{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:21:13Z","timestamp":1790108473829,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["WF220408211"],"award-info":[{"award-number":["WF220408211"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2017MS18"],"award-info":[{"award-number":["YG2017MS18"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018635","name":"Thousand Young Talents Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jid.2022.04.026","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T20:32:39Z","timestamp":1653337959000},"page":"3052-3061.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prophylactic Effect of Nitric Oxide Donors on Rat Models of EGFR Inhibitor\u2012Induced Cutaneous Toxicities"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-8542","authenticated-orcid":false,"given":"Xinran","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-4177","authenticated-orcid":false,"given":"Leying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-0060","authenticated-orcid":false,"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-1557","authenticated-orcid":false,"given":"Zhaoyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-4015","authenticated-orcid":false,"given":"Dazhao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8943-9287","authenticated-orcid":false,"given":"Yurui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-4778","authenticated-orcid":false,"given":"Jie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-5992","authenticated-orcid":false,"given":"Shiyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.04.026_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1089\/ars.2011.4455","article-title":"S-nitrosoglutathione and endothelial nitric oxide synthase-derived nitric oxide regulate compartmentalized ras S-nitrosylation and stimulate cell proliferation","volume":"18","author":"Batista","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jid.2022.04.026_bib2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fonc.2018.00272","article-title":"Computational structural biology of S-nitrosylation of cancer targets","volume":"8","author":"Bignon","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib3","first-page":"3943","article-title":"EGFR inhibitor-induced skin reactions: differentiating acneiform rash from superimposed bacterial infections","volume":"24","author":"Braden","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jid.2022.04.026_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1534\/genetics.111.127910","article-title":"Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF\/Rho-family\/JNK pathway is a central driver of tumorigenesis","volume":"188","author":"Brumby","year":"2011","journal-title":"Genetics"},{"issue":"Suppl 1","key":"10.1016\/j.jid.2022.04.026_bib5","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.6004\/jnccn.2009.0074","article-title":"NCCN Task Force Report: management of dermatologic and other toxicities associated with EGFR inhibition in patients with cancer","volume":"7","author":"Burtness","year":"2009","journal-title":"J\u00a0Natl Compr Canc Netw"},{"key":"10.1016\/j.jid.2022.04.026_bib6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1046\/j.1365-2133.2001.04226.x","article-title":"Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225","volume":"144","author":"Busam","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.04.026_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1158\/0008-5472.CAN-11-1982","article-title":"JNK-induced apoptosis, compensatory growth, and cancer stem cells","volume":"72","author":"Chen","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2022.04.026_bib8","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1021\/bi992954b","article-title":"Recruitment and activation of Raf-1 kinase by nitric oxide-activated Ras","volume":"39","author":"Deora","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.jid.2022.04.026_bib54","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.04.026_bib9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ejca.2006.11.016","article-title":"Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors","volume":"43","author":"Galimont-Collen","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jid.2022.04.026_bib10","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0151-9638(06)71093-6","article-title":"Clinical appearance and management of cutaneous side effects of EGF receptor inhibitors","volume":"133","author":"Guillot","year":"2006","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.04.026_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00105-005-1033-3","article-title":"Cutaneous side effects of EGF-receptor inhibition and their management","volume":"57","author":"Gutzmer","year":"2006","journal-title":"Hautarzt"},{"key":"10.1016\/j.jid.2022.04.026_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejmech.2013.05.026","article-title":"Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors","volume":"66","author":"Han","year":"2013","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.jid.2022.04.026_bib13","article-title":"Mechanisms underlying skin disorders induced by EGFR inhibitors","volume":"2","author":"Holcmann","year":"2015","journal-title":"Mol Cell Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib14","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.04.026_bib15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/cncr.23621","article-title":"Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB)","volume":"113","author":"Jatoi","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.jid.2022.04.026_bib16","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s12035-016-9763-z","article-title":"RAS promotes proliferation and resistances to apoptosis in meningioma","volume":"54","author":"Jiang","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jid.2022.04.026_bib17","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1002\/cncr.25090","article-title":"Effects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life","volume":"116","author":"Joshi","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.jid.2022.04.026_bib18","first-page":"505","article-title":"The EGF receptor \u2013 an essential regulator of multiple epidermal functions","volume":"10","author":"Jost","year":"2000","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.jid.2022.04.026_bib19","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1128\/MCB.23.16.5726-5737.2003","article-title":"Activation of the phosphatidylinositol 3-kinase\/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis","volume":"23","author":"Kawasaki","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jid.2022.04.026_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax2693","article-title":"Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy","volume":"11","author":"Klufa","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2022.04.026_bib21","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc1970","article-title":"Mechanisms of cutaneous toxicities to EGFR inhibitors","volume":"6","author":"Lacouture","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jid.2022.04.026_bib22","first-page":"1079","article-title":"Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities","volume":"19","author":"Lacouture","year":"2011","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jid.2022.04.026_bib23","first-page":"236","article-title":"The SERIES clinic: an interdisciplinary approach to the management of toxicities of EGFR inhibitors","volume":"4","author":"Lacouture","year":"2006","journal-title":"J\u00a0Support Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib24","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1200\/JCO.2008.21.7828","article-title":"Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer","volume":"28","author":"Lacouture","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib25","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1158\/1541-7786.MCR-08-0113","article-title":"Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation","volume":"6","author":"Lee","year":"2008","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jid.2022.04.026_bib26","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1200\/JCO.2012.45.3753","article-title":"Genotyping and genomic profiling of non\u2013small-cell lung cancer: implications