{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:53:35Z","timestamp":1773719615352,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972938"],"award-info":[{"award-number":["81972938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273541"],"award-info":[{"award-number":["82273541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jid.2023.04.035","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T11:04:35Z","timestamp":1688123075000},"page":"2366-2377.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["FOXE1 Contributes to the Development of Psoriasis by Regulating WNT5A"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9920-5599","authenticated-orcid":false,"given":"Meng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-0519","authenticated-orcid":false,"given":"Guanfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9481-7625","authenticated-orcid":false,"given":"Ziyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-2766","authenticated-orcid":false,"given":"Xinyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-6678","authenticated-orcid":false,"given":"Ke","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-0301","authenticated-orcid":false,"given":"Ruiting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-7152","authenticated-orcid":false,"given":"Qiqi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-7521","authenticated-orcid":false,"given":"Ruimin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-0086","authenticated-orcid":false,"given":"Yuqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-3211","authenticated-orcid":false,"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-1070","authenticated-orcid":false,"given":"Yongping","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2023.04.035_bib1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/cancers8090079","article-title":"Wnt5a signaling in cancer","volume":"8","author":"Asem","year":"2016","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jid.2023.04.035_bib2","article-title":"The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis","volume":"2014","author":"Batycka-Baran","year":"2014","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.jid.2023.04.035_bib3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2023.04.035_bib4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1006\/geno.1997.4692","article-title":"FKHL15, a new human member of the forkhead gene family located on chromosome 9q22","volume":"41","author":"Chadwick","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/j.jid.2023.04.035_bib5","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1038\/s41598-018-26996-z","article-title":"C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes","volume":"8","author":"Chen","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2023.04.035_bib6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/364412a0","article-title":"Co-crystal structure of the HNF-3\/fork head DNA-recognition motif resembles histone H5","volume":"364","author":"Clark","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jid.2023.04.035_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/1294","article-title":"Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia","volume":"19","author":"Clifton-Bligh","year":"1998","journal-title":"Nat Genet"},{"issue":"Suppl 1","key":"10.1016\/j.jid.2023.04.035_bib8","first-page":"46","article-title":"The histopathology of psoriasis","volume":"59","author":"De Rosa","year":"2007","journal-title":"Reumatismo"},{"key":"10.1016\/j.jid.2023.04.035_bib9","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.0022-202X.2004.22505.x","article-title":"FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma","volume":"122","author":"Eichberger","year":"2004","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-1050-2_3","article-title":"Tissue processing and hematoxylin and eosin staining","volume":"1180","author":"Feldman","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2023.04.035_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062849","article-title":"New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells","volume":"8","author":"Fern\u00e1ndez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2023.04.035_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrendo.2014.186","article-title":"Thyroid transcription factors in development, differentiation and disease","volume":"11","author":"Fern\u00e1ndez","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jid.2023.04.035_bib13","volume":"2","author":"Greb","year":"2016","journal-title":"Psoriasis. Nat Rev Dis Primers"},{"key":"10.1016\/j.jid.2023.04.035_bib14","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.4049\/jimmunol.0902464","article-title":"Skin inflammation induced by the synergistic action of IL-17A, IL-22, oncostatin M, IL-1{alpha}, and TNF-{alpha} recapitulates some features of psoriasis","volume":"184","author":"Guilloteau","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2023.04.035_bib15","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2023.04.035_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/cpr.12168","article-title":"IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes","volume":"48","author":"Hsieh","year":"2015","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jid.2023.04.035_bib17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3803\/EnM.2018.33.2.175","article-title":"Genome-wide association studies of autoimmune thyroid diseases, thyroid function, and thyroid cancer","volume":"33","author":"Hwangbo","year":"2018","journal-title":"Endocrinol Metab (Seoul)"},{"key":"10.1016\/j.jid.2023.04.035_bib18","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jid.2016.02.005","article-title":"Yes-associated protein contributes to the development of human cutaneous squamous cell carcinoma via activation of RAS","volume":"136","author":"Jia","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2133.2004.06304.x","article-title":"The mitogen-activated protein kinases p38 and ERK1\/2 are increased in lesional psoriatic skin","volume":"152","author":"Johansen","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jaad.2018.06.057","article-title":"Psoriasis: which therapy for which patient: psoriasis comorbidities and preferred systemic agents","volume":"80","author":"Kaushik","year":"2019","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2023.04.035_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0168-9525(03)00111-2","article-title":"Fox's