{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T21:46:08Z","timestamp":1778363168988,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701579"],"award-info":[{"award-number":["81701579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903230"],"award-info":[{"award-number":["81903230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003369"],"award-info":[{"award-number":["82003369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173430"],"award-info":[{"award-number":["82173430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jid.2023.04.019","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T02:00:25Z","timestamp":1683943225000},"page":"2264-2274.e18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["IL-23\/IL-23R Promote Macrophage Pyroptosis and T Helper 1\/T Helper 17 Cell Differentiation in Mycobacterial Infection"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-8431","authenticated-orcid":false,"given":"Chuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-6117","authenticated-orcid":false,"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-2471","authenticated-orcid":false,"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-3756","authenticated-orcid":false,"given":"Wenchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5511-1352","authenticated-orcid":false,"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-6374","authenticated-orcid":false,"given":"Zihao","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-0745","authenticated-orcid":false,"given":"Xiaotong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-2634","authenticated-orcid":false,"given":"Peidian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4553-2871","authenticated-orcid":false,"given":"Yonghu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-8864","authenticated-orcid":false,"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-5749","authenticated-orcid":false,"given":"Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-7242","authenticated-orcid":false,"given":"Fangfang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8099-9947","authenticated-orcid":false,"given":"Wenjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-0372","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-1973","authenticated-orcid":false,"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2023.04.019_bib1","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1038\/s41467-020-16143-6","article-title":"Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection","volume":"11","author":"Beckwith","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.04.019_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13073-021-00948-1","article-title":"An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration","volume":"13","author":"Brands","year":"2021","journal-title":"Genome Med"},{"key":"10.1016\/j.jid.2023.04.019_bib3","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049414","article-title":"Pyroptosis in host defence against bacterial infection","volume":"15","author":"Brokatzky","year":"2022","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jid.2023.04.019_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/JLB.5HI0720-466R","article-title":"Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19","volume":"110","author":"Corley","year":"2021","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2023.04.019_bib5","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.cell.2021.02.046","article-title":"A\u00a0non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization","volume":"184","author":"Cronan","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.04.019_bib6","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3389\/fimmu.2015.00498","article-title":"IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages","volume":"6","author":"Cruz","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib7","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1172\/JCI134622","article-title":"DNA hypermethylation during tuberculosis dampens host immune responsiveness","volume":"130","author":"DiNardo","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2023.04.019_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101850","article-title":"Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection","volume":"298","author":"Dong","year":"2022","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2023.04.019_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ejcb.2016.06.003","article-title":"DNA methylation in fibrosis","volume":"95","author":"Dowson","year":"2016","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jid.2023.04.019_bib10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41385-021-00381-y","article-title":"Epithelium-autonomous NAIP\/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice","volume":"14","author":"Fattinger","year":"2021","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib11","doi-asserted-by":"crossref","first-page":"e00069","DOI":"10.1128\/CMR.00069-18","article-title":"Cutaneous mycobacterial infections","volume":"32","author":"Franco-Paredes","year":"2018","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jid.2023.04.019_bib12","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/s41467-022-29174-y","article-title":"Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23","volume":"13","author":"Galle-Treger","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.04.019_bib13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","article-title":"Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis","volume":"397","author":"Ghoreschi","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2023.04.019_bib14","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/mi.2012.135","article-title":"Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis","volume":"6","author":"Gopal","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2023.04.019_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.16.1.593","article-title":"The immunogenetics of human infectious diseases","volume":"16","author":"Hill","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0140-6736(98)06322-3","article-title":"Leprosy","volume":"353","author":"Jacobson","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2023.04.019_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.jid.2023.04.019_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/imr.12287","article-title":"Pyroptotic cell death defends against intracellular pathogens","volume":"265","author":"Jorgensen","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2023.04.019_bib20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib21","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.4049\/jimmunol.1101377","article-title":"IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung","volume":"187","author":"Khader","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/imr.12951","article-title":"Host-directed therapy to combat mycobacterial infections","volume":"301","author":"Kilin\u00e7","year":"2021","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jid.2023.04.019_bib23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.07.002","article-title":"Noncanonical inflammasome activation of caspase-4\/caspase-11 mediates epithelial defenses against enteric bacterial pathogens","volume":"16","author":"Knodler","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jid.2023.04.019_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41569-019-0265-3","article-title":"Transcriptional and epigenetic regulation of macrophages in atherosclerosis","volume":"17","author":"Kuznetsova","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jid.2023.04.019_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/978-1-4939-6673-8_20","article-title":"Murine Mycobacterium marinum infection as a model for tuberculosis","volume":"1535","author":"Lienard","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2023.04.019_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng.3212","article-title":"Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy","volume":"47","author":"Liu","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2023.04.019_bib27","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ajhg.2012.09.010","article-title":"Identification of IL18RAP\/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases","volume":"91","author":"Liu","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2023.04.019_bib28","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1016\/j.jid.2017.08.004","article-title":"Genome-wide