{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:22:59Z","timestamp":1781731379190,"version":"3.54.5"},"reference-count":98,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004739","name":"CAS Youth Innovation Promotion","doi-asserted-by":"publisher","award":["2020276"],"award-info":[{"award-number":["2020276"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDA160101XX"],"award-info":[{"award-number":["XDA160101XX"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB38020400"],"award-info":[{"award-number":["XDB38020400"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YSBR-077"],"award-info":[{"award-number":["YSBR-077"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92249302"],"award-info":[{"award-number":["92249302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471385"],"award-info":[{"award-number":["31471385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070730"],"award-info":[{"award-number":["32070730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673104"],"award-info":[{"award-number":["81673104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2017SHZDZX01"],"award-info":[{"award-number":["2017SHZDZX01"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21JC1406400"],"award-info":[{"award-number":["21JC1406400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0103500"],"award-info":[{"award-number":["2017YFA0103500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0102800"],"award-info":[{"award-number":["2017YFA0102800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jid.2022.11.016","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T02:08:22Z","timestamp":1671847702000},"page":"1062-1072.e25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Variants in Telomerase Reverse Transcriptase Contribute to Solar Lentigines"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-5706","authenticated-orcid":false,"given":"Qianqian","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-127X","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6005-417X","authenticated-orcid":false,"given":"Anke","family":"Huels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-5097","authenticated-orcid":false,"given":"Canfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-1342","authenticated-orcid":false,"given":"Yao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-197X","authenticated-orcid":false,"given":"Wenqing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-5426","authenticated-orcid":false,"given":"Xiyang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4179-7533","authenticated-orcid":false,"given":"Yuepu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-9374","authenticated-orcid":false,"given":"Tamara","family":"Schikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3411-8686","authenticated-orcid":false,"given":"Katja","family":"Merches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-1265","authenticated-orcid":false,"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5713-0103","authenticated-orcid":false,"given":"Yajun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-0620","authenticated-orcid":false,"given":"Jiucun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-2212","authenticated-orcid":false,"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-2321","authenticated-orcid":false,"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-9199","authenticated-orcid":false,"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-1517","authenticated-orcid":false,"given":"Jean","family":"Krutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-7867","authenticated-orcid":false,"given":"Sijia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.11.016_bib1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41467-018-08147-0","article-title":"A\u00a0GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia","volume":"10","author":"Adhikari","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.11.016_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13073-021-00827-9","article-title":"Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility","volume":"13","author":"Adolphe","year":"2021","journal-title":"Genome Med"},{"key":"10.1016\/j.jid.2022.11.016_bib3","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bbrc.2016.08.094","article-title":"Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1","volume":"478","author":"Ali","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2022.11.016_bib4","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.0022-202X.2005.23721.x","article-title":"Upregulation of the IFN-gamma-stimulated genes in the development of delayed pigmented spots on the dorsal skin of F1 mice of HR-1 x HR\/De","volume":"124","author":"Aoki","year":"2005","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib5","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/j.1365-2133.2007.07830.x","article-title":"Gene expression profiling analysis of solar lentigo in relation to immunohistochemical characteristics","volume":"156","author":"Aoki","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib6","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.1365-4632.2009.04374.x","article-title":"Study of telomerase reverse transcriptase (hTERT) expression in normal, aged, and photo-aged skin","volume":"49","author":"Attia","year":"2010","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000495404","article-title":"Keratinocytic malfunction as a trigger for the development of solar lentigines","volume":"6","author":"Barysch","year":"2019","journal-title":"Dermatopathology (Basel)"},{"key":"10.1016\/j.jid.2022.11.016_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ng.2566","article-title":"Multiple independent variants at the tert locus are associated with telomere length and risks of breast and ovarian cancer","volume":"45","author":"Bojesen","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1600-0625.2009.00957.x","article-title":"The role of keratinocyte growth factor