{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:24:09Z","timestamp":1790745849901,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173410"],"award-info":[{"award-number":["82173410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903208"],"award-info":[{"award-number":["81903208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SSha"],"award-info":[{"award-number":["SSha"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jid.2022.08.041","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T03:35:15Z","timestamp":1662435315000},"page":"197-208.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["CXCL12\/CXCR4 Axis Drives the Chemotaxis and Differentiation of B Cells in Bullous Pemphigoid"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-5863","authenticated-orcid":false,"given":"Hui","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-4636","authenticated-orcid":false,"given":"Ke","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-5906","authenticated-orcid":false,"given":"Tianyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-7270","authenticated-orcid":false,"given":"Qingyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4761-6673","authenticated-orcid":false,"given":"Erle","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9988-8924","authenticated-orcid":false,"given":"Yanghe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-9514","authenticated-orcid":false,"given":"Jieyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-0181","authenticated-orcid":false,"given":"Pei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-1199","authenticated-orcid":false,"given":"Jiaoling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-1413","authenticated-orcid":false,"given":"Jingyi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6312-8245","authenticated-orcid":false,"given":"Shengxian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-9616","authenticated-orcid":false,"given":"Bingyu","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-0399","authenticated-orcid":false,"given":"Yaxing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-5559","authenticated-orcid":false,"given":"Hongjiang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-1864","authenticated-orcid":false,"given":"Shuai","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-8080","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.08.041_bib2","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1073\/pnas.1621512114","article-title":"CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor","volume":"114","author":"Becker","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.08.041_bib3","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1038\/s41598-019-40203-7","article-title":"Author Correction: B-celldepletion induces a shift in self antigen specific B-cell repertoire and cytokine pattern in patients with bullous pemphigoid","volume":"9","author":"Berkani","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2022.08.041_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.658535","article-title":"Hematopoietic multipotent progenitors and plasma cells: neighbors or roommates in the mouse bone marrow ecosystem?","volume":"12","author":"Bonaud","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13075-018-1569-0","article-title":"Characterizationof inflammatory cell infiltrate of scleroderma skin: B cells and skin score progression","volume":"20","author":"Bosello","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jid.2022.08.041_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-immunol-092419-031130","article-title":"Age-associated B cells","volume":"38","author":"Cancro","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib7","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.4049\/jimmunol.1502448","article-title":"Age-associated B cells with proinflammatory characteristics are expanded in a proportion of multiple sclerosis patients","volume":"197","author":"Claes","year":"2016","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/cells9020523","article-title":"MYC\u2019s fine line between B cell development and malignancy","volume":"9","author":"de Barrios","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jid.2022.08.041_bib9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2020.02.013","article-title":"Autoimmune bullous skin diseases, pemphigus and pemphigoid","volume":"145","author":"Egami","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1615\/CritRevImmunol.v32.i4.30","article-title":"The role of the proto-oncogene c-myc in B lymphocyte differentiation","volume":"32","author":"Fernandez","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib11","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.3390\/cells9122627","article-title":"Skin-associated B cells in the pathogenesis of cutaneous autoimmune diseases-implications for therapeutic approaches","volume":"9","author":"Fetter","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jid.2022.08.041_bib12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1083\/jcb.200704173","article-title":"Myc stimulates B lymphocyte differentiation and amplifies calcium signaling","volume":"179","author":"Habib","year":"2007","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jid.2022.08.041_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-pathol-012615-044313","article-title":"Mechanisms of disease: pemphigus and bullous pemphigoid","volume":"11","author":"Hammers","year":"2016","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jid.2022.08.041_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1084\/jem.194.1.45","article-title":"A\u00a0coordinated change in chemokine responsiveness guides plasma cell movements","volume":"194","author":"Hargreaves","year":"2001","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.08.041_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/cmi.2017.107","article-title":"The unique structural and functional features of CXCL12","volume":"15","author":"Janssens","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/imr.12741","article-title":"Extrafollicular responses in humans and