{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:54:18Z","timestamp":1790830458460,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jid.2023.09.287","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T10:07:15Z","timestamp":1700215635000},"page":"1099-1111.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dengue Virus Infects Human Skin Langerhans Cells through Langerin for Dissemination to Dendritic Cells"],"prefix":"10.1016","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1200-2225","authenticated-orcid":false,"given":"Leanne C.","family":"Helgers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8032-3701","authenticated-orcid":false,"given":"Nadia C.H.","family":"Keijzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-9441","authenticated-orcid":false,"given":"John L.","family":"van Hamme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-0028","authenticated-orcid":false,"given":"Joris K.","family":"Sprokholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-2839","authenticated-orcid":false,"given":"Teunis B.H.","family":"Geijtenbeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2023.09.287_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2023.09.287_bib2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jcv.2018.08.007","article-title":"Ongoing and emerging arbovirus threats in Europe","volume":"107","author":"Barzon","year":"2018","journal-title":"J\u00a0Clin Virol"},{"key":"10.1016\/j.jid.2023.09.287_bib3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jid.2023.09.287_bib4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1189\/jlb.1HI0714-351R","article-title":"Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells","volume":"97","author":"Bigley","year":"2015","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2023.09.287_bib5","doi-asserted-by":"crossref","first-page":"13325","DOI":"10.1128\/JVI.01568-07","article-title":"Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in\u00a0vitro","volume":"81","author":"Blackley","year":"2007","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jid.2023.09.287_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004548","article-title":"Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection","volume":"10","author":"Cerny","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2023.09.287_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-60761-421-0_4","article-title":"Isolation of immature primary Langerhans cells from human epidermal skin","volume":"595","author":"de Jong","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2023.09.287_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nm1541","article-title":"Langerin is a natural barrier to HIV-1 transmission by Langerhans cells","volume":"13","author":"De Witte","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2023.09.287_bib9","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jid.2017.10.018","article-title":"Interplay between keratinocytes and myeloid cells drives dengue virus spread in human skin","volume":"138","author":"Duangkhae","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.09.287_bib10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/intimm\/dxh088","article-title":"Expression of C-type lectin receptors by subsets of dendritic cells in human skin","volume":"16","author":"Ebner","year":"2004","journal-title":"Int Immunol"},{"key":"10.1016\/j.jid.2023.09.287_bib11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nri723","article-title":"C-type lectin receptors on dendritic cells and Langerhans cells","volume":"2","author":"Figdor","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2023.09.287_bib12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80694-7","article-title":"DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.09.287_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jmv.21051","article-title":"Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells","volume":"80","author":"Kou","year":"2008","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.jid.2023.09.287_bib14","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1128\/JCM.43.7.3267-3272.2005","article-title":"Flow cytometry-based assay for titrating dengue virus","volume":"43","author":"Lambeth","year":"2005","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jid.2023.09.287_bib15","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1084\/jem.172.5.1483","article-title":"Migration and maturation of langerhans cells in skin transplants and explants","volume":"172","author":"Larsen","year":"1990","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2023.09.287_bib16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.virol.2008.02.016","article-title":"Autophagic machinery activated by dengue virus enhances virus replication","volume":"374","author":"Lee","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.jid.2023.09.287_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.0959-9673.2005.00445.x","article-title":"Dengue virus inoculation to human skin explants: an effective approach to assess in situ the early infection and the effects on cutaneous dendritic cells","volume":"86","author":"Limon-Flores","year":"2005","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.jid.2023.09.287_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-202x.2001.00037.x","article-title":"Human dendritic cells as targets of dengue virus infection","volume":"6","author":"Marovich","year":"2001","journal-title":"J\u00a0Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jid.2023.09.287_bib19","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: an integrated view","volume":"22","author":"Martina","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jid.2023.09.287_bib20","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1371\/journal.ppat.0040017","article-title":"The mannose receptor mediates dengue virus infection of macrophages","volume":"4","author":"Miller","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2023.09.287_bib21","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.4049\/jimmunol.1501304","article-title":"Functional Langerinhigh-expressing Langerhans-like Cells Can Arise from CD14 high CD16\u00a0\u2212 human Blood monocytes in Serum-Free Condition","volume":"196","author":"Picarda","year":"2016","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2023.09.287_bib22","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature20567","article-title":"Receptor usage dictates HIV-1 restriction by human TRIM5\u03b1 in dendritic cell subsets","volume":"540","author":"Ribeiro","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jid.2023.09.287_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2180-7-9","article-title":"Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes","volume":"7","author":"Salazar","year":"2007","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jid.2023.09.287_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000632","article-title":"Dengue virus capsid protein usurps lipid droplets for viral particle formation","volume":"5","author":"Samsa","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2023.09.287_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-4690-11-52","article-title":"Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission","volume":"11","author":"Sarrami-Forooshani","year":"2014","journal-title":"Retrovirology"},{"key":"10.1016\/j.jid.2023.09.287_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF02867407","article-title":"Molecular mechanism of pathogenesis of dengue virus: entry and fusion with target cell","volume":"20","author":"Seema","year":"2005","journal-title":"Indian J Clin Biochem"},{"key":"10.1016\/j.jid.2023.09.287_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/glycob\/cwg045","article-title":"Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells","volume":"13","author":"Stambach","year":"2003","journal-title":"Glycobiology"},{"key":"10.1016\/j.jid.2023.09.287_bib28","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1371\/journal.ppat.0030132","article-title":"Mosquitoes inoculate high doses of West Nile virus as they probe and feed on live hosts","volume":"3","author":"Styer","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2023.09.287_bib29","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.meegid.2011.06.009","article-title":"Dengue virus replication in infected human keratinocytes leads to activation of antiviral innate immune responses","volume":"11","author":"Surasombatpattana","year":"2011","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.jid.2023.09.287_bib30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells","volume":"197","author":"Tassaneetrithep","year":"2003","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jid.2023.09.287_bib31","first-page":"664","article-title":"In\u00a0vivo and in\u00a0vitro studies on the morphological change in the monkey epidermal Langerhans cells following exposure to dengue 2 (16681) virus","volume":"27","author":"Taweechaisupapong","year":"1996","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.jid.2023.09.287_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1099\/00222615-45-2-138","article-title":"Langerhans cell density and serological changes following intradermal immunisation of mice with dengue 2 virus","volume":"45","author":"Taweechaisupapong","year":"1996","journal-title":"J\u00a0Med Microbiol"},{"key":"10.1016\/j.jid.2023.09.287_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.antiviral.2013.05.011","article-title":"Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication","volume":"99","author":"van Cleef","year":"2013","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jid.2023.09.287_bib34","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.4049\/jimmunol.1402356","article-title":"Langerhans cell-dendritic cell cross-talk via langerin and hyaluronic acid mediates antigen transfer and cross-presentation of HIV-1","volume":"195","author":"van den Berg","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2023.09.287_bib35","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117589119","article-title":"Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host","volume":"119","author":"Wei Xiang","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2023.09.287_bib36","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/77553","article-title":"Human skin Langerhans cells are targets of dengue virus infection","volume":"6","author":"Wu","year":"2000","journal-title":"Nat Med"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23030567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X23030567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T10:58:59Z","timestamp":1729162739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X23030567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0022202X23030567"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2023.09.287","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dengue Virus Infects Human Skin Langerhans Cells through Langerin for Dissemination to Dendritic Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2023.09.287","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}