{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:41:06Z","timestamp":1787668866770,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K08182"],"award-info":[{"award-number":["JP21K08182"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K08476"],"award-info":[{"award-number":["JP21K08476"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jid.2022.12.008","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T14:23:10Z","timestamp":1672237390000},"page":"989-998.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Positive Loop Formed by SOX11 and Periostin Upregulates TGF-\u03b2 Signals Leading to Skin Fibrosis"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4454-6553","authenticated-orcid":false,"given":"Yasuhiro","family":"Nanri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9315-4185","authenticated-orcid":false,"given":"Satoshi","family":"Nunomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-8791","authenticated-orcid":false,"given":"Yuko","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3284-0613","authenticated-orcid":false,"given":"Hironobu","family":"Takedomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-6627","authenticated-orcid":false,"given":"Yukie","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-907X","authenticated-orcid":false,"given":"Kenji","family":"Izuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2022.12.008_bib1","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1093\/rheumatology\/keab168","article-title":"IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGF\u03b2-mediated activation of dermal fibroblasts","volume":"60","author":"Adami","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jid.2022.12.008_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.matbio.2013.02.010","article-title":"Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies","volume":"32","author":"Agarwal","year":"2013","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2022.12.008_bib3","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/biomedicines10010163","article-title":"Systemic sclerosis: from pathophysiology to novel therapeutic approaches","volume":"10","author":"Benfaremo","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jid.2022.12.008_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ncomms1008","article-title":"Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors","volume":"1","author":"Bhattaram","year":"2010","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.12.008_bib5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/cei.13238","article-title":"The immunopathogenesis of fibrosis in systemic sclerosis","volume":"195","author":"Brown","year":"2019","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2022.12.008_bib6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41584-019-0322-7","article-title":"Shared and distinct mechanisms of fibrosis","volume":"15","author":"Distler","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2022.12.008_bib7","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/1529-0131(199907)42:7<1451::AID-ANR19>3.0.CO;2-6","article-title":"Identification of multiple, differentially expressed messenger RNAs in dermal fibroblasts from patients with systemic sclerosis","volume":"42","author":"Feghali","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2022.12.008_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/1523-1747.ep12874503","article-title":"Transcription and expression of transforming growth factor type \u03b2 in the skin of progressive systemic sclerosis: a mediator of fibrosis?","volume":"94","author":"Gruschwitz","year":"1990","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.12.008_bib9","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1007\/s00018-017-2648-0","article-title":"Periostin in inflammation and allergy","volume":"74","author":"Izuhara","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jid.2022.12.008_bib10","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1242\/dev.091793","article-title":"Sox proteins: regulators of cell fate specification and differentiation","volume":"140","author":"Kamachi","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.jid.2022.12.008_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jdermsci.2018.02.001","article-title":"Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-\u03b2 signaling","volume":"90","author":"Kanaoka","year":"2018","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2022.12.008_bib12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.addr.2017.07.014","article-title":"The good and the bad collagens of fibrosis - Their role in signaling and organ function","volume":"121","author":"Karsdal","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jid.2022.12.008_bib13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5021\/ad.2017.29.3.268","article-title":"Periostin in mature stage localized scleroderma","volume":"29","author":"Kim","year":"2017","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jid.2022.12.008_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.trsl.2019.02.010","article-title":"Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis","volume":"209","author":"Korman","year":"2019","journal-title":"Transl Res"},{"key":"10.1016\/j.jid.2022.12.008_bib15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1172\/JCI114793","article-title":"Co-localization of transforming growth factor beta 2 with alpha1(I) procollagen mRNA in tissue\u00a0sections of patients with systemic sclerosis","volume":"86","author":"Kulozik","year":"1990","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.12.008_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92264","article-title":"Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPAR\u03b1-regulated dermatopontin","volume":"2","author":"Lefebvre","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2022.12.008_bib17","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.jid.2017.03.032","article-title":"Blockade of PDGF receptors by crenolanib has therapeutic effect in patient fibroblasts and in preclinical models of systemic sclerosis","volume":"137","author":"Makino","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.12.008_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131597","article-title":"Transcriptional regulatory model of fibrosis progression in the human lung","volume":"4","author":"McDonough","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2022.12.008_bib19","doi-asserted-by":"crossref","first-page":"14646","DOI":"10.1074\/jbc.RA117.001364","article-title":"Hierarchical control of interleukin 13 (IL-13) signals in lung fibroblasts by STAT6 and SOX11","volume":"293","author":"Mitamura","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.12.008_bib20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1165\/rcmb.2019-0245OC","article-title":"Cross-talk between transforming growth factor-\u03b2 and periostin can be targeted for pulmonary fibrosis","volume":"62","author":"Nanri","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jid.2022.12.008_bib21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/bj3370537","article-title":"Dermatopontin interacts with transforming growth factor \u03b2 and enhances its biological activity","volume":"337","author":"Okamoto","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2022.12.008_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/oxfordjournals.jbchem.a021194","article-title":"Extracellular matrix 22-kDa protein interacts with decorin core protein and is expressed in cutaneous