{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:39:59Z","timestamp":1768264799349,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["HU0001-17-2-0009"],"award-info":[{"award-number":["HU0001-17-2-0009"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["2P41EB015871-31"],"award-info":[{"award-number":["2P41EB015871-31"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jid.2022.07.018","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T04:50:50Z","timestamp":1660711850000},"page":"134-141.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cryoneurolysis with Injectable Ice Slurry Modulates Mechanical Skin Pain"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-408X","authenticated-orcid":false,"given":"Sara","family":"Moradi Tuchayi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-3222","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-576X","authenticated-orcid":false,"given":"Alla","family":"Khodorova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-1374","authenticated-orcid":false,"given":"Isaac J.","family":"Pence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2185-6505","authenticated-orcid":false,"given":"Conor L.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-3035","authenticated-orcid":false,"given":"R. Rox","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5480-4133","authenticated-orcid":false,"given":"Ethan A.","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-3897","authenticated-orcid":false,"given":"Clifford J.","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-0887","authenticated-orcid":false,"given":"Lilit","family":"Garibyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.07.018_bib1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1097\/j.pain.0000000000000979","article-title":"Dose-response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation","volume":"158","author":"Andersen","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jid.2022.07.018_bib2","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1364\/BOE.4.002003","article-title":"Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach","volume":"4","author":"B\u00e9gin","year":"2013","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.jid.2022.07.018_bib3","first-page":"967","article-title":"Pain and pain management in dermatology","volume":"13","author":"Beiteke","year":"2015","journal-title":"J\u00a0Dtsch Dermatol Ges"},{"key":"10.1016\/j.jid.2022.07.018_bib4","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.36076\/ppj.2008\/11\/S105","article-title":"Opioid complications and side effects","volume":"11","author":"Benyamin","year":"2008","journal-title":"Pain Physician"},{"key":"10.1016\/j.jid.2022.07.018_bib5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/ALN.0b013e318182c26b","article-title":"Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat","volume":"109","author":"Brummett","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jid.2022.07.018_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3959(88)90027-9","article-title":"Myelinated afferents signal the hyperalgesia associated with nerve injury","volume":"32","author":"Campbell","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.jid.2022.07.018_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0304-3959(86)90174-0","article-title":"Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain","volume":"26","author":"Coderre","year":"1986","journal-title":"Pain"},{"key":"10.1016\/j.jid.2022.07.018_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.jid.2022.07.018_bib9","series-title":"Clinical pain management: practical applications and procedures","first-page":"247","article-title":"Neurolytic blocks","author":"De Medicis","year":"2003"},{"key":"10.1016\/j.jid.2022.07.018_bib10","first-page":"899","article-title":"An improved rodent model of trigeminal neuropathic pain by unilateral chronic constriction injury of distal infraorbital nerve","volume":"18","author":"Ding","year":"2017","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.jid.2022.07.018_bib11","first-page":"1879","article-title":"Analysis of myelinated fibers in human skin biopsies of patients with neuropathies","volume":"259","author":"Doppler","year":"2012","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.jid.2022.07.018_bib12","first-page":"129","article-title":"Ultrasound-guided percutaneous cryoneurolysis for acute pain management: a case report","volume":"9","author":"Gabriel","year":"2017","journal-title":"A\u00a0A Case Rep"},{"key":"10.1016\/j.jid.2022.07.018_bib13","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1038\/jid.2015.233","article-title":"Transient alterations of cutaneous sensory nerve function by noninvasive cryolipolysis","volume":"135","author":"Garibyan","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.018_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/ALN.0000000000003124","article-title":"Neural selective cryoneurolysis with ice slurry injection in a rat model","volume":"133","author":"Garibyan","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jid.2022.07.018_bib15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41583-021-00489-x","article-title":"The mechanosensory neurons of touch and their mechanisms of activation","volume":"22","author":"Handler","year":"2021","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jid.2022.07.018_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A\u00a0new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.jid.2022.07.018_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.tins.2020.03.004","article-title":"Getting in touch with mechanical pain mechanisms","volume":"43","author":"Hill","year":"2020","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jid.2022.07.018_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/mus.24306","article-title":"Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies","volume":"51","author":"Hsu","year":"2015","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.jid.2022.07.018_bib19","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/ALN.0000000000003532","article-title":"Cryoneurolysis