{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:31:46Z","timestamp":1788582706268,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1R21AR081475-01"],"award-info":[{"award-number":["1R21AR081475-01"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jid.2023.01.024","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T20:21:28Z","timestamp":1676578888000},"page":"1724-1734.e15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prediction and Demonstration of Retinoic Acid Receptor Agonist Ch55 as an Antifibrotic Agent in the Dermis"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-4294","authenticated-orcid":false,"given":"David M.","family":"Dolivo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-1070","authenticated-orcid":false,"given":"Adrian E.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-6483","authenticated-orcid":false,"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-1633","authenticated-orcid":false,"given":"Thomas A.","family":"Mustoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-7437","authenticated-orcid":false,"given":"Seok Jong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2023.01.024_bib1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.stem.2020.07.008","article-title":"Distinct regulatory programs control the latent regenerative potential of dermal fibroblasts during wound healing","volume":"27","author":"Abbasi","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jid.2023.01.024_bib2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/archderm.1985.01660050084020","article-title":"Retinoid modulation of connective tissue metabolism in keloid fibroblast cultures","volume":"121","author":"Abergel","year":"1985","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib3","first-page":"521","article-title":"Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts","volume":"127","author":"Al Tanoury","year":"2014","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib4","doi-asserted-by":"crossref","first-page":"587062","DOI":"10.3389\/fonc.2020.587062","article-title":"A\u00a0Phase 1 study of IRX195183, a RAR\u03b1-selective CYP26 resistant retinoid, in patients with relapsed or refractory AML","volume":"10","author":"Ambinder","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.jid.2023.01.024_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/exd.14516","article-title":"Roles of cutaneous cell-cell communication in wound healing outcome: an emphasis on keratinocyte-fibroblast crosstalk","volume":"31","author":"Amiri","year":"2022","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1001\/archderm.1985.01660030028010","article-title":"Isotretinoin therapy for progressive systemic sclerosis","volume":"121","author":"Bahmer","year":"1985","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib7","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1016\/S0960-894X(02)00647-9","article-title":"Synthesis and biological activity of retinoic acid receptor-\u03b1 specific amides","volume":"12","author":"Beard","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jid.2023.01.024_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/jdv.15794","article-title":"Long-term safety and efficacy of trifarotene 50 \u03bcg\/g cream, a first-in-class RAR-\u03b3 selective topical retinoid, in patients with moderate facial and truncal acne","volume":"34","author":"Blume-Peytavi","year":"2020","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2023.01.024_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/bs.pmch.2017.12.003","article-title":"Big data in drug discovery","volume":"57","author":"Brown","year":"2018","journal-title":"Prog Med Chem"},{"key":"10.1016\/j.jid.2023.01.024_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-021-03549-5","article-title":"Cross-tissue organization of the fibroblast lineage","volume":"593","author":"Buechler","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jid.2023.01.024_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj9152","article-title":"Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting","volume":"14","author":"Chen","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2023.01.024_bib12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/biomedicines9030237","article-title":"Trifarotene: a current review and perspectives in dermatology","volume":"9","author":"Cosio","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jid.2023.01.024_bib13","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S0190-9622(86)70248-X","article-title":"Retinoid effects on fibroblast proliferation and collagen synthesis in\u00a0vitro and on fibrotic disease in\u00a0vivo","volume":"15","author":"Daly","year":"1986","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/art.1780360716","article-title":"The synthetic retinoid (4-hydroxyphenyl)retinamide decreases collagen expression in\u00a0vitro and in the tight-skin mouse","volume":"36","author":"Delany","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jid.2023.01.024_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2023.01.008","article-title":"Epidermal potentiation of dermal fibrosis: lessons from occlusion and mucosal healing","author":"Dolivo","year":"2023","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2023.01.024_bib16","first-page":"734","article-title":"Update: mechanisms of topical retinoids in acne","volume":"21","author":"Dreno","year":"2022","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib17","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.jbiomech.2014.03.031","article-title":"Mechanotransduction and fibrosis","volume":"47","author":"Duscher","year":"2014","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.jid.2023.01.024_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/jcs.93.1.155","article-title":"Modulation of melanoma cell adhesion to basement membrane components by retinoic acid","volume":"93","author":"Edward","year":"1989","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/1523-1747.ep12469889","article-title":"Retinoic acid receptor gene expression in human skin","volume":"96","author":"Elder","year":"1991","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib20","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1038\/s41467-020-18042-2","article-title":"Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine","volume":"11","author":"Ferreira","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.01.024_bib21","doi-asserted-by":"crossref","first-page":"20629","DOI":"10.1016\/S0021-9258(17)32039-2","article-title":"Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin","volume":"269","author":"Fisher","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2023.01.024_bib22","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1038\/s41375-020-0790-4","article-title":"Overcoming