fibrosis","volume":"119","author":"Okamoto","year":"1996","journal-title":"J\u00a0Biochem"},{"key":"10.1016\/j.jid.2022.12.008_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.gene.2014.09.026","article-title":"Study of promoter DNA methylation of Sox11 and its correlation with tissue-specific expression in the laboratory mouse","volume":"552","author":"Pamnani","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.jid.2022.12.008_bib24","doi-asserted-by":"crossref","first-page":"R1113","DOI":"10.1186\/ar1790","article-title":"Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis","volume":"7","author":"Rajkumar","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jid.2022.12.008_bib25","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.5152\/eurjrheum.2020.19112","article-title":"Epigenetics and systemic sclerosis: an answer to disease onset and evolution?","volume":"7","author":"Ramahi","year":"2020","journal-title":"Eur J Rheumatol"},{"key":"10.1016\/j.jid.2022.12.008_bib26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/2397198319855872","article-title":"Epigenetics of scleroderma: integrating genetic, ethnic, age, and environmental effects","volume":"4","author":"Ramos","year":"2019","journal-title":"J\u00a0Scleroderma Relat Disord"},{"key":"10.1016\/j.jid.2022.12.008_bib27","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1172\/JCI77958","article-title":"Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients","volume":"125","author":"Rice","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2022.12.008_bib28","first-page":"706","article-title":"COMP-assisted collagen secretion--a novel intracellular function required for fibrosis","volume":"129","author":"Schulz","year":"2016","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2022.12.008_bib29","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1128\/MCB.24.15.6635-6644.2004","article-title":"Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling","volume":"24","author":"Sock","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jid.2022.12.008_bib30","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/art.40455","article-title":"Skin gene expression is prognostic for the trajectory of skin disease in patients with diffuse cutaneous systemic sclerosis","volume":"70","author":"Stifano","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jid.2022.12.008_bib31","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1038\/s41467-021-24607-6","article-title":"Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin","volume":"12","author":"Tabib","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.12.008_bib32","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1046\/j.1523-1747.2002.01863.x","article-title":"Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis","volume":"119","author":"Takeda","year":"2002","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2022.12.008_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5301\/jsrd.5000254","article-title":"Certainties and uncertainties concerning the contribution of pericytes to the pathogenesis of systemic sclerosis","volume":"3","author":"Talotta","year":"2018","journal-title":"J\u00a0Scleroderma Relat Disord"},{"key":"10.1016\/j.jid.2022.12.008_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcancer.2020.06.015","article-title":"Regulatory roles for SOX11 in development, stem cells and cancer","volume":"67","author":"Tsang","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jid.2022.12.008_bib35","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nrrheum.2009.26","article-title":"Transforming growth factor beta as a therapeutic target in systemic sclerosis","volume":"5","author":"Varga","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2022.12.008_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2332\/allergolint.13-RAI-0685","article-title":"Periostin in skin tissue skin-related diseases","volume":"63","author":"Yamaguchi","year":"2014","journal-title":"Allergol Int"},{"key":"10.1016\/j.jid.2022.12.008_bib38","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/bjd.12117","article-title":"Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis","volume":"168","author":"Yamaguchi","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2022.12.008_bib39","article-title":"Periostin facilitates skin sclerosis via PI3K\/Akt dependent mechanism in a mouse model of scleroderma","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2022.12.008_bib40","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.2147\/IJGM.S356877","article-title":"Epigenetic modifications in the pathogenesis of systemic sclerosis","volume":"15","author":"Yu","year":"2022","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.jid.2022.12.008_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ncomms1008","article-title":"Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors","volume":"1","author":"Bhattaram","year":"2010","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2022.12.008_bib42","article-title":"Inter and intraobserver variability of total skin thickness score (Modified Rodnan TSS) in systemic sclerosis","volume":"22","author":"Clements","year":"1995","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jid.2022.12.008_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/art.30159","article-title":"Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension","volume":"63","author":"Hsu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2022.12.008_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.04.050","article-title":"Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids","volume":"132","author":"Kanemitsu","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2022.12.008_bib45","series-title":"Arthritis and allied conditions: a textbook of rheumatology","first-page":"1118e65","article-title":"Systemic sclerosis (scleroderma), localized scleroderma, eosinophilic fasciitis and calcinosis","author":"Medsger","year":"1989"},{"key":"10.1016\/j.jid.2022.12.008_bib46","doi-asserted-by":"crossref","first-page":"14646","DOI":"10.1074\/jbc.RA117.001364","article-title":"Hierarchical control of interleukin 13 (IL-13) signals in lung fibroblasts by STAT6 and SOX11","volume":"293","author":"Mitamura","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2022.12.008_bib47","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.jaci.2021.05.017","article-title":"The FADS mouse: A novel mouse model of atopic keratoconjunctivitis","volume":"148","author":"Nunomura","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2022.12.008_bib48","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 Classification criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"72","author":"Van Den Hoogen","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2022.12.008_bib49","doi-asserted-by":"crossref","DOI":"10.1046\/j.1523-1747.1999.00528.x","article-title":"Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma","volume":"112","author":"Yamamoto","year":"1999","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22029025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X22029025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:52:15Z","timestamp":1762206735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X22029025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0022202X22029025"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2022.12.008","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Positive Loop Formed by SOX11 and Periostin Upregulates TGF-\u03b2 Signals Leading to Skin Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2022.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}