{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:16:57Z","timestamp":1777666617657,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B6005644"],"award-info":[{"award-number":["2018R1C1B6005644"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jid.2023.07.029","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:25:28Z","timestamp":1697628328000},"page":"612-620.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cav3.2 T-Type Calcium Channel Mediates Acute Itch and Contributes to Chronic Itch and Inflammation in Experimental Atopic Dermatitis"],"prefix":"10.1016","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6951-5422","authenticated-orcid":false,"given":"Ji-Woong","family":"Ahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-7310","authenticated-orcid":false,"given":"Song-Ee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-9854","authenticated-orcid":false,"given":"Do-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7458-1464","authenticated-orcid":false,"given":"Inhye","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-3411","authenticated-orcid":false,"given":"Sohyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3119-9628","authenticated-orcid":false,"given":"Seungsoo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-9955","authenticated-orcid":false,"given":"Sang Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2023.07.029_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ceca.2006.09.002","article-title":"Calcium microdomains: organization and function","volume":"40","author":"Berridge","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jid.2023.07.029_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7600515","article-title":"Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception","volume":"24","author":"Bourinet","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2023.07.029_bib3","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41583-021-00526-9","article-title":"A\u00a0neuropeptide code for itch","volume":"22","author":"Chen","year":"2021","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jid.2023.07.029_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1601-183X.2006.00268.x","article-title":"Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels","volume":"6","author":"Choi","year":"2007","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.jid.2023.07.029_bib5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2018.03.023","article-title":"Peripheral and central mechanisms of itch","volume":"98","author":"Dong","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jid.2023.07.029_bib6","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1038\/s41467-022-29725-3","article-title":"Cav\u03b21 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function","volume":"13","author":"Erdogmus","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.07.029_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pain.2012.10.023","article-title":"State-dependent properties of a new T-type calcium channel blocker enhance Ca(V)3.2 selectivity and support analgesic effects","volume":"154","author":"Francois","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.jid.2023.07.029_bib8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.celrep.2014.12.042","article-title":"The low-threshold calcium channel Cav3.2 determines low-threshold mechanoreceptor function","volume":"10","author":"Fran\u00e7ois","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2023.07.029_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13041-020-00663-9","article-title":"Cav3.2 T-type calcium channels control acute itch in mice","volume":"13","author":"Gadotti","year":"2020","journal-title":"Mol Brain"},{"key":"10.1016\/j.jid.2023.07.029_bib10","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1152\/jn.01031.2007","article-title":"Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve","volume":"99","author":"Jagodic","year":"2008","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.jid.2023.07.029_bib11","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1523\/JNEUROSCI.4866-06.2007","article-title":"Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons","volume":"27","author":"Jagodic","year":"2007","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2023.07.029_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.alit.2016.10.003","article-title":"The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin","volume":"66","author":"Kittaka","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.jid.2023.07.029_bib13","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/s41598-020-59092-2","article-title":"Complementary roles of murine Nav1.7, Nav1. 8 and Nav1. 9 in acute itch signalling","volume":"10","author":"K\u00fchn","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2023.07.029_bib14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.cell.2014.03.064","article-title":"A\u00a0monoclonal antibody that targets a NaV1. 7 channel voltage sensor for pain and itch relief [published retraction appears in Cell 2020;181:1695]","volume":"157","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.07.029_bib15","doi-asserted-by":"crossref","first-page":"11736","DOI":"10.1073\/pnas.0604575103","article-title":"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis","volume":"103","author":"Li","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2023.07.029_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/j.pain.0000000000000774","article-title":"Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy","volume":"158","author":"Li","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.jid.2023.07.029_bib17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.bbrc.2017.04.127","article-title":"T-type calcium channels, but not Cav3.2, in the peripheral sensory afferents are involved in acute itch in mice","volume":"487","author":"Lin","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2023.07.029_bib18","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.1073\/pnas.1100869108","article-title":"T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome","volume":"108","author":"Marger","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2023.07.029_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-3565(24)38902-5","article-title":"Mibefradil block of cloned T-type calcium channels","volume":"295","author":"Martin","year":"2000","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jid.2023.07.029_bib20","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/exd.14014","article-title":"Interaction of peripheral nerves and mast cells, eosinophils, and basophils in the development of pruritus","volume":"28","author":"Nakashima","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2023.07.029_bib21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.neuron.2008.08.019","article-title":"Multiple roles of calcium ions in the regulation of neurotransmitter release","volume":"59","author":"Neher","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.jid.2023.07.029_bib22","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1523\/JNEUROSCI.2527-05.2005","article-title":"The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors","volume":"25","author":"Nelson","year":"2005","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2023.07.029_bib23","doi-asserted-by":"crossref","first-page":"12577","DOI":"10.1523\/JNEUROSCI.2206-07.2007","article-title":"Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate","volume":"27","author":"Nelson","year":"2007","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jid.2023.07.029_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","article-title":"Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.07.029_bib25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuron.2019.06.016","article-title":"Identification of a spinal circuit for mechanical and persistent spontaneous itch","volume":"103","author":"Pan","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.jid.2023.07.029_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuroscience.2013.07.005","article-title":"Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse","volume":"250","author":"Rose","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jid.2023.07.029_bib27","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/exd.14143","article-title":"New insights into the mechanisms behind mechanical itch","volume":"29","author":"Sakai","year":"2020","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2023.07.029_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","article-title":"Neuronal voltage-gated calcium channels: structure, function, and dysfunction","volume":"82","author":"Simms","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jid.2023.07.029_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jid.2023.07.029_bib30","article-title":"Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice [published correction appears in Sci Rep 2017;7:46906","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2023.07.029_bib31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular architecture of the mouse nervous system","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.07.029_bib32","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1113\/expphysiol.2011.059444","article-title":"Intracellular acidification evoked by moderate extracellular acidosis attenuates transient receptor potential V1 (TRPV1) channel activity in rat dorsal root ganglion neurons","volume":"96","author":"Chung","year":"2011","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jid.2023.07.029_bib33","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.jid.2018.09.038","article-title":"A\u00a0homozygous nonsense mutation in the DSG3 gene causes acantholytic blisters in the oral and laryngeal mucosa","volume":"139","author":"Kim","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.07.029_bib34","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00006123-199803000-00054","article-title":"Isolation and long-term survival of adult human sensory neurons in\u00a0vitro","volume":"42","author":"Sosa","year":"1998","journal-title":"Neurosurgery"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23029196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23029196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:43:32Z","timestamp":1777448612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X23029196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0022202X23029196"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2023.07.029","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cav3.2 T-Type Calcium Channel Mediates Acute Itch and Contributes to Chronic Itch and Inflammation in Experimental Atopic Dermatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2023.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}