SLE","volume":"288","author":"Jenks","year":"2019","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2022.08.041_bib17","article-title":"Peripheral B cell subsets in autoimmune diseases: clinical implications and effects of B cell-targeted therapies","volume":"2020","author":"Jin","year":"2020","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.jid.2022.08.041_bib18","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/S0140-6736(17)30070-3","article-title":"First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial","volume":"389","author":"Joly","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2022.08.041_bib19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJMoa067752","article-title":"A\u00a0single cycle of rituximab for the treatment of severe pemphigus","volume":"357","author":"Joly","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2022.08.041_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41577-020-00446-2","article-title":"Transcriptional regulation of memory B cell differentiation","volume":"21","author":"Laidlaw","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41573-020-00092-2","article-title":"B\u00a0cell depletion therapies in autoimmune disease: advances and mechanistic insights","volume":"20","author":"Lee","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jid.2022.08.041_bib22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1046\/j.1523-1747.2003.12071.x","article-title":"Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in\u00a0vitro to synthesize autoantibodies","volume":"120","author":"Leyendeckers","year":"2003","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.08.041_bib23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41598-018-19226-z","article-title":"Dysfunction of CD19+CD24hiCD27+ B regulatory cells in patients with bullous pemphigoid","volume":"8","author":"Liu","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2022.08.041_bib24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/imr.12388","article-title":"Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?","volume":"270","author":"Low","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2022.08.041_bib25","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1084\/jem.20041185","article-title":"The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity","volume":"200","author":"Nie","year":"2004","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2022.08.041_bib26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"Nutt","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/exd.14228","article-title":"The role of dipeptidyl peptidase-4 in cutaneous disease","volume":"30","author":"Patel","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.08.041_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nri.2017.24","article-title":"Altered B cell signalling in autoimmunity","volume":"17","author":"Rawlings","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41583-019-0233-2","article-title":"B\u00a0cells in autoimmune and neurodegenerative central nervous system diseases","volume":"20","author":"Sabatino","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jid.2022.08.041_bib30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41569-018-0106-9","article-title":"The role of B cells in atherosclerosis","volume":"16","author":"Sage","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jid.2022.08.041_bib31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/CCID.S128144","article-title":"Pemphigoid gestationis: current perspectives","volume":"10","author":"S\u00e4vervall","year":"2017","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.jid.2022.08.041_bib32","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2022.08.041_bib33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stemcr.2015.01.011","article-title":"A\u00a0progesterone-CXCR4 axis controls mammary progenitor cell fate in the adult gland","volume":"4","author":"Shiah","year":"2015","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.jid.2022.08.041_bib34","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2022.08.041_bib35","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3389\/fimmu.2019.01238","article-title":"Dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid","volume":"10","author":"Tasanen","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib36","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ni.3175","article-title":"Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus","volume":"16","author":"Tipton","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib37","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.4049\/jimmunol.1002753","article-title":"B\u00a0lymphocyte commitment program is driven by the proto-oncogene c-Myc","volume":"186","author":"Vallespin\u00f3s","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2022.08.041_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.pharmtox.48.121806.154841","article-title":"Chemokines and their receptors: drug targets in immunity and inflammation","volume":"48","author":"Viola","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jid.2022.08.041_bib41","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.jid.2017.05.032","article-title":"Pivotal role of lesional and perilesional T\/B lymphocytes in pemphigus pathogenesis","volume":"137","author":"Yuan","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.08.041_bib42","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.4049\/jimmunol.1302209","article-title":"MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling","volume":"192","author":"Klasen","year":"2014","journal-title":"J\u00a0Immunol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22018930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22018930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:09:31Z","timestamp":1777417771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22018930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0022202X22018930"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.08.041","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CXCL12\/CXCR4 Axis Drives the Chemotaxis and Differentiation of B Cells in Bullous Pemphigoid","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}