{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:59:12Z","timestamp":1792897152443,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18J12760"],"award-info":[{"award-number":["18J12760"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jid.2022.06.006","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T12:54:10Z","timestamp":1657112050000},"page":"3167-3174.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Role of PD-L1 on Langerhans Cells in the Regulation of Psoriasis"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7887-8126","authenticated-orcid":false,"given":"Ryota","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0375-2243","authenticated-orcid":false,"given":"Yuki","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-680X","authenticated-orcid":false,"given":"Noriko","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3681-2441","authenticated-orcid":false,"given":"Risa","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0166-2658","authenticated-orcid":false,"given":"Yoshiyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-5817","authenticated-orcid":false,"given":"Seiya","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8540-7760","authenticated-orcid":false,"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-4872","authenticated-orcid":false,"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-6446","authenticated-orcid":false,"given":"Toshifumi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5398-0773","authenticated-orcid":false,"given":"Naoko","family":"Okiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.06.006_bib1","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1111\/jdv.14011","article-title":"Anti-PD1-induced psoriasis: a study of 21 patients","volume":"31","author":"Bonigen","year":"2017","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.06.006_bib2","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1084\/jem.20060244","article-title":"IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis","volume":"203","author":"Chan","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.06.006_bib3","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1172\/JCI29441","article-title":"Misbehaving macrophages in the pathogenesis of psoriasis","volume":"116","author":"Clark","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.06.006_bib5","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/70932","article-title":"B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion","volume":"5","author":"Dong","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.06.006_bib6","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1002\/eji.201444891","article-title":"Defining Th-cell subsets in a classical and tissue-specific manner: examples from the skin","volume":"44","author":"Eyerich","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2022.06.006_bib7","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1038\/jid.2010.165","article-title":"A\u00a0subpopulation of CD163-positive macrophages is classically activated in psoriasis","volume":"130","author":"Fuentes-Duculan","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib8","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/archderm.140.12.1490","article-title":"Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors","volume":"140","author":"Gilliet","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib9","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1172\/JCI59725","article-title":"Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells","volume":"122","author":"Gomez de Ag\u00fcero","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.06.006_bib10","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4049\/jimmunol.1800013","article-title":"Discovery of the IL-23\/IL-17 signaling pathway and the treatment of psoriasis","volume":"201","author":"Hawkes","year":"2018","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.06.006_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046776","article-title":"Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy","volume":"7","author":"Hitzler","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.06.006_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.immuni.2011.06.005","article-title":"Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses","volume":"35","author":"Igy\u00e1rt\u00f3","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2022.06.006_bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cia2.12087","article-title":"A\u00a0case of de novo psoriasis induced by atezolizumab in a patient with advanced lung cancer","volume":"2","author":"Iijima","year":"2019","journal-title":"J\u00a0cutan Immunol All"},{"key":"10.1016\/j.jid.2022.06.006_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4049\/jimmunol.1500448","article-title":"Cutting edge: PD-1 regulates imiquimod-induced psoriasiform dermatitis through inhibition\u00a0of IL-17A expression by innate \u03b3\u03b4-low T cells","volume":"195","author":"Imai","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.06.006_bib15","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1084\/jem.20071401","article-title":"Autocrine\/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells","volume":"204","author":"Kaplan","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.06.006_bib16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1084\/jem.20102318","article-title":"Langerhans cells are negative regulators of the anti-Leishmania response","volume":"208","author":"Kautz-Neu","year":"2011","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.06.006_bib17","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1084\/jem.20091527","article-title":"External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers","volume":"206","author":"Kubo","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.06.006_bib18","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.jid.2020.09.018","article-title":"Langerhans cells suppress CD8+ T cells in situ during mucocutaneous acute graft-versus host disease","volume":"141","author":"Kubota","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.06.006_bib20","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jid.2016.11.033","article-title":"Dynamic changes in resident and infiltrating epidermal dendritic cells in active and resolved psoriasis","volume":"137","author":"Martini","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2340\/00015555-2212","article-title":"Exacerbation of psoriasis during nivolumab therapy for metastatic melanoma","volume":"96","author":"Matsumura","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2022.06.006_bib22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1001\/jamadermatol.2015.0249","article-title":"Occurrence of psoriasiform eruption during nivolumab therapy for primary oral mucosal melanoma","volume":"151","author":"Ohtsuka","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2230.2005.01938.x","article-title":"Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas","volume":"31","author":"Rajan","year":"2006","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib24","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1002\/eji.200324270","article-title":"Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis","volume":"33","author":"Rodig","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2022.06.006_bib25","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.immuni.2012.03.018","article-title":"Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells","volume":"36","author":"Seneschal","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2022.06.006_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s42003-020-01308-2","article-title":"Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like dermatitis through IL-6","volume":"3","author":"Tanaka","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.jid.2022.06.006_bib27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jid.2021.06.026","article-title":"Differential involvement of programmed cell death ligands in skin immune responses","volume":"142","author":"Tanaka","year":"2022","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jdermsci.2016.12.019","article-title":"Serum level of interleukin-6 is increased in nivolumab-associated psoriasiform dermatitis and tumor necrosis factor-alpha is a biomarker of nivolumab recativity","volume":"86","author":"Tanaka","year":"2017","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.06.006_bib29","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1002\/eji.200324084","article-title":"Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses","volume":"33","author":"Tsushima","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jid.2022.06.006_bib30","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.06.006_bib31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jdermsci.2016.12.003","article-title":"Activation of Langerhans cells promotes the inflammation in imiquimod-induced psoriasis-like dermatitis","volume":"85","author":"Xiao","year":"2017","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.06.006_bib32","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1038\/jid.2014.98","article-title":"IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing \u03b3\u03b4T cells","volume":"134","author":"Yoshiki","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.06.006_bib33","doi-asserted-by":"crossref","first-page":"328rv4","DOI":"10.1126\/scitranslmed.aad7118","article-title":"PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations","volume":"8","author":"Zou","year":"2016","journal-title":"Sci Transl Med"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22016451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22016451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:50:23Z","timestamp":1762206623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22016451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0022202X22016451"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.06.006","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of PD-L1 on Langerhans Cells in the Regulation of Psoriasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}