{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:56:09Z","timestamp":1794009369948,"version":"4.8.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030B_185392"],"award-info":[{"award-number":["310030B_185392"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003006","name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","doi-asserted-by":"publisher","award":["SKINTEGRITY.CH"],"award-info":[{"award-number":["SKINTEGRITY.CH"]}],"id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jid.2022.05.1089","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T20:38:40Z","timestamp":1656448720000},"page":"3313-3326.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mediators of Capillary-to-Venule Conversion in the Chronic Inflammatory Skin Disease Psoriasis"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-2125","authenticated-orcid":false,"given":"Yuliang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-1433","authenticated-orcid":false,"given":"Jihye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-7555","authenticated-orcid":false,"given":"Carlotta","family":"Tacconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-711X","authenticated-orcid":false,"given":"Jonathan","family":"Moody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-5710","authenticated-orcid":false,"given":"Lothar C.","family":"Dieterich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-0626","authenticated-orcid":false,"given":"Florian","family":"Anzengruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-1545","authenticated-orcid":false,"given":"Julia-Tatjana","family":"Maul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-8237","authenticated-orcid":false,"given":"Epameinondas","family":"Gousopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-2364","authenticated-orcid":false,"given":"Gaetana","family":"Restivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-6265","authenticated-orcid":false,"given":"Mitchell P.","family":"Levesque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-1004","authenticated-orcid":false,"given":"Nicole","family":"Lindenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-3533","authenticated-orcid":false,"given":"Jay W.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-7577","authenticated-orcid":false,"given":"Chung-Chau","family":"Hon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-5054","authenticated-orcid":false,"given":"Michael","family":"Detmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.05.1089_bib2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.autrev.2017.07.008","article-title":"Endothelial cells: from innocent bystanders to active participants in immune responses","volume":"16","author":"Al-Soudi","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2022.05.1089_bib3","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fimmu.2019.00536","article-title":"Defective induction of COX-2 expression by psoriatic fibroblasts promotes pro-inflammatory activation of macrophages","volume":"10","author":"Arasa","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib4","doi-asserted-by":"crossref","first-page":"D711","DOI":"10.1093\/nar\/gky964","article-title":"ArrayExpress update - from bulk to single-cell expression data","volume":"47","author":"Athar","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.05.1089_bib5","first-page":"1241","article-title":"Assessment of dermal papillary and microvascular parameters in psoriasis vulgaris using in\u00a0vivo reflectance confocal microscopy","volume":"15","author":"Batani","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jid.2022.05.1089_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2022.05.1089_bib7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/ATVBAHA.116.308020","article-title":"Postnatal deletion of podoplanin in lymphatic endothelium results in blood\u00a0filling of the lymphatic system and impairs dendritic cell migration to\u00a0lymph nodes","volume":"37","author":"Bianchi","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2022.05.1089_bib8","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1038\/jid.1989.2","article-title":"Ultrastructure and organization of the cutaneous microvasculature in normal and pathologic states","volume":"93","author":"Braverman","year":"1989","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.05.1089_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/1523-1747.ep12497850","article-title":"Role of the microcirculation in the treatment and pathogenesis of psoriasis","volume":"78","author":"Braverman","year":"1982","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.05.1089_bib11","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.aau0730","article-title":"Joint profiling of chromatin accessibility and gene expression in thousands of single cells","volume":"361","author":"Cao","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jid.2022.05.1089_bib12","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.celrep.2018.09.006","article-title":"Transcriptional programming of normal and inflamed human epidermis at single-cell resolution","volume":"25","author":"Cheng","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2022.05.1089_bib13","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1038\/s41467-021-23808-3","article-title":"Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells","volume":"12","author":"Cifarelli","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.05.1089_bib14","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the endothelial barrier: identifying and reconciling controversies","volume":"27","author":"Claesson-Welsh","year":"2021","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jid.2022.05.1089_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jaut.2011.09.003","article-title":"MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases","volume":"37","author":"Dagur","year":"2011","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2022.05.1089_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.autrev.2015.01.003","article-title":"Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: