{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:58:50Z","timestamp":1791644330701,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903208"],"award-info":[{"award-number":["81903208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173830"],"award-info":[{"award-number":["82173830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2022ZDLSF05-19"],"award-info":[{"award-number":["2022ZDLSF05-19"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["2020JQ-445"],"award-info":[{"award-number":["2020JQ-445"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jid.2022.07.026","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:03:06Z","timestamp":1661806986000},"page":"419-430.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Decreasing GDF15 Promotes Inflammatory Signals and Neutrophil Infiltration in Psoriasis Models"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-9514","authenticated-orcid":false,"given":"Jieyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4631-2291","authenticated-orcid":false,"given":"Lei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-144X","authenticated-orcid":false,"given":"Zhaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-1864","authenticated-orcid":false,"given":"Shuai","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-0181","authenticated-orcid":false,"given":"Pei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-282X","authenticated-orcid":false,"given":"Jine","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9014-5649","authenticated-orcid":false,"given":"Kuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1140-8493","authenticated-orcid":false,"given":"Caixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8096-9660","authenticated-orcid":false,"given":"Yingqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-8080","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-3003","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.07.026_bib1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41598-017-00902-5","article-title":"Growth differentiation Factor-15 deficiency augments inflammatory response and exacerbates septic heart and renal injury induced by lipopolysaccharide","volume":"7","author":"Abulizi","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2022.07.026_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/biom11030383","article-title":"Parallel multi-omics in high-risk subjects for the identification of integrated biomarker signatures of Type 1 diabetes","volume":"11","author":"Alcazar","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jid.2022.07.026_bib3","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jid.2022.07.026_bib4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood-2016-01-696617","article-title":"GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5\/TGF-\u03b2RII heterodimer","volume":"128","author":"Artz","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.07.026_bib5","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00424-020-02459-1","article-title":"GDF15, an update of the physiological and pathological roles it plays: a review","volume":"472","author":"Assadi","year":"2020","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jid.2022.07.026_bib6","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1182\/blood-2018-04-846766","article-title":"Direct Rap1\/Talin1 interaction regulates platelet and neutrophil integrin activity in mice","volume":"132","author":"Bromberger","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.07.026_bib7","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41590-018-0256-2","article-title":"The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis","volume":"19","author":"Dainichi","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2022.07.026_bib8","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3389\/fimmu.2019.01107","article-title":"Immune control by TRAF6-mediated pathways of epithelial cells in the EIME (epithelial immune microenvironment)","volume":"10","author":"Dainichi","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.026_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1084\/jem.20100370","article-title":"Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis","volume":"208","author":"de Jager","year":"2011","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.07.026_bib10","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nm.4393","article-title":"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL","volume":"23","author":"Emmerson","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.07.026_bib11","volume":"2","author":"Greb","year":"2016","journal-title":"Psoriasis. Nat Rev Dis Primers"},{"key":"10.1016\/j.jid.2022.07.026_bib12","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2022.07.026_bib13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2022.07.026_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jid.2020.07.009","article-title":"Small extracellular vesicles containing miR-381-3p from keratinocytes promote T helper Type 1 and T helper Type 17 polarization in psoriasis","volume":"141","author":"Jiang","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.026_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nm.2354","article-title":"GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice","volume":"17","author":"Kempf","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.07.026_bib16","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1038\/s41598-018-25098-0","article-title":"Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice","volume":"8","author":"Kim","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2022.07.026_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/pros.22911","article-title":"Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate","volume":"75","author":"Lambert","year":"2015","journal-title":"Prostate"},{"key":"10.1016\/j.jid.2022.07.026_bib18","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2019.07.033","article-title":"GDF15 is an inflammation-induced central mediator of tissue tolerance","volume":"178","author":"Luan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jid.2022.07.026_bib19","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1182\/blood.V92.6.2133","article-title":"Activation of the small GTPase rap1 in human neutrophils","volume":"92","author":"M'Rabet","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.07.026_bib20","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/nm.4392","article-title":"GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates","volume":"23","author":"Mullican","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.07.026_bib21","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1172\/JCI91561","article-title":"NF-kB regulates GDF-15 to suppress macrophage surveillance during early tumor development","volume":"127","author":"Ratnam","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.07.026_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165798","article-title":"Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis","volume":"1866","author":"Rochette","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jid.2022.07.026_bib23","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jid.2016.03.002","article-title":"Increased Lipocalin-2 contributes to the pathogenesis of psoriasis by modulating neutrophil chemotaxis and cytokine secretion","volume":"136","author":"Shao","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.026_bib24","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3389\/fimmu.2019.00746","article-title":"Neutrophil extracellular traps promote inflammatory responses in psoriasis via activating epidermal TLR4\/IL-36R crosstalk","volume":"10","author":"Shao","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.026_bib25","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/mi.2017.3","article-title":"Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure","volume":"10","author":"Verhamme","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jid.2022.07.026_bib26","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jid.2022.07.026_bib27","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1182\/blood.2021013500","article-title":"Molecular mechanisms of leukocyte beta2 integrin activation","volume":"139","author":"Wen","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.07.026_bib28","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/nm.4394","article-title":"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand","volume":"23","author":"Yang","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.07.026_bib29","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3389\/fimmu.2018.02407","article-title":"GDF15 regulates Malat-1 circular RNA and inactivates NFkB signaling leading to immune tolerogenic DCs for preventing alloimmune rejection in heart transplantation","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.026_bib30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jid.2020.07.009","article-title":"Small extracellular vesicles containing miR-381-3p from keratinocytes promote T helper Type 1 and T helper Type 17 polarization in psoriasis","volume":"141","author":"Jiang","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.026_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100115","article-title":"Protocol for flow cytometric detection of immune cell infiltration in the epidermis and dermis of a psoriasis mouse model","volume":"1","author":"Lou","year":"2020","journal-title":"STAR Protoc"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22018851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22018851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:30:39Z","timestamp":1758303039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22018851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0022202X22018851"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.026","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreasing GDF15 Promotes Inflammatory Signals and Neutrophil Infiltration in Psoriasis Models","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}