microenvironment-mediated protection from ATRA using CYP26-resistant retinoids","volume":"34","author":"Hernandez","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.jid.2023.01.024_bib23","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2023.01.024_bib24","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jid.2023.01.024_bib25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2332\/allergolint.54.419","article-title":"Vitamin A derivative etretinate improves bleomycin-induced scleroderma","volume":"54","author":"Ikeda","year":"2005","journal-title":"Allergol Int"},{"key":"10.1016\/j.jid.2023.01.024_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jdermsci.2003.11.007","article-title":"The vitamin A derivative etretinate improves skin sclerosis in patients with systemic sclerosis","volume":"34","author":"Ikeda","year":"2004","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2133.1980.tb07251.x","article-title":"The local treatment of hypertrophic scars and keloids with topical retinoic acid","volume":"103","author":"Janssen de Limpens","year":"1980","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib28","first-page":"3523","article-title":"New benzoic acid derivatives with retinoid activity: lack of direct correlation between biological activity and binding to cellular retinoic acid binding protein","volume":"47","author":"Jetten","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2023.01.024_bib29","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.jid.2016.03.022","article-title":"The aldo-keto reductase AKR1B10 is up-regulated in keloid epidermis, implicating retinoic acid pathway dysregulation in the pathogenesis of keloid disease","volume":"136","author":"Jumper","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib30","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/jocd.13340","article-title":"Selective RAR agonists for acne vulgaris: a narrative review","volume":"19","author":"Kassir","year":"2020","journal-title":"J\u00a0Cosmet Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib31","first-page":"1183","article-title":"Retinoids and butyrate modulate fibroblast growth and contraction of collagen matrices","volume":"31","author":"Kim","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207915","article-title":"Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis","volume":"13","author":"Korfei","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2023.01.024_bib33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/ijms19030711","article-title":"Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.stem.2017.05.019","article-title":"Direct reprogramming of fibroblasts via a chemically induced XEN-like state","volume":"21","author":"Li","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jid.2023.01.024_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ejphar.2017.09.027","article-title":"Homoharringtonine prevents surgery-induced epidural fibrosis through endoplasmic reticulum stress signaling pathway","volume":"815","author":"Li","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jid.2023.01.024_bib36","doi-asserted-by":"crossref","first-page":"W501","DOI":"10.1093\/nar\/gkx372","article-title":"Pathview Web: user friendly pathway visualization and data integration","volume":"45","author":"Luo","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2023.01.024_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.stem.2021.12.011","article-title":"Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing","volume":"29","author":"Mascharak","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jid.2023.01.024_bib38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2133.1989.tb01431.x","article-title":"Isotretinoin in the treatment of systemic sclerosis","volume":"121","author":"Maurice","year":"1989","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib39","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1158\/1078-0432.CCR-09-3277","article-title":"In\u00a0vitro and in\u00a0vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762Radiosensitization","volume":"16","author":"Mitchell","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jid.2023.01.024_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1346-8138.1999.tb03502.x","article-title":"Topical tocoretinate improved hypertrophic scar, skin sclerosis in systemic sclerosis and morphea","volume":"26","author":"Mizutani","year":"1999","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib41","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/art.1780300407","volume":"30","author":"Ohta","year":"1987","journal-title":"Arthritis Rheum Off J Am Coll Rheumatol"},{"key":"10.1016\/j.jid.2023.01.024_bib42","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.227900","article-title":"The myofibroblast at a glance","volume":"133","author":"Pakshir","year":"2020","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1242\/jcs.102.1.113","article-title":"Retinoic acid receptor expression in human skin keratinocytes and dermal fibroblasts in\u00a0vitro","volume":"102","author":"Redfern","year":"1992","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/1523-1747.ep12284435","article-title":"Expression of the \u03b1 and \u03b2 retinoic acid receptors in skin","volume":"93","author":"Rees","year":"1989","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib45","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3389\/fimmu.2020.00648","article-title":"Interplay between keratinocytes and fibroblasts: a systematic review providing a new angle for understanding skin fibrotic disorders","volume":"11","author":"Russo","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2023.01.024_bib46","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/BOR.0000000000000895","article-title":"Contribution of keratinocytes to dermal fibrosis","volume":"34","author":"Russo","year":"2022","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jid.2023.01.024_bib47","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cellsig.2012.10.003","article-title":"TGF-\u03b2 signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities","volume":"25","author":"Samarakoon","year":"2013","journal-title":"Cell Signal"},{"key":"10.1016\/j.jid.2023.01.024_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2016.04.021","article-title":"Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and