analysis of protein-coding variants in leprosy","volume":"137","author":"Liu","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.04.019_bib29","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2017.07.030","article-title":"A\u00a0macrophage response to Mycobacterium leprae phenolic glycolipid initiates nerve damage in leprosy","volume":"170","author":"Madigan","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.04.019_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6759","article-title":"Human IFN-\u03b3 immunity to mycobacteria is governed by both IL-12 and IL-23","volume":"3","author":"Mart\u00ednez-Barricarte","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41421-021-00353-3","article-title":"The immune-suppressive landscape in lepromatous leprosy revealed by single-cell RNA sequencing","volume":"8","author":"Mi","year":"2022","journal-title":"Cell Discov"},{"key":"10.1016\/j.jid.2023.04.019_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw082","article-title":"Role of epigenetics in modulation of immune response at the junction of host-pathogen interaction and danger molecule signaling","volume":"74","author":"Morandini","year":"2016","journal-title":"Pathog Dis"},{"key":"10.1016\/j.jid.2023.04.019_bib33","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","article-title":"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12","volume":"13","author":"Oppmann","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2023.04.019_bib34","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1101\/gr.192005.115","article-title":"Bacterial infection remodels the DNA methylation landscape of human dendritic cells","volume":"25","author":"Pacis","year":"2015","journal-title":"Genome Res"},{"key":"10.1016\/j.jid.2023.04.019_bib35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/ACI.0000000000000130","article-title":"DNA methylation, bacteria and airway inflammation: latest insights","volume":"15","author":"P\u00e9rez-Novo","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba4733","article-title":"Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1\u03b2 immune pathway","volume":"6","author":"Qu","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.jid.2023.04.019_bib37","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2016.03.046","article-title":"Inflammasome complexes: emerging mechanisms and effector functions","volume":"165","author":"Rathinam","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.04.019_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105511","article-title":"Different cell death mechanisms are involved in leprosy pathogenesis","volume":"166","author":"Rodrigues de Sousa","year":"2022","journal-title":"Microb Pathog"},{"key":"10.1016\/j.jid.2023.04.019_bib39","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nature06421","article-title":"Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis","volume":"450","author":"Sanjuan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jid.2023.04.019_bib40","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/01902148.2021.1962433","article-title":"IL23R on myeloid cells is involved in murine pulmonary granuloma formation","volume":"47","author":"Schreiber","year":"2021","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.jid.2023.04.019_bib41","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/1440-1681.13689","article-title":"Elevated IL-23 in skin promotes IL-23 derived Th17 responses in leprosy patients","volume":"49","author":"Shi","year":"2022","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jid.2023.04.019_bib42","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI112930","article-title":"Genetic epidemiology of the susceptibility to leprosy","volume":"79","author":"Shields","year":"1987","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2023.04.019_bib43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/gutjnl-2020-323636","article-title":"Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence","volume":"71","author":"Spalinger","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jid.2023.04.019_bib44","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1101\/gr.075069.107","article-title":"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis","volume":"18","author":"Stinear","year":"2008","journal-title":"Genome Res"},{"key":"10.1016\/j.jid.2023.04.019_bib45","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/imm.13402","article-title":"The IL-23\/IL-17 axis promotes the formation of retinal neovascularization by activating the NLRP3 inflammasome in macrophages in an experimental retinopathy mouse model","volume":"164","author":"Sui","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2023.04.019_bib46","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jcmgh.2020.05.007","article-title":"IL23 promotes antimicrobial pathways in human macrophages, which are reduced with the IBD-protective IL23R R381Q variant","volume":"10","author":"Sun","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jid.2023.04.019_bib47","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/gutjnl-2018-316830","article-title":"IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes","volume":"69","author":"Sun","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jid.2023.04.019_bib48","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/15548627.2017.1320636","article-title":"IL17A augments autophagy in Mycobacterium tuberculosis-infected monocytes from patients with active tuberculosis in association with the severity of the disease","volume":"13","author":"Tateosian","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.jid.2023.04.019_bib49","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1093\/bioinformatics\/btx513","article-title":"ChAMP: updated methylation analysis pipeline for Illumina BeadChips","volume":"33","author":"Tian","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2023.04.019_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.lfs.2019.04.031","article-title":"NLRP3 inflammasome activates interleukin-23\/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice","volume":"227","author":"Wang","year":"2019","journal-title":"Life Sci"},{"key":"10.1016\/j.jid.2023.04.019_bib51","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ng.973","article-title":"Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy","volume":"43","author":"Zhang","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2023.04.019_bib52","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1056\/NEJMoa0903753","article-title":"Genomewide association study of leprosy","volume":"361","author":"Zhang","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2023.04.019_bib53","article-title":"Pyroptosis: a new frontier in kidney diseases","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jid.2023.04.019_bib54","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41577-019-0151-6","article-title":"Epigenetic regulation of the innate immune response to infection","volume":"19","author":"Zhang","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib55","first-page":"e22","article-title":"Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes","volume":"45","author":"Zhou","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2023.04.019_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714943","article-title":"Janus kinase inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition","volume":"12","author":"Zhu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2023.04.019_bib57","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.3748\/wjg.14.3650","article-title":"Partial overlap of anti-mycobacterial, and anti-Saccharomyces cerevisiae mannan antibodies in Crohn's disease","volume":"14","author":"M\u00fcller","year":"2008","journal-title":"World J Gastroenterol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23020626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23020626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:53:46Z","timestamp":1762206826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X23020626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0022202X23020626"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2023.04.019","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-23\/IL-23R Promote Macrophage Pyroptosis and T Helper 1\/T Helper 17 Cell Differentiation in Mycobacterial Infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2023.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}