{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:29:08Z","timestamp":1791242948620,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jid.2023.01.012","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T04:55:20Z","timestamp":1674881720000},"page":"1157-1167.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-315X","authenticated-orcid":false,"given":"Alina I.","family":"Marusina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-181X","authenticated-orcid":false,"given":"Antonio","family":"Ji-Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-7010","authenticated-orcid":false,"given":"Stephanie T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-3418","authenticated-orcid":false,"given":"Atrin","family":"Toussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-5722","authenticated-orcid":false,"given":"Lam C.","family":"Tsoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-0583","authenticated-orcid":false,"given":"Guillaume","family":"Luxardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9620-3045","authenticated-orcid":false,"given":"Jordan","family":"Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-0519","authenticated-orcid":false,"given":"Lauren","family":"Downing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-656X","authenticated-orcid":false,"given":"Annie R.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2792-038X","authenticated-orcid":false,"given":"Nikolay Y.","family":"Kuzminykh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-426X","authenticated-orcid":false,"given":"Olga","family":"Kruglinskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-6254","authenticated-orcid":false,"given":"Marie-Charlotte","family":"Br\u00fcggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-2965","authenticated-orcid":false,"given":"Iannis E.","family":"Adamopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-7233","authenticated-orcid":false,"given":"Alexander A.","family":"Merleev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-0812","authenticated-orcid":false,"given":"Johann E.","family":"Gudjonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-6294","authenticated-orcid":false,"given":"Emanual","family":"Maverakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2023.01.012_bib1","first-page":"79","article-title":"KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking","volume":"20","author":"Abdullah","year":"2015","journal-title":"Discov Med"},{"key":"10.1016\/j.jid.2023.01.012_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001157","article-title":"Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation","volume":"6","author":"Andr\u00e9s","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2023.01.012_bib3","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.4049\/jimmunol.2100686","article-title":"ERAP1 controls the autoimmune response against melanocytes in psoriasis by generating the melanocyte autoantigen and regulating its amount for HLA-C\u221706:02 presentation","volume":"207","author":"Arakawa","year":"2021","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2023.01.012_bib4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2023.01.012_bib5","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/jcp.21454","article-title":"Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues","volume":"216","author":"Fruci","year":"2008","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jid.2023.01.012_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ajhg.2018.04.002","article-title":"The post-GWAS era: from association to function","volume":"102","author":"Gallagher","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2023.01.012_bib7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/oxfordjournals.jbchem.a022371","article-title":"Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase\/oxytocinase","volume":"125","author":"Hattori","year":"1999","journal-title":"J\u00a0Biochem"},{"key":"10.1016\/j.jid.2023.01.012_bib8","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1093\/hmg\/ddu307","article-title":"A\u00a0genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy","volume":"23","author":"Kuiper","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2023.01.012_bib24","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.012_bib9","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.3389\/fimmu.2018.02463","article-title":"How ERAP1 and ERAP2 shape the peptidomes of disease-associated MHC-I proteins","volume":"9","author":"L\u00f3pez de Castro","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2023.01.012_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/jid.2012.280","article-title":"Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-c\u221706","volume":"133","author":"Lysell","year":"2013","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.012_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaut.2008.02.004","article-title":"Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide","volume":"31","author":"Maverakis","year":"2008","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jid.2023.01.012_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159762","article-title":"Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes","volume":"7","author":"Merleev","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2023.01.012_bib13","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3389\/fimmu.2020.01576","article-title":"The multifaceted nature of aminopeptidases ERAP1, ERAP2, and LNPEP: from evolution to disease","volume":"11","author":"Paladini","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2023.01.012_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28799-8","article-title":"An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes","volume":"8","author":"Paladini","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2023.01.012_bib15","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20171503","article-title":"The role of polymorphic ERAP1 in autoinflammatory disease","volume":"38","author":"Reeves","year":"2018","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jid.2023.01.012_bib16","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1073\/pnas.1618856114","article-title":"ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations","volume":"114","author":"Roberts","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jid.2023.01.012_bib17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nri1149","article-title":"Mhc-guided processing: binding of large antigen fragments","volume":"3","author":"Sercarz","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2023.01.012_bib23","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jid.2018.12.018","article-title":"Atopic dermatitis is an IL-13-dominant disease with greater molecular heterogeneity compared to psoriasis","volume":"139","author":"Tsoi","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.012_bib18","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.jid.2021.02.764","article-title":"New frontiers in psoriatic disease research, part I: genetics, environmental triggers, immunology, pathophysiology, and precision medicine","volume":"141","author":"Yan","year":"2021","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.012_bib19","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/BJ20102049","article-title":"Probing the S1 specificity pocket of the aminopeptidases\u00a0that generate antigenic peptides","volume":"435","author":"Zervoudi","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2023.01.012_bib27","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.012_bib20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2023.01.012_bib25","author":"Maechler"},{"key":"10.1016\/j.jid.2023.01.012_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.141193","article-title":"Proprotein convertase subtilisin\/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G","volume":"7","author":"Merleev","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2023.01.012_bib26","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jid.2018.12.018","article-title":"Atopic dermatitis is an IL-13-dominant disease with greater molecular heterogeneity compared to psoriasis","volume":"139","author":"Tsoi","year":"2019","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.012_bib22","first-page":"1","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J\u00a0Stat Softw"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23000313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23000313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T22:51:04Z","timestamp":1714776664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X23000313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0022202X23000313"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2023.01.012","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2023.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}