paxillin","volume":"430","author":"Sanchez","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jid.2023.01.024_bib49","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s40265-019-01218-6","article-title":"Trifarotene: first approval","volume":"79","author":"Scott","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.jid.2023.01.024_bib50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000367707","article-title":"A\u00a0patient with localized scleroderma successfully treated with etretinate","volume":"6","author":"Shima","year":"2014","journal-title":"Case Rep Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib51","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A\u00a0next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.01.024_bib52","first-page":"4931","article-title":"Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells","volume":"57","author":"Sun","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2023.01.024_bib53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13018-020-02150-2","article-title":"Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K\/AKT\/mTOR pathway-mediated apoptosis","volume":"16","author":"Sun","year":"2021","journal-title":"J\u00a0Orthop Surg Res"},{"key":"10.1016\/j.jid.2023.01.024_bib54","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.jaad.2019.02.044","article-title":"Randomized phase 3 evaluation of trifarotene 50 \u03bcg\/g cream treatment of moderate facial and truncal acne","volume":"80","author":"Tan","year":"2019","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib55","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/15419060009109023","article-title":"Differentiation, proliferation and adhesion of human neuroblastoma cells after treatment with retinoic acid","volume":"7","author":"Voigt","year":"2000","journal-title":"Cell Adhes Commun"},{"key":"10.1016\/j.jid.2023.01.024_bib56","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.matbio.2018.02.020","article-title":"Therapeutic approaches to control tissue repair and fibrosis: extracellular matrix as a game changer","volume":"71\u201372","author":"Walraven","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2023.01.024_bib57","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2023.01.024_bib58","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1365-2230.2008.02727.x","article-title":"9-Cis-retinoic acid exhibits antifibrotic activity via the induction of cyclooxygenase-2 expression and prostaglandin E2 production in scleroderma fibroblasts","volume":"33","author":"Xiao","year":"2008","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib59","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1346-8138.2010.00993.x","article-title":"Retinoic acids exhibit anti-fibrotic activity through the inhibition of 5-lipoxygenase expression in scleroderma fibroblasts","volume":"38","author":"Xiao","year":"2011","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41421-018-0034-1","article-title":"Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry","volume":"4","author":"Yang","year":"2018","journal-title":"Cell Discov"},{"key":"10.1016\/j.jid.2023.01.024_bib61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cr.2015.142","article-title":"Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds","volume":"26","author":"Ye","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.jid.2023.01.024_bib62","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2023.01.024_bib63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/ijms14010226","article-title":"The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways","volume":"14","author":"Zhou","year":"2012","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2023.01.024_bib64","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000056361","article-title":"Retinoids\u2013which dermatological indications will benefit in the near future?","volume":"14","author":"Zouboulis","year":"2001","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1016\/j.jid.2023.01.024_bib65","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J\u00a0R Stat Soc B (Methodol)"},{"key":"10.1016\/j.jid.2023.01.024_bib66","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2023.01.024_bib67","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/jocd.15142","article-title":"Simvastatin cream alleviates dermal fibrosis in a rabbit ear hypertrophic scar model","volume":"22","author":"Dolivo","year":"2023","journal-title":"J\u00a0Cosmet Dermatol"},{"key":"10.1016\/j.jid.2023.01.024_bib68","doi-asserted-by":"crossref","first-page":"W395","DOI":"10.1093\/nar\/gkaa434","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2020 update","volume":"48","author":"Jalili","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2023.01.024_bib69","article-title":"Local application of statins significantly reduced hypertrophic scarring in a rabbit ear model","volume":"5","author":"Jia","year":"2017","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"10.1016\/j.jid.2023.01.024_bib70","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2023.01.024_bib71","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2023.01.024_bib72","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2023.01.024_bib73","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2023.01.024_bib74","doi-asserted-by":"crossref","first-page":"W501","DOI":"10.1093\/nar\/gkx372","article-title":"Pathview Web: user friendly pathway visualization and data integration","volume":"45","author":"Luo","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2023.01.024_bib75","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2023.01.024_bib76","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/wrr.12811","article-title":"Liposome-encapsulated statins reduce hypertrophic scarring through topical application","volume":"28","author":"Xie","year":"2020","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2023.01.024_bib77","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23000908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23000908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:52:36Z","timestamp":1762206756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X23000908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":77,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0022202X23000908"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2023.01.024","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction and Demonstration of Retinoic Acid Receptor Agonist Ch55 as an Antifibrotic Agent in the Dermis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2023.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}