{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:33:36Z","timestamp":1777419216749,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009103","name":"Von-Behring-R\u00f6ntgen-Stiftung","doi-asserted-by":"publisher","award":["59-0012"],"award-info":[{"award-number":["59-0012"]}],"id":[{"id":"10.13039\/100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EM 80\/3-2"],"award-info":[{"award-number":["EM 80\/3-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE 1602\/16-2"],"award-info":[{"award-number":["HE 1602\/16-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TI 291\/10-2"],"award-info":[{"award-number":["TI 291\/10-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jid.2022.07.030","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T02:09:07Z","timestamp":1662689347000},"page":"254-263.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-6882","authenticated-orcid":false,"given":"Christoph","family":"Hudemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-7489","authenticated-orcid":false,"given":"Yvonne","family":"Exner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-516X","authenticated-orcid":false,"given":"Robert","family":"Pollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-1623","authenticated-orcid":false,"given":"Karina","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-3706","authenticated-orcid":false,"given":"Anna","family":"Zakrzewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-6596","authenticated-orcid":false,"given":"Simon","family":"Feldhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7021-2090","authenticated-orcid":false,"given":"Thomas","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1302-5421","authenticated-orcid":false,"given":"Volker","family":"Spindler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7850-3199","authenticated-orcid":false,"given":"David","family":"Rafei-Shamsabadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-4908","authenticated-orcid":false,"given":"Frauke","family":"V\u00f6llner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-5422","authenticated-orcid":false,"given":"Jens","family":"Waschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-1825","authenticated-orcid":false,"given":"Ritva","family":"Tikkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-2461","authenticated-orcid":false,"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-3360","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Eming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.07.030_bib1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/exd.13106","article-title":"Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology","volume":"25","author":"Ahmed","year":"2016","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/jid.2011.390","article-title":"Desmoglein as a target in skin disease and beyond","volume":"132","author":"Amagai","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib3","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s40265-018-0976-5","article-title":"Targeted therapies for autoimmune bullous diseases: current status","volume":"78","author":"Amber","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.jid.2022.07.030_bib4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/sj.jid.5701080","article-title":"Induction of p38MAPK and HSP27 phosphorylation in pemphigus patient skin","volume":"128","author":"Berkowitz","year":"2008","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib5","doi-asserted-by":"crossref","first-page":"23778","DOI":"10.1074\/jbc.M501365200","article-title":"Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization","volume":"280","author":"Berkowitz","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.07.030_bib6","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.celrep.2019.06.066","article-title":"Single-cell analysis suggests that ongoing affinity maturation drives the emergence of pemphigus vulgaris autoimmune disease","volume":"28","author":"Cho","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2022.07.030_bib7","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1074\/jbc.M710046200","article-title":"Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism","volume":"283","author":"Delva","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.07.030_bib8","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1172\/JCI64413","article-title":"Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface","volume":"122","author":"Di Zenzo","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.07.030_bib9","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3389\/fimmu.2019.01418","article-title":"Pemphigus: current and future therapeutic strategies","volume":"10","author":"Didona","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib10","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.4049\/jimmunol.1401081","article-title":"Pathogenic IgG antibodies against desmoglein 3 in pemphigus vulgaris are regulated by HLA-DRB1\u221704:02-restricted T cells","volume":"193","author":"Eming","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0190-9622(03)02160-1","article-title":"Conformational epitope mapping and IgG subclass distribution of desmoglein 3 in paraneoplastic pemphigus","volume":"49","author":"Futei","year":"2003","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/jid.2013.439","article-title":"A\u00a0new light on an old disease: adhesion signaling in pemphigus vulgaris","volume":"134","author":"Galichet","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.bbamem.2007.07.014","article-title":"Desmosome structure, composition and function","volume":"1778","author":"Garrod","year":"2008","journal-title":"Biochim biophys acta"},{"key":"10.1016\/j.jid.2022.07.030_bib14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1600-0625.2009.00934.x","article-title":"Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis","volume":"18","author":"Grando","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib15","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.1073\/pnas.1606272113","article-title":"Structural basis of adhesive binding by desmocollins and desmogleins","volume":"113","author":"Harrison","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.07.030_bib16","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.181.3.1825","article-title":"Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction","volume":"181","author":"Heupel","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib17","doi-asserted-by":"crossref","first-page":"8727","DOI":"10.1073\/pnas.95.15.8727","article-title":"Evidence