{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:58:38Z","timestamp":1791644318075,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005345","name":"American Association for Dental, Oral, and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL006193-07"],"award-info":[{"award-number":["HL006193-07"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jid.2022.05.1085","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T11:06:21Z","timestamp":1655809581000},"page":"2909-2919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of S100A8\/A9 with Lipid-Rich Necrotic Core and Treatment with Biologic Therapy in Patients with Psoriasis: Results from an Observational Cohort Study"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-0181","authenticated-orcid":false,"given":"Alexander R.","family":"Berg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-0746","authenticated-orcid":false,"given":"Christin G.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-1663","authenticated-orcid":false,"given":"Maryia","family":"Svirydava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-1346","authenticated-orcid":false,"given":"Haiou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-3316","authenticated-orcid":false,"given":"Philip M.","family":"Parel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9128-6160","authenticated-orcid":false,"given":"Elizabeth","family":"Florida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-756X","authenticated-orcid":false,"given":"Ross","family":"O\u2019Hagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-3752","authenticated-orcid":false,"given":"Carla J.","family":"Pantoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-833X","authenticated-orcid":false,"given":"Sundus S.","family":"Lateef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-7889","authenticated-orcid":false,"given":"Paula","family":"Anzenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-4806","authenticated-orcid":false,"given":"Charlotte L.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4404-7727","authenticated-orcid":false,"given":"Grace","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-5004","authenticated-orcid":false,"given":"Wunan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-4888","authenticated-orcid":false,"given":"Alexander V.","family":"Sorokin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-9369","authenticated-orcid":false,"given":"Marcus Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-4252","authenticated-orcid":false,"given":"Heather L.","family":"Teague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-4835","authenticated-orcid":false,"given":"Andrew J.","family":"Buckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-7266","authenticated-orcid":false,"given":"Martin P.","family":"Playford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-2661","authenticated-orcid":false,"given":"Joel M.","family":"Gelfand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-5130","authenticated-orcid":false,"given":"Nehal N.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.05.1085_bib1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.tcm.2019.11.001","article-title":"Chronic inflammation, cardiometabolic diseases and effects of treatment: psoriasis as a human model","volume":"30","author":"Aksentijevich","year":"2020","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jid.2022.05.1085_bib2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41584-018-0058-9","article-title":"S100 proteins in rheumatic diseases","volume":"14","author":"Austermann","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2022.05.1085_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/ATVBAHA.111.236927","article-title":"S100A8 and S100A9 in cardiovascular biology and disease","volume":"32","author":"Averill","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2022.05.1085_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2133.2006.07198.x","article-title":"Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis","volume":"155","author":"Benoit","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.05.1085_bib5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/mi.2016.14","article-title":"Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications","volume":"9","author":"Boyapati","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jid.2022.05.1085_bib6","first-page":"33","article-title":"S100A8\/A9 in psoriatic plaques from patients with psoriatic arthritis","volume":"44","author":"Chimenti","year":"2016","journal-title":"J\u00a0Int Med Res"},{"key":"10.1016\/j.jid.2022.05.1085_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.120.011199","article-title":"Treatment of psoriasis with biologic therapy is associated with improvement of coronary artery plaque lipid-rich necrotic core: results from a prospective, observational study","volume":"13","author":"Choi","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jid.2022.05.1085_bib8","first-page":"1170","article-title":"Evaluation of coronary plaque characteristics with coronary computed tomography angiography in patients with non-obstructive coronary artery disease: a long-term follow-up study","volume":"18","author":"Conte","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jid.2022.05.1085_bib9","first-page":"24","article-title":"Intestinal epithelium in inflammatory bowel disease","volume":"1","author":"Coskun","year":"2014","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jid.2022.05.1085_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/ATVBAHA.113.302432","article-title":"Plasma S100A8\/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals","volume":"34","author":"Cotoi","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2022.05.1085_bib11","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J Anaesth"},{"key":"10.1016\/j.jid.2022.05.1085_bib12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil extracellular traps in atherosclerosis and atherothrombosis","volume":"120","author":"D\u00f6ring","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jid.2022.05.1085_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213344","article-title":"Observational study on Swedish plaque psoriasis patients receiving narrowband-UVB treatment show decreased S100A8\/A9 protein and gene expression levels in lesional psoriasis skin but no effect on S100A8\/A9 protein levels in serum","volume":"14","author":"Duvetorp","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.05.1085_bib14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/cvr\/cvz009","article-title":"Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study","volume":"115","author":"Elnabawi","year":"2019","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jid.2022.05.1085_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jcmg.2014.10.009","article-title":"Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans","volume":"8","author":"Emami","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jid.2022.05.1085_bib16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamacardio.2017.4973","article-title":"Use