in development and disease","volume":"19","author":"Lehmann","year":"2003","journal-title":"Trends Genet"},{"key":"10.1016\/j.jid.2023.04.035_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41419-020-03377-x","article-title":"Wnt5a promotes renal tubular inflammation in diabetic nephropathy by binding to CD146 through noncanonical Wnt signaling","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2023.04.035_bib24","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.7150\/ijbs.40535","article-title":"Wnt5a\/CaMKII\/ERK\/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression","volume":"16","author":"Liu","year":"2020","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jid.2023.04.035_bib25","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.jid.2017.03.019","article-title":"TWEAK\/Fn14 activation contributes to the pathogenesis of bullous pemphigoid","volume":"137","author":"Liu","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib26","doi-asserted-by":"crossref","first-page":"17739","DOI":"10.1002\/jcp.28399","article-title":"FOXE1 supports the tumor promotion of Gli2 on papillary thyroid carcinoma by the Wnt\/beta-catenin pathway","volume":"234","author":"Ma","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jid.2023.04.035_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.663683","article-title":"SFRP5 enhances Wnt5a induced-inflammation in rheumatoid arthritis fibroblast-like synoviocytes","volume":"12","author":"Mahmoud","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2023.04.035_bib28","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra0804595","volume":"361","author":"Nestle","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jid.2023.04.035_bib29","doi-asserted-by":"crossref","first-page":"15213","DOI":"10.1074\/jbc.274.21.15213","article-title":"The interaction between the forkhead thyroid transcription factor TTF-2 and the constitutive factor CTF\/NF-1 is required for efficient hormonal regulation of\u00a0the thyroperoxidase gene transcription","volume":"274","author":"Ortiz","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2023.04.035_bib30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1684\/ejd.2014.2299","article-title":"Psoriasis beyond the skin: a review of the literature on cardiometabolic and psychological co-morbidities of psoriasis","volume":"24","author":"Puig","year":"2014","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.jid.5700488","article-title":"Increased expression of Wnt5a in psoriatic plaques","volume":"127","author":"Reischl","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/exd.13860","article-title":"Isolation and culture of human primary keratinocytes-a methods review","volume":"28","author":"\u015acie\u017cy\u0144ska","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4062\/biomolther.2012.20.2.171","article-title":"HaCaT keratinocytes and primary epidermal keratinocytes have different transcriptional profiles of cornified envelope-associated genes to T helper cell cytokines","volume":"20","author":"Seo","year":"2012","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.jid.2023.04.035_bib34","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1245\/s10434-016-5289-x","article-title":"Aberrant methylation of FOXE1 contributes to a poor prognosis for patients with colorectal cancer","volume":"23","author":"Sugimachi","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jid.2023.04.035_bib35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13073-017-0415-3","article-title":"Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis","volume":"9","author":"Swindell","year":"2017","journal-title":"Genome Med"},{"key":"10.1016\/j.jid.2023.04.035_bib36","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1365-2133.2009.09560.x","article-title":"FOXE1 is a target for aberrant methylation in cutaneous squamous cell carcinoma","volume":"162","author":"Venza","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2023.04.035_bib37","doi-asserted-by":"crossref","first-page":"7184","DOI":"10.1038\/ncomms8184","article-title":"Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression","volume":"6","author":"Xu","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.04.035_bib38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.yexmp.2007.05.002","article-title":"Expression and localization of the activated mitogen-activated protein kinase in lesional psoriatic skin","volume":"83","author":"Yu","year":"2007","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.jid.2023.04.035_bib39","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1093\/emboj\/16.11.3185","article-title":"TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation","volume":"16","author":"Zannini","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2023.04.035_bib40","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/hep.27491","article-title":"Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1\/Q1\/E1 regulates hepatocellular carcinoma tumor growth and metastasis","volume":"61","author":"Zhang","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jid.2023.04.035_bib41","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1159\/000430158","article-title":"Wnt\/beta-catenin and\u00a0Wnt5a\/Ca pathways regulate proliferation and apoptosis of keratinocytes in psoriasis lesions","volume":"36","author":"Zhang","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jid.2023.04.035_bib42","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s41419-021-04152-2","article-title":"Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload","volume":"12","author":"Zou","year":"2021","journal-title":"Cell Death Dis"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23023990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23023990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:32:16Z","timestamp":1758303136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X23023990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0022202X23023990"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2023.04.035","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FOXE1 Contributes to the Development of Psoriasis by Regulating WNT5A","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2023.04.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}