{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:16:20Z","timestamp":1783664180413,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571917"],"award-info":[{"award-number":["81571917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772100"],"award-info":[{"award-number":["81772100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003371"],"award-info":[{"award-number":["82003371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20YF1423600"],"award-info":[{"award-number":["20YF1423600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jid.2022.09.657","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T04:45:02Z","timestamp":1665636302000},"page":"566-577.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Apelin Receptor Can Act as a Specific Marker and Promising Therapeutic Target for Infantile Hemangioma"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-0112","authenticated-orcid":false,"given":"Qianyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-5724","authenticated-orcid":false,"given":"Hanru","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-9901","authenticated-orcid":false,"given":"Zhang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-984X","authenticated-orcid":false,"given":"Lei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-6116","authenticated-orcid":false,"given":"Zongan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8445-0823","authenticated-orcid":false,"given":"Jialin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-6725","authenticated-orcid":false,"given":"Shih-Jen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2628-254X","authenticated-orcid":false,"given":"Yajing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-1367","authenticated-orcid":false,"given":"Xiaoxi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.09.657_bib1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00431-015-2561-1","article-title":"Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma","volume":"174","author":"Aly","year":"2015","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jid.2022.09.657_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1067\/mjd.2000.111632","article-title":"Differential expression of active mitogen-activated protein kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy","volume":"44","author":"Arbiser","year":"2001","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2022.09.657_bib3","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1172\/JCI80102","article-title":"RAP1-mediated MEK\/ERK pathway defects in Kabuki syndrome","volume":"125","author":"B\u00f6gershausen","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.09.657_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10456-009-9148-2","article-title":"Vasculogenesis in infantile hemangioma","volume":"12","author":"Boscolo","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jid.2022.09.657_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/bjd.12417","article-title":"Propranolol-resistant infantile haemangiomas","volume":"169","author":"Causs\u00e9","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.09.657_bib7","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1097\/SCS.0000000000004152","article-title":"Intralesional bleomycin injection for propranolol-resistant hemangiomas","volume":"29","author":"Chang","year":"2018","journal-title":"J\u00a0Craniofac Surg"},{"key":"10.1016\/j.jid.2022.09.657_bib8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1542\/peds.2007-2767","article-title":"Growth characteristics of infantile hemangiomas: implications for management","volume":"122","author":"Chang","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jid.2022.09.657_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1139\/bcb-2014-0072","article-title":"The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR","volume":"92","author":"Chapman","year":"2014","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.jid.2022.09.657_bib10","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.7150\/thno.34713","article-title":"APLN promotes hepatocellular carcinoma through activating PI3K\/Akt pathway and is a druggable target","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jid.2022.09.657_bib11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrclinonc.2009.94","article-title":"Adverse effects of anticancer agents that target the VEGF pathway","volume":"6","author":"Chen","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jid.2022.09.657_bib12","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/hep.31545","article-title":"The apelin-apelin receptor axis triggers cholangiocyte proliferation and liver fibrosis during mouse models of cholestasis","volume":"73","author":"Chen","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jid.2022.09.657_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ydbio.2006.04.452","article-title":"Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo","volume":"296","author":"Cox","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2022.09.657_bib14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jaad.2010.06.048","article-title":"Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants","volume":"65","author":"de Graaf","year":"2011","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2022.09.657_bib15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1542\/peds.2012-1691","article-title":"Initiation and use of propranolol for infantile hemangioma: report of a consensus conference","volume":"131","author":"Drolet","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.jid.2022.09.657_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/ped.13830","article-title":"Infantile hemangioma: efficacy of low-dose propranolol and of intralesional bleomycin injection for propranolol non-response","volume":"61","author":"D\u00fczenli Kar","year":"2019","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jid.2022.09.657_bib17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00431-020-03872-5","article-title":"Recurrence rate of infantile hemangioma after oral propranolol therapy","volume":"180","author":"Frongia","year":"2021","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jid.2022.09.657_bib18","doi-asserted-by":"crossref","first-page":"16349","DOI":"10.1074\/jbc.274.23.16349","article-title":"Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner","volume":"274","author":"Fujio","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.09.657_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.canlet.2016.11.025","article-title":"Inhibition of the apelin\/apelin receptor axis decreases cholangiocarcinoma growth","volume":"386","author":"Hall","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jid.2022.09.657_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/0253-7613.150337","article-title":"Effects of bleomycin A5 on caspase-3, P53, bcl-2 expression and telomerase activity in vascular endothelial cells","volume":"47","author":"Huang","year":"2015","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.jid.2022.09.657_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fsurg.2014.00038","article-title":"Biology of infantile hemangioma","volume":"1","author":"Itinteang","year":"2014","journal-title":"Front Surg"},{"key":"10.1016\/j.jid.2022.09.657_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1756-8722-7-13","article-title":"Signaling pathways in the development of infantile hemangioma","volume":"7","author":"Ji","year":"2014","journal-title":"J\u00a0Hematol Oncol"},{"key":"10.1016\/j.jid.2022.09.657_bib23","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm.1877","article-title":"Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma","volume":"14","author":"Jinnin","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2022.09.657_bib24","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.3390\/ijms23095140","article-title":"Is infantile hemangioma a neuroendocrine tumor?","volume":"23","author":"Kaulanjan-Checkmodine","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2022.09.657_bib25","first-page":"2592","article-title":"Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice","volume":"118","author":"Khan","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.09.657_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1182\/blood-2006-03-006478","article-title":"Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin","volume":"108","author":"Khan","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jid.2022.09.657_bib27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/sj.emboj.7601982","article-title":"Spatial and temporal role of the apelin\/APJ system in the caliber size regulation of blood vessels during