for gene silencing by endogenous DNA methylation","volume":"95","author":"Holliday","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.07.030_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057587","article-title":"Pemphigus vulgaris autoantibody profiling by proteomic technique","volume":"8","author":"Kalantari-Dehaghi","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.jid.2022.07.030_bib19","doi-asserted-by":"crossref","first-page":"16916","DOI":"10.1074\/jbc.M113.472100","article-title":"Mechanisms of mitochondrial damage in keratinocytes by pemphigus vulgaris antibodies","volume":"288","author":"Kalantari-Dehaghi","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.07.030_bib20","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/08916930600971943","article-title":"Pathogenic monoclonal antibody against desmoglein 3 augments desmoglein 3 and p38 MAPK phosphorylation in human squamous carcinoma cell line","volume":"39","author":"Kawasaki","year":"2006","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jid.2022.07.030_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.kjms.2012.08.001","article-title":"New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease","volume":"29","author":"Kitajima","year":"2013","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.jid.2022.07.030_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/sj.jidsp.5640197","article-title":"Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell datachment induced by pemphigus IgG in cultured keratinocytes: involvement of protein kinase C","volume":"4","author":"Kitajima","year":"1999","journal-title":"J\u00a0Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jid.2022.07.030_bib23","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1083\/jcb.137.5.1091","article-title":"Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris","volume":"137","author":"Koch","year":"1997","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jid.2022.07.030_bib24","first-page":"1","article-title":"Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules","volume":"53","author":"Koch","year":"1990","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jid.2022.07.030_bib25","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/256495a0","article-title":"Continuous cultures of fused cells secreting antibody of predefined specificity","volume":"256","author":"K\u00f6hler","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.jid.2022.07.030_bib26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3389\/fimmu.2019.00626","article-title":"Role of Src and cortactin in pemphigus skin blistering","volume":"10","author":"Kugelmann","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib27","doi-asserted-by":"crossref","first-page":"12524","DOI":"10.1074\/jbc.M808204200","article-title":"Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis","volume":"284","author":"Lee","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.07.030_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/exd.12317","article-title":"Signalling pathways in pemphigus vulgaris","volume":"23","author":"Li","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1172\/JCI5252","article-title":"Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris","volume":"103","author":"Mahoney","year":"1999","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.07.030_bib30","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1074\/jbc.M110.172874","article-title":"p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris","volume":"286","author":"Mao","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.07.030_bib31","article-title":"p38 MAPK signaling in pemphigus: implications for skin autoimmunity","volume":"2013","author":"Mavropoulos","year":"2013","journal-title":"Autoimmune Dis"},{"key":"10.1016\/j.jid.2022.07.030_bib32","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1600-0625.2006.00451.x","article-title":"IgG reactivity against non-conformational NH-terminal epitopes of the desmoglein 3 ectodomain relates to clinical activity and phenotype of pemphigus vulgaris","volume":"15","author":"M\u00fcller","year":"2006","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0625.2007.00615.x","article-title":"IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris","volume":"17","author":"M\u00fcller","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib34","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1172\/JCI10305","article-title":"Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions","volume":"106","author":"Nguyen","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.07.030_bib35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0092-8674(90)90222-Z","article-title":"Localization of specificity determining sites in cadherin cell adhesion molecules","volume":"61","author":"Nose","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jid.2022.07.030_bib36","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/1523-1747.ep12289726","article-title":"Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate\/cytoskeleton fractions in human keratinocytes","volume":"108","author":"Osada","year":"1997","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib37","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2230.2011.04092.x","article-title":"The pathogenic role of autoantibodies in pemphigus vulgaris","volume":"36","author":"Pan","year":"2011","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12016-017-8662-z","article-title":"Pemphigus: a comprehensive review on pathogenesis, clinical presentation and novel therapeutic approaches","volume":"54","author":"Pollmann","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib39","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2133.2000.03328.x","article-title":"Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris","volume":"142","author":"Proby","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050696","article-title":"Signaling dependent and independent mechanisms in pemphigus vulgaris blister formation","volume":"7","author":"Saito","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.07.030_bib41","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/jid.2011.299","article-title":"An adult passive transfer mouse model to study desmoglein 3 signaling in pemphigus