characterization and role in human autoimmune diseases","volume":"14","author":"Dagur","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2022.05.1089_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tig.2008.01.008","article-title":"The functional consequences of alternative promoter use in mammalian genomes","volume":"24","author":"Davuluri","year":"2008","journal-title":"Trends Genet"},{"key":"10.1016\/j.jid.2022.05.1089_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00370733","article-title":"Reappraisal of in situ immunophenotypic analysis of psoriasis skin: interaction of activated HLA-DR+ immunocompetent cells and endothelial cells is a major feature of psoriatic lesions","volume":"286","author":"de Boer","year":"1994","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2022.05.1089_bib19","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.cell.2019.08.018","article-title":"A\u00a0Pan-cancer transcriptome analysis reveals pervasive regulation through alternative promoters","volume":"178","author":"Demircio\u011flu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jid.2022.05.1089_bib20","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1084\/jem.180.3.1141","article-title":"Overexpression of vascular permeability factor\/vascular endothelial growth\u00a0factor and its receptors in psoriasis","volume":"180","author":"Detmar","year":"1994","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.05.1089_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nm1351","article-title":"Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation","volume":"12","author":"Fiedler","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.05.1089_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2022.05.1089_bib23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41588-018-0081-4","article-title":"Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types","volume":"50","author":"Finucane","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.05.1089_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040443","article-title":"Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS","volume":"7","author":"Flanagan","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jid.2022.05.1089_bib25","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/ATVBAHA.119.314008","article-title":"Activated platelets induce endothelial cell inflammatory response in psoriasis via COX-1","volume":"40","author":"Garshick","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2022.05.1089_bib26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s40257-017-0337-2","article-title":"Malignancy risk and recurrence with psoriasis and its treatments: a concise update","volume":"19","author":"Geller","year":"2018","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jid.2022.05.1089_bib27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3390\/ijms20030739","article-title":"Advances in understanding the immunological pathways in psoriasis","volume":"20","author":"Georgescu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2022.05.1089_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fphar.2020.00117","article-title":"Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities","volume":"11","author":"Gisondi","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jid.2022.05.1089_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd1607","article-title":"Psoriasis: emerging therapeutic strategies","volume":"4","author":"Gottlieb","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jid.2022.05.1089_bib30","first-page":"22","article-title":"5\u2019 scRNA-seq reveals vessel subtype-specific transcriptional reprogramming in the chronic inflammatory skin disease psoriasis","volume":"50","author":"He","year":"2021","journal-title":"Vasa"},{"key":"10.1016\/j.jid.2022.05.1089_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/jidsymp.2011.5","article-title":"The cutaneous vascular system in chronic skin inflammation","volume":"15","author":"Huggenberger","year":"2011","journal-title":"J\u00a0Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jid.2022.05.1089_bib32","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1084\/jem.20100559","article-title":"Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation","volume":"207","author":"Huggenberger","year":"2010","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.05.1089_bib33","doi-asserted-by":"crossref","first-page":"33671","DOI":"10.1074\/jbc.M702889200","article-title":"Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1","volume":"282","author":"Johnson","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.05.1089_bib34","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","article-title":"Single-cell transcriptome atlas of murine endothelial cells","volume":"180","author":"Kalucka","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jid.2022.05.1089_bib35","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1242\/jcs.186767","article-title":"DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C","volume":"129","author":"Klein","year":"2016","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2022.05.1089_bib36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41467-018-08126-5","article-title":"C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution","volume":"10","author":"Kouno","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.05.1089_bib37","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/01.RES.0000259593.07661.1e","article-title":"Endothelial cell migration during angiogenesis","volume":"100","author":"Lamalice","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jid.2022.05.1089_bib38","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2022.05.1089_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/jid.2014.317","article-title":"IL-17A production in human psoriatic blood and lesions by CD146+ T cells","volume":"135","author":"Mehta","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.05.1089_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/21541264.2015.1128517","article-title":"Transcriptional