{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:51:07Z","timestamp":1786992667827,"version":"build-2736575974"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR007175"],"award-info":[{"award-number":["AR007175"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR061106"],"award-info":[{"award-number":["AR061106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM007569"],"award-info":[{"award-number":["GM007569"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002889","name":"Foundation for Prader-Willi Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002889","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHN 569\/4-2"],"award-info":[{"award-number":["SCHN 569\/4-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P 32225-B"],"award-info":[{"award-number":["P 32225-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jid.2022.07.029","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T23:20:07Z","timestamp":1663284007000},"page":"332-335.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["ALOX12B and PNPLA1 Have Distinct Roles in Epidermal Lipid Lamellar Organization"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-3510","authenticated-orcid":false,"given":"Jason M.","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-4372","authenticated-orcid":false,"given":"Kate\u0159ina","family":"V\u00e1vrov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3466-0181","authenticated-orcid":false,"given":"Franz P.W.","family":"Radner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-4053","authenticated-orcid":false,"given":"Holm","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-2964","authenticated-orcid":false,"given":"Angela","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-0070","authenticated-orcid":false,"given":"Theodora M.","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7989-4032","authenticated-orcid":false,"given":"Peter M.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.07.029_bib1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jid.2018.11.005","article-title":"Mutations in recessive congenital ichthyoses illuminate the origin and functions of the corneocyte lipid envelope","volume":"139","author":"Crumrine","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/1523-1747.ep12614489","article-title":"Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses","volume":"99","author":"Ghadially","year":"1992","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jid.2016.08.036","article-title":"PNPLA1 deficiency in mice and humans leads to a defect in the synthesis of omega-O-acylceramides","volume":"137","author":"Grond","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jid.2019.06.134","article-title":"Conditional Alox12b knockout: degradation of the corneocyte lipid envelope in a mouse model of autosomal recessive congenital ichthyoses","volume":"140","author":"Krieg","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jdermsci.2013.08.003","article-title":"Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis","volume":"72","author":"Loiseau","year":"2013","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.07.029_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1085\/jgp.200709848","article-title":"Structural determinants of water permeability through the lipid membrane","volume":"131","author":"Mathai","year":"2008","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.jid.2022.07.029_bib7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ajpath.2021.02.005","article-title":"Unbound corneocyte lipid envelopes in 12R-Lipoxygenase deficiency support a specific role in lipid-protein cross-linking","volume":"191","author":"Meyer","year":"2021","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2022.07.029_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0925-4439(93)90135-N","article-title":"Ceramide composition of the psoriatic scale","volume":"1182","author":"Motta","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2022.07.029_bib9","doi-asserted-by":"crossref","first-page":"12894","DOI":"10.1021\/acs.langmuir.6b03082","article-title":"Omega-O-acylceramides in skin lipid membranes: effects of concentration, sphingoid base, and model complexity on microstructure and permeability","volume":"32","author":"Op\u00e1lka","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.jid.2022.07.029_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2022.100226","article-title":"\u03c9-O-Acylceramides but not \u03c9-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids","volume":"63","author":"Op\u00e1lka","year":"2022","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jid.2022.07.029_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2133.1994.tb08452.x","article-title":"Quantification of stratum corneum ceramides and lipid envelope ceramides in the hereditary ichthyoses","volume":"131","author":"Paige","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1046\/j.0022-202x.2001.01455.x","article-title":"Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis","volume":"117","author":"Pilgram","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib13","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1023\/A:1018987721531","article-title":"Organization of stratum corneum lipids in relation to permeability: influence of sodium lauryl sulfate and preheating","volume":"11","author":"Ribaud","year":"1994","journal-title":"Pharm Res"},{"key":"10.1016\/j.jid.2022.07.029_bib14","doi-asserted-by":"crossref","first-page":"15624","DOI":"10.1021\/la4037474","article-title":"Ceramides in the skin lipid membranes: length matters","volume":"29","author":"Skolov\u00e1","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.jid.2022.07.029_bib15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1001\/jamadermatol.2021.4242","article-title":"The genomic and phenotypic landscape of ichthyosis: an analysis of 1000 kindreds","volume":"158","author":"Sun","year":"2022","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib16","doi-asserted-by":"crossref","first-page":"394\u2012402","DOI":"10.1016\/j.jid.2016.08.036","article-title":"PNPLA1 deficiency in mice and humans leads to a defect in the synthesis of omega-O-acylceramides","volume":"137","author":"Grond","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.029_bib17","doi-asserted-by":"crossref","first-page":"249\u2012253","DOI":"10.1016\/j.jid.2019.06.134","article-title":"Conditional Alox12b knockout: degradation of the corneocyte lipid envelope in a mouse model of autosomal recessive congenital ichthyoses","volume":"140","author":"Krieg","year":"2020","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22018942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22018942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:29:55Z","timestamp":1758302995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22018942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0022202X22018942"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.029","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALOX12B and PNPLA1 Have Distinct Roles in Epidermal Lipid Lamellar Organization","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}