for current and future therapies","volume":"31","author":"Li","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005886","article-title":"Epidermal EGFR controls cutaneous host defense and prevents inflammation","volume":"5","author":"Lichtenberger","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2022.04.026_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2018.02.006","article-title":"Acquired resistance to EGFR targeted therapy in non-small cell lung cancer: mechanisms and therapeutic strategies","volume":"65","author":"Lim","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jid.2022.04.026_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ccr.2005.05.007","article-title":"Nuclear interaction of EGFR and STAT3 in the activation of the iNOS\/NO pathway","volume":"7","author":"Lo","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jid.2022.04.026_bib30","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1634\/theoncologist.12-5-610","article-title":"Epidermal growth factor receptor inhibitor\u2013associated cutaneous toxicities: an evolving paradigm in clinical management","volume":"12","author":"Lynch","year":"2007","journal-title":"Oncologist"},{"key":"10.1016\/j.jid.2022.04.026_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005773","article-title":"Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy","volume":"5","author":"Mascia","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2022.04.026_bib32","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.3747\/co.v18i2.605","article-title":"Rash rates with EGFR inhibitors: meta-analysis","volume":"18","author":"Mittmann","year":"2011","journal-title":"Curr Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib33","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/ki.2013.214","article-title":"Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression","volume":"84","author":"Miyazawa","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.jid.2022.04.026_bib34","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1089\/ars.2007.1853","article-title":"Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling","volume":"10","author":"Monteiro","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jid.2022.04.026_bib35","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4103\/2319-4170.158624","article-title":"Nitric oxide: protein tyrosine phosphorylation and protein S-nitrosylation in cancer","volume":"38","author":"Monteiro","year":"2015","journal-title":"Biomed J"},{"key":"10.1016\/j.jid.2022.04.026_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/17246008070221s407","article-title":"Clinical management of cutaneous toxicity of anti-EGFR agents","volume":"22","author":"Monti","year":"2007","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.jid.2022.04.026_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.abb.2014.06.011","article-title":"Endothelium-derived nitric oxide (NO) activates the NO-epidermal growth factor receptor-mediated signaling pathway in bradykinin-stimulated angiogenesis","volume":"558","author":"Moraes","year":"2014","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jid.2022.04.026_bib38","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/15384047.2016.1139249","article-title":"Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells","volume":"17","author":"Munoz","year":"2016","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.jid.2022.04.026_bib39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0891-5849(03)00311-3","article-title":"Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells","volume":"35","author":"Oliveira","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jid.2022.04.026_bib40","doi-asserted-by":"crossref","first-page":"24076","DOI":"10.1074\/jbc.M116.752071","article-title":"Formation of nitric oxide by aldehyde dehydrogenase-2 is necessary and sufficient for vascular bioactivation of nitroglycerin","volume":"291","author":"Opelt","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.04.026_bib41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1634\/theoncologist.10-5-345","article-title":"HER1\/EGFR inhibitor-associated rash: future directions for management and investigation outcomes from the HER1\/EGFR inhibitor rash management forum","volume":"10","author":"P\u00e9rez-Soler","year":"2005","journal-title":"Oncologist"},{"key":"10.1016\/j.jid.2022.04.026_bib42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1470-2045(05)70243-6","article-title":"Cutaneous side-effects of kinase inhibitors and blocking antibodies","volume":"6","author":"Robert","year":"2005","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s40257-013-0021-0","article-title":"Impact of dermatologic adverse events on quality of life in 283 cancer patients: a questionnaire study in a dermatology referral clinic","volume":"14","author":"Rosen","year":"2013","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jid.2022.04.026_bib44","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1074\/jbc.274.11.6823","article-title":"Nitric oxide inhibits caspase-3 by S-Nitrosationin\u00a0vivo","volume":"274","author":"R\u00f6ssig","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.04.026_bib45","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1200\/JCO.2007.12.6987","article-title":"Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption","volume":"25","author":"Scope","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib46","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1610-0387.2005.05058.x","article-title":"The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies","volume":"3","author":"Segaert","year":"2005","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.jid.2022.04.026_bib47","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/annonc\/mdi279","article-title":"Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors","volume":"16","author":"Segaert","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jid.2022.04.026_bib48","first-page":"22","article-title":"Clinical management of EGFRI dermatologic toxicities: the European perspective","volume":"21","author":"Segaert","year":"2007","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.jid.2022.04.026_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/457637","article-title":"Involvement of cell proliferation induced by dual intracellular signaling of HB-EGF in the development of colitis-associated cancer during ulcerative colitis","volume":"2011","author":"Tanida","year":"2011","journal-title":"Ulcers"},{"key":"10.1016\/j.jid.2022.04.026_bib50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3390\/cancers10080248","article-title":"Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells","volume":"10","author":"Testa","year":"2018","journal-title":"Cancers"},{"key":"10.1016\/j.jid.2022.04.026_bib51","doi-asserted-by":"crossref","first-page":"31860","DOI":"10.1074\/jbc.273.48.31860","article-title":"Peroxynitrite induces covalent dimerization of epidermal growth factor receptors in A431 epidermoid carcinoma cells","volume":"273","author":"Van Der Vliet","year":"1998","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.04.026_bib52","first-page":"34","article-title":"Dermatologic toxicities associated with EGFR inhibitors: the clinical psychologist's perspective. Impact on health-related quality of life and implications for clinical management of psychological sequelae","volume":"21","author":"Wagner","year":"2007","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.jid.2022.04.026_bib53","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1038\/onc.2016.517","article-title":"Ras\u2013Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function","volume":"36","author":"Zahavi","year":"2017","journal-title":"Oncogene"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22003992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22003992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:49:45Z","timestamp":1762206585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22003992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0022202X22003992"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.04.026","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic Effect of Nitric Oxide Donors on Rat Models of EGFR Inhibitor\u2012Induced Cutaneous Toxicities","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}