and percutaneous peripheral nerve stimulation to treat acute pain","volume":"133","author":"Ilfeld","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jid.2022.07.018_bib20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/17434440.2016.1204229","article-title":"Novel cryoneurolysis device for the treatment of sensory and motor peripheral nerves","volume":"13","author":"Ilfeld","year":"2016","journal-title":"Expert Rev Med Devices"},{"key":"10.1016\/j.jid.2022.07.018_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/pmrj.12234","article-title":"Cryoneurolysis for the treatment of lateral femoral cutaneous nerve pain: a case report","volume":"12","author":"Johnson","year":"2020","journal-title":"PM R"},{"key":"10.1016\/j.jid.2022.07.018_bib22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuroscience.2013.09.046","article-title":"The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw","volume":"254","author":"Khodorova","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jid.2022.07.018_bib23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1876386300902010030","article-title":"Dual roles for endothelin-B receptors in modulating adjuvant-induced inflammatory hyperalgesia in rats","volume":"2","author":"Khodorova","year":"2009","journal-title":"Open Pain J"},{"key":"10.1016\/j.jid.2022.07.018_bib24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1468-1331.2010.03023.x","volume":"17","author":"Lauria","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jid.2022.07.018_bib25","first-page":"71","article-title":"The theory of chronic deafferentation dysesthesias","volume":"34","author":"Levitt","year":"1990","journal-title":"J\u00a0Neurosurg Sci"},{"key":"10.1016\/j.jid.2022.07.018_bib26","first-page":"16","article-title":"Current concepts of neurolysis and clinical applications","volume":"2","author":"Linqiu","year":"2014","journal-title":"J\u00a0Analgesics"},{"key":"10.1016\/j.jid.2022.07.018_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0885-3924(98)00026-8","article-title":"The human capsaicin model of allodynia and hyperalgesia: sources of variability and methods for reduction","volume":"16","author":"Liu","year":"1998","journal-title":"J\u00a0Pain Symptom Manage"},{"key":"10.1016\/j.jid.2022.07.018_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.660203","article-title":"Cutaneous neuroimmune interactions in peripheral neuropathic pain states","volume":"12","author":"Lowy","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.018_bib29","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/brain\/awab048","article-title":"Studying human nociceptors: from fundamentals to clinic","volume":"144","author":"Middleton","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.jid.2022.07.018_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw1297","article-title":"An ultrafast system for signaling mechanical pain in human skin","volume":"5","author":"Nagi","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.jid.2022.07.018_bib31","doi-asserted-by":"crossref","DOI":"10.1177\/1744806920903848","article-title":"D-4F, an ApoA-I mimetic peptide ameliorating TRPA1-mediated nocifensive behaviour in a model of neurogenic inflammation","volume":"16","author":"Oehler","year":"2020","journal-title":"Mol Pain"},{"key":"10.1016\/j.jid.2022.07.018_bib32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2022.07.018_bib33","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.0304-12.2012","article-title":"Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury","volume":"32","author":"Shields","year":"2012","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2022.07.018_bib34","series-title":"Surgical management of pain","first-page":"633","article-title":"Ablative neurosurgical techniques in the treatment of chronic pain","author":"Steel","year":"2002"},{"key":"10.1016\/j.jid.2022.07.018_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0304-3959(94)90013-2","article-title":"Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve","volume":"57","author":"Tal","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.jid.2022.07.018_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.artd.2021.06.008","article-title":"A\u00a0multimodal pain management protocol including preoperative cryoneurolysis for total knee arthroplasty to reduce pain, opioid consumption, and length of stay","volume":"10","author":"Urban","year":"2021","journal-title":"Arthroplast Today"},{"key":"10.1016\/j.jid.2022.07.018_bib37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1179\/016164104225013833","article-title":"Methods for the experimental functional assessment of rat sciatic nerve regeneration","volume":"26","author":"Varej\u00e3o","year":"2004","journal-title":"Neurol Res"},{"key":"10.1016\/j.jid.2022.07.018_bib38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2147\/LRA.S223961","article-title":"Case report of cryoneurolysis for the treatment of refractory intercostobrachial neuralgia with postherpetic neuralgia","volume":"12","author":"Weber","year":"2019","journal-title":"Local Reg Anesth"},{"key":"10.1016\/j.jid.2022.07.018_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0304-3959(00)00342-0","article-title":"Comparison of autotomy behavior induced in rats by various clinically-used neurectomy methods","volume":"89","author":"Zeltser","year":"2000","journal-title":"Pain"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22017730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22017730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:50:25Z","timestamp":1762206625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22017730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0022202X22017730"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.018","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryoneurolysis with Injectable Ice Slurry Modulates Mechanical Skin Pain","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}