"61","author":"Legaki","year":"2020","journal-title":"Hellenic J Cardiol"},{"key":"10.1016\/j.jid.2022.03.013_bib39","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/009286150804200501","article-title":"VigiBase, the WHO global ICSR database system: basic facts","volume":"42","author":"Lindquist","year":"2008","journal-title":"Drug Inf J"},{"key":"10.1016\/j.jid.2022.03.013_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3892\/etm.2020.9541","article-title":"miR-335-5P contributes to human osteoarthritis by targeting HBP1","volume":"21","author":"Lu","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jid.2022.03.013_bib41","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1172\/JCI7739","article-title":"IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion","volume":"105","author":"Lubberts","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.03.013_bib42","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s40123-019-0191-9","article-title":"Ocular surface diseases induced by dupilumab in severe atopic dermatitis","volume":"8","author":"Maudinet","year":"2019","journal-title":"Ophthalmol Ther"},{"key":"10.1016\/j.jid.2022.03.013_bib43","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","article-title":"A\u00a0proposed classification of the immunological diseases","volume":"3","author":"McGonagle","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.jid.2022.03.013_bib44","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2147\/TCRM.S207402","article-title":"A\u00a0case of chronic eosinophilic pneumonia in a patient treated with dupilumab","volume":"15","author":"Menzella","year":"2019","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.jid.2022.03.013_bib45","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ni.1899","article-title":"Effector T cell plasticity: flexibility in the face of changing circumstances","volume":"11","author":"Murphy","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2022.03.013_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-immunol-051116-052350","article-title":"Th2 cells in health and disease","volume":"35","author":"Nakayama","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2022.03.013_bib47","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/bjd.19459","article-title":"Increased expression of IL-23A in lesional skin of atopic dermatitis patients with psoriasiform reaction during dupilumab treatment","volume":"184","author":"Napolitano","year":"2021","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.03.013_bib48","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4049\/jimmunol.1102216","article-title":"IL-13 regulates Th17 secretion of IL-17A in an IL-10\u2013dependent manner","volume":"188","author":"Newcomb","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.03.013_bib49","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.0803868","article-title":"A\u00a0functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production","volume":"182","author":"Newcomb","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.03.013_bib50","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/icb.2013.21","article-title":"Pathogenesis of allergen-induced eosinophilic esophagitis is independent of interleukin (IL)-13","volume":"91","author":"Niranjan","year":"2013","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jid.2022.03.013_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002510050001","article-title":"Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease","volume":"51","author":"Olavesen","year":"2000","journal-title":"Immunogenetics"},{"key":"10.1016\/j.jid.2022.03.013_bib52","first-page":"S131","article-title":"Aortic involvement in ankylosing spondylitis","volume":"26","author":"Palazzi","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jid.2022.03.013_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bav028","article-title":"DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes","volume":"2015","author":"Pi\u00f1ero","year":"2015","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.jid.2022.03.013_bib54","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.jid.2021.02.007","article-title":"Dupilumab: an opportunity to unravel in\u00a0vivo actions of IL-4 and IL-13 in humans","volume":"141","author":"Roesner","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.03.013_bib55","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nrrheum.2017.188","article-title":"Enthesitis: from pathophysiology to treatment","volume":"13","author":"Schett","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2022.03.013_bib56","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9440(10)64206-X","article-title":"T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm","volume":"161","author":"Sch\u00f6nbeck","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2022.03.013_bib57","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/17512433.2018.1449642","article-title":"Dupilumab for treatment of atopic dermatitis","volume":"11","author":"Seegr\u00e4ber","year":"2018","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.jid.2022.03.013_bib58","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3389\/fimmu.2014.00628","article-title":"Identification of the IgG1 induction factor (interleukin 4)","volume":"5","author":"Severinson","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.03.013_bib59","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00280-014-2433-9","article-title":"DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development","volume":"73","author":"Shah","year":"2014","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jid.2022.03.013_bib60","doi-asserted-by":"crossref","first-page":"105698","DOI":"10.1016\/j.intimp.2019.105698","article-title":"Adenovirus-mediated down-regulation of miR-21-5p alleviates experimental autoimmune uveoretinitis in mice","volume":"74","author":"Shi","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jid.2022.03.013_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/psp4.12765","article-title":"Advancing drug safety science by integrating molecular knowledge with post-marketing adverse event reports","author":"Soldatos","year":"2022","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10.1016\/j.jid.2022.03.013_bib62","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.micinf.2005.09.006","article-title":"Induction of chronic colitis in IL-10 deficient mice requires IL-4","volume":"8","author":"Specht","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jid.2022.03.013_bib63","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/sj.gene.6363782","article-title":"Dextran sulphate sodium-induced colitis is ameliorated in interleukin 4 deficient mice","volume":"2","author":"Stevceva","year":"2001","journal-title":"Genes Immun"},{"key":"10.1016\/j.jid.2022.03.013_bib64","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.03.013_bib65","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/gutjnl-2015-309464","article-title":"Failure of interleukin 13 blockade in ulcerative colitis","volume":"64","author":"Tilg","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jid.2022.03.013_bib66","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12891-015-0652-9","article-title":"Signature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis","volume":"16","author":"Tornero-Esteban","year":"2015","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.jid.2022.03.013_bib67","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/bjd.18031","article-title":"Development of inflammatory arthritis and enthesitis in patients on dupilumab: a case series","volume":"181","author":"Willsmore","year":"2019","journal-title":"Br J Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22002561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22002561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:27:34Z","timestamp":1758302854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22002561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0022202X22002561"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.03.013","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T Helper 2 IL-4\/IL-13 Dual Blockade with Dupilumab Is Linked to Some Emergent T Helper 17\u2012Type Diseases, Including Seronegative Arthritis and Enthesitis\/Enthesopathy, but Not to Humoral Autoimmune Diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}