vulgaris","volume":"132","author":"Schulze","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib42","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.4049\/jimmunol.167.9.5439","article-title":"Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins","volume":"167","author":"Sekiguchi","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib43","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0014-4827(89)90047-5","article-title":"Involvement of protein kinase C in translocation of desmoplakins from cytosol to plasma membrane during desmosome formation in human squamous cell carcinoma cells grown in low to normal calcium concentration","volume":"185","author":"Sheu","year":"1989","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jid.2022.07.030_bib44","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/jid.2014.21","article-title":"Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling","volume":"134","author":"Spindler","year":"2014","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jid.2017.06.022","article-title":"Mechanisms causing loss of keratinocyte cohesion in pemphigus","volume":"138","author":"Spindler","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib46","doi-asserted-by":"crossref","first-page":"30556","DOI":"10.1074\/jbc.M109.024810","article-title":"Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus","volume":"284","author":"Spindler","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.07.030_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/15419061.2013.877000","article-title":"Desmosomal cadherins and signaling: lessons from autoimmune disease","volume":"21","author":"Spindler","year":"2014","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.jid.2022.07.030_bib48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0065-2776(08)60503-9","article-title":"Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid, bullous diseases due to defective epidermal cell adhesion","volume":"53","author":"Stanley","year":"1993","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/bj3620317","article-title":"Molecular interactions between desmosomal cadherins","volume":"362","author":"Syed","year":"2002","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2022.07.030_bib50","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.4049\/jimmunol.170.4.2170","article-title":"Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3","volume":"170","author":"Tsunoda","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib51","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.nano.2014.10.006","article-title":"Atomic force microscopy identifies regions of distinct desmoglein 3 adhesive properties on living keratinocytes","volume":"11","author":"Vielmuth","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jid.2022.07.030_bib52","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1038\/jid.2015.324","article-title":"Loss of desmoglein binding is not sufficient for keratinocyte dissociation in pemphigus","volume":"135","author":"Vielmuth","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1089\/15368590252917629","article-title":"Generation of monoclonal antibodies specific for desmoglein family members","volume":"21","author":"Wahl","year":"2002","journal-title":"Hybrid Hybridomics"},{"key":"10.1016\/j.jid.2022.07.030_bib54","doi-asserted-by":"crossref","first-page":"17866","DOI":"10.1074\/jbc.M607963200","article-title":"Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity","volume":"282","author":"Yamamoto","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.07.030_bib55","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.clim.2006.03.006","article-title":"Pathogenic human monoclonal antibody against desmoglein 3","volume":"120","author":"Yeh","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jid.2022.07.030_bib56","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2133.2012.10929.x","article-title":"Detection of antibodies against the non-calcium-dependent epitopes of desmoglein 3 in pemphigus vulgaris and their pathogenic significance","volume":"167","author":"Kamiya","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib57","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1600-0625.2006.00451.x","article-title":"IgG reactivity against non-conformational NH-terminal epitopes of the desmoglein 3 ectodomain relates to clinical activity and phenotype of pemphigus vulgaris","volume":"15","author":"M\u00fcller","year":"2006","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0625.2007.00615.x","article-title":"IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris","volume":"17","author":"M\u00fcller","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib59","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ajpath.2010.10.016","article-title":"IgG autoantibodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion [published correction appears in Am J Pathol 2013;182:610]","volume":"178","author":"Rafei","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2022.07.030_bib60","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.nano.2014.10.006","article-title":"Atomic force microscopy identifies regions of distinct desmoglein 3 adhesive properties on living keratinocytes","volume":"11","author":"Vielmuth","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jid.2022.07.030_bib61","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1038\/jid.2015.324","article-title":"Loss of desmoglein binding is not sufficient for keratinocyte dissociation in pemphigus","volume":"135","author":"Vielmuth","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.07.030_bib62","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3390\/cells11060942","article-title":"Stabilization of keratinocyte monolayer integrity in the presence of anti-desmoglein-3 antibodies through FcRn blockade with efgartigimod: novel treatment paradigm for pemphigus [published correction appears in Cells 2022;11:1700]?","volume":"11","author":"Zakrzewicz","year":"2022","journal-title":"Cells"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22019017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22019017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:50:57Z","timestamp":1762206657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22019017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0022202X22019017"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.030","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}