enhancers: transcription, function and flexibility","volume":"7","author":"Melamed","year":"2016","journal-title":"Transcription"},{"key":"10.1016\/j.jid.2022.05.1089_bib41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1101\/gad.308619.117","article-title":"The degree of enhancer or promoter activity is reflected by the levels\u00a0and directionality of eRNA transcription","volume":"32","author":"Mikhaylichenko","year":"2018","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2022.05.1089_bib42","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1369\/0022155418782693","article-title":"Re-investigating the basement membrane zone of psoriatic epidermal lesions: is laminin-511 a new player in psoriasis pathogenesis?","volume":"66","author":"Natsumi","year":"2018","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.jid.2022.05.1089_bib43","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00403-013-1432-8","article-title":"DNA methylation analysis of CD4+ T cells in patients with psoriasis","volume":"306","author":"Park","year":"2014","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2022.05.1089_bib44","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1038\/s41467-020-18513-6","article-title":"Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis","volume":"11","author":"Penkava","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.05.1089_bib45","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/1523-1747.ep12394720","article-title":"Inducibility and expression of microvascular endothelial adhesion molecules in lesional, perilesional, and uninvolved skin of psoriatic patients","volume":"103","author":"Petzelbauer","year":"1994","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.05.1089_bib46","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.molcel.2018.06.044","article-title":"Cicero predicts cis-regulatory DNA interactions from single-cell chromatin accessibility data","volume":"71","author":"Pliner","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.jid.2022.05.1089_bib47","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3389\/fimmu.2017.01907","article-title":"Antigen presentation by vascular cells","volume":"8","author":"Pober","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib48","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib49","doi-asserted-by":"crossref","first-page":"a016345","DOI":"10.1101\/cshperspect.a016345","article-title":"Inflammation and the blood microvascular system","volume":"7","author":"Pober","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jid.2022.05.1089_bib50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2016.12.002","article-title":"Epigenetics of psoriatic disease: a systematic review and critical appraisal","volume":"78","author":"Pollock","year":"2017","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2022.05.1089_bib51","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/gene.2009.51","article-title":"Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes","volume":"10","author":"Quaranta","year":"2009","journal-title":"Genes Immun"},{"key":"10.1016\/j.jid.2022.05.1089_bib52","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/s41467-020-15463-x","article-title":"Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension","volume":"11","author":"Reyes-Palomares","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.05.1089_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba6500","article-title":"Developmental cell programs are co-opted in inflammatory skin disease","volume":"371","author":"Reynolds","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jid.2022.05.1089_bib54","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00018-017-2694-7","article-title":"Human endoglin as a potential new partner involved in platelet-endothelium interactions","volume":"75","author":"Rossi","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jid.2022.05.1089_bib55","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1182\/blood-2012-06-435347","article-title":"Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration","volume":"121","author":"Rossi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.05.1089_bib56","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1038\/ncomms7771","article-title":"Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction","volume":"6","author":"Rouhani","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.05.1089_bib57","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1046\/j.1538-7836.2003.00260.x","article-title":"Von Willebrand factor, platelets and endothelial cell interactions","volume":"1","author":"Ruggeri","year":"2003","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jid.2022.05.1089_bib58","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41587-019-0071-9","article-title":"A\u00a0comparison of single-cell trajectory inference methods","volume":"37","author":"Saelens","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2022.05.1089_bib59","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3389\/fimmu.2019.01033","article-title":"The antigen processing and presentation machinery in lymphatic endothelial cells","volume":"10","author":"Santambrogio","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib60","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2022.05.1089_bib61","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2022.05.1089_bib62","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.vph.2018.08.001","article-title":"Cellular traffic through afferent lymphatic vessels","volume":"112","author":"Schineis","year":"2019","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.jid.2022.05.1089_bib63","doi-asserted-by":"crossref","first-page":"21264","DOI":"10.1073\/pnas.0907550106","article-title":"Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis","volume":"106","author":"Schonthaler","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.05.1089_bib64","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124850","article-title":"Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation","volume":"3","author":"Schwager","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2022.05.1089_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000076129","article-title":"Secondary