{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:35:17Z","timestamp":1783427717337,"version":"3.54.6"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jid.2022.08.049","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T03:43:33Z","timestamp":1663040613000},"page":"328-331.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biomarkers of Tissue Turnover and Systemic Inflammation Are Associated with Disease Severity and Activity in Patients with Hidradenitis Suppurativa"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-1014","authenticated-orcid":false,"given":"Signe","family":"Holm Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig Skovlund","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-2767","authenticated-orcid":false,"given":"Yiqiu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4256-116X","authenticated-orcid":false,"given":"Astrid-Helene Ravn","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-6009","authenticated-orcid":false,"given":"Valdemar Wendelboe","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-8740","authenticated-orcid":false,"given":"Morten","family":"Karsdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-9297","authenticated-orcid":false,"given":"Anne-Christine","family":"Bay-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-300X","authenticated-orcid":false,"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.08.049_bib1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/bjd.14338","article-title":"Ustekinumab in hidradenitis suppurativa: clinical results and a search for potential biomarkers in serum","volume":"174","author":"Blok","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.08.049_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/14789450.2020.1773261","article-title":"Skin proteomics \u2013 analysis of the extracellular matrix in health and disease","volume":"17","author":"Dengjel","year":"2020","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.jid.2022.08.049_bib3","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1016\/S2665-9913(20)30385-4","article-title":"Circulating collagen neo-epitopes and their role in the prediction of fibrosis in patients with systemic sclerosis: a multicentre cohort study","volume":"3","author":"Dobrota","year":"2021","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.jid.2022.08.049_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.2010.531","article-title":"Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts","volume":"80","author":"Gansevoort","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.jid.2022.08.049_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fmed.2019.00253","article-title":"A\u00a0scoping review of non-invasive imaging modalities in dermatological disease: potential novel biomarkers in hidradenitis suppurativa","volume":"6","author":"Grand","year":"2019","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jid.2022.08.049_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120971","article-title":"S100A8\/A9 stimulates keratinocyte proliferation in the development of squamous cell carcinoma of the skin via the receptor for advanced glycation-end products","volume":"10","author":"Iotzova-Weiss","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.08.049_bib7","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/jdv.16183","article-title":"Defining hidradenitis suppurativa phenotypes based on the elementary lesion pattern: results of a prospective study","volume":"34","author":"Martorell","year":"2020","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.08.049_bib8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-2133.2007.08332.x","article-title":"Long-term efficacy of a single course of infliximab in hidradenitis suppurativa","volume":"158","author":"Mekkes","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.08.049_bib9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/ecco-jcc\/jjv123","article-title":"Fragments of citrullinated and MMP-degraded vimentin and MMP-degraded type III collagen are novel serological biomarkers to differentiate crohn\u2019s disease from ulcerative colitis","volume":"9","author":"Mortensen","year":"2015","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.jid.2022.08.049_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.360","article-title":"Liver enzyme levels are associated with markers of systemic inflammation, disease severity, and metabolic syndrome in patients with hidradenitis suppurativa","volume":"4","author":"Nielsen","year":"2021","journal-title":"Health Sci Rep"},{"key":"10.1016\/j.jid.2022.08.049_bib11","first-page":"e21","article-title":"Further histological and cellular characterization of hidradenitis suppurativa in 11 patients","volume":"19","author":"Nisar","year":"2019","journal-title":"EPlasty"},{"key":"10.1016\/j.jid.2022.08.049_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/adt.2017.820","article-title":"Development of a neo-epitope specific assay for serological assessment of Type VII collagen turnover and its relevance in fibroproliferative disorders","volume":"16","author":"Sand","year":"2018","journal-title":"Assay Drug Dev Technol"},{"key":"10.1016\/j.jid.2022.08.049_bib13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2133.2009.09198.x","article-title":"Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity","volume":"161","author":"Sartorius","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.08.049_bib14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1365-2133.2012.10807.x","article-title":"Treatment of severe hidradenitis suppurativa with infliximab in combination with surgical interventions","volume":"167","author":"Van Rappard","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.08.049_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12102786","article-title":"Granzyme B degraded type IV collagen products in serum identify melanoma patients responding to immune checkpoint blockade","volume":"12","author":"Jensen","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jid.2022.08.049_bib16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3109\/1354750X.2011.620628","article-title":"A\u00a0novel marker for assessment of liver matrix remodeling: an enzyme-linked immunosorbent assay (ELISA) detecting a MMP generated type I collagen neo-epitope (C1M)","volume":"16","author":"Leeming","year":"2011","journal-title":"Biomarkers"},{"key":"10.1016\/j.jid.2022.08.049_bib17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1872-034X.2011.00946.x","article-title":"Enzyme-linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): a marker related to the extracellular matrix remodeling during liver fibrogenesis","volume":"42","author":"Leeming","year":"2012","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jid.2022.08.049_bib18","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/ecco-jcc\/jjac047","article-title":"A\u00a0specific calprotectin neo-epitope (CPa9-HNE) in serum from inflammatory bowel disease patients is associated with neutrophil activity and endoscopic severity","volume":"16","author":"Mortensen","year":"2022","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.jid.2022.08.049_bib19","first-page":"303","article-title":"The neo-epitope specific PRO-C3 ELISA measures true formation of type III collagen associated with liver and muscle parameters","volume":"5","author":"Nielsen","year":"2013","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jid.2022.08.049_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084934","article-title":"MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays","volume":"8","author":"Sand","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.08.049_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/adt.2017.820","article-title":"Development of a neo-epitope specific assay for serological assessment of Type VII collagen turnover and its relevance in fibroproliferative disorders","volume":"16","author":"Sand","year":"2018","journal-title":"Assay Drug Dev Technol"},{"key":"10.1016\/j.jid.2022.08.049_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144525","article-title":"Collagen Type III and VI turnover in response to long-term immobilization","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.08.049_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1479-5876-10-140","article-title":"Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker","volume":"10","author":"Vassiliadis","year":"2012","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.jid.2022.08.049_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-5945-11-6","article-title":"Measurement of matrix metalloproteinase 9-mediated collagen type III degradation fragment as a marker of skin fibrosis","volume":"11","author":"Vassiliadis","year":"2011","journal-title":"BMC Dermatol"},{"key":"10.1016\/j.jid.2022.08.049_bib25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.clinbiochem.2012.02.007","article-title":"MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis","volume":"45","author":"Veidal","year":"2012","journal-title":"Clin Biochem"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22019054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22019054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:50:47Z","timestamp":1762206647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22019054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0022202X22019054"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.08.049","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers of Tissue Turnover and Systemic Inflammation Are Associated with Disease Severity and Activity in Patients with Hidradenitis Suppurativa","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.08.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}