angiogenesis","volume":"27","author":"Kidoya","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2022.09.657_bib28","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1161\/ATVBAHA.107.150284","article-title":"Hypoxia-induced mediators of stem\/progenitor cell trafficking are increased in children with hemangioma","volume":"27","author":"Kleinman","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2022.09.657_bib29","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/01.RES.0000259593.07661.1e","article-title":"Endothelial cell migration during angiogenesis","volume":"100","author":"Lamalice","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jid.2022.09.657_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(16)00645-0","article-title":"Infantile haemangioma","volume":"390","author":"L\u00e9aut\u00e9-Labr\u00e8ze","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2022.09.657_bib31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1056\/NEJMoa1404710","article-title":"A\u00a0randomized, controlled trial of oral propranolol in infantile hemangioma","volume":"372","author":"L\u00e9aut\u00e9-Labr\u00e8ze","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2022.09.657_bib32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ajhg.2016.06.010","article-title":"GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activation","volume":"99","author":"Lim","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2022.09.657_bib33","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1038\/ncomms7020","article-title":"Genetic targeting of sprouting angiogenesis using Apln-CreER","volume":"6","author":"Liu","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.09.657_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014476","article-title":"Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration","volume":"5","author":"Logie","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.09.657_bib35","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1016\/j.jpedsurg.2013.08.020","article-title":"Effect of propranolol vs prednisolone vs propranolol with prednisolone in the management of infantile hemangioma: a randomized controlled study","volume":"48","author":"Malik","year":"2013","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.jid.2022.09.657_bib36","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1016\/j.bmcl.2012.08.105","article-title":"Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor","volume":"22","author":"Maloney","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jid.2022.09.657_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2018690118","article-title":"Critical role of Aquaporin-1 and telocytes in infantile hemangioma response to propranolol beta blockade","volume":"118","author":"Moisan","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.09.657_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0046-8177(00)80192-6","article-title":"GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas","volume":"31","author":"North","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jid.2022.09.657_bib39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0378-1119(93)90495-O","article-title":"A\u00a0human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11","volume":"136","author":"O'Dowd","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.jid.2022.09.657_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling - in control of vascular function","volume":"7","author":"Olsson","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jid.2022.09.657_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43026","article-title":"R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma","volume":"8","author":"Overman","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jid.2022.09.657_bib42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ejca.2013.11.017","article-title":"Tumour co-expression of apelin and its receptor is the basis of an autocrine loop involved in the growth of colon adenocarcinomas","volume":"50","author":"Picault","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jid.2022.09.657_bib43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/pde.12422","article-title":"Eighteen cases of soft tissue atrophy after intralesional bleomycin a5 injections for the treatment of infantile hemangiomas: a long-term follow-up","volume":"32","author":"Qiu","year":"2015","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jid.2022.09.657_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151109","article-title":"Non-beta blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma","volume":"132","author":"Seebauer","year":"2022","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.09.657_bib45","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1242\/dev.137919","article-title":"Vegfa signals through ERK to promote angiogenesis, but not artery differentiation","volume":"143","author":"Shin","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.jid.2022.09.657_bib46","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nature05577","article-title":"Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries","volume":"445","author":"Siekmann","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jid.2022.09.657_bib47","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.ajpath.2012.08.030","article-title":"E-selectin mediates stem cell adhesion and formation of blood vessels in a murine model of infantile hemangioma","volume":"181","author":"Smadja","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2022.09.657_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008283","article-title":"Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis","volume":"4","author":"Srinivasan","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.09.657_bib49","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/emboj\/20.11.2768","article-title":"A\u00a0single autophosphorylation site on KDR\/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells","volume":"20","author":"Takahashi","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2022.09.657_bib50","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809266","article-title":"Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy","volume":"11","author":"Uribesalgo","year":"2019","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jid.2022.09.657_bib51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.devcel.2016.03.015","article-title":"The complexity of translating anti-angiogenesis therapy from basic science to the clinic","volume":"37","author":"Ye","year":"2016","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2022.09.657_bib52","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/01.PRS.0000170804.80834.5F","article-title":"Circulating level of vascular endothelial growth factor in differentiating hemangioma from vascular malformation patients","volume":"116","author":"Zhang","year":"2005","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jid.2022.09.657_bib53","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.celrep.2018.10.015","article-title":"Apj+ vessels drive tumor growth and represent a tractable therapeutic target [published correction appears in Cell Rep 2022;41:111450","volume":"25","author":"Zhao","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2022.09.657_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ab.2013.07.006","article-title":"Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma","volume":"442","author":"Zhen","year":"2013","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jid.2022.09.657_bib55","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1158\/1078-0432.CCR-18-3533","article-title":"LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by enhancing HIF1A protein translation","volume":"25","author":"Huang","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jid.2022.09.657_bib56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00666038","article-title":"Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors","volume":"36","author":"Weidner","year":"1995","journal-title":"Breast Cancer Res Treat"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22026434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22026434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:51:10Z","timestamp":1762206670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22026434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0022202X22026434"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.09.657","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apelin Receptor Can Act as a Specific Marker and Promising Therapeutic Target for Infantile Hemangioma","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.09.657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}