lymphoid tissue chemokine (CCL21) is upregulated in\u00a0allergic contact dermatitis","volume":"133","author":"Serra","year":"2004","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249068","article-title":"Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice","volume":"16","author":"Sigmund","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.jid.2022.05.1089_bib67","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.it.2017.06.002","article-title":"Regulation of the immune system by laminins","volume":"38","author":"Simon","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib68","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.celrep.2016.12.092","article-title":"Endothelial basement membrane laminin 511 contributes to endothelial junctional tightness and thereby inhibits leukocyte transmigration","volume":"18","author":"Song","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2022.05.1089_bib69","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics","volume":"19","author":"Street","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jid.2022.05.1089_bib70","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.celrep.2018.10.045","article-title":"Revealing the critical regulators of cell identity in the mouse cell atlas","volume":"25","author":"Suo","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2022.05.1089_bib71","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/acsptsci.9b00037","article-title":"Antibody-mediated delivery of VEGFC ameliorates experimental chronic colitis","volume":"2","author":"Tacconi","year":"2019","journal-title":"ACS Pharmacol Transl Sci"},{"key":"10.1016\/j.jid.2022.05.1089_bib72","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0002-9440(10)65654-4","article-title":"Angiogenesis in mice with chronic airway inflammation: strain-dependent differences","volume":"153","author":"Thurston","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2022.05.1089_bib73","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/qjmed\/hcu073","article-title":"Psoriasis and risk of venous thromboembolism: a systematic review and meta-analysis","volume":"107","author":"Ungprasert","year":"2014","journal-title":"Qjm"},{"key":"10.1016\/j.jid.2022.05.1089_bib74","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41467-020-14766-3","article-title":"Trajectory-based differential expression analysis for single-cell sequencing data","volume":"11","author":"Van den Berge","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.05.1089_bib75","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.cell.2018.05.061","article-title":"Recovering gene interactions from single-cell data using data diffusion","volume":"174","author":"van Dijk","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jid.2022.05.1089_bib76","doi-asserted-by":"crossref","first-page":"24100","DOI":"10.1073\/pnas.1914143116","article-title":"Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration","volume":"116","author":"Voigt","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.05.1089_bib77","first-page":"1","article-title":"Lymphatic vessels in inflammation","volume":"05","author":"Vranova","year":"2014","journal-title":"J\u00a0Clin Cell Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib78","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1172\/JCI73683","article-title":"Laminins affect T cell trafficking and allograft fate","volume":"124","author":"Warren","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.05.1089_bib79","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.4049\/jimmunol.170.9.4638","article-title":"Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis","volume":"170","author":"Weninger","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.05.1089_bib80","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2353\/ajpath.2008.080101","article-title":"Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells","volume":"173","author":"Wick","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2022.05.1089_bib81","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J Integr Biol"},{"key":"10.1016\/j.jid.2022.05.1089_bib82","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1002\/art.30421","article-title":"Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice","volume":"63","author":"Zhou","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2022.05.1089_bib83","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/hq0302.104517","article-title":"Novel 5' exon of scavenger receptor CD36 is expressed in cultured human vascular smooth muscle cells and atherosclerotic plaques","volume":"22","author":"Zingg","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2022.05.1089_bib84","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2022.05.1089_bib85","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"Schizophrenia Working Group of the Psychiatric Genomics Consortium, et\u00a0al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.05.1089_bib86","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.celrep.2018.10.045","article-title":"Revealing the critical regulators of cell identity in the mouse cell atlas","volume":"25","author":"Suo","year":"2018","journal-title":"Cell Rep"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22015421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22015421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:50:09Z","timestamp":1762206609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22015421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":84,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0022202X22015421"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.05.1089","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mediators of Capillary-to-Venule Conversion in the Chronic Inflammatory Skin Disease Psoriasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.05.1089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}