of high-risk coronary atherosclerotic plaque detection for risk stratification of patients with stable chest pain: a secondary analysis of the PROMISE randomized clinical trial","volume":"3","author":"Ferencik","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jid.2022.05.1085_bib17","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1038\/jid.2009.112","article-title":"The risk of stroke in patients with psoriasis","volume":"129","author":"Gelfand","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.05.1085_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.chom.2020.12.016","article-title":"Induction of alarmin S100A8\/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19","volume":"29","author":"Guo","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jid.2022.05.1085_bib19","article-title":"S-calprotectin (S100A8\/S100A9): a potential marker of inflammation in patients with psoriatic arthritis","volume":"2014","author":"Hansson","year":"2014","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.jid.2022.05.1085_bib20","doi-asserted-by":"crossref","first-page":"H867","DOI":"10.1152\/ajpheart.00774.2016","article-title":"Psoriasis as a human model of disease to study inflammatory atherogenesis","volume":"312","author":"Harrington","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jid.2022.05.1085_bib21","first-page":"658","article-title":"Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation","volume":"43","author":"Ishimori","year":"2002","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.jid.2022.05.1085_bib22","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ahj.2016.09.003","volume":"182","author":"Lee","year":"2016","journal-title":"Am Heart J"},{"key":"10.1016\/j.jid.2022.05.1085_bib23","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.jcmg.2018.04.015","article-title":"Effects of statins on coronary atherosclerotic plaques: the PARADIGM study","volume":"11","author":"Lee","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jid.2022.05.1085_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/CIRCULATIONAHA.116.026859","article-title":"Coronary plaque characterization in psoriasis reveals high-risk features that improve after treatment in a prospective observational study","volume":"136","author":"Lerman","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jid.2022.05.1085_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11739-016-1543-2","article-title":"An exploratory look at NETosis in atherosclerosis","volume":"12","author":"Mozzini","year":"2017","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jid.2022.05.1085_bib26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cmet.2013.04.001","article-title":"Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis","volume":"17","author":"Nagareddy","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.jid.2022.05.1085_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2021.11.008","article-title":"Heightened splenic and bone marrow uptake of 18F-FDG PET\/CT is associated with systemic inflammation and subclinical atherosclerosis by CCTA in psoriasis: an observational study","volume":"339","author":"Patel","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jid.2022.05.1085_bib28","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2022.05.1085_bib29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fimmu.2018.00447","article-title":"Secretion of the phosphorylated form of S100A9 from neutrophils is essential for the proinflammatory functions of extracellular S100A8\/A9","volume":"9","author":"Schenten","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.05.1085_bib30","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.immuni.2013.11.011","article-title":"S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3","volume":"39","author":"Schonthaler","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2022.05.1085_bib31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41573-021-00198-1","article-title":"Targeting inflammation in atherosclerosis - from experimental insights to the clinic","volume":"20","author":"Soehnlein","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jid.2022.05.1085_bib32","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1161\/CIRCULATIONAHA.119.043833","article-title":"Neutrophil-derived S100A8\/A9 amplify granulopoiesis after myocardial infarction","volume":"141","author":"Sreejit","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jid.2022.05.1085_bib33","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.05.1085_bib34","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1172\/JCI70966","article-title":"Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis","volume":"124","author":"Wang","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.05.1085_bib35","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.119.044720","article-title":"Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: results from the multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART)","volume":"141","author":"Williams","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jid.2022.05.1085_bib36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jacc.2018.10.066","article-title":"Coronary artery plaque characteristics associated with adverse outcomes in the SCOT-HEART Study","volume":"73","author":"Williams","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jid.2022.05.1085_bib37","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jdv.13269","article-title":"Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity","volume":"30","author":"Wilsmann-Theis","year":"2016","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.05.1085_bib38","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.3389\/fimmu.2017.01908","article-title":"S100 Proteins as an important regulator of macrophage inflammation","volume":"8","author":"Xia","year":"2017","journal-title":"Front Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22015275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22015275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:27:44Z","timestamp":1758302864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22015275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0022202X22015275"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.05.1085","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of S100A8\/A9 with Lipid-Rich Necrotic Core and Treatment with Biologic Therapy in Patients with Psoriasis: Results from an Observational Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.05.1085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}