{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:34:01Z","timestamp":1771875241825,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016332","name":"Medical Research Center Oulu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["294738"],"award-info":[{"award-number":["294738"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["325965"],"award-info":[{"award-number":["325965"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["330822"],"award-info":[{"award-number":["330822"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006196","name":"Oulun Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jid.2022.07.019","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T04:51:13Z","timestamp":1660711873000},"page":"48-56.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Absence of NC14A Domain of COLXVII\/BP180 in Mice Results in IL-17\u2012Associated Skin Inflammation"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2130-5714","authenticated-orcid":false,"given":"Outi","family":"Lindgren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5436-9397","authenticated-orcid":false,"given":"Gwena\u00eblle","family":"Le Menn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-6442","authenticated-orcid":false,"given":"Jussi","family":"Tuusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-7463","authenticated-orcid":false,"given":"Zhi Jane","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8056-5949","authenticated-orcid":false,"given":"Kaisa","family":"Tasanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-4892","authenticated-orcid":false,"given":"Nina","family":"Kokkonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.07.019_bib1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.autrev.2017.03.010","article-title":"Bullous pemphigoid","volume":"16","author":"Ba\u011fc\u0131","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2022.07.019_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imr.12350","article-title":"Mouse and human FcR effector functions","volume":"268","author":"Bruhns","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2022.07.019_bib3","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3389\/fimmu.2019.01162","article-title":"Interleukin-36 in infectious and inflammatory skin diseases","volume":"10","author":"Buhl","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaut.2018.09.003","article-title":"IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid","volume":"96","author":"Chakievska","year":"2019","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2022.07.019_bib5","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1182\/blood-2013-02-486217","article-title":"Mast cell and macrophage chemokines CXCL1\/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation","volume":"121","author":"De Filippo","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.07.019_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/exd.12863","article-title":"Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion","volume":"25","author":"Dragatin","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.019_bib7","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1111\/jdv.16057","article-title":"Development of bullous pemphigoid in junctional epidermolysis bullosa","volume":"34","author":"Fania","year":"2020","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.07.019_bib8","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.3389\/fimmu.2019.01506","article-title":"New insights into the pathogenesis of bullous pemphigoid: 2019 update","volume":"10","author":"Genovese","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.matbio.2018.04.001","article-title":"Epidermolysis bullosa: molecular pathology of connective tissue components in the cutaneous basement membrane zone","volume":"71\u201372","author":"Has","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2022.07.019_bib10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41467-020-20604-3","article-title":"Granzyme B inhibition reduces disease severity in autoimmune blistering diseases","volume":"12","author":"Hiroyasu","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.07.019_bib11","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/jid.2014.443","article-title":"Deletion of the major bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in mice","volume":"135","author":"Hurskainen","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.019_bib13","doi-asserted-by":"crossref","first-page":"7491","DOI":"10.1038\/s41388-019-0961-9","article-title":"The dysfunction of BP180\/collagen XVII in keratinocytes promotes melanoma progression","volume":"38","author":"Hwang","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.jid.2022.07.019_bib14","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.autrev.2019.03.009","article-title":"Serum and blister fluid levels of cytokines and chemokines in pemphigus and bullous pemphigoid","volume":"18","author":"Kowalski","year":"2019","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jid.2022.07.019_bib15","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.3389\/fimmu.2019.01972","article-title":"IL-23\/IL-17 axis activates IL-1\u03b2-associated inflammasome in macrophages and generates an auto-inflammatory response in a subgroup of patients with bullous pemphigoid","volume":"10","author":"Le Jan","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib16","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1038\/jid.2014.263","article-title":"Innate immune cell-produced IL-17 sustains inflammation in bullous pemphigoid","volume":"134","author":"Le Jan","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.019_bib17","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.4049\/jimmunol.1000667","article-title":"Human IgG1 monoclonal antibody against human Collagen 17 noncollagenous 16A domain induces blisters via complement activation in experimental bullous pemphigoid model","volume":"185","author":"Li","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib18","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4049\/jimmunol.1100123","article-title":"Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis","volume":"187","author":"Lin","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib19","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.4049\/jimmunol.2000784","article-title":"Non\u2013cell-autonomous activity of the hemidesmosomal protein BP180\/collagen XVII in granulopoiesis in humanized NC16A mice","volume":"205","author":"Lin","year":"2020","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.594735","article-title":"The IL-23\/IL-17 pathway in inflammatory skin diseases: from bench to bedside","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib21","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3389\/fimmu.2017.01752","article-title":"BP180 is critical in the autoimmunity of bullous pemphigoid","volume":"8","author":"Liu","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jaut.2008.08.009","article-title":"Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model","volume":"31","author":"Liu","year":"2008","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2022.07.019_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/vaccines7040124","article-title":"Genetic variation in the magnitude and longevity of the igg subclass response to a diphtheria-tetanus-acellular pertussis (dtap) vaccine in mice","volume":"7","author":"Mosley","year":"2019","journal-title":"Vaccines"},{"key":"10.1016\/j.jid.2022.07.019_bib24","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/exd.13550","article-title":"Life before and beyond blistering: the role of collagen XVII in epidermal physiology","volume":"28","author":"Natsuga","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.019_bib25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","article-title":"Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease","volume":"129","author":"Onishi","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2022.07.019_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/antib10020019","article-title":"A\u00a0review of acquired autoimmune blistering diseases in inherited epidermolysis bullosa: implications for the future of gene therapy","volume":"10","author":"Patel","year":"2021","journal-title":"Antibodies (Basel)"},{"key":"10.1016\/j.jid.2022.07.019_bib27","doi-asserted-by":"crossref","first-page":"9690","DOI":"10.1038\/s41598-018-28070-0","article-title":"Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction","volume":"8","author":"Russo","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2022.07.019_bib28","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.ajpath.2014.05.007","article-title":"Fc\u03b3 receptors III and IV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid","volume":"184","author":"Schulze","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2022.07.019_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00403-007-0734-0","article-title":"The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases","volume":"299","author":"Sitaru","year":"2007","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2022.07.019_bib30","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3389\/fimmu.2019.01918","article-title":"Learning from success and failure: biologics for non-approved skin diseases","volume":"10","author":"Speeckaert","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib31","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.4049\/jimmunol.176.7.4102","article-title":"Mast cell-associated TNF promotes dendritic cell migration","volume":"176","author":"Suto","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212233","article-title":"BP180\/collagen XVII: a molecular view","volume":"22","author":"Tuusa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2022.07.019_bib33","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.4049\/jimmunol.0903101","article-title":"A\u00a0novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen","volume":"184","author":"Ujiie","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.019_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.2007.00565.x","article-title":"\u201cYin-Yang\u201d functions of transforming growth factor-beta and T regulatory cells in immune regulation","volume":"220","author":"Wan","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2022.07.019_bib35","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1073\/pnas.1721805115","article-title":"BP180 dysfunction triggers spontaneous skin inflammation in mice","volume":"115","author":"Zhang","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.07.019_bib36","article-title":"Emerging biomarkers and therapeutic strategies for refractory bullous pemphigoid","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22017778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22017778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:51:13Z","timestamp":1762206673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22017778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0022202X22017778"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.019","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Absence of NC14A Domain of COLXVII\/BP180 in Mice Results in IL-17\u2012Associated Skin Inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}