in melanogenesis: a possible mechanism for the initiation of solar lentigines","volume":"19","author":"Chen","year":"2010","journal-title":"Exp Dermatol"},{"issue":"422\u20137","key":"10.1016\/j.jid.2022.11.016_bib11","first-page":"427e1\u20122","article-title":"Identification of seven loci affecting mean telomere length and their association with disease","volume":"45","author":"Codd","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib12","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1038\/s41467-019-10443-2","article-title":"Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies","volume":"10","author":"Dorajoo","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.11.016_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cbpc.2011.05.005","article-title":"Characterization of telomeres and telomerase expression in Xiphophorus","volume":"155","author":"Downs","year":"2012","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1016\/j.jid.2022.11.016_bib14","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ajhb.22678","article-title":"Association study confirms the role of two OCA2 polymorphisms in normal skin pigmentation variation in East Asian populations","volume":"27","author":"Eaton","year":"2015","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.jid.2022.11.016_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000867","article-title":"Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation","volume":"6","author":"Edwards","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib16","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.1038\/s41598-018-27145-2","article-title":"Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations","volume":"8","author":"Endo","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2022.11.016_bib17","doi-asserted-by":"crossref","first-page":"e345","DOI":"10.1111\/j.1468-3083.2012.04685.x","article-title":"Freckles and solar lentigines have different risk factors in Caucasian women","volume":"27","author":"Ezzedine","year":"2013","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2022.11.016_bib18","doi-asserted-by":"crossref","first-page":"R88","DOI":"10.1093\/hmg\/ddab007","article-title":"Evolutionary genetics of skin pigmentation in African populations","volume":"30","author":"Feng","year":"2021","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jdermsci.2016.12.017","article-title":"Genetic variants associated with skin aging in the Chinese Han population","volume":"86","author":"Gao","year":"2017","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13059-016-0926-z","article-title":"Systematic identification of genetic influences on methylation across the human life course","volume":"17","author":"Gaunt","year":"2016","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2022.11.016_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biochi.2020.11.015","article-title":"Fundamental insights into the interaction between telomerase\/tert and intracellular signaling pathways","volume":"181","author":"Ghareghomi","year":"2021","journal-title":"Biochimie"},{"key":"10.1016\/j.jid.2022.11.016_bib22","doi-asserted-by":"crossref","first-page":"D1311","DOI":"10.1093\/nar\/gkaa840","article-title":"Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics","volume":"49","author":"Ghoussaini","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.11.016_bib23","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/bjd.20483","article-title":"Air pollution-induced tanning of human skin","volume":"185","author":"Grether-Beck","year":"2021","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008021","article-title":"Why some women look young for their age","volume":"4","author":"Gunn","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.11.016_bib25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2133.2008.08963.x","article-title":"FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo","volume":"160","author":"Hafner","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.5021\/ad.2015.27.5.626","article-title":"Possible involvement of keratinocyte growth factor in the persistence of hyperpigmentation in both human facial solar lentigines and Melasma","volume":"27","author":"Hasegawa","year":"2015","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib27","doi-asserted-by":"crossref","first-page":"67203","DOI":"10.18632\/oncotarget.18226","article-title":"Functional dissection of breast cancer risk-associated tert promoter variants","volume":"8","author":"Helbig","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2022.11.016_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.celrep.2014.03.016","article-title":"Linkage of DNA methylation quantitative trait loci to human cancer risk","volume":"7","author":"Heyn","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2022.11.016_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1034\/j.1600-0749.2002.02052.x","article-title":"Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless mice","volume":"15","author":"Hirobe","year":"2002","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2022.11.016_bib30","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jid.2015.12.045","article-title":"Traffic-related air pollution contributes to development of facial lentigines: further epidemiological evidence from Caucasians and Asians","volume":"136","author":"H\u00fcls","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib31","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/jid.2015.62","article-title":"A\u00a0genome-wide association study identifies the skin color genes IRF4, MC1R, ASIP, and BNC2 influencing facial pigmented spots","volume":"135","author":"Jacobs","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib32","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/s41588-019-0530-8","article-title":"A\u00a0resource-efficient tool for mixed model association analysis of large-scale data","volume":"51","author":"Jiang","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/ajhb.23734","article-title":"MC1R diversity and its role in skin pigmentation variation in West Maharashtra, India","volume":"34","author":"Jonnalagadda","year":"2022","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.jid.2022.11.016_bib34","first-page":"118","article-title":"The evolution of skin pigmentation-associated variation in West Eurasia","author":"Ju","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2022.11.016_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004722","article-title":"Integrating functional data to prioritize causal variants in statistical fine-mapping studies","volume":"10","author":"Kichaev","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib36","doi-asserted-by":"crossref","first-page":"684","DOI":"10.18632\/oncotarget.6331","article-title":"The tert promoter SNP rs2853669 decreases E2F1 transcription factor binding and increases mortality and recurrence risks in liver cancer","volume":"7","author":"Ko","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2022.11.016_bib37","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1365-2133.2010.09946.x","article-title":"Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo","volume":"163","author":"Kovacs","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib38","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/pcmr.12502","article-title":"A\u00a0genome-wide association study in Caucasian women suggests the involvement of HLA genes in the severity of facial solar lentigines","volume":"29","author":"Laville","year":"2016","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2022.11.016_bib39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ajhg.2020.02.006","article-title":"Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length","volume":"106","author":"Li","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib40","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jdermsci.2010.06.006","article-title":"Immuno-histochemical evaluation of solar lentigines: the association of KGF\/KGFR and other factors with lesion development","volume":"59","author":"Lin","year":"2010","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jdermsci.2019.08.010","article-title":"Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population","volume":"96","author":"Liu","year":"2019","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib42","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41467-017-02697-5","article-title":"GWAS of epigenetic aging rates in blood reveals a critical role for tert","volume":"9","author":"Lu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.11.016_bib43","doi-asserted-by":"crossref","first-page":"301.e1","DOI":"10.1016\/j.urolonc.2019.01.014","article-title":"The tert locus genotypes of rs2736100-CC\/CA and rs2736098-AA predict shorter survival in renal cell carcinoma","volume":"37","author":"Ma","year":"2019","journal-title":"Urol Oncol"},{"key":"10.1016\/j.jid.2022.11.016_bib44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13059-021-02398-9","article-title":"Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging","volume":"22","author":"McCartney","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2022.11.016_bib45","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41588-020-0631-4","article-title":"Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics","volume":"52","author":"Morrison","year":"2020","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib46","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0749.2007.00364.x","article-title":"Effect of Val92Met and Arg163Gln variants of the MC1R gene on freckles and solar lentigines in Japanese","volume":"20","author":"Motokawa","year":"2007","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2022.11.016_bib47","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/sj.jid.5701192","article-title":"Polymorphism patterns in the promoter region of the MC1R gene are associated with development of freckles and solar lentigines","volume":"128","author":"Motokawa","year":"2008","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib48","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41588-021-00945-5","article-title":"An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci","volume":"53","author":"Mountjoy","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/hgv.2015.58","article-title":"Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations","volume":"2","author":"Murray","year":"2015","journal-title":"Hum Genome Var"},{"key":"10.1016\/j.jid.2022.11.016_bib50","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/exd.12690","article-title":"Environment-induced lentigines: formation of solar lentigines beyond ultraviolet radiation","volume":"24","author":"Nakamura","year":"2015","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib51","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1530\/JME-16-0195","article-title":"Tert biology and function in cancer: beyond immortalisation","volume":"58","author":"Pestana","year":"2017","journal-title":"J\u00a0Mol Endocrinol"},{"key":"10.1016\/j.jid.2022.11.016_bib52","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1093\/hmg\/ddt355","article-title":"A\u00a0genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk","volume":"22","author":"Pooley","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib53","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.3951","article-title":"Genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry","volume":"5","author":"Rawofi","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.jid.2022.11.016_bib54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00239-019-09902-7","article-title":"The evolutionary history of human skin pigmentation","volume":"88","author":"Rocha","year":"2020","journal-title":"J\u00a0Mol Evol"},{"key":"10.1016\/j.jid.2022.11.016_bib55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1465-9921-6-152","article-title":"Long-term air pollution exposure and living close to busy roads are associated with COPD in women","volume":"6","author":"Schikowski","year":"2005","journal-title":"Respir Res"},{"key":"10.1016\/j.jid.2022.11.016_bib56","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.ijheh.2018.06.002","article-title":"Traffic-related air pollution and eczema in the elderly: findings from the SALIA cohort","volume":"221","author":"Schnass","year":"2018","journal-title":"Int J Hyg Environ Health"},{"key":"10.1016\/j.jid.2022.11.016_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/srep45704","article-title":"Genetic and epigenetic alterations of tert are associated with inferior outcome in adolescent and young adult patients with melanoma","volume":"7","author":"Seynnaeve","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2022.11.016_bib58","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/carcin\/bgs325","article-title":"Tert polymorphisms modify the risk of acute lymphoblastic leukemia in Chinese children","volume":"34","author":"Sheng","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jid.2022.11.016_bib59","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jid.2020.08.007","article-title":"GWAS analysis of 17,019 Korean women identifies the variants associated with facial pigmented spots","volume":"141","author":"Shin","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib60","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/jid.2011.350","article-title":"Development of lentigines in German and Japanese women correlates with variants in the SLC45A2 gene","volume":"132","author":"Vierk\u00f6tter","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jdermsci.2008.10.001","article-title":"The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing","volume":"53","author":"Vierk\u00f6tter","year":"2009","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib62","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/jid.2010.204","article-title":"Airborne particle exposure and extrinsic skin aging","volume":"130","author":"Vierk\u00f6tter","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib63","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gky057","article-title":"an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome","volume":"46","author":"Wang","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.11.016_bib64","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/1471-2458-9-223","article-title":"Rationales, design and recruitment of the Taizhou Longitudinal Study","volume":"9","author":"Wang","year":"2009","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jid.2022.11.016_bib65","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2022.11.016_bib66","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/exd.12496","article-title":"Accelerated differentiation of melanocyte stem cells contributes to the formation of hyperpigmented maculae","volume":"23","author":"Yamada","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib67","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/exd.13949","article-title":"UV irradiation-induced DNA hypomethylation around WNT1 gene: implications for solar lentigines","volume":"28","author":"Yamada","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib68","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ng.3390","article-title":"Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index","volume":"47","author":"Yang","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib69","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1093\/molbev\/msy136","article-title":"Darwinian positive selection on the pleiotropic effects of KITLG explain skin pigmentation and winter temperature adaptation in eurasians","volume":"35","author":"Yang","year":"2018","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jid.2022.11.016_bib70","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/molbev\/msw003","article-title":"A\u00a0genetic mechanism for convergent skin lightening during recent human evolution","volume":"33","author":"Yang","year":"2016","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jid.2022.11.016_bib71","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1038\/s41388-019-0872-9","article-title":"Mechanisms underlying the activation of tert transcription and telomerase activity in human cancer: old actors and new players","volume":"38","author":"Yuan","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.jid.2022.11.016_bib72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13073-021-00827-9","article-title":"Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility","volume":"13","author":"Adolphe","year":"2021","journal-title":"Genome Med"},{"key":"10.1016\/j.jid.2022.11.016_bib73","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2022.11.016_bib74","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ng.2566","article-title":"Multiple independent variants at the tert locus are associated with telomere length and risks of breast and ovarian cancer","volume":"45","author":"Bojesen","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib96","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"Cawthon","year":"2002","journal-title":"Nucleic acids research"},{"key":"10.1016\/j.jid.2022.11.016_bib75","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ng.2528","article-title":"Identification of seven loci affecting mean telomere length and their association with disease","volume":"45","author":"Codd","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib76","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1038\/s41467-019-10443-2","article-title":"Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies","volume":"10","author":"Dorajoo","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.11.016_bib77","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.envint.2018.12.047","article-title":"Tropospheric ozone and skin aging: results from two German cohort studies","volume":"124","author":"Fuks","year":"2019","journal-title":"Environ Int"},{"key":"10.1016\/j.jid.2022.11.016_bib78","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jdermsci.2016.12.017","article-title":"Genetic variants associated with skin aging in the Chinese Han population","volume":"86","author":"Gao","year":"2017","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib79","doi-asserted-by":"crossref","first-page":"D1311","DOI":"10.1093\/nar\/gkaa840","article-title":"Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics","volume":"49","author":"Ghoussaini","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2022.11.016_bib97","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jid.2022.11.016_bib80","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostat (Oxf Engl)"},{"key":"10.1016\/j.jid.2022.11.016_bib81","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4161\/epi.1.3.3327","article-title":"Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector","volume":"1","author":"Klug","year":"2006","journal-title":"Epigenetics"},{"key":"10.1016\/j.jid.2022.11.016_bib82","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ajhg.2020.02.006","article-title":"Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length","volume":"106","author":"Li","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib83","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jdermsci.2015.04.001","article-title":"Epidemiological evidence that indoor air pollution from cooking with solid fuels\u00a0accelerates skin aging in Chinese women","volume":"79","author":"Li","year":"2015","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib84","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jdermsci.2019.08.010","article-title":"Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population","volume":"96","author":"Liu","year":"2019","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib85","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41467-017-02697-5","article-title":"GWAS of epigenetic aging rates in blood reveals a critical role for tert","volume":"9","author":"Lu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.11.016_bib98","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jid.2019.11.003","article-title":"Research Techniques Made Simple: Cutaneous Colorimetry: A Reliable Technique for Objective Skin Color Measurement","volume":"140","author":"Ly","year":"2020","journal-title":"The Journal of investigative dermatology"},{"key":"10.1016\/j.jid.2022.11.016_bib86","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13059-021-02398-9","article-title":"Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging","volume":"22","author":"McCartney","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2022.11.016_bib87","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41588-020-0631-4","article-title":"Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics","volume":"52","author":"Morrison","year":"2020","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib88","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41588-021-00945-5","article-title":"An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci","volume":"53","author":"Mountjoy","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib89","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1093\/hmg\/ddt355","article-title":"A\u00a0genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk","volume":"22","author":"Pooley","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2022.11.016_bib90","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2022.11.016_bib91","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/bioinformatics\/bts680","article-title":"A\u00a0beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data","volume":"29","author":"Teschendorff","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2022.11.016_bib92","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jdermsci.2016.05.011","article-title":"Extrinsic skin ageing in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and anatomical site","volume":"83","author":"Vierk\u00f6tter","year":"2016","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib93","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jdermsci.2008.10.001","article-title":"The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing","volume":"53","author":"Vierk\u00f6tter","year":"2009","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.11.016_bib94","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/jid.2010.204","article-title":"Airborne particle exposure and extrinsic skin aging","volume":"130","author":"Vierk\u00f6tter","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.11.016_bib99","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.jid.2021.07.186","article-title":"A Genome-Wide Scan on Individual Typology Angle Found Variants at SLC24A2 Associated with Skin Color Variation in Chinese Populations","volume":"142","author":"Wang","year":"2022","journal-title":"The Journal of investigative dermatology"},{"key":"10.1016\/j.jid.2022.11.016_bib95","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13148-017-0401-z","article-title":"DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding","volume":"9","author":"Zhu","year":"2017","journal-title":"Clin Epigenetics"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22028469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22028469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:09:27Z","timestamp":1777417767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22028469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":98,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0022202X22028469"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.11.016","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic Variants in Telomerase Reverse Transcriptase